UniProtKB - O15945 (ARNT_DROME)
Protein
Aryl hydrocarbon receptor nuclear translocator homolog
Gene
tgo
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation.4 Publications
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: FlyBase
- DNA-binding transcription factor activity Source: FlyBase
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- myosin binding Source: FlyBase
- protein heterodimerization activity Source: FlyBase
- sequence-specific DNA binding Source: FlyBase
GO - Biological processi
- appendage development Source: FlyBase
- brain development Source: FlyBase
- cellular response to hypoxia Source: FlyBase
- cellular response to insulin stimulus Source: FlyBase
- central nervous system development Source: FlyBase
- glial cell migration Source: FlyBase
- imaginal disc-derived leg joint morphogenesis Source: FlyBase
- insulin receptor signaling pathway Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- oogenesis Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of R7 cell differentiation Source: FlyBase
- regulation of transcription, DNA-templated Source: FlyBase
- regulation of transcription by RNA polymerase II Source: FlyBase
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-1234158, Regulation of gene expression by Hypoxia-inducible Factor R-DME-8937144, Aryl hydrocarbon receptor signalling |
SignaLinki | O15945 |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor nuclear translocator homologShort name: dARNT Alternative name(s): Hypoxia-inducible factor 1-beta Protein tango |
Gene namesi | Name:tgo Synonyms:ARNT, HIF-1-beta ORF Names:CG11987 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0264075, tgo |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: FlyBase
Other locations
- cytoplasm Source: InterPro
- protein-containing complex Source: FlyBase
- RNA polymerase II transcription regulator complex Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127117 | 1 – 642 | Aryl hydrocarbon receptor nuclear translocator homologAdd BLAST | 642 |
Proteomic databases
PaxDbi | O15945 |
PRIDEi | O15945 |
Expressioni
Tissue specificityi
At stage 11, expression is detected in tracheal pits. At later stages, strong expression is also detected in the CNS.2 Publications
Developmental stagei
Expressed both maternally and zygotically in pupae at a low level.2 Publications
Gene expression databases
Bgeei | FBgn0264075, Expressed in embryo and 54 other tissues |
ExpressionAtlasi | O15945, baseline and differential |
Genevisiblei | O15945, DM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with ahr, trh or sim.
3 PublicationsBinary interactionsi
O15945
With | #Exp. | IntAct |
---|---|---|
sim [P05709] | 3 | EBI-172695,EBI-88929 |
GO - Molecular functioni
- myosin binding Source: FlyBase
- protein heterodimerization activity Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 66252, 13 interactors |
IntActi | O15945, 9 interactors |
STRINGi | 7227.FBpp0081483 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 66 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 85 – 156 | PAS 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 271 – 341 | PAS 2PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 346 – 389 | PACAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 404 – 563 | Gln-richAdd BLAST | 160 | |
Compositional biasi | 566 – 604 | His/Pro-richAdd BLAST | 39 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000169286 |
HOGENOMi | CLU_011864_1_0_1 |
InParanoidi | O15945 |
OMAi | MHGAPLD |
OrthoDBi | 331262at2759 |
PhylomeDBi | O15945 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O15945-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEANIQDKE RFASRENHCE IERRRRNKMT AYITELSDMV PTCSALARKP
60 70 80 90 100
DKLTILRMAV AHMKALRGTG NTSSDGTYKP SFLTDQELKH LILEAADGFL
110 120 130 140 150
FVVSCDSGRV IYVSDSVTPV LNYTQSDWYG TSLYEHIHPD DREKIREQLS
160 170 180 190 200
TQESQNAGRI LDLKSGTVKK EGHQSSMRLS MGARRGFICR MRVGNVNPES
210 220 230 240 250
MVSGHLNRLK QRNSLGPSRD GTNYAVVHCT GYIKNWPPTD MFPNMHMERD
260 270 280 290 300
VDDMSSHCCL VAIGRLQVTS TAANDMSGSN NQSEFITRHA MDGKFTFVDQ
310 320 330 340 350
RVLNILGYTP TELLGKICYD FFHPEDQSHM KESFDQVLKQ KGQMFSLLYR
360 370 380 390 400
ARAKNSEYVW LRTQAYAFLN PYTDEVEYIV CTNSSGKTMH GAPLDAAAAH
410 420 430 440 450
TPEQVQQQQQ QEQHVYVQAA PGVDYARREL TPVGSATNDG MYQTHMLAMQ
460 470 480 490 500
APTPQQQQQQ QQRPGSAQTT PVGYTYDTTH SPYSAGGPSP LAKIPKSGTS
510 520 530 540 550
PTPVAPNSWA ALRPQQQQQQ QQPVTEGYQY QQTSPARSPS GPTYTQLSAG
560 570 580 590 600
NGNRQQAQPG AYQAGPPPPP NAPGMWDWQQ AGGHPHPPHP TAHPHHPHAH
610 620 630 640
PGGPAGAGQP QGQEFSDMLQ MLDHTPTTFE DLNINMFSTP FE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KFJ2 | A0A0B4KFJ2_DROME | Tango, isoform B | tgo ARNT, Arnt, arnt, bHLHe4, DARNT | 642 | Annotation score: |
Sequence cautioni
The sequence AAA28838 differs from that shown. Reason: Frameshift.Curated
The sequence AAB69695 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 | V → M in BAA22868 (PubMed:9374395).Curated | 1 | |
Sequence conflicti | 410 | Q → QQQ in AAB69695 (PubMed:9284047).Curated | 1 | |
Sequence conflicti | 410 | Q → QQQ in AAB88882 (PubMed:9409674).Curated | 1 | |
Sequence conflicti | 410 | Q → QQQ in AAD38396 (PubMed:10581393).Curated | 1 | |
Sequence conflicti | 465 | G → R in BAA22868 (PubMed:9374395).Curated | 1 | |
Sequence conflicti | 488 | P → T in AAB69695 (PubMed:9284047).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002556 mRNA Translation: BAA22868.1 AF016053 mRNA Translation: AAB69695.1 Frameshift. AF020426 mRNA Translation: AAB88882.1 AF154417 mRNA Translation: AAD38396.1 AE014297 Genomic DNA Translation: AAF54329.1 AY069581 mRNA Translation: AAL39726.1 M14550 Genomic DNA Translation: AAA28838.1 Frameshift. |
RefSeqi | NP_001262397.1, NM_001275468.1 NP_731308.1, NM_169254.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0082005; FBpp0081483; FBgn0264075 FBtr0336755; FBpp0307731; FBgn0264075 |
GeneIDi | 41084 |
KEGGi | dme:Dmel_CG11987 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002556 mRNA Translation: BAA22868.1 AF016053 mRNA Translation: AAB69695.1 Frameshift. AF020426 mRNA Translation: AAB88882.1 AF154417 mRNA Translation: AAD38396.1 AE014297 Genomic DNA Translation: AAF54329.1 AY069581 mRNA Translation: AAL39726.1 M14550 Genomic DNA Translation: AAA28838.1 Frameshift. |
RefSeqi | NP_001262397.1, NM_001275468.1 NP_731308.1, NM_169254.2 |
3D structure databases
SMRi | O15945 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 66252, 13 interactors |
IntActi | O15945, 9 interactors |
STRINGi | 7227.FBpp0081483 |
Proteomic databases
PaxDbi | O15945 |
PRIDEi | O15945 |
Genome annotation databases
EnsemblMetazoai | FBtr0082005; FBpp0081483; FBgn0264075 FBtr0336755; FBpp0307731; FBgn0264075 |
GeneIDi | 41084 |
KEGGi | dme:Dmel_CG11987 |
Organism-specific databases
CTDi | 41084 |
FlyBasei | FBgn0264075, tgo |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000169286 |
HOGENOMi | CLU_011864_1_0_1 |
InParanoidi | O15945 |
OMAi | MHGAPLD |
OrthoDBi | 331262at2759 |
PhylomeDBi | O15945 |
Enzyme and pathway databases
Reactomei | R-DME-1234158, Regulation of gene expression by Hypoxia-inducible Factor R-DME-8937144, Aryl hydrocarbon receptor signalling |
SignaLinki | O15945 |
Miscellaneous databases
BioGRID-ORCSi | 41084, 0 hits in 3 CRISPR screens |
ChiTaRSi | tgo, fly |
GenomeRNAii | 41084 |
PROi | PR:O15945 |
Gene expression databases
Bgeei | FBgn0264075, Expressed in embryo and 54 other tissues |
ExpressionAtlasi | O15945, baseline and differential |
Genevisiblei | O15945, DM |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARNT_DROME | |
Accessioni | O15945Primary (citable) accession number: O15945 Secondary accession number(s): O16167 Q9VHI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | March 21, 2012 | |
Last modified: | December 2, 2020 | |
This is version 195 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase