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UniProtKB - O15535 (ZSC9_HUMAN)
Protein
Zinc finger and SCAN domain-containing protein 9
Gene
ZSCAN9
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 254 – 276 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O15535 |
SignaLinki | O15535 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 9Alternative name(s): Cell proliferation-inducing gene 12 protein PRD51 Zinc finger protein 193 |
Gene namesi | Name:ZSCAN9 Synonyms:ZNF193 ORF Names:PIG12 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12984, ZSCAN9 |
MIMi | 602246, gene |
neXtProti | NX_O15535 |
VEuPathDBi | HostDB:ENSG00000137185 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7746 |
OpenTargetsi | ENSG00000137185 |
PharmGKBi | PA37564 |
Miscellaneous databases
Pharosi | O15535, Tdark |
Genetic variation databases
BioMutai | ZSCAN9 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047446 | 1 – 394 | Zinc finger and SCAN domain-containing protein 9Add BLAST | 394 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 26 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 215 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 238 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MassIVEi | O15535 |
MaxQBi | O15535 |
PeptideAtlasi | O15535 |
PRIDEi | O15535 |
ProteomicsDBi | 18685 48744 [O15535-1] |
PTM databases
iPTMneti | O15535 |
PhosphoSitePlusi | O15535 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137185, Expressed in subventricular zone (inner) (primate) and 185 other tissues |
ExpressionAtlasi | O15535, baseline and differential |
Genevisiblei | O15535, HS |
Organism-specific databases
HPAi | ENSG00000137185, Low tissue specificity |
Interactioni
Binary interactionsi
O15535
Protein-protein interaction databases
BioGRIDi | 113530, 18 interactors |
IntActi | O15535, 29 interactors |
MINTi | O15535 |
Miscellaneous databases
RNActi | O15535, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 134 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 254 – 276 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
GeneTreei | ENSGT00940000163521 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | O15535 |
OMAi | DEMTKTE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O15535 |
TreeFami | TF338304 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O15535-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNTNSKEVLS LGVQVPEAWE ELLTMKVEAK SHLQWQESRL KRSNPLAREI
60 70 80 90 100
FRRHFRQLCY QETPGPREAL TRLQELCYQW LRPHVSTKEQ ILDLLVLEQF
110 120 130 140 150
LSILPKELQG WVREHCPESG EEAVILLEDL ERELDEPQHE MVAHRHRQEV
160 170 180 190 200
LCKEMVPLAE QTPLTLQSQP KEPQLTCDSA QKCHSIGETD EVTKTEDREL
210 220 230 240 250
VLRKDCPKIV EPHGKMFNEQ TWEVSQQDPS HGEVGEHKDR IERQWGNLLG
260 270 280 290 300
EGQHKCDECG KSFTQSSGLI RHQRIHTGER PYECNECGKA FSRSSGLFNH
310 320 330 340 350
RGIHNIQKRY HCKECGKVFS QSAGLIQHQR IHKGEKPYQC SQCSKSYSRR
360 370 380 390
SFLIEHQRSH TGERPHQCIE CGKSFNRHCN LIRHQKIHTV AELV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3KQV4 | U3KQV4_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN9 | 197 | Annotation score: | ||
A0A0B4J224 | A0A0B4J224_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN9 | 261 | Annotation score: | ||
E9PQL7 | E9PQL7_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN9 | 369 | Annotation score: | ||
U3KQB2 | U3KQB2_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN9 | 160 | Annotation score: | ||
E9PLJ4 | E9PLJ4_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN9 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | E → G in BAG64928 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076868 | 254 | H → R1 PublicationCorresponds to variant dbSNP:rs148219046Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044798 | 189 | T → TDLIRSLRRRAVLIPLGAHL FSTDTFLFSKPVVIPQLKGG GETWPNNRGVLR in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62392 mRNA Translation: AAC51659.1 U88082, U88081 Genomic DNA Translation: AAC51661.1 AK304013 mRNA Translation: BAG64928.1 AY550973 mRNA Translation: AAT52219.1 AL022393 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03140.1 BC010374 mRNA Translation: AAH10374.1 |
CCDSi | CCDS4646.1 [O15535-1] CCDS56407.1 [O15535-2] |
RefSeqi | NP_001186408.1, NM_001199479.1 [O15535-2] NP_001186409.1, NM_001199480.1 [O15535-1] NP_006290.1, NM_006299.4 [O15535-1] XP_016866756.1, XM_017011267.1 [O15535-1] |
Genome annotation databases
Ensembli | ENST00000252207; ENSP00000252207; ENSG00000137185 ENST00000425468; ENSP00000404074; ENSG00000137185 [O15535-2] ENST00000531979; ENSP00000433402; ENSG00000137185 |
GeneIDi | 7746 |
KEGGi | hsa:7746 |
MANE-Selecti | ENST00000252207.10; ENSP00000252207.5; NM_006299.5; NP_006290.1 |
UCSCi | uc003nkq.3, human [O15535-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62392 mRNA Translation: AAC51659.1 U88082, U88081 Genomic DNA Translation: AAC51661.1 AK304013 mRNA Translation: BAG64928.1 AY550973 mRNA Translation: AAT52219.1 AL022393 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03140.1 BC010374 mRNA Translation: AAH10374.1 |
CCDSi | CCDS4646.1 [O15535-1] CCDS56407.1 [O15535-2] |
RefSeqi | NP_001186408.1, NM_001199479.1 [O15535-2] NP_001186409.1, NM_001199480.1 [O15535-1] NP_006290.1, NM_006299.4 [O15535-1] XP_016866756.1, XM_017011267.1 [O15535-1] |
3D structure databases
SMRi | O15535 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113530, 18 interactors |
IntActi | O15535, 29 interactors |
MINTi | O15535 |
PTM databases
iPTMneti | O15535 |
PhosphoSitePlusi | O15535 |
Genetic variation databases
BioMutai | ZSCAN9 |
Proteomic databases
MassIVEi | O15535 |
MaxQBi | O15535 |
PeptideAtlasi | O15535 |
PRIDEi | O15535 |
ProteomicsDBi | 18685 48744 [O15535-1] |
Protocols and materials databases
Antibodypediai | 25843, 161 antibodies from 20 providers |
DNASUi | 7746 |
Genome annotation databases
Ensembli | ENST00000252207; ENSP00000252207; ENSG00000137185 ENST00000425468; ENSP00000404074; ENSG00000137185 [O15535-2] ENST00000531979; ENSP00000433402; ENSG00000137185 |
GeneIDi | 7746 |
KEGGi | hsa:7746 |
MANE-Selecti | ENST00000252207.10; ENSP00000252207.5; NM_006299.5; NP_006290.1 |
UCSCi | uc003nkq.3, human [O15535-1] |
Organism-specific databases
CTDi | 7746 |
DisGeNETi | 7746 |
GeneCardsi | ZSCAN9 |
HGNCi | HGNC:12984, ZSCAN9 |
HPAi | ENSG00000137185, Low tissue specificity |
MIMi | 602246, gene |
neXtProti | NX_O15535 |
OpenTargetsi | ENSG00000137185 |
PharmGKBi | PA37564 |
VEuPathDBi | HostDB:ENSG00000137185 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000163521 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | O15535 |
OMAi | DEMTKTE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O15535 |
TreeFami | TF338304 |
Enzyme and pathway databases
PathwayCommonsi | O15535 |
SignaLinki | O15535 |
Miscellaneous databases
BioGRID-ORCSi | 7746, 2 hits in 1066 CRISPR screens |
GeneWikii | ZNF193 |
GenomeRNAii | 7746 |
Pharosi | O15535, Tdark |
PROi | PR:O15535 |
RNActi | O15535, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137185, Expressed in subventricular zone (inner) (primate) and 185 other tissues |
ExpressionAtlasi | O15535, baseline and differential |
Genevisiblei | O15535, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSC9_HUMAN | |
Accessioni | O15535Primary (citable) accession number: O15535 Secondary accession number(s): B4E1W6, E7EVQ2, Q2TTR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families