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Protein

P2X purinoceptor 6

Gene

P2RX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.By similarity

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

GO - Molecular functioni

  • ATP binding Source: BHF-UCL
  • ATP-gated ion channel activity Source: GO_Central
  • channel activity Source: ProtInc
  • extracellularly ATP-gated cation channel activity Source: GO_Central
  • identical protein binding Source: BHF-UCL
  • purinergic nucleotide receptor activity Source: GO_Central
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 6
Short name:
P2X6
Alternative name(s):
ATP receptor
P2XM
Purinergic receptor
Purinergic receptor P2X-like 1
Gene namesi
Name:P2RX6
Synonyms:P2RXL1, P2X6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099957.16
HGNCiHGNC:8538 P2RX6
MIMi608077 gene
neXtProtiNX_O15547

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini11 – 39CytoplasmicSequence analysisAdd BLAST29
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 333ExtracellularSequence analysisAdd BLAST273
Transmembranei334 – 354Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini355 – 441CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9127
OpenTargetsiENSG00000099957
PharmGKBiPA162398523

Chemistry databases

ChEMBLiCHEMBL2670

Polymorphism and mutation databases

BioMutaiP2RX6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615571 – 441P2X purinoceptor 6Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Phosphotyrosine1 Publication1
Disulfide bondi127 ↔ 177By similarity
Disulfide bondi138 ↔ 161By similarity
Disulfide bondi144 ↔ 171By similarity
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi228 ↔ 238By similarity
Disulfide bondi272 ↔ 281By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO15547
PeptideAtlasiO15547
PRIDEiO15547
ProteomicsDBi48751

PTM databases

iPTMnetiO15547
PhosphoSitePlusiO15547

Expressioni

Tissue specificityi

Expressed predominantly in skeletal muscle.

Gene expression databases

BgeeiENSG00000099957 Expressed in 89 organ(s), highest expression level in muscle of leg
CleanExiHS_P2RX6
ExpressionAtlasiO15547 baseline and differential
GenevisibleiO15547 HS

Organism-specific databases

HPAiHPA028776
HPA028777

Interactioni

Subunit structurei

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114575, 4 interactors
IntActiO15547, 1 interactor
STRINGi9606.ENSP00000416193

Chemistry databases

BindingDBiO15547

Structurei

3D structure databases

ProteinModelPortaliO15547
SMRiO15547
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiO15547
KOiK05221
OMAiRPHYSFQ
OrthoDBiEOG091G0A2U
PhylomeDBiO15547
TreeFamiTF328633

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003049 P2X6_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF21 PTHR10125:SF21, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01313 P2X6RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15547-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCPQLAGAGS MGSPGATTGW GLLDYKTEKY VMTRNWRVGA LQRLLQFGIV
60 70 80 90 100
VYVVGWALLA KKGYQERDLE PQFSIITKLK GVSVTQIKEL GNRLWDVADF
110 120 130 140 150
VKPPQGENVF FLVTNFLVTP AQVQGRCPEH PSVPLANCWV DEDCPEGEGG
160 170 180 190 200
THSHGVKTGQ CVVFNGTHRT CEIWSWCPVE SGVVPSRPLL AQAQNFTLFI
210 220 230 240 250
KNTVTFSKFN FSKSNALETW DPTYFKHCRY EPQFSPYCPV FRIGDLVAKA
260 270 280 290 300
GGTFEDLALL GGSVGIRVHW DCDLDTGDSG CWPHYSFQLQ EKSYNFRTAT
310 320 330 340 350
HWWEQPGVEA RTLLKLYGIR FDILVTGQAG KFGLIPTAVT LGTGAAWLGV
360 370 380 390 400
VTFFCDLLLL YVDREAHFYW RTKYEEAKAP KATANSVWRE LALASQARLA
410 420 430 440
ECLRRSSAPA PTATAAGSQT QTPGWPCPSS DTHLPTHSGS L
Length:441
Mass (Da):48,829
Last modified:November 2, 2010 - v2
Checksum:iEFD45BDC81234A64
GO
Isoform 2 (identifier: O15547-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-55: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):45,808
Checksum:i3E32A59741527671
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C140H7C140_HUMAN
p2X purinoceptor 6
P2RX6
120Annotation score:
H7C2V4H7C2V4_HUMAN
p2X purinoceptor 6
P2RX6
101Annotation score:
E7ES48E7ES48_HUMAN
p2X purinoceptor 6
P2RX6
80Annotation score:
H7C266H7C266_HUMAN
p2X purinoceptor 6
P2RX6
130Annotation score:

Sequence cautioni

The sequence AAF13303 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAF13303 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH33488 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI09210 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA22046 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA22047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti393L → F in AAF13303 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05766438V → G. Corresponds to variant dbSNP:rs2006846Ensembl.1
Natural variantiVAR_020338242R → H1 PublicationCorresponds to variant dbSNP:rs2277838Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04479930 – 55Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002059 Genomic DNA Translation: BAA22047.1 Different initiation.
AB002058 mRNA Translation: BAA22046.1 Different initiation.
CR456535 mRNA Translation: CAG30421.1
AC002472 Genomic DNA No translation available.
BC033488 mRNA Translation: AAH33488.1 Different initiation.
BC109209 mRNA Translation: AAI09210.1 Different initiation.
AF065385 mRNA Translation: AAF13303.1 Sequence problems.
CCDSiCCDS13788.2 [O15547-1]
CCDS54504.1 [O15547-2]
RefSeqiNP_001153026.1, NM_001159554.1 [O15547-2]
NP_005437.2, NM_005446.3 [O15547-1]
UniGeneiHs.113275

Genome annotation databases

EnsembliENST00000401443; ENSP00000385309; ENSG00000099957 [O15547-2]
ENST00000413302; ENSP00000416193; ENSG00000099957 [O15547-1]
GeneIDi9127
KEGGihsa:9127
UCSCiuc002ztz.3 human [O15547-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002059 Genomic DNA Translation: BAA22047.1 Different initiation.
AB002058 mRNA Translation: BAA22046.1 Different initiation.
CR456535 mRNA Translation: CAG30421.1
AC002472 Genomic DNA No translation available.
BC033488 mRNA Translation: AAH33488.1 Different initiation.
BC109209 mRNA Translation: AAI09210.1 Different initiation.
AF065385 mRNA Translation: AAF13303.1 Sequence problems.
CCDSiCCDS13788.2 [O15547-1]
CCDS54504.1 [O15547-2]
RefSeqiNP_001153026.1, NM_001159554.1 [O15547-2]
NP_005437.2, NM_005446.3 [O15547-1]
UniGeneiHs.113275

3D structure databases

ProteinModelPortaliO15547
SMRiO15547
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114575, 4 interactors
IntActiO15547, 1 interactor
STRINGi9606.ENSP00000416193

Chemistry databases

BindingDBiO15547
ChEMBLiCHEMBL2670

PTM databases

iPTMnetiO15547
PhosphoSitePlusiO15547

Polymorphism and mutation databases

BioMutaiP2RX6

Proteomic databases

PaxDbiO15547
PeptideAtlasiO15547
PRIDEiO15547
ProteomicsDBi48751

Protocols and materials databases

DNASUi9127
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401443; ENSP00000385309; ENSG00000099957 [O15547-2]
ENST00000413302; ENSP00000416193; ENSG00000099957 [O15547-1]
GeneIDi9127
KEGGihsa:9127
UCSCiuc002ztz.3 human [O15547-1]

Organism-specific databases

CTDi9127
DisGeNETi9127
EuPathDBiHostDB:ENSG00000099957.16
GeneCardsiP2RX6
HGNCiHGNC:8538 P2RX6
HPAiHPA028776
HPA028777
MIMi608077 gene
neXtProtiNX_O15547
OpenTargetsiENSG00000099957
PharmGKBiPA162398523
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiO15547
KOiK05221
OMAiRPHYSFQ
OrthoDBiEOG091G0A2U
PhylomeDBiO15547
TreeFamiTF328633

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Miscellaneous databases

GeneWikiiP2RX6
GenomeRNAii9127
PROiPR:O15547
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099957 Expressed in 89 organ(s), highest expression level in muscle of leg
CleanExiHS_P2RX6
ExpressionAtlasiO15547 baseline and differential
GenevisibleiO15547 HS

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003049 P2X6_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF21 PTHR10125:SF21, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01313 P2X6RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX6_HUMAN
AccessioniPrimary (citable) accession number: O15547
Secondary accession number(s): F6V3D7
, Q32MB6, Q58F04, Q6IC33, Q9UL50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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