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UniProtKB - O15539 (RGS5_HUMAN)

Entry version 173 (10 Feb 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Regulator of G-protein signaling 5

Gene

RGS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15539

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 5
Short name:
RGS5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10001, RGS5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603276, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15539

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143248.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8490

MalaCards human disease database

More...MalaCardsi		RGS5

Open Targets

More...OpenTargetsi		ENSG00000143248

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34376

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15539, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RGS5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041881 – 181Regulator of G-protein signaling 5Add BLAST181

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15539

PeptideAtlas

More...PeptideAtlasi		O15539

PRoteomics IDEntifications database

More...PRIDEi		O15539

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		22176
48746 [O15539-1]
48747 [O15539-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15539

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15539

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143248, Expressed in blood vessel layer and 261 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15539, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15539, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143248, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114062, 10 interactors

Protein interaction database and analysis system

More...IntActi		O15539, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000433001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15539, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15539

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O15539

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 180RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3589, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157380

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_2704096_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15539

Identification of Orthologs from Complete Genome Data

More...OMAi		MAQKRIF

Database of Orthologous Groups

More...OrthoDBi		1416350at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15539

TreeFam database of animal gene trees

More...TreeFami		TF315837

Family and domain databases

Conserved Domains Database

More...CDDi		cd08717, RGS_RGS5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.196.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016137, RGS
IPR034955, RGS5
IPR034956, RGS_RGS5
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3

The PANTHER Classification System

More...PANTHERi		PTHR10845:SF42, PTHR10845:SF42, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097, SSF48097, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT 
        60         70         80         90        100
QKTSLDEALQ WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY 
       110        120        130        140        150
KKIKSPAKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSLSS 
       160        170        180 
FDMAQKRIHA LMEKDSLPRF VRSEFYQELI K
Length:181
Mass (Da):20,946
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E08CB0179DE7687
GO
Isoform 2 (identifier: O15539-2) [UniParc]FASTAAdd to basket
Also known as: RGS5s

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: Acts as an endogenous negative regulator of isoform 1.Curated
Show »
Length:73
Mass (Da):8,664
Checksum:i3B9DE08FBE577E5D
GO
Isoform 3 (identifier: O15539-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: E → EVGLW

Show »
Length:185
Mass (Da):21,402
Checksum:i3B1840D1AB0D8DC0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1APM2B1APM2_HUMAN
Regulator of G-protein signaling 5
RGS5 hCG_15193
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS96E9PS96_HUMAN
Regulator of G-protein signaling 5
RGS5
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430941 – 108Missing in isoform 2. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_045086128E → EVGLW in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF030108 mRNA Translation: AAB84001.1
AB008109 mRNA Translation: BAA22889.1
AF159570 mRNA Translation: AAD40957.1
AJ891044 mRNA Translation: CAI76926.1
AF493929 mRNA Translation: AAM12643.1
BX537427 mRNA Translation: CAD97669.1
AL451063 Genomic DNA No translation available.
AL583850 Genomic DNA No translation available.
AL499616 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90731.1
BC030059 mRNA Translation: AAH30059.1
BU172751 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1244.1 [O15539-1]
CCDS55652.1 [O15539-2]
CCDS58041.1 [O15539-3]

NCBI Reference Sequences

More...RefSeqi		NP_001182232.1, NM_001195303.2 [O15539-2]
NP_001241677.1, NM_001254748.1 [O15539-2]
NP_001241678.1, NM_001254749.1 [O15539-3]
NP_003608.1, NM_003617.3 [O15539-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313961; ENSP00000319308; ENSG00000143248 [O15539-1]
ENST00000527988; ENSP00000432313; ENSG00000143248 [O15539-2]
ENST00000530507; ENSP00000433001; ENSG00000143248 [O15539-3]
ENST00000618415; ENSP00000480891; ENSG00000143248 [O15539-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8490

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8490

UCSC genome browser

More...UCSCi		uc001gcn.4, human [O15539-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030108 mRNA Translation: AAB84001.1
AB008109 mRNA Translation: BAA22889.1
AF159570 mRNA Translation: AAD40957.1
AJ891044 mRNA Translation: CAI76926.1
AF493929 mRNA Translation: AAM12643.1
BX537427 mRNA Translation: CAD97669.1
AL451063 Genomic DNA No translation available.
AL583850 Genomic DNA No translation available.
AL499616 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90731.1
BC030059 mRNA Translation: AAH30059.1
BU172751 mRNA No translation available.
CCDSiCCDS1244.1 [O15539-1]
CCDS55652.1 [O15539-2]
CCDS58041.1 [O15539-3]
RefSeqiNP_001182232.1, NM_001195303.2 [O15539-2]
NP_001241677.1, NM_001254748.1 [O15539-2]
NP_001241678.1, NM_001254749.1 [O15539-3]
NP_003608.1, NM_003617.3 [O15539-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRPNMR-A44-180[»]
SMRiO15539
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114062, 10 interactors
IntActiO15539, 2 interactors
STRINGi9606.ENSP00000433001

PTM databases

iPTMnetiO15539
PhosphoSitePlusiO15539

Genetic variation databases

BioMutaiRGS5

Proteomic databases

PaxDbiO15539
PeptideAtlasiO15539
PRIDEiO15539
ProteomicsDBi22176
48746 [O15539-1]
48747 [O15539-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		982, 385 antibodies

The DNASU plasmid repository

More...DNASUi		8490

Genome annotation databases

EnsembliENST00000313961; ENSP00000319308; ENSG00000143248 [O15539-1]
ENST00000527988; ENSP00000432313; ENSG00000143248 [O15539-2]
ENST00000530507; ENSP00000433001; ENSG00000143248 [O15539-3]
ENST00000618415; ENSP00000480891; ENSG00000143248 [O15539-2]
GeneIDi8490
KEGGihsa:8490
UCSCiuc001gcn.4, human [O15539-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8490
DisGeNETi8490

GeneCards: human genes, protein and diseases

More...GeneCardsi		RGS5
HGNCiHGNC:10001, RGS5
HPAiENSG00000143248, Low tissue specificity
MalaCardsiRGS5
MIMi603276, gene
neXtProtiNX_O15539
OpenTargetsiENSG00000143248
PharmGKBiPA34376
VEuPathDBiHostDB:ENSG00000143248.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3589, Eukaryota
GeneTreeiENSGT00940000157380
HOGENOMiCLU_2704096_0_0_1
InParanoidiO15539
OMAiMAQKRIF
OrthoDBi1416350at2759
PhylomeDBiO15539
TreeFamiTF315837

Enzyme and pathway databases

PathwayCommonsiO15539
ReactomeiR-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8490, 3 hits in 859 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RGS5, human
EvolutionaryTraceiO15539

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RGS5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8490
PharosiO15539, Tbio

Protein Ontology

More...PROi		PR:O15539
RNActiO15539, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143248, Expressed in blood vessel layer and 261 other tissues
ExpressionAtlasiO15539, baseline and differential
GenevisibleiO15539, HS

Family and domain databases

CDDicd08717, RGS_RGS5, 1 hit
Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137, RGS
IPR034955, RGS5
IPR034956, RGS_RGS5
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
PANTHERiPTHR10845:SF42, PTHR10845:SF42, 1 hit
PfamiView protein in Pfam
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132, RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15539
Secondary accession number(s): E9PMP5, Q53XA9, Q599J0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 10, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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