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UniProtKB - O15552 (FFAR2_HUMAN)

Entry version 161 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Free fatty acid receptor 2

Gene

FFAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301).

Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).

Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604).

Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).

7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processImmunity, Inflammatory response
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15552

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-416476, G alpha (q) signalling events
R-HSA-444209, Free fatty acid receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		O15552

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001558

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Free fatty acid receptor 2
Alternative name(s):
G-protein coupled receptor 43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FFAR2
Synonyms:FFA2, GPCR43, GPR43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4501, FFAR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603823, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15552

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126262.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12ExtracellularSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini34 – 41Cytoplasmic8
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 84ExtracellularSequence analysisAdd BLAST22
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 126CytoplasmicSequence analysisAdd BLAST21
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 173ExtracellularSequence analysisAdd BLAST26
Transmembranei174 – 194Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini195 – 219CytoplasmicSequence analysisAdd BLAST25
Transmembranei220 – 240Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini241 – 255ExtracellularSequence analysisAdd BLAST15
Transmembranei256 – 276Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini277 – 330CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90Y → A: Partial loss of propionate-induced G protein-coupled receptor activity. 2 Publications1
Mutagenesisi90Y → W: Complete loss of acetate-induced G protein-coupled receptor activity. 2 Publications1
Mutagenesisi106E → A: Partial loss of SCFA-induced G protein-coupled receptor activity. 1 Publication1
Mutagenesisi108Y → A: Complete loss of SCFA-induced G protein-coupled receptor activity. 1 Publication1
Mutagenesisi140H → A: Partial loss of SCFA-induced G protein-coupled receptor activity. 2 Publications1
Mutagenesisi148Q → A: No effect on SCFA-induced G protein-coupled receptor activity. 1 Publication1
Mutagenesisi148Q → E: Partial loss of SCFA-induced G protein-coupled receptor activity. 1 Publication1
Mutagenesisi159G → E: Partial loss of SCFA-independent constitutive G protein-coupled receptor activity. 1 Publication1
Mutagenesisi165Y → A: Partial loss of propionate-induced G protein-coupled receptor activity. 1 Publication1
Mutagenesisi180R → A, K, L or S: Complete loss of SCFA-induced G protein-coupled receptor activity. 3 Publications1
Mutagenesisi238Y → A: Partial loss of propionate-induced G protein-coupled receptor activity. 1 Publication1
Mutagenesisi239N → A: Complete loss of acetate-induced G protein-coupled receptor activity. 1 Publication1
Mutagenesisi242H → A or F: Complete loss of SCFA-induced G protein-coupled receptor activity. 3 Publications1
Mutagenesisi255R → A: Complete loss of SCFA-induced G protein-coupled receptor activity. 3 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		2867

Open Targets

More...OpenTargetsi		ENSG00000126262

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28890

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15552, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5493

DrugCentral

More...DrugCentrali		O15552

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		226

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FFAR2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000695711 – 330Free fatty acid receptor 2Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15552

PeptideAtlas

More...PeptideAtlasi		O15552

PRoteomics IDEntifications database

More...PRIDEi		O15552

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48754

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O15552, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15552

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15552

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at relatively high levels in peripheral blood leukocytes and, to lesser extent, in spleen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126262, Expressed in blood and 115 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15552, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15552, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126262, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FCN1 (via Fibrinogen C-terminal domain).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O15552
With#Exp.IntAct
AGPAT4 [Q9NRZ5]3EBI-2833872,EBI-1754287
AGTRAP - isoform 2 [Q6RW13-2]3EBI-2833872,EBI-11522760
ALOX5AP [P20292]3EBI-2833872,EBI-3904621
APOD [P05090]3EBI-2833872,EBI-715495
ATP13A1 - isoform C [Q9HD20-3]3EBI-2833872,EBI-12069500
ATP6V0C [P27449]3EBI-2833872,EBI-721179
BMP10 [O95393]3EBI-2833872,EBI-3922513
BNIP3 [Q12983]3EBI-2833872,EBI-749464
BTN2A2 [Q8WVV5]3EBI-2833872,EBI-8648738
C11orf24 [Q96F05]3EBI-2833872,EBI-2836238
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-2833872,EBI-12003442
CACNG1 [Q06432]3EBI-2833872,EBI-9686780
CBLIF [P27352]3EBI-2833872,EBI-3953638
CCDC167 [Q9P0B6]3EBI-2833872,EBI-9083477
CD82 [P27701]3EBI-2833872,EBI-682379
CDIPT [O14735]3EBI-2833872,EBI-358858
CFHR5 [Q9BXR6]3EBI-2833872,EBI-11579371
CGRRF1 [Q99675]3EBI-2833872,EBI-2130213
CLDN4 [O14493]3EBI-2833872,EBI-9316372
CLDND2 [Q8NHS1]3EBI-2833872,EBI-11959453
CLEC1A [Q8NC01]3EBI-2833872,EBI-11996768
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-2833872,EBI-11522780
CMTM7 [Q96FZ5]3EBI-2833872,EBI-2807956
CNIH1 [O95406]3EBI-2833872,EBI-12172273
COL4A5 - isoform 2 [P29400-2]3EBI-2833872,EBI-12211159
CXCL16 [A0A6I8PIU0]3EBI-2833872,EBI-10176529
CXCL9 [Q07325]3EBI-2833872,EBI-3911467
CYB561A3 [Q8NBI2]3EBI-2833872,EBI-10269179
DERL1 [Q9BUN8]3EBI-2833872,EBI-398977
EDDM3B [P56851]3EBI-2833872,EBI-10215665
EMP1 [P54849]3EBI-2833872,EBI-4319440
ERG28 [Q9UKR5]3EBI-2833872,EBI-711490
FAM20B [O75063]3EBI-2833872,EBI-11090967
FAM3C [Q92520]3EBI-2833872,EBI-2876774
FAXDC2 [Q96IV6]3EBI-2833872,EBI-12142299
Ficolin-1 (PRO_0000009136)7EBI-2833872,EBI-11784425
FIS1 [Q9Y3D6]3EBI-2833872,EBI-3385283
FXYD3 - isoform 3 [Q14802-3]3EBI-2833872,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-2833872,EBI-713304
FZD7 [O75084]3EBI-2833872,EBI-746917
GALNT15 [Q8N3T1]3EBI-2833872,EBI-3925203
GJB2 [P29033]3EBI-2833872,EBI-3905204
GPR37L1 [O60883]3EBI-2833872,EBI-2927498
GUCA2A [Q02747]3EBI-2833872,EBI-12244272
GYPA [P02724]3EBI-2833872,EBI-702665
IFITM3 [Q01628]3EBI-2833872,EBI-7932862
KRT1 [P04264]3EBI-2833872,EBI-298429
KTN1 - isoform 3 [Q86UP2-3]3EBI-2833872,EBI-12007212
LAPTM4A [Q15012]3EBI-2833872,EBI-723416
LAT - isoform 2 [O43561-2]3EBI-2833872,EBI-8070286
LEPROTL1 [O95214]3EBI-2833872,EBI-750776
LHFPL5 [Q8TAF8]3EBI-2833872,EBI-2820517
LPAR3 [Q9UBY5]3EBI-2833872,EBI-12033434
MALL [Q13021]3EBI-2833872,EBI-750078
MFSD5 [Q6N075]3EBI-2833872,EBI-3920969
MS4A13 [Q5J8X5]3EBI-2833872,EBI-12070086
NAT8 [Q9UHE5]3EBI-2833872,EBI-2863634
NIPAL4 [Q0D2K0]3EBI-2833872,EBI-9550165
NKG7 [Q16617]3EBI-2833872,EBI-3919611
NRM [Q8IXM6]3EBI-2833872,EBI-10262547
NSG1 [P42857]3EBI-2833872,EBI-6380741
OR10AG1 [Q8NH19]3EBI-2833872,EBI-13339917
PEX16 [Q9Y5Y5]3EBI-2833872,EBI-981985
PLP1 - isoform DM-20 [P60201-2]3EBI-2833872,EBI-12188331
PMP22 [Q01453]3EBI-2833872,EBI-2845982
PNLIPRP1 [P54315]3EBI-2833872,EBI-8652812
RPRM [Q9NS64]3EBI-2833872,EBI-1052363
RTP2 [Q5QGT7]3EBI-2833872,EBI-10244780
RUSF1 [Q96GQ5]3EBI-2833872,EBI-8636004
SACM1L [Q9NTJ5]3EBI-2833872,EBI-3917235
SCGB1D1 [O95968]3EBI-2833872,EBI-12825395
SELENOK [Q9Y6D0]3EBI-2833872,EBI-9679163
SLC30A2 [Q9BRI3]3EBI-2833872,EBI-8644112
SLC35B4 [Q969S0]3EBI-2833872,EBI-10281213
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-2833872,EBI-17295964
SLC35E3 [Q7Z769]3EBI-2833872,EBI-13389236
SLC38A1 [Q9H2H9]3EBI-2833872,EBI-9978441
SLC39A9 [Q9NUM3]3EBI-2833872,EBI-2823239
SLC41A1 [Q8IVJ1]3EBI-2833872,EBI-12266234
SMAGP [Q0VAQ4]3EBI-2833872,EBI-10226799
SMCO4 [Q9NRQ5]3EBI-2833872,EBI-8640191
SMIM1 [B2RUZ4]3EBI-2833872,EBI-12188413
STRIT1 [P0DN84]3EBI-2833872,EBI-12200293
STX8 [Q9UNK0]3EBI-2833872,EBI-727240
SYNDIG1 [Q9H7V2]3EBI-2833872,EBI-726331
TEX264 [Q9Y6I9]3EBI-2833872,EBI-10329860
TM4SF4 [P48230]3EBI-2833872,EBI-8650934
TMEM11 [P17152]3EBI-2833872,EBI-723946
TMEM120B [A0PK00]3EBI-2833872,EBI-10171534
TMEM144 [Q7Z5S9]3EBI-2833872,EBI-12876358
TMEM147 [Q9BVK8]3EBI-2833872,EBI-348587
TMEM203 [Q969S6]3EBI-2833872,EBI-12274070
TMEM239 - isoform 2 [Q8WW34-2]3EBI-2833872,EBI-11528917
TMEM262 [E9PQX1]3EBI-2833872,EBI-17180389
TMEM60 [Q9H2L4]3EBI-2833872,EBI-2852148
TMEM86A [Q8N2M4]3EBI-2833872,EBI-12015604
TMEM97 [Q5BJF2]3EBI-2833872,EBI-12111910
TNF [P01375]3EBI-2833872,EBI-359977
TSPO2 [Q5TGU0]3EBI-2833872,EBI-12195249
TTMP [Q5BVD1]3EBI-2833872,EBI-10243654
UNC50 [Q53HI1]3EBI-2833872,EBI-7601760
UPK1B [O75841]3EBI-2833872,EBI-12237619
YIF1A [O95070]3EBI-2833872,EBI-2799703
YIPF2 [Q9BWQ6]3EBI-2833872,EBI-751204
YIPF6 [Q96EC8]3EBI-2833872,EBI-751210

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109125, 108 interactors

Protein interaction database and analysis system

More...IntActi		O15552, 110 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000473159

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O15552

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15552, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni299 – 330DisorderedSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQGM, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203527

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15552

Identification of Orthologs from Complete Genome Data

More...OMAi		WVMSFGH

Database of Orthologous Groups

More...OrthoDBi		1129026at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15552

TreeFam database of animal gene trees

More...TreeFami		TF350010

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR013312, GPR40-rel_orph

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01904, GPR40FAMILY

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O15552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPDWKSSLI LMAYIIIFLT GLPANLLALR AFVGRIRQPQ PAPVHILLLS 
        60         70         80         90        100
LTLADLLLLL LLPFKIIEAA SNFRWYLPKV VCALTSFGFY SSIYCSTWLL 
       110        120        130        140        150
AGISIERYLG VAFPVQYKLS RRPLYGVIAA LVAWVMSFGH CTIVIIVQYL 
       160        170        180        190        200
NTTEQVRSGN EITCYENFTD NQLDVVLPVR LELCLVLFFI PMAVTIFCYW 
       210        220        230        240        250
RFVWIMLSQP LVGAQRRRRA VGLAVVTLLN FLVCFGPYNV SHLVGYHQRK 
       260        270        280        290        300
SPWWRSIAVV FSSLNASLDP LLFYFSSSVV RRAFGRGLQV LRNQGSSLLG 
       310        320        330
RRGKDTAEGT NEDRGVGQGE GMPSSDFTTE
Length:330
Mass (Da):37,144
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4A8AC6AFBDF1E90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227T → M in AAH96201 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011861211L → H. Corresponds to variant dbSNP:rs409093Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF024690 Genomic DNA Translation: AAB86713.1
AC002511 Genomic DNA Translation: AAB67886.1
EU432114 Genomic DNA Translation: ABY87913.1
BC095535 mRNA Translation: AAH95535.1
BC096198 mRNA Translation: AAH96198.1
BC096199 mRNA Translation: AAH96199.1
BC096200 mRNA Translation: AAH96200.1
BC096201 mRNA Translation: AAH96201.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12461.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC5717

NCBI Reference Sequences

More...RefSeqi		NP_005297.1, NM_005306.2
XP_016882198.1, XM_017026709.1
XP_016882199.1, XM_017026710.1
XP_016882200.1, XM_017026711.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246549; ENSP00000246549; ENSG00000126262
ENST00000599180; ENSP00000473159; ENSG00000126262

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2867

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2867

UCSC genome browser

More...UCSCi		uc010eea.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024690 Genomic DNA Translation: AAB86713.1
AC002511 Genomic DNA Translation: AAB67886.1
EU432114 Genomic DNA Translation: ABY87913.1
BC095535 mRNA Translation: AAH95535.1
BC096198 mRNA Translation: AAH96198.1
BC096199 mRNA Translation: AAH96199.1
BC096200 mRNA Translation: AAH96200.1
BC096201 mRNA Translation: AAH96201.1
CCDSiCCDS12461.1
PIRiJC5717
RefSeqiNP_005297.1, NM_005306.2
XP_016882198.1, XM_017026709.1
XP_016882199.1, XM_017026710.1
XP_016882200.1, XM_017026711.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109125, 108 interactors
IntActiO15552, 110 interactors
STRINGi9606.ENSP00000473159

Chemistry databases

BindingDBiO15552
ChEMBLiCHEMBL5493
DrugCentraliO15552
GuidetoPHARMACOLOGYi226
SwissLipidsiSLP:000001558

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniO15552, 2 sites
iPTMnetiO15552
PhosphoSitePlusiO15552

Genetic variation databases

BioMutaiFFAR2

Proteomic databases

PaxDbiO15552
PeptideAtlasiO15552
PRIDEiO15552
ProteomicsDBi48754

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15916, 334 antibodies

The DNASU plasmid repository

More...DNASUi		2867

Genome annotation databases

EnsembliENST00000246549; ENSP00000246549; ENSG00000126262
ENST00000599180; ENSP00000473159; ENSG00000126262
GeneIDi2867
KEGGihsa:2867
UCSCiuc010eea.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2867
DisGeNETi2867

GeneCards: human genes, protein and diseases

More...GeneCardsi		FFAR2
HGNCiHGNC:4501, FFAR2
HPAiENSG00000126262, Tissue enhanced (blood, lymphoid tissue)
MIMi603823, gene
neXtProtiNX_O15552
OpenTargetsiENSG00000126262
PharmGKBiPA28890
VEuPathDBiHostDB:ENSG00000126262.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQGM, Eukaryota
GeneTreeiENSGT00990000203527
HOGENOMiCLU_009579_8_4_1
InParanoidiO15552
OMAiWVMSFGH
OrthoDBi1129026at2759
PhylomeDBiO15552
TreeFamiTF350010

Enzyme and pathway databases

PathwayCommonsiO15552
ReactomeiR-HSA-416476, G alpha (q) signalling events
R-HSA-444209, Free fatty acid receptors
SIGNORiO15552

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2867, 5 hits in 984 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2867
PharosiO15552, Tchem

Protein Ontology

More...PROi		PR:O15552
RNActiO15552, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126262, Expressed in blood and 115 other tissues
ExpressionAtlasiO15552, baseline and differential
GenevisibleiO15552, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR013312, GPR40-rel_orph
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01904, GPR40FAMILY
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFFAR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15552
Secondary accession number(s): B0M0J9
, Q4VAZ3, Q4VAZ5, Q4VBL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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