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Protein

Chromodomain-helicase-DNA-binding protein 3

Gene

Chd3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possible transcription activator.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 82PHD-typePROSITE-ProRule annotationAdd BLAST48
Nucleotide bindingi292 – 299ATPPROSITE-ProRule annotationCurated8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: FlyBase
  • helicase activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW
  • nucleosome binding Source: FlyBase
  • nucleosome-dependent ATPase activity Source: FlyBase

GO - Biological processi

  • chromatin assembly or disassembly Source: UniProtKB
  • nucleosome mobilization Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-3214815 HDACs deacetylate histones
R-DME-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 3 (EC:3.6.4.12)
Alternative name(s):
ATP-dependent helicase Chd3
Gene namesi
Name:Chd3
ORF Names:CG9594
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0023395 Chd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802351 – 892Chromodomain-helicase-DNA-binding protein 3Add BLAST892

Proteomic databases

PaxDbiO16102
PRIDEiO16102

Expressioni

Gene expression databases

BgeeiFBgn0023395
ExpressionAtlasiO16102 baseline and differential
GenevisibleiO16102 DM

Interactioni

Protein-protein interaction databases

BioGridi65382, 2 interactors
DIPiDIP-21327N
IntActiO16102, 1 interactor
STRINGi7227.FBpp0074766

Structurei

3D structure databases

ProteinModelPortaliO16102
SMRiO16102
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 156Chromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini179 – 240Chromo 2PROSITE-ProRule annotationAdd BLAST62
Domaini279 – 458Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST180
Domaini590 – 739Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi409 – 412DEAH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 82PHD-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0383 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00760000119067
InParanoidiO16102
KOiK11643
OMAiLELWAPE
OrthoDBiEOG091G00G4
PhylomeDBiO16102

Family and domain databases

CDDicd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit
Gene3Di3.30.40.10, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR009463 DUF1087
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR019786 Zinc_finger_PHD-type_CS
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00385 Chromo, 2 hits
PF06465 DUF1087, 1 hit
PF00271 Helicase_C, 1 hit
PF00628 PHD, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O16102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKRGADPD WKTPGKASKD KRPKTNAKKQ KFRDEEYCKV CSDGGDLLCC
60 70 80 90 100
DSCPSVYHRT CLSPPLKSIP KGDWICPRCI PLPGKAEKIL SWRWALDRSV
110 120 130 140 150
ELRTSKGEKR REYFIKWHGM SYWHCEWIPE GQMLLHHASM VASFQRRSDM
160 170 180 190 200
EEPSLEELDD QDGNLHERFY RYGIKPEWLL VQRVINHSEE PNGGTMYLVK
210 220 230 240 250
WRELSYNDSS WERESDSIPG LNQAIALYKK LRSSNKGRQR DRPAPTIDLN
260 270 280 290 300
KKYEDQPVFL KEAGLKLHPF QIEGVSWLRY SWGQGIPTIL ADEMGLGKTI
310 320 330 340 350
QTVVFLYSLF KEGHCRGPFL ISVPLSTLTN WERELELWAP ELYCVTYVGG
360 370 380 390 400
KTARAVIRKH EISFEEVTTK TMRENQTQYK FNVMLTSYEF ISVDAAFLGC
410 420 430 440 450
IDWAALVVDE AHRLRSNQSK FFRILSKYRI GYKLLLTGTP LQNNLEELFH
460 470 480 490 500
LLNFLSSGKF NDLQTFQAEF TDVSKEEQVK RLHEILEPHM LRRLKADVLK
510 520 530 540 550
SMPPKSEFIV RVELSSMQKK FYKHILTKNF KALNQKGGGR VCSLLNIMMD
560 570 580 590 600
LRKCCNHPYL FPSAAEEATI SPSGLYEMSS LTKASGKLDL LSKMLKQLKA
610 620 630 640 650
DNHRVLLFSQ MTKMLNVLEH FLEGEGYQYD RIDGSIKGDL RQKAIDRFND
660 670 680 690 700
PVSEHFVFLL STRAGGLGIN LATADTVIIF DSDWNPHNDV QAFSRAHRMG
710 720 730 740 750
QKKKVMIYRF VTHNSVEERI MQVAKHKMML THLVVRPGMG GMTTNFSKDE
760 770 780 790 800
LEDILRFGTE DLFKDGKSEA IHYDDKAVAD LLDRTNRGIE EKESWANEYL
810 820 830 840 850
SSFKVASYAT KEDHEEHDDY NNDAENTDPF YWENLMGKSQ PKLPKKQKKQ
860 870 880 890
SQQSQVDVES IMGKGKRIRK EIDYSNQYPS PNRATPSSIV LM
Length:892
Mass (Da):103,022
Last modified:October 1, 2002 - v3
Checksum:iE11DF7F65A1F6D6D
GO

Sequence cautioni

The sequence AAB87384 differs from that shown. Cloning artifacts.Curated
The sequence AAL49125 differs from that shown. Reason: Frameshift at position 720.Curated
The sequence AAL49125 differs from that shown. Reason: Erroneous termination at position 628. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti617V → I in AAB87384 (PubMed:9326634).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49162.2
AY071503 mRNA Translation: AAL49125.1 Frameshift.
AF007780 mRNA Translation: AAB87384.1 Sequence problems.
RefSeqiNP_649111.1, NM_140854.3
UniGeneiDm.20115

Genome annotation databases

EnsemblMetazoaiFBtr0074998; FBpp0074766; FBgn0023395
GeneIDi40111
KEGGidme:Dmel_CG9594
UCSCiCG9594-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCHD3_DROME
AccessioniPrimary (citable) accession number: O16102
Secondary accession number(s): Q8SYJ8, Q9VVZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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