Claudin-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3."
    Milatz S., Piontek J., Schulzke J.D., Blasig I.E., Fromm M., Gunzel D.
    Biochem J 468:449-458(2015) [PubMed] [Europe PMC] [Abstract]
• structural molecule activity Source: InterPro
• transmembrane signaling receptor activity Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.2

    "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo."
    Katahira J., Sugiyama H., Inoue N., Horiguchi Y., Matsuda M., Sugimoto N.
    J. Biol. Chem. 272:26652-26658(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

GO - Biological processⁱ

• actin cytoskeleton reorganization Source: ARUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• bicellular tight junction assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3."
    Milatz S., Piontek J., Schulzke J.D., Blasig I.E., Fromm M., Gunzel D.
    Biochem J 468:449-458(2015) [PubMed] [Europe PMC] [Abstract]
• calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: Ensembl
• cell adhesion Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell junction maintenance Source: ARUK-UCL
• epithelial cell morphogenesis Source: UniProtKB
• establishment of endothelial blood-brain barrier Source: ARUK-UCL
• maintenance of blood-brain barrier Source: ARUK-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Blood-Brain Barrier: From Physiology to Disease and Back."
    Sweeney M.D., Zhao Z., Montagne A., Nelson A.R., Zlokovic B.V.
    Physiol Rev 99:21-78(2019) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of wound healing Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of bicellular tight junction assembly Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes."
    Milatz S., Krug S.M., Rosenthal R., Gunzel D., Muller D., Schulzke J.D., Amasheh S., Fromm M.
    Biochim Biophys Acta 1798:2048-2057(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell junction assembly Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity."
    Agarwal R., D'Souza T., Morin P.J.
    Cancer Res 65:7378-7385(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of metallopeptidase activity Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity."
    Agarwal R., D'Souza T., Morin P.J.
    Cancer Res 65:7378-7385(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of wound healing Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity."
    Agarwal R., D'Souza T., Morin P.J.
    Cancer Res 65:7378-7385(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of cell morphogenesis Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity."
    Agarwal R., D'Souza T., Morin P.J.
    Cancer Res 65:7378-7385(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of membrane permeability Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes."
    Milatz S., Krug S.M., Rosenthal R., Gunzel D., Muller D., Schulzke J.D., Amasheh S., Fromm M.
    Biochim Biophys Acta 1798:2048-2057(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of transepithelial transport Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
    Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
    Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: Ensembl
• response to hypoxia Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study."
    Scheurer S.B., Rybak J.N., Rosli C., Neri D., Elia G.
    Proteomics 4:1737-1760(2004) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: UniProtKBInferred from physical interactionⁱ
  • "Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3."
    Milatz S., Piontek J., Schulzke J.D., Blasig I.E., Fromm M., Gunzel D.
    Biochem J 468:449-458(2015) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW 
        60         70         80         90        100
MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG 
       110        120        130        140        150
AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPV 
       160        170        180        190        200
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPREKK YTATKVVYSA 
       210        220
PRSTGPGASL GTGYDRKDYV                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 7
   Human chromosome 7: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families