UniProtKB - O15550 (KDM6A_HUMAN)
Protein
Lysine-specific demethylase 6A
Gene
KDM6A
Organism
Homo sapiens (Human)
Status
Functioni
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).By similarity4 Publications
Miscellaneous
Escapes X chromosome inactivation.
Catalytic activityi
- 2 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N6-methyl-L-lysyl27-[histone H3] + 2 succinate4 PublicationsEC:1.14.11.684 Publications
Cofactori
Protein has several cofactor binding sites:- L-ascorbate1 Publication
- Fe2+1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 1146 | Iron1 Publication | 1 | |
Metal bindingi | 1148 | Iron1 Publication | 1 | |
Metal bindingi | 1226 | Iron1 Publication | 1 | |
Metal bindingi | 1331 | Zinc1 Publication | 1 | |
Metal bindingi | 1334 | Zinc1 Publication | 1 | |
Metal bindingi | 1358 | Zinc1 Publication | 1 | |
Metal bindingi | 1361 | Zinc1 Publication | 1 |
GO - Molecular functioni
- chromatin DNA binding Source: GO_Central
- dioxygenase activity Source: UniProtKB-KW
- histone demethylase activity (H3-K27 specific) Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- chromatin remodeling Source: UniProtKB
- heart development Source: GO_Central
- histone H3-K27 demethylation Source: GO_Central
- histone H3-K4 methylation Source: UniProtKB
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator, Dioxygenase, Oxidoreductase |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000147050-MONOMER |
PathwayCommonsi | O15550 |
Reactomei | R-HSA-3214842, HDMs demethylate histones R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis |
SIGNORi | O15550 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysine-specific demethylase 6A (EC:1.14.11.684 Publications)Alternative name(s): Histone demethylase UTX Ubiquitously-transcribed TPR protein on the X chromosome Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein [histone H3]-trimethyl-L-lysine(27) demethylase 6ACurated |
Gene namesi | Name:KDM6A Synonyms:UTX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12637, KDM6A |
MIMi | 300128, gene |
neXtProti | NX_O15550 |
VEuPathDBi | HostDB:ENSG00000147050.14 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- histone methyltransferase complex Source: MGI
- MLL3/4 complex Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Kabuki syndrome 2 (KABUK2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA congenital mental retardation syndrome with additional features, including postnatal dwarfism, a peculiar facies characterized by long palpebral fissures with eversion of the lateral third of the lower eyelids, a broad and depressed nasal tip, large prominent earlobes, a cleft or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads, radiographic abnormalities of the vertebrae, hands, and hip joints, and recurrent otitis media in infancy.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1146 | H → A: Abolishes histone demethylase activity. 3 Publications | 1 |
Keywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 7403 |
GeneReviewsi | KDM6A |
MalaCardsi | KDM6A |
MIMi | 300867, phenotype |
OpenTargetsi | ENSG00000147050 |
Orphaneti | 2322, Kabuki syndrome |
PharmGKBi | PA37262 |
Miscellaneous databases
Pharosi | O15550, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2069164 |
GuidetoPHARMACOLOGYi | 2684 |
Genetic variation databases
BioMutai | KDM6A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106409 | 1 – 1401 | Lysine-specific demethylase 6AAdd BLAST | 1401 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 519 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 549 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 769 | PhosphoserineCombined sources | 1 | |
Modified residuei | 827 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 829 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | O15550 |
jPOSTi | O15550 |
MassIVEi | O15550 |
MaxQBi | O15550 |
PaxDbi | O15550 |
PeptideAtlasi | O15550 |
PRIDEi | O15550 |
ProteomicsDBi | 48752 |
PTM databases
iPTMneti | O15550 |
PhosphoSitePlusi | O15550 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147050, Expressed in kidney and 235 other tissues |
ExpressionAtlasi | O15550, baseline and differential |
Genevisiblei | O15550, HS |
Organism-specific databases
HPAi | ENSG00000147050, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TLE1 (By similarity).
Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A (or KDM6B), PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (PubMed:17500065, PubMed:17713478).
Interacts with SUPT6H.
Interacts with SMARCA4 (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsO15550
With | #Exp. | IntAct |
---|---|---|
GSC2 [O15499] | 3 | EBI-4292203,EBI-19954058 |
MEOX2 [Q6FHY5] | 3 | EBI-4292203,EBI-16439278 |
WDR5 [P61964] | 6 | EBI-4292203,EBI-540834 |
Protein-protein interaction databases
BioGRIDi | 113246, 62 interactors |
CORUMi | O15550 |
DIPi | DIP-46192N |
IntActi | O15550, 22 interactors |
MINTi | O15550 |
STRINGi | 9606.ENSP00000367203 |
Chemistry databases
BindingDBi | O15550 |
Miscellaneous databases
RNActi | O15550, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O15550 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 93 – 126 | TPR 1Add BLAST | 34 | |
Repeati | 130 – 163 | TPR 2Add BLAST | 34 | |
Repeati | 170 – 199 | TPR 3Add BLAST | 30 | |
Repeati | 205 – 238 | TPR 4Add BLAST | 34 | |
Repeati | 250 – 283 | TPR 5Add BLAST | 34 | |
Repeati | 284 – 317 | TPR 6Add BLAST | 34 | |
Repeati | 318 – 351 | TPR 7Add BLAST | 34 | |
Repeati | 352 – 385 | TPR 8Add BLAST | 34 | |
Domaini | 1095 – 1258 | JmjCPROSITE-ProRule annotationAdd BLAST | 164 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 1095 | Interaction with SUPT6HBy similarityAdd BLAST | 1095 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 17 | Poly-Ala | 9 |
Sequence similaritiesi
Belongs to the UTX family.Curated
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1124, Eukaryota KOG1246, Eukaryota |
GeneTreei | ENSGT00940000155202 |
InParanoidi | O15550 |
OrthoDBi | 268901at2759 |
PhylomeDBi | O15550 |
TreeFami | TF317405 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
IDEALi | IID00431 |
InterProi | View protein in InterPro IPR003347, JmjC_dom IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF02373, JmjC, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
O15550-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSCGVSLAT AAAAAAAFGD EEKKMAAGKA SGESEEASPS LTAEEREALG
60 70 80 90 100
GLDSRLFGFV RFHEDGARTK ALLGKAVRCY ESLILKAEGK VESDFFCQLG
110 120 130 140 150
HFNLLLEDYP KALSAYQRYY SLQSDYWKNA AFLYGLGLVY FHYNAFQWAI
160 170 180 190 200
KAFQEVLYVD PSFCRAKEIH LRLGLMFKVN TDYESSLKHF QLALVDCNPC
210 220 230 240 250
TLSNAEIQFH IAHLYETQRK YHSAKEAYEQ LLQTENLSAQ VKATVLQQLG
260 270 280 290 300
WMHHTVDLLG DKATKESYAI QYLQKSLEAD PNSGQSWYFL GRCYSSIGKV
310 320 330 340 350
QDAFISYRQS IDKSEASADT WCSIGVLYQQ QNQPMDALQA YICAVQLDHG
360 370 380 390 400
HAAAWMDLGT LYESCNQPQD AIKCYLNATR SKSCSNTSAL AARIKYLQAQ
410 420 430 440 450
LCNLPQGSLQ NKTKLLPSIE EAWSLPIPAE LTSRQGAMNT AQQNTSDNWS
460 470 480 490 500
GGHAVSHPPV QQQAHSWCLT PQKLQHLEQL RANRNNLNPA QKLMLEQLES
510 520 530 540 550
QFVLMQQHQM RPTGVAQVRS TGIPNGPTAD SSLPTNSVSG QQPQLALTRV
560 570 580 590 600
PSVSQPGVRP ACPGQPLANG PFSAGHVPCS TSRTLGSTDT ILIGNNHITG
610 620 630 640 650
SGSNGNVPYL QRNALTLPHN RTNLTSSAEE PWKNQLSNST QGLHKGQSSH
660 670 680 690 700
SAGPNGERPL SSTGPSQHLQ AAGSGIQNQN GHPTLPSNSV TQGAALNHLS
710 720 730 740 750
SHTATSGGQQ GITLTKESKP SGNILTVPET SRHTGETPNS TASVEGLPNH
760 770 780 790 800
VHQMTADAVC SPSHGDSKSP GLLSSDNPQL SALLMGKANN NVGTGTCDKV
810 820 830 840 850
NNIHPAVHTK TDNSVASSPS SAISTATPSP KSTEQTTTNS VTSLNSPHSG
860 870 880 890 900
LHTINGEGME ESQSPMKTDL LLVNHKPSPQ IIPSMSVSIY PSSAEVLKAC
910 920 930 940 950
RNLGKNGLSN SSILLDKCPP PRPPSSPYPP LPKDKLNPPT PSIYLENKRD
960 970 980 990 1000
AFFPPLHQFC TNPNNPVTVI RGLAGALKLD LGLFSTKTLV EANNEHMVEV
1010 1020 1030 1040 1050
RTQLLQPADE NWDPTGTKKI WHCESNRSHT TIAKYAQYQA SSFQESLREE
1060 1070 1080 1090 1100
NEKRSHHKDH SDSESTSSDN SGRRRKGPFK TIKFGTNIDL SDDKKWKLQL
1110 1120 1130 1140 1150
HELTKLPAFV RVVSAGNLLS HVGHTILGMN TVQLYMKVPG SRTPGHQENN
1160 1170 1180 1190 1200
NFCSVNINIG PGDCEWFVVP EGYWGVLNDF CEKNNLNFLM GSWWPNLEDL
1210 1220 1230 1240 1250
YEANVPVYRF IQRPGDLVWI NAGTVHWVQA IGWCNNIAWN VGPLTACQYK
1260 1270 1280 1290 1300
LAVERYEWNK LQSVKSIVPM VHLSWNMARN IKVSDPKLFE MIKYCLLRTL
1310 1320 1330 1340 1350
KQCQTLREAL IAAGKEIIWH GRTKEEPAHY CSICEVEVFD LLFVTNESNS
1360 1370 1380 1390 1400
RKTYIVHCQD CARKTSGNLE NFVVLEQYKM EDLMQVYDQF TLAPPLPSAS
S
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0R0 | A0A087X0R0_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,453 | Annotation score: | ||
F5H6S1 | F5H6S1_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,356 | Annotation score: | ||
F5H5V6 | F5H5V6_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,322 | Annotation score: | ||
F8W8R6 | F8W8R6_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,408 | Annotation score: | ||
A0A6Q8PFK0 | A0A6Q8PFK0_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,367 | Annotation score: | ||
A0A6Q8PHB6 | A0A6Q8PHB6_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,427 | Annotation score: | ||
A0A6Q8PFD0 | A0A6Q8PFD0_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,256 | Annotation score: | ||
A0A6Q8PG32 | A0A6Q8PG32_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,355 | Annotation score: | ||
A0A6Q8PG92 | A0A6Q8PG92_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,293 | Annotation score: | ||
A0A6Q8PGN0 | A0A6Q8PGN0_HUMAN | Lysine-specific demethylase 6A | KDM6A | 1,336 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | L → V in AAC51839 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 173 | L → V in AAC51840 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 585 | L → R in AAC51839 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 585 | L → R in AAC51840 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 601 | S → N in AAC51839 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 601 | S → N in AAC51840 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 629 | E → K in AAC51839 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 629 | E → K in AAC51840 (PubMed:9381176).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014492 | 30 | A → T. Corresponds to variant dbSNP:rs6529EnsemblClinVar. | 1 | |
Natural variantiVAR_067225 | 270 | I → V in a patient with chronic myelomonocytic leukemia. 1 Publication | 1 | |
Natural variantiVAR_014493 | 497 | Q → H. Corresponds to variant dbSNP:rs6530Ensembl. | 1 | |
Natural variantiVAR_046527 | 581 | T → A. Corresponds to variant dbSNP:rs34922269EnsemblClinVar. | 1 | |
Natural variantiVAR_020313 | 726 | T → K1 PublicationCorresponds to variant dbSNP:rs2230018Ensembl. | 1 | |
Natural variantiVAR_067226 | 834 | E → D in a patient with chronic myelomonocytic leukemia. 1 Publication | 1 | |
Natural variantiVAR_067227 | 922 | R → K in a patient with chronic myelomonocytic leukemia. 1 Publication | 1 | |
Natural variantiVAR_035871 | 1106 | L → R in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000992 mRNA Translation: AAC51839.1 AF000993 mRNA Translation: AAC51840.1 AC136488 Genomic DNA No translation available. AL133545 Genomic DNA No translation available. AL138744 Genomic DNA No translation available. CH471141 Genomic DNA Translation: EAW59368.1 BC093868 mRNA Translation: AAH93868.1 BC113381 mRNA Translation: AAI13382.1 |
CCDSi | CCDS14265.1 |
PIRi | T02255 |
RefSeqi | NP_066963.2, NM_021140.3 |
Genome annotation databases
Ensembli | ENST00000377967; ENSP00000367203; ENSG00000147050 |
GeneIDi | 7403 |
KEGGi | hsa:7403 |
UCSCi | uc004dge.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000992 mRNA Translation: AAC51839.1 AF000993 mRNA Translation: AAC51840.1 AC136488 Genomic DNA No translation available. AL133545 Genomic DNA No translation available. AL138744 Genomic DNA No translation available. CH471141 Genomic DNA Translation: EAW59368.1 BC093868 mRNA Translation: AAH93868.1 BC113381 mRNA Translation: AAI13382.1 |
CCDSi | CCDS14265.1 |
PIRi | T02255 |
RefSeqi | NP_066963.2, NM_021140.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3AVR | X-ray | 1.80 | A | 880-1401 | [»] | |
3AVS | X-ray | 1.85 | A | 880-1401 | [»] | |
6FUK | X-ray | 2.00 | A | 877-1401 | [»] | |
6FUL | X-ray | 1.65 | A | 877-1401 | [»] | |
SMRi | O15550 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113246, 62 interactors |
CORUMi | O15550 |
DIPi | DIP-46192N |
IntActi | O15550, 22 interactors |
MINTi | O15550 |
STRINGi | 9606.ENSP00000367203 |
Chemistry databases
BindingDBi | O15550 |
ChEMBLi | CHEMBL2069164 |
GuidetoPHARMACOLOGYi | 2684 |
PTM databases
iPTMneti | O15550 |
PhosphoSitePlusi | O15550 |
Genetic variation databases
BioMutai | KDM6A |
Proteomic databases
EPDi | O15550 |
jPOSTi | O15550 |
MassIVEi | O15550 |
MaxQBi | O15550 |
PaxDbi | O15550 |
PeptideAtlasi | O15550 |
PRIDEi | O15550 |
ProteomicsDBi | 48752 |
Protocols and materials databases
Antibodypediai | 639, 200 antibodies |
Genome annotation databases
Ensembli | ENST00000377967; ENSP00000367203; ENSG00000147050 |
GeneIDi | 7403 |
KEGGi | hsa:7403 |
UCSCi | uc004dge.5, human |
Organism-specific databases
CTDi | 7403 |
DisGeNETi | 7403 |
GeneCardsi | KDM6A |
GeneReviewsi | KDM6A |
HGNCi | HGNC:12637, KDM6A |
HPAi | ENSG00000147050, Low tissue specificity |
MalaCardsi | KDM6A |
MIMi | 300128, gene 300867, phenotype |
neXtProti | NX_O15550 |
OpenTargetsi | ENSG00000147050 |
Orphaneti | 2322, Kabuki syndrome |
PharmGKBi | PA37262 |
VEuPathDBi | HostDB:ENSG00000147050.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1124, Eukaryota KOG1246, Eukaryota |
GeneTreei | ENSGT00940000155202 |
InParanoidi | O15550 |
OrthoDBi | 268901at2759 |
PhylomeDBi | O15550 |
TreeFami | TF317405 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000147050-MONOMER |
PathwayCommonsi | O15550 |
Reactomei | R-HSA-3214842, HDMs demethylate histones R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis |
SIGNORi | O15550 |
Miscellaneous databases
BioGRID-ORCSi | 7403, 24 hits in 626 CRISPR screens |
ChiTaRSi | KDM6A, human |
GeneWikii | UTX_(gene) |
GenomeRNAii | 7403 |
Pharosi | O15550, Tchem |
PROi | PR:O15550 |
RNActi | O15550, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147050, Expressed in kidney and 235 other tissues |
ExpressionAtlasi | O15550, baseline and differential |
Genevisiblei | O15550, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
IDEALi | IID00431 |
InterProi | View protein in InterPro IPR003347, JmjC_dom IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF02373, JmjC, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KDM6A_HUMAN | |
Accessioni | O15550Primary (citable) accession number: O15550 Secondary accession number(s): Q52LL9, Q5JVQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families