UniProtKB - O15551 (CLD3_HUMAN)
Protein
Claudin-3
Gene
CLDN3
Organism
Homo sapiens (Human)
Status
Functioni
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- structural molecule activity Source: InterPro
- transmembrane signaling receptor activity Source: ProtInc
GO - Biological processi
- actin cytoskeleton reorganization Source: ARUK-UCL
- bicellular tight junction assembly Source: UniProtKB
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: Ensembl
- cell adhesion Source: GO_Central
- cell junction maintenance Source: ARUK-UCL
- epithelial cell morphogenesis Source: UniProtKB
- establishment of endothelial blood-brain barrier Source: ARUK-UCL
- maintenance of blood-brain barrier Source: ARUK-UCL
- negative regulation of cell migration Source: ARUK-UCL
- negative regulation of cell population proliferation Source: ARUK-UCL
- negative regulation of gene expression Source: ARUK-UCL
- negative regulation of wound healing Source: ARUK-UCL
- positive regulation of bicellular tight junction assembly Source: ARUK-UCL
- positive regulation of cell junction assembly Source: ARUK-UCL
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of metallopeptidase activity Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: ARUK-UCL
- positive regulation of wound healing Source: ARUK-UCL
- regulation of cell morphogenesis Source: ARUK-UCL
- regulation of membrane permeability Source: ARUK-UCL
- regulation of transepithelial transport Source: ARUK-UCL
- response to ethanol Source: Ensembl
- response to hypoxia Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | O15551 |
Reactomei | R-HSA-420029, Tight junction interactions |
SIGNORi | O15551 |
Protein family/group databases
TCDBi | 1.H.1.1.15, the claudin tight junction (claudin1) family |
Names & Taxonomyi
Protein namesi | Recommended name: Claudin-3Alternative name(s): Clostridium perfringens enterotoxin receptor 2 Short name: CPE-R 2 Short name: CPE-receptor 2 Rat ventral prostate.1 protein homolog Short name: hRVP1 |
Gene namesi | Name:CLDN3 Synonyms:C7orf1, CPETR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2045, CLDN3 |
MIMi | 602910, gene |
neXtProti | NX_O15551 |
VEuPathDBi | HostDB:ENSG00000165215.6 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- tight junction By similarity
Plasma Membrane
- apicolateral plasma membrane Source: Ensembl
- integral component of plasma membrane Source: ProtInc
- lateral plasma membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- apical junction complex Source: ARUK-UCL
- bicellular tight junction Source: UniProtKB
- cell-cell junction Source: ARUK-UCL
- cytoplasm Source: Ensembl
- integral component of membrane Source: ProtInc
- protein-containing complex Source: UniProtKB
- tight junction Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 80 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 102 – 115 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 137 – 159 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 181 – 220 | CytoplasmicSequence analysisAdd BLAST | 40 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPathology & Biotechi
Involvement in diseasei
CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Keywords - Diseasei
Williams-Beuren syndromeOrganism-specific databases
DisGeNETi | 1365 |
OpenTargetsi | ENSG00000165215 |
PharmGKBi | PA26571 |
Miscellaneous databases
Pharosi | O15551, Tbio |
Genetic variation databases
BioMutai | CLDN3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144738 | 1 – 220 | Claudin-3Add BLAST | 220 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 198 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineBy similarity | 1 | |
Modified residuei | 209 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O15551 |
jPOSTi | O15551 |
MassIVEi | O15551 |
PaxDbi | O15551 |
PeptideAtlasi | O15551 |
PRIDEi | O15551 |
ProteomicsDBi | 48753 |
PTM databases
iPTMneti | O15551 |
PhosphoSitePlusi | O15551 |
SwissPalmi | O15551 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165215, Expressed in mucosa of transverse colon and 153 other tissues |
ExpressionAtlasi | O15551, baseline and differential |
Genevisiblei | O15551, HS |
Organism-specific databases
HPAi | ENSG00000165215, Tissue enhanced (intestine, thyroid gland) |
Interactioni
Subunit structurei
Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107757, 8 interactors |
DIPi | DIP-61079N |
IntActi | O15551, 3 interactors |
STRINGi | 9606.ENSP00000378577 |
Miscellaneous databases
RNActi | O15551, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 219 – 220 | Interactions with TJP1, TJP2 and TJP3By similarity | 2 |
Sequence similaritiesi
Belongs to the claudin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRZ8, Eukaryota |
GeneTreei | ENSGT00940000162095 |
HOGENOMi | CLU_076370_1_2_1 |
InParanoidi | O15551 |
OMAi | LCTIVCC |
OrthoDBi | 1231389at2759 |
PhylomeDBi | O15551 |
TreeFami | TF331936 |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR003549, Claudin3 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01378, CLAUDIN3 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
i Sequence
Sequence statusi: Complete.
O15551-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPV
160 170 180 190 200
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPREKK YTATKVVYSA
210 220
PRSTGPGASL GTGYDRKDYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007189 Genomic DNA Translation: AAC78277.1 AB000714 mRNA Translation: BAA22986.1 BC016056 mRNA Translation: AAH16056.1 |
CCDSi | CCDS5559.1 |
RefSeqi | NP_001297.1, NM_001306.3 |
Genome annotation databases
Ensembli | ENST00000395145; ENSP00000378577; ENSG00000165215 |
GeneIDi | 1365 |
KEGGi | hsa:1365 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007189 Genomic DNA Translation: AAC78277.1 AB000714 mRNA Translation: BAA22986.1 BC016056 mRNA Translation: AAH16056.1 |
CCDSi | CCDS5559.1 |
RefSeqi | NP_001297.1, NM_001306.3 |
3D structure databases
SMRi | O15551 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107757, 8 interactors |
DIPi | DIP-61079N |
IntActi | O15551, 3 interactors |
STRINGi | 9606.ENSP00000378577 |
Protein family/group databases
TCDBi | 1.H.1.1.15, the claudin tight junction (claudin1) family |
PTM databases
iPTMneti | O15551 |
PhosphoSitePlusi | O15551 |
SwissPalmi | O15551 |
Genetic variation databases
BioMutai | CLDN3 |
Proteomic databases
EPDi | O15551 |
jPOSTi | O15551 |
MassIVEi | O15551 |
PaxDbi | O15551 |
PeptideAtlasi | O15551 |
PRIDEi | O15551 |
ProteomicsDBi | 48753 |
Protocols and materials databases
ABCDi | O15551, 6 sequenced antibodies |
Antibodypediai | 3638, 549 antibodies |
DNASUi | 1365 |
Genome annotation databases
Ensembli | ENST00000395145; ENSP00000378577; ENSG00000165215 |
GeneIDi | 1365 |
KEGGi | hsa:1365 |
Organism-specific databases
CTDi | 1365 |
DisGeNETi | 1365 |
GeneCardsi | CLDN3 |
HGNCi | HGNC:2045, CLDN3 |
HPAi | ENSG00000165215, Tissue enhanced (intestine, thyroid gland) |
MIMi | 602910, gene |
neXtProti | NX_O15551 |
OpenTargetsi | ENSG00000165215 |
PharmGKBi | PA26571 |
VEuPathDBi | HostDB:ENSG00000165215.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRZ8, Eukaryota |
GeneTreei | ENSGT00940000162095 |
HOGENOMi | CLU_076370_1_2_1 |
InParanoidi | O15551 |
OMAi | LCTIVCC |
OrthoDBi | 1231389at2759 |
PhylomeDBi | O15551 |
TreeFami | TF331936 |
Enzyme and pathway databases
PathwayCommonsi | O15551 |
Reactomei | R-HSA-420029, Tight junction interactions |
SIGNORi | O15551 |
Miscellaneous databases
BioGRID-ORCSi | 1365, 8 hits in 870 CRISPR screens |
GeneWikii | CLDN3 |
GenomeRNAii | 1365 |
Pharosi | O15551, Tbio |
PROi | PR:O15551 |
RNActi | O15551, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165215, Expressed in mucosa of transverse colon and 153 other tissues |
ExpressionAtlasi | O15551, baseline and differential |
Genevisiblei | O15551, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR003549, Claudin3 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01378, CLAUDIN3 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLD3_HUMAN | |
Accessioni | O15551Primary (citable) accession number: O15551 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families