CLDN3

Functionⁱ

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
structural molecule activity Source: InterPro
transmembrane signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9334247

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bicellular tight junction assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25849148
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: Ensembl
epithelial cell morphogenesis Source: UniProtKB
protein heterooligomerization
Source: UniProtKB
Inferred from genetic interactionⁱ
- 25849148
protein homooligomerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25849148
response to ethanol Source: Ensembl
response to hypoxia
Source: UniProtKB
Inferred from expression patternⁱ
- 15174142

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-420029 Tight junction interactions
SIGNORⁱ	O15551

Protein family/group databases

TCDBⁱ	1.H.1.1.15 the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.15 the claudin tight junction (claudin1) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-3 Alternative name(s): Clostridium perfringens enterotoxin receptor 2 Short name: CPE-R 2 Short name: CPE-receptor 2 Rat ventral prostate.1 protein homolog Short name: hRVP1
Gene namesⁱ	Name:CLDN3 Synonyms:C7orf1, CPETR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165215.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2045 CLDN3
MIMⁱ	602910 gene
neXtProtⁱ	NX_O15551

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 8	CytoplasmicSequence analysis	8
Transmembraneⁱ	9 – 29	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	30 – 80	ExtracellularSequence analysisAdd BLAST	51
Transmembraneⁱ	81 – 101	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	102 – 115	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	116 – 136	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	137 – 159	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	160 – 180	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	181 – 220	CytoplasmicSequence analysisAdd BLAST	40

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Involvement in diseaseⁱ

CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseaseⁱ

Williams-Beuren syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1365
Open Targets More...OpenTargetsⁱ	ENSG00000165215
PharmGKBⁱ	PA26571

Polymorphism and mutation databases

BioMutaⁱ	CLDN3

BioMutaⁱ

CLDN3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144738	1 – 220	Claudin-3Add BLAST		220

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	198	PhosphotyrosineBy similarity	1
Modified residueⁱ	199	PhosphoserineBy similarity	1
Modified residueⁱ	209	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O15551
PaxDbⁱ	O15551
PeptideAtlas More...PeptideAtlasⁱ	O15551
PRIDEⁱ	O15551
ProteomicsDBⁱ	48753

PTM databases

iPTMnetⁱ	O15551
PhosphoSitePlusⁱ	O15551
SwissPalmⁱ	O15551

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000165215 Expressed in 140 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_CLDN3
ExpressionAtlasⁱ	O15551 baseline and differential
Genevisibleⁱ	O15551 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002702 HPA014361

HPAⁱ

CAB002702
HPA014361

Interactionⁱ

Subunit structureⁱ

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107757, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-61079N
IntActⁱ	O15551, 2 interactors
STRINGⁱ	9606.ENSP00000378577

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15551
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	219 – 220	Interactions with TJP1, TJP2 and TJP3By similarity		2

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR Eukaryota ENOG410YA61 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	O15551
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	TKILYSA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MMR
PhylomeDBⁱ	O15551
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003549 Claudin3 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01378 CLAUDIN3
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O15551-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW 
        60         70         80         90        100
MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG 
       110        120        130        140        150
AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPV 
       160        170        180        190        200
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPREKK YTATKVVYSA 
       210        220
PRSTGPGASL GTGYDRKDYV

Length:220

Mass (Da):23,319

Last modified:January 1, 1998 - v1

Checksum:ⁱ1C826EFFF1563C56

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF007189 Genomic DNA Translation: AAC78277.1 AB000714 mRNA Translation: BAA22986.1 BC016056 mRNA Translation: AAH16056.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5559.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001297.1, NM_001306.3
UniGeneⁱ	Hs.647023

Genome annotation databases

Ensemblⁱ	ENST00000395145; ENSP00000378577; ENSG00000165215
GeneIDⁱ	1365
KEGGⁱ	hsa:1365

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15551	Claudin		HUMAN		220	UniRef100_O15551
Claudin		PANTR		220
Claudin		PANPA		220
Claudin		GORGO		220

Protein	Similar proteins		Species	Score	Length	Source
O15551	Claudin		HUMAN		220	UniRef90_O15551
Claudin		PANTR		220
Claudin		PANPA		220
Claudin		GORGO		220
Claudin		CALJA		220
+12

Protein	Similar proteins		Species	Score	Length	Source
O15551	Claudin-3		BOVIN		219	UniRef50_O15551
Claudin-9		HUMAN		217
Claudin-9		MOUSE		217
Claudin		PANTR		220
Claudin		PANPA		220
+218

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF007189 Genomic DNA Translation: AAC78277.1 AB000714 mRNA Translation: BAA22986.1 BC016056 mRNA Translation: AAH16056.1
CCDSⁱ	CCDS5559.1
RefSeqⁱ	NP_001297.1, NM_001306.3
UniGeneⁱ	Hs.647023

3D structure databases

ProteinModelPortalⁱ	O15551
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107757, 4 interactors
DIPⁱ	DIP-61079N
IntActⁱ	O15551, 2 interactors
STRINGⁱ	9606.ENSP00000378577

Protein family/group databases

TCDBⁱ	1.H.1.1.15 the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.15 the claudin tight junction (claudin1) family

PTM databases

iPTMnetⁱ	O15551
PhosphoSitePlusⁱ	O15551
SwissPalmⁱ	O15551

Polymorphism and mutation databases

BioMutaⁱ	CLDN3

BioMutaⁱ

CLDN3

Proteomic databases

EPDⁱ	O15551
PaxDbⁱ	O15551
PeptideAtlasⁱ	O15551
PRIDEⁱ	O15551
ProteomicsDBⁱ	48753

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1365
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000395145; ENSP00000378577; ENSG00000165215
GeneIDⁱ	1365
KEGGⁱ	hsa:1365

Organism-specific databases

CTDⁱ	1365
DisGeNETⁱ	1365
EuPathDBⁱ	HostDB:ENSG00000165215.6
GeneCardsⁱ	CLDN3
HGNCⁱ	HGNC:2045 CLDN3
HPAⁱ	CAB002702 HPA014361
MIMⁱ	602910 gene
neXtProtⁱ	NX_O15551
OpenTargetsⁱ	ENSG00000165215
PharmGKBⁱ	PA26571
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIJR Eukaryota ENOG410YA61 LUCA
GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	O15551
KOⁱ	K06087
OMAⁱ	TKILYSA
OrthoDBⁱ	EOG091G0MMR
PhylomeDBⁱ	O15551
TreeFamⁱ	TF331936

Enzyme and pathway databases

Reactomeⁱ	R-HSA-420029 Tight junction interactions
SIGNORⁱ	O15551

Miscellaneous databases

GeneWikiⁱ	CLDN3
GenomeRNAiⁱ	1365
Protein Ontology More...PROⁱ	PR:O15551
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165215 Expressed in 140 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_CLDN3
ExpressionAtlasⁱ	O15551 baseline and differential
Genevisibleⁱ	O15551 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR003549 Claudin3 IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01378 CLAUDIN3
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD3_HUMAN
Accessionⁱ	O15551Primary (citable) accession number: O15551
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - O15551 (CLD3_HUMAN)

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Claudin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ