RGS5

Functionⁱ

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).By similarity

GO - Molecular functionⁱ

GTPase activator activity
Source: ProtInc
Traceable author statementⁱ
- 10471929

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of signal transduction Source: UniProtKB-KW
regulation of G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10471929

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor

Molecular function

Signal transduction inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 5 Short name: RGS5
Gene namesⁱ	Name:RGS5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143248.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10001 RGS5
MIMⁱ	603276 gene
neXtProtⁱ	NX_O15539

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8490
MalaCards human disease database More...MalaCardsⁱ	RGS5
Open Targets More...OpenTargetsⁱ	ENSG00000143248
PharmGKBⁱ	PA34376

Polymorphism and mutation databases

BioMutaⁱ	RGS5

BioMutaⁱ

RGS5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204188	1 – 181	Regulator of G-protein signaling 5Add BLAST		181

Proteomic databases

PaxDbⁱ	O15539
PeptideAtlas More...PeptideAtlasⁱ	O15539
PRIDEⁱ	O15539
ProteomicsDBⁱ	48746 48747 [O15539-2]

PTM databases

iPTMnetⁱ	O15539
PhosphoSitePlusⁱ	O15539

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143248 Expressed in 252 organ(s), highest expression level in blood vessel layer
CleanExⁱ	HS_RGS5
ExpressionAtlasⁱ	O15539 baseline and differential
Genevisibleⁱ	O15539 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001821

HPAⁱ

HPA001821

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114062, 9 interactors
IntActⁱ	O15539, 1 interactor
STRINGⁱ	9606.ENSP00000319308

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	55 – 58	Combined sources	4
Helixⁱ	60 – 63	Combined sources	4
Helixⁱ	65 – 70	Combined sources	6
Helixⁱ	72 – 84	Combined sources	13
Helixⁱ	88 – 101	Combined sources	14
Helixⁱ	108 – 119	Combined sources	12
Helixⁱ	133 – 141	Combined sources	9
Helixⁱ	149 – 151	Combined sources	3
Helixⁱ	152 – 164	Combined sources	13
Helixⁱ	166 – 172	Combined sources	7
Helixⁱ	174 – 180	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	O15539
SMRⁱ	O15539
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O15539

EvolutionaryTraceⁱ

O15539

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	64 – 180	RGSPROSITE-ProRule annotationAdd BLAST		117

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	O15539
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	KRIYALM
PhylomeDBⁱ	O15539
TreeFamⁱ	TF315837

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08717 RGS_RGS5, 1 hit
Gene3Dⁱ	1.10.196.10, 1 hit
InterProⁱ	View protein in InterPro IPR016137 RGS IPR034955 RGS5 IPR034956 RGS_RGS5 IPR036305 RGS_sf IPR024066 RGS_subdom1/3
PANTHERⁱ	PTHR10845:SF42 PTHR10845:SF42, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O15539-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT 
        60         70         80         90        100
QKTSLDEALQ WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY 
       110        120        130        140        150
KKIKSPAKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSLSS 
       160        170        180 
FDMAQKRIHA LMEKDSLPRF VRSEFYQELI K

Length:181

Mass (Da):20,946

Last modified:January 1, 1998 - v1

Checksum:ⁱ2E08CB0179DE7687

GO

Isoform 2 (identifier: O15539-2) [UniParc]FASTA Add to basket

Also known as: RGS5s

The sequence of this isoform differs from the canonical sequence as follows:
1-108: Missing.

« Hide

        10         20         30         40         50
MAEKAKQIYE EFIQTEAPKE VNIDHFTKDI TMKNLVEPSL SSFDMAQKRI 
        60         70 
HALMEKDSLP RFVRSEFYQE LIK

Note: Acts as an endogenous negative regulator of isoform 1.

Show »

Length:73

Mass (Da):8,664

Checksum:ⁱ3B9DE08FBE577E5D

GO

Isoform 3 (identifier: O15539-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
128-128: E → EVGLW

« Hide

        10         20         30         40         50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT 
        60         70         80         90        100
QKTSLDEALQ WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY 
       110        120        130        140        150
KKIKSPAKMA EKAKQIYEEF IQTEAPKEVG LWVNIDHFTK DITMKNLVEP 
       160        170        180 
SLSSFDMAQK RIHALMEKDS LPRFVRSEFY QELIK

Note: No experimental confirmation available.

Show »

Length:185

Mass (Da):21,402

Checksum:ⁱ3B1840D1AB0D8DC0

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1APM2	B1APM2_HUMAN	Regulator of G-protein signalling 5... Regulator of G-protein signalling 5, isoform CRA_a (Regulator of G-protein-signaling 5)	RGS5 hCG_15193	201	Annotation score:
E9PS96	E9PS96_HUMAN	Regulator of G-protein-signaling 5 Regulator of G-protein-signaling 5	RGS5	71	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043094	1 – 108	Missing in isoform 2. 1 PublicationAdd BLAST		108
Alternative sequenceⁱVSP_045086	128	E → EVGLW in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF030108 mRNA Translation: AAB84001.1 AB008109 mRNA Translation: BAA22889.1 AF159570 mRNA Translation: AAD40957.1 AJ891044 mRNA Translation: CAI76926.1 AF493929 mRNA Translation: AAM12643.1 BX537427 mRNA Translation: CAD97669.1 AL451063 Genomic DNA No translation available. AL583850 Genomic DNA No translation available. AL499616 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90731.1 BC030059 mRNA Translation: AAH30059.1 BU172751 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1244.1 [O15539-1] CCDS55652.1 [O15539-2] CCDS58041.1 [O15539-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182232.1, NM_001195303.2 [O15539-2] NP_001241677.1, NM_001254748.1 [O15539-2] NP_001241678.1, NM_001254749.1 [O15539-3] NP_003608.1, NM_003617.3 [O15539-1]
UniGeneⁱ	Hs.24950 Hs.677623

Genome annotation databases

Ensemblⁱ	ENST00000313961; ENSP00000319308; ENSG00000143248 [O15539-1] ENST00000527988; ENSP00000432313; ENSG00000143248 [O15539-2] ENST00000530507; ENSP00000433001; ENSG00000143248 [O15539-3] ENST00000618415; ENSP00000480891; ENSG00000143248 [O15539-2]
GeneIDⁱ	8490
KEGGⁱ	hsa:8490
UCSC genome browser More...UCSCⁱ	uc001gcn.4 human [O15539-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15539	Regulator of G-protein signalling 5, isoform CRA_b		HUMAN		181	UniRef100_O15539
O15539-2	Regulator of G-protein signalling 5, isoform CRA_a		HUMAN		201	UniRef100_B1APM2
RGS5 isoform 11		PANTR		73
RGS5 isoform 11		PONAB		73
RGS5 (Fragment)		MACMU		35

Protein	Similar proteins		Species	Score	Length	Source
O15539	Regulator of G-protein signalling 5, isoform CRA_b		HUMAN		181	UniRef90_O15539
RGS5 isoform 11		PANTR		73
RGS5 isoform 11		PONAB		73
RGS5 (Fragment)		MACMU		35
Uncharacterized protein		MACFA		201
+60

Protein	Similar proteins		Species	Score	Length	Source
O15539	Regulator of G-protein signaling 5		BOVIN		181	UniRef50_O15539
Regulator of G-protein signalling 5, isoform CRA_b		HUMAN		181
RGS5 isoform 6		PANTR		201
RGS5 isoform 6 (Fragment)		PONAB		201
Uncharacterized protein		MACMU		201
+290

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF030108 mRNA Translation: AAB84001.1 AB008109 mRNA Translation: BAA22889.1 AF159570 mRNA Translation: AAD40957.1 AJ891044 mRNA Translation: CAI76926.1 AF493929 mRNA Translation: AAM12643.1 BX537427 mRNA Translation: CAD97669.1 AL451063 Genomic DNA No translation available. AL583850 Genomic DNA No translation available. AL499616 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90731.1 BC030059 mRNA Translation: AAH30059.1 BU172751 mRNA No translation available.
CCDSⁱ	CCDS1244.1 [O15539-1] CCDS55652.1 [O15539-2] CCDS58041.1 [O15539-3]
RefSeqⁱ	NP_001182232.1, NM_001195303.2 [O15539-2] NP_001241677.1, NM_001254748.1 [O15539-2] NP_001241678.1, NM_001254749.1 [O15539-3] NP_003608.1, NM_003617.3 [O15539-1]
UniGeneⁱ	Hs.24950 Hs.677623

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CRP	NMR	-	A	44-180	[»]
ProteinModelPortalⁱ	O15539
SMRⁱ	O15539
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114062, 9 interactors
IntActⁱ	O15539, 1 interactor
STRINGⁱ	9606.ENSP00000319308

PTM databases

iPTMnetⁱ	O15539
PhosphoSitePlusⁱ	O15539

Polymorphism and mutation databases

BioMutaⁱ	RGS5

BioMutaⁱ

RGS5

Proteomic databases

PaxDbⁱ	O15539
PeptideAtlasⁱ	O15539
PRIDEⁱ	O15539
ProteomicsDBⁱ	48746 48747 [O15539-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8490
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000313961; ENSP00000319308; ENSG00000143248 [O15539-1] ENST00000527988; ENSP00000432313; ENSG00000143248 [O15539-2] ENST00000530507; ENSP00000433001; ENSG00000143248 [O15539-3] ENST00000618415; ENSP00000480891; ENSG00000143248 [O15539-2]
GeneIDⁱ	8490
KEGGⁱ	hsa:8490
UCSCⁱ	uc001gcn.4 human [O15539-1]

Organism-specific databases

CTDⁱ	8490
DisGeNETⁱ	8490
EuPathDBⁱ	HostDB:ENSG00000143248.12
GeneCardsⁱ	RGS5
HGNCⁱ	HGNC:10001 RGS5
HPAⁱ	HPA001821
MalaCardsⁱ	RGS5
MIMⁱ	603276 gene
neXtProtⁱ	NX_O15539
OpenTargetsⁱ	ENSG00000143248
PharmGKBⁱ	PA34376
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	O15539
KOⁱ	K16449
OMAⁱ	KRIYALM
PhylomeDBⁱ	O15539
TreeFamⁱ	TF315837

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSⁱ	RGS5 human
EvolutionaryTraceⁱ	O15539
GeneWikiⁱ	RGS5
GenomeRNAiⁱ	8490
Protein Ontology More...PROⁱ	PR:O15539
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143248 Expressed in 252 organ(s), highest expression level in blood vessel layer
CleanExⁱ	HS_RGS5
ExpressionAtlasⁱ	O15539 baseline and differential
Genevisibleⁱ	O15539 HS

Family and domain databases

CDDⁱ	cd08717 RGS_RGS5, 1 hit
Gene3Dⁱ	1.10.196.10, 1 hit
InterProⁱ	View protein in InterPro IPR016137 RGS IPR034955 RGS5 IPR034956 RGS_RGS5 IPR036305 RGS_sf IPR024066 RGS_subdom1/3
PANTHERⁱ	PTHR10845:SF42 PTHR10845:SF42, 1 hit
Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS5_HUMAN
Accessionⁱ	O15539Primary (citable) accession number: O15539 Secondary accession number(s): E9PMP5, Q53XA9, Q599J0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O15539 (RGS5_HUMAN)

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Regulator of G-protein signaling 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ