UniProtKB - O15539 (RGS5_HUMAN)
Protein
Regulator of G-protein signaling 5
Gene
RGS5
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).By similarity
GO - Molecular functioni
- GTPase activator activity Source: ProtInc
- GTPase activity Source: Reactome
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of signal transduction Source: UniProtKB-KW
- regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Keywordsi
Molecular function | Signal transduction inhibitor |
Enzyme and pathway databases
PathwayCommonsi | O15539 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 5Short name: RGS5 |
Gene namesi | Name:RGS5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10001, RGS5 |
MIMi | 603276, gene |
neXtProti | NX_O15539 |
VEuPathDBi | HostDB:ENSG00000143248.12 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8490 |
MalaCardsi | RGS5 |
OpenTargetsi | ENSG00000143248 |
PharmGKBi | PA34376 |
Miscellaneous databases
Pharosi | O15539, Tbio |
Genetic variation databases
BioMutai | RGS5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204188 | 1 – 181 | Regulator of G-protein signaling 5Add BLAST | 181 |
Proteomic databases
PaxDbi | O15539 |
PeptideAtlasi | O15539 |
PRIDEi | O15539 |
ProteomicsDBi | 22176 48746 [O15539-1] 48747 [O15539-2] |
PTM databases
iPTMneti | O15539 |
PhosphoSitePlusi | O15539 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143248, Expressed in blood vessel layer and 261 other tissues |
ExpressionAtlasi | O15539, baseline and differential |
Genevisiblei | O15539, HS |
Organism-specific databases
HPAi | ENSG00000143248, Low tissue specificity |
Interactioni
Binary interactionsi
O15539
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-12017832,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 114062, 10 interactors |
IntActi | O15539, 2 interactors |
STRINGi | 9606.ENSP00000433001 |
Miscellaneous databases
RNActi | O15539, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O15539 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15539 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 180 | RGSPROSITE-ProRule annotationAdd BLAST | 117 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000157380 |
HOGENOMi | CLU_2704096_0_0_1 |
InParanoidi | O15539 |
OMAi | MAQKRIF |
OrthoDBi | 1416350at2759 |
PhylomeDBi | O15539 |
TreeFami | TF315837 |
Family and domain databases
CDDi | cd08717, RGS_RGS5, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR034955, RGS5 IPR034956, RGS_RGS5 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF42, PTHR10845:SF42, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O15539-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT
60 70 80 90 100
QKTSLDEALQ WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY
110 120 130 140 150
KKIKSPAKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSLSS
160 170 180
FDMAQKRIHA LMEKDSLPRF VRSEFYQELI K
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1APM2 | B1APM2_HUMAN | Regulator of G-protein signaling 5 | RGS5 hCG_15193 | 201 | Annotation score: | ||
E9PS96 | E9PS96_HUMAN | Regulator of G-protein signaling 5 | RGS5 | 71 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043094 | 1 – 108 | Missing in isoform 2. 1 PublicationAdd BLAST | 108 | |
Alternative sequenceiVSP_045086 | 128 | E → EVGLW in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF030108 mRNA Translation: AAB84001.1 AB008109 mRNA Translation: BAA22889.1 AF159570 mRNA Translation: AAD40957.1 AJ891044 mRNA Translation: CAI76926.1 AF493929 mRNA Translation: AAM12643.1 BX537427 mRNA Translation: CAD97669.1 AL451063 Genomic DNA No translation available. AL583850 Genomic DNA No translation available. AL499616 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90731.1 BC030059 mRNA Translation: AAH30059.1 BU172751 mRNA No translation available. |
CCDSi | CCDS1244.1 [O15539-1] CCDS55652.1 [O15539-2] CCDS58041.1 [O15539-3] |
RefSeqi | NP_001182232.1, NM_001195303.2 [O15539-2] NP_001241677.1, NM_001254748.1 [O15539-2] NP_001241678.1, NM_001254749.1 [O15539-3] NP_003608.1, NM_003617.3 [O15539-1] |
Genome annotation databases
Ensembli | ENST00000313961; ENSP00000319308; ENSG00000143248 [O15539-1] ENST00000527988; ENSP00000432313; ENSG00000143248 [O15539-2] ENST00000530507; ENSP00000433001; ENSG00000143248 [O15539-3] ENST00000618415; ENSP00000480891; ENSG00000143248 [O15539-2] |
GeneIDi | 8490 |
KEGGi | hsa:8490 |
UCSCi | uc001gcn.4, human [O15539-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF030108 mRNA Translation: AAB84001.1 AB008109 mRNA Translation: BAA22889.1 AF159570 mRNA Translation: AAD40957.1 AJ891044 mRNA Translation: CAI76926.1 AF493929 mRNA Translation: AAM12643.1 BX537427 mRNA Translation: CAD97669.1 AL451063 Genomic DNA No translation available. AL583850 Genomic DNA No translation available. AL499616 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90731.1 BC030059 mRNA Translation: AAH30059.1 BU172751 mRNA No translation available. |
CCDSi | CCDS1244.1 [O15539-1] CCDS55652.1 [O15539-2] CCDS58041.1 [O15539-3] |
RefSeqi | NP_001182232.1, NM_001195303.2 [O15539-2] NP_001241677.1, NM_001254748.1 [O15539-2] NP_001241678.1, NM_001254749.1 [O15539-3] NP_003608.1, NM_003617.3 [O15539-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CRP | NMR | - | A | 44-180 | [»] | |
SMRi | O15539 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114062, 10 interactors |
IntActi | O15539, 2 interactors |
STRINGi | 9606.ENSP00000433001 |
PTM databases
iPTMneti | O15539 |
PhosphoSitePlusi | O15539 |
Genetic variation databases
BioMutai | RGS5 |
Proteomic databases
PaxDbi | O15539 |
PeptideAtlasi | O15539 |
PRIDEi | O15539 |
ProteomicsDBi | 22176 48746 [O15539-1] 48747 [O15539-2] |
Protocols and materials databases
Antibodypediai | 982, 385 antibodies |
DNASUi | 8490 |
Genome annotation databases
Ensembli | ENST00000313961; ENSP00000319308; ENSG00000143248 [O15539-1] ENST00000527988; ENSP00000432313; ENSG00000143248 [O15539-2] ENST00000530507; ENSP00000433001; ENSG00000143248 [O15539-3] ENST00000618415; ENSP00000480891; ENSG00000143248 [O15539-2] |
GeneIDi | 8490 |
KEGGi | hsa:8490 |
UCSCi | uc001gcn.4, human [O15539-1] |
Organism-specific databases
CTDi | 8490 |
DisGeNETi | 8490 |
GeneCardsi | RGS5 |
HGNCi | HGNC:10001, RGS5 |
HPAi | ENSG00000143248, Low tissue specificity |
MalaCardsi | RGS5 |
MIMi | 603276, gene |
neXtProti | NX_O15539 |
OpenTargetsi | ENSG00000143248 |
PharmGKBi | PA34376 |
VEuPathDBi | HostDB:ENSG00000143248.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000157380 |
HOGENOMi | CLU_2704096_0_0_1 |
InParanoidi | O15539 |
OMAi | MAQKRIF |
OrthoDBi | 1416350at2759 |
PhylomeDBi | O15539 |
TreeFami | TF315837 |
Enzyme and pathway databases
PathwayCommonsi | O15539 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 8490, 3 hits in 859 CRISPR screens |
ChiTaRSi | RGS5, human |
EvolutionaryTracei | O15539 |
GeneWikii | RGS5 |
GenomeRNAii | 8490 |
Pharosi | O15539, Tbio |
PROi | PR:O15539 |
RNActi | O15539, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143248, Expressed in blood vessel layer and 261 other tissues |
ExpressionAtlasi | O15539, baseline and differential |
Genevisiblei | O15539, HS |
Family and domain databases
CDDi | cd08717, RGS_RGS5, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR034955, RGS5 IPR034956, RGS_RGS5 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF42, PTHR10845:SF42, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS5_HUMAN | |
Accessioni | O15539Primary (citable) accession number: O15539 Secondary accession number(s): E9PMP5, Q53XA9, Q599J0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references