Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 127 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Mitochondrial sodium/calcium exchanger protein

Gene

ncx-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC-dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit (PubMed:28196860).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the sodium/calcium exchanger inhibitor CGP-37157.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Sensory transduction, Sodium transport, Transport
LigandCalcium, Sodium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.19.4.14, the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial sodium/calcium exchanger proteinCurated
Alternative name(s):
Sodium/calcium exchanger 91 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ncx-91 PublicationImported
ORF Names:C13D9.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
C13D9.8 ; CE52885 ; WBGene00003574 ; ncx-9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini? – 50ExtracellularCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 91CytoplasmicCuratedAdd BLAST20
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 126ExtracellularCuratedAdd BLAST14
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 161CytoplasmicCuratedAdd BLAST14
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183ExtracellularCurated1
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 398CytoplasmicCuratedAdd BLAST194
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 428ExtracellularCurated9
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 458CytoplasmicCurated9
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Topological domaini480 – 486ExtracellularCurated7
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 510CytoplasmicCurated3
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Topological domaini532 – 559ExtracellularCuratedAdd BLAST28
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 595CytoplasmicCuratedAdd BLAST15
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Topological domaini617 – 626ExtracellularCurated10
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 651CytoplasmicCurated4

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi205G → E in gk-773708; development defects in stereotyped left/right axon guidance choices within the GABAergic motor neuron circuit. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionCurated
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000440955? – 651Mitochondrial sodium/calcium exchanger protein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O16242

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the seam cells of the organism. Expression is visible in the seam cells across all larval stages, and expression persists into the adult stage of the organism.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003574, Expressed in adult organism and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C13D9.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2399, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000196478

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004979_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O16242

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDEERPP

Database of Orthologous Groups

More...
OrthoDBi
478735at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O16242

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004837, NaCa_Exmemb

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01699, Na_Ca_ex, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O16242-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSSEECLID KSWTSEEKCE YIKCNQDSCE GGGYLTWSHY VKCQYNIGVR
60 70 80 90 100
VILIILGILY LIILFVIMSS IADDFFCPAI SGIVSHLRMS ESIAGVTFLA
110 120 130 140 150
FGNGAPDVFS SISSVLTTPK PKADLALGDL FGTSIFVTTV VLAIIIFTKS
160 170 180 190 200
FKVAIIPTLR DLIFYMTTLA FIVFCFLKFD KIEVWMPATF LGIYGVYVVT
210 220 230 240 250
VIILGIYRTH RKKRNLKKKN KELEDFLSRP SSAASTTPIF GAMKLKEETI
260 270 280 290 300
SVSALFHFMI GYSQFIKNLT RANLKRTTNN NNNDNKNEKR GIVNLGFSEP
310 320 330 340 350
YSIPSERKIS TIFKQNTFET DLESLESLAD LDGSDDEGRE EKFGYAHHTV
360 370 380 390 400
FTSHDQISLV ASEIEEIEIT TWRSWDWVWD LFNHLKSWPS RDEFSEMNIF
410 420 430 440 450
IKIVTVIKVV PVFFFKLTVP SNEMSWCKPL FILHCFASIQ FALFSIQIIT
460 470 480 490 500
LKPFDGSPGL WLYGLGFSAI LAMVAMYFLP LSKEQKYYKE IYSYLGFLMS
510 520 530 540 550
IAWIYATSNE IVSVVTMIGV VTGLSMELLG LTIMAWSNCI GDIVADIAVV
560 570 580 590 600
KQGYPKMAMA AAIGGPLFNL LIGFGLPFTI AAAQGKEMEL LINPVYRLLM
610 620 630 640 650
LFLGISLVTT FVALFIQRFT VRRPHAVLLI FIFVVFLIFI CLAEFHVLEW

N
Length:651
Mass (Da):73,508
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29CED65FDA0221AD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD64394.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T03889

NCBI Reference Sequences

More...
RefSeqi
NP_504342.1, NM_071941.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C13D9.8.1; C13D9.8.1; WBGene00003574

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
182576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C13D9.8

UCSC genome browser

More...
UCSCi
C13D9.8, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD64394.1
PIRiT03889
RefSeqiNP_504342.1, NM_071941.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C13D9.8

Protein family/group databases

TCDBi2.A.19.4.14, the ca(2+):cation antiporter (caca) family

Proteomic databases

PaxDbiO16242

Genome annotation databases

EnsemblMetazoaiC13D9.8.1; C13D9.8.1; WBGene00003574
GeneIDi182576
KEGGicel:CELE_C13D9.8
UCSCiC13D9.8, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
182576
WormBaseiC13D9.8 ; CE52885 ; WBGene00003574 ; ncx-9

Phylogenomic databases

eggNOGiKOG2399, Eukaryota
GeneTreeiENSGT00970000196478
HOGENOMiCLU_004979_3_1_1
InParanoidiO16242
OMAiHDEERPP
OrthoDBi478735at2759
PhylomeDBiO16242

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O16242

Gene expression databases

BgeeiWBGene00003574, Expressed in adult organism and 2 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR004837, NaCa_Exmemb
PfamiView protein in Pfam
PF01699, Na_Ca_ex, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCX9_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O16242
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again