UniProtKB - O15534 (PER1_HUMAN)
Protein
Period circadian protein homolog 1
Gene
PER1
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.1 Publication
GO - Molecular functioni
- chromatin DNA binding Source: UniProtKB
- E-box binding Source: BHF-UCL
- kinase binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: BHF-UCL
- transcription corepressor binding Source: GO_Central
- transcription factor binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- circadian regulation of gene expression Source: UniProtKB
- circadian regulation of translation Source: UniProtKB
- circadian rhythm Source: UniProtKB
- entrainment of circadian clock Source: ProtInc
- entrainment of circadian clock by photoperiod Source: UniProtKB
- histone H3 acetylation Source: UniProtKB
- histone H3 deacetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- negative regulation of glucocorticoid receptor signaling pathway Source: UniProtKB
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of JNK cascade Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- posttranscriptional regulation of gene expression Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of cytokine production involved in inflammatory response Source: UniProtKB
- regulation of hair cycle Source: UniProtKB
- regulation of p38MAPK cascade Source: UniProtKB
- regulation of sodium ion transport Source: UniProtKB
- response to cAMP Source: Ensembl
- response to light stimulus Source: GO_Central
Keywordsi
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-400253 Circadian Clock |
SIGNORi | O15534 |
Names & Taxonomyi
Protein namesi | Recommended name: Period circadian protein homolog 1Short name: hPER1 Alternative name(s): Circadian clock protein PERIOD 1 Circadian pacemaker protein Rigui |
Gene namesi | Name:PER1 Synonyms:KIAA0482, PER, RIGUI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179094.13 |
HGNCi | HGNC:8845 PER1 |
MIMi | 602260 gene |
neXtProti | NX_O15534 |
Subcellular locationi
Nucleus
Other locations
Note: Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2 (By similarity).By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 121 – 126 | TSGCSS → AAGCSA: Strongly decreases interaction with BTRC and FBXW11 and inhibits degradation promoted by CSNK1E. | 6 | |
Mutagenesisi | 210 – 213 | SEYT → AEYA: No effect on interaction with BTRC and FBXW11. 1 Publication | 4 | |
Mutagenesisi | 714 – 726 | SVVSV…CSFSS → AVVAVTAQCAFAA: No effect on interaction with BTRC and FBXW11. 1 PublicationAdd BLAST | 13 | |
Mutagenesisi | 794 – 798 | FLSRF → ALSRA: Strongly decreases interaction with BTRC and FBXW11. 1 Publication | 5 |
Organism-specific databases
DisGeNETi | 5187 |
OpenTargetsi | ENSG00000179094 |
PharmGKBi | PA33184 |
Polymorphism and mutation databases
BioMutai | PER1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162627 | 1 – 1290 | Period circadian protein homolog 1Add BLAST | 1290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 121 | Phosphothreonine; by CSNK1ESequence analysis | 1 | |
Modified residuei | 122 | Phosphoserine; by CSNK1ESequence analysis | 1 | |
Modified residuei | 126 | Phosphoserine; by CSNK1ESequence analysis | 1 | |
Modified residuei | 661 | PhosphoserineBy similarity | 1 | |
Modified residuei | 663 | PhosphoserineBy similarity | 1 | |
Modified residuei | 704 | PhosphoserineCombined sources | 1 | |
Modified residuei | 815 | PhosphoserineCombined sources | 1 | |
Modified residuei | 979 | PhosphoserineCombined sources | 1 | |
Modified residuei | 980 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated on serine residues by CSNK1D, CSNK1E and probably also by CSNK1G2. Phosphorylation by CSNK1D or CSNK1E promotes nuclear location of PER proteins as well as ubiquitination and subsequent degradation. May be dephosphorylated by PP1.1 Publication
Ubiquitinated; requires phosphorylation by CSNK1E and interaction with BTRC and FBXW11. Deubiquitinated by USP2 (By similarity).By similarity1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O15534 |
jPOSTi | O15534 |
PaxDbi | O15534 |
PeptideAtlasi | O15534 |
PRIDEi | O15534 |
ProteomicsDBi | 48743 |
PTM databases
iPTMneti | O15534 |
PhosphoSitePlusi | O15534 |
Expressioni
Tissue specificityi
Widely expressed. Expressed in hair follicles (at protein level).Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle.4 Publications
Inductioni
Serum-induced levels in fibroblasts show circadian oscillations. Maximum levels after 1 hour stimulation, minimum levels after 12 hours. Another peak is then observed after 20 hours. Protein levels show maximum levels at 6 hours, decrease to reach minimum levels at 20 hours, and increase again to reach a second peak after 26 hours. Levels then decrease slightly and then increase to maximum levels at 32 hours. Levels of phosphorylated form increase between 3 hours and 12 hours.1 Publication
Gene expression databases
Bgeei | ENSG00000179094 Expressed in 224 organ(s), highest expression level in right adrenal gland |
ExpressionAtlasi | O15534 baseline and differential |
Genevisiblei | O15534 HS |
Organism-specific databases
HPAi | HPA047947 HPA067064 |
Interactioni
Subunit structurei
Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interacts with ARNTL/BMAL1 and CLOCK. Interacts with GPRASP1. Interacts (phosphorylated) with BTRC and FBXW11; the interactions trigger proteasomal degradation. Interacts with NONO, WDR5 and SFPQ. Interacts with USP2 (By similarity).By similarity1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Cry2 | Q9R194 | 3 | EBI-2557276,EBI-1266619 | From Mus musculus. |
GO - Molecular functioni
- kinase binding Source: UniProtKB
- transcription corepressor binding Source: GO_Central
- transcription factor binding Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 111210, 46 interactors |
ComplexPortali | CPX-3221 Cry2-Per1 complex CPX-3222 Cry1-Per1 complex |
DIPi | DIP-56603N |
IntActi | O15534, 11 interactors |
MINTi | O15534 |
STRINGi | 9606.ENSP00000314420 |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UL6 | model | - | A | 830-845 | [»] | |
ProteinModelPortali | O15534 | |||||
SMRi | O15534 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 208 – 275 | PAS 1PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 348 – 414 | PAS 2PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 422 – 465 | PACAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 151 | Interaction with BTRC1 PublicationAdd BLAST | 151 | |
Regioni | 596 – 815 | Required for phosphorylation by CSNK1EBy similarityAdd BLAST | 220 | |
Regioni | 1149 – 1290 | CRY binding domainBy similarityAdd BLAST | 142 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 138 – 147 | Nuclear export signal 1By similarity | 10 | |
Motifi | 489 – 498 | Nuclear export signal 2By similarity | 10 | |
Motifi | 827 – 843 | Nuclear localization signalBy similarityAdd BLAST | 17 | |
Motifi | 982 – 989 | Nuclear export signal 3By similarity | 8 | |
Motifi | 1043 – 1047 | LXXLL | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 129 | Ser-richAdd BLAST | 81 | |
Compositional biasi | 653 – 656 | Poly-Ser | 4 | |
Compositional biasi | 848 – 1013 | Pro-richAdd BLAST | 166 | |
Compositional biasi | 1030 – 1104 | Ser-richAdd BLAST | 75 | |
Compositional biasi | 1269 – 1273 | Poly-Glu | 5 | |
Compositional biasi | 1276 – 1279 | Poly-Ser | 4 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IMRF Eukaryota ENOG410ZBUP LUCA |
GeneTreei | ENSGT00940000159217 |
HOGENOMi | HOG000231111 |
HOVERGENi | HBG008167 |
InParanoidi | O15534 |
KOi | K21944 |
OMAi | RHHQTPR |
OrthoDBi | 145617at2759 |
PhylomeDBi | O15534 |
TreeFami | TF318445 |
Family and domain databases
CDDi | cd00130 PAS, 1 hit |
InterProi | View protein in InterPro IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013655 PAS_fold_3 IPR022728 Period_circadian-like_C |
Pfami | View protein in Pfam PF08447 PAS_3, 1 hit PF12114 Period_C, 1 hit |
SMARTi | View protein in SMART SM00091 PAS, 2 hits |
SUPFAMi | SSF55785 SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50112 PAS, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform Rigui 4.7 (identifier: O15534-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSGPLEGADG GGDPRPGESF CPGGVPSPGP PQHRPCPGPS LADDTDANSN
60 70 80 90 100
GSSGNESNGH ESRGASQRSS HSSSSGNGKD SALLETTESS KSTNSQSPSP
110 120 130 140 150
PSSSIAYSLL SASSEQDNPS TSGCSSEQSA RARTQKELMT ALRELKLRLP
160 170 180 190 200
PERRGKGRSG TLATLQYALA CVKQVQANQE YYQQWSLEEG EPCSMDMSTY
210 220 230 240 250
TLEELEHITS EYTLQNQDTF SVAVSFLTGR IVYISEQAAV LLRCKRDVFR
260 270 280 290 300
GTRFSELLAP QDVGVFYGST APSRLPTWGT GASAGSGLRD FTQEKSVFCR
310 320 330 340 350
IRGGPDRDPG PRYQPFRLTP YVTKIRVSDG APAQPCCLLI AERIHSGYEA
360 370 380 390 400
PRIPPDKRIF TTRHTPSCLF QDVDERAAPL LGYLPQDLLG APVLLFLHPE
410 420 430 440 450
DRPLMLAIHK KILQLAGQPF DHSPIRFCAR NGEYVTMDTS WAGFVHPWSR
460 470 480 490 500
KVAFVLGRHK VRTAPLNEDV FTPPAPSPAP SLDTDIQELS EQIHRLLLQP
510 520 530 540 550
VHSPSPTGLC GVGAVTSPGP LHSPGSSSDS NGGDAEGPGP PAPVTFQQIC
560 570 580 590 600
KDVHLVKHQG QQLFIESRAR PQSRPRLPAT GTFKAKALPC QSPDPELEAG
610 620 630 640 650
SAPVQAPLAL VPEEAERKEA SSCSYQQINC LDSILRYLES CNLPSTTKRK
660 670 680 690 700
CASSSSYTTS SASDDDRQRT GPVSVGTKKD PPSAALSGEG ATPRKEPVVG
710 720 730 740 750
GTLSPLALAN KAESVVSVTS QCSFSSTIVH VGDKKPPESD IIMMEDLPGL
760 770 780 790 800
APGPAPSPAP SPTVAPDPAP DAYRPVGLTK AVLSLHTQKE EQAFLSRFRD
810 820 830 840 850
LGRLRGLDSS STAPSALGER GCHHGPAPPS RRHHCRSKAK RSRHHQNPRA
860 870 880 890 900
EAPCYVSHPS PVPPSTPWPT PPATTPFPAV VQPYPLPVFS PRGGPQPLPP
910 920 930 940 950
APTSVPPAAF PAPLVTPMVA LVLPNYLFPT PSSYPYGALQ TPAEGPPTPA
960 970 980 990 1000
SHSPSPSLPA LAPSPPHRPD SPLFNSRCSS PLQLNLLQLE ELPRAEGAAV
1010 1020 1030 1040 1050
AGGPGSSAGP PPPSAEAAEP EARLAEVTES SNQDALSGSS DLLELLLQED
1060 1070 1080 1090 1100
SRSGTGSAAS GSLGSGLGSG SGSGSHEGGS TSASITRSSQ SSHTSKYFGS
1110 1120 1130 1140 1150
IDSSEAEAGA ARGGAEPGDQ VIKYVLQDPI WLLMANADQR VMMTYQVPSR
1160 1170 1180 1190 1200
DMTSVLKQDR ERLRAMQKQQ PRFSEDQRRE LGAVHSWVRK GQLPRALDVM
1210 1220 1230 1240 1250
ACVDCGSSTQ DPGHPDDPLF SELDGLGLEP MEEGGGEQGS SGGGSGEGEG
1260 1270 1280 1290
CEEAQGGAKA SSSQDLAMEE EEEGRSSSSP ALPTAGNCTS
Isoform Rigui 3.0 (identifier: O15534-2)
Sequence is not available
Length:–
Mass (Da):–
Isoform Rigui 6.6 (identifier: O15534-3)
Also known as: Truncated
Sequence is not available
Length:–
Mass (Da):–
Isoform 2 (identifier: O15534-4) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-32: MSGPLEGADGGGDPRPGESFCPGGVPSPGPPQ → MLEVLEEIWSVRARRA
822-875: CHHGPAPPSR...TPWPTPPATT → SHLGPPGACP...GTGPSLASPH
876-1290: Missing.
Note: No experimental confirmation available.
Show »Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KRL7 | J3KRL7_HUMAN | Period circadian protein homolog 1 | PER1 | 1,267 | Annotation score: | ||
J3QLQ5 | J3QLQ5_HUMAN | Period circadian protein homolog 1 | PER1 | 112 | Annotation score: | ||
J3KSL6 | J3KSL6_HUMAN | Period circadian protein homolog 1 | PER1 | 117 | Annotation score: | ||
J3QSH9 | J3QSH9_HUMAN | Period circadian protein homolog 1 | PER1 hCG_31279 | 572 | Annotation score: | ||
J3KTM2 | J3KTM2_HUMAN | Period circadian protein homolog 1 | PER1 | 824 | Annotation score: | ||
J3QL55 | J3QL55_HUMAN | Period circadian protein homolog 1 | PER1 | 175 | Annotation score: | ||
J3QL46 | J3QL46_HUMAN | Period circadian protein homolog 1 | PER1 | 168 | Annotation score: |
Sequence cautioni
The sequence BAC06326 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079176 | 422 | H → Q Found in a patient with Moyamoya disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1464745710Ensembl. | 1 | |
Natural variantiVAR_036038 | 696 | E → Q in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_047899 | 962 | A → P7 PublicationsCorresponds to variant dbSNP:rs2585405Ensembl. | 1 | |
Natural variantiVAR_047900 | 968 | R → H. Corresponds to variant dbSNP:rs3027193Ensembl. | 1 | |
Natural variantiVAR_036039 | 985 | N → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1323588262Ensembl. | 1 | |
Natural variantiVAR_036040 | 1060 | S → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs761958964Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056205 | 1 – 32 | MSGPL…PGPPQ → MLEVLEEIWSVRARRA in isoform 2. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_056206 | 822 – 875 | CHHGP…PPATT → SHLGPPGACPLPSLGLDCWG VGLKGGVSAPGTQAGVASTT RPCLGTGPSLASPH in isoform 2. 1 PublicationAdd BLAST | 54 | |
Alternative sequenceiVSP_056207 | 876 – 1290 | Missing in isoform 2. 1 PublicationAdd BLAST | 415 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF022991 mRNA Translation: AAC51765.1 AB002107 mRNA Translation: BAA22633.1 AF102137 Genomic DNA Translation: AAF15544.1 AB030817 Genomic DNA Translation: BAA94085.1 AB088477 mRNA Translation: BAC06326.2 Different initiation. AK295410 mRNA Translation: BAG58361.1 AC129492 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90090.1 CH471108 Genomic DNA Translation: EAW90091.1 BC137346 mRNA Translation: AAI37347.1 |
CCDSi | CCDS11131.1 [O15534-1] |
PIRi | T00018 |
RefSeqi | NP_002607.2, NM_002616.2 [O15534-1] XP_005256746.1, XM_005256689.1 [O15534-1] |
UniGenei | Hs.445534 |
Genome annotation databases
Ensembli | ENST00000317276; ENSP00000314420; ENSG00000179094 [O15534-1] ENST00000354903; ENSP00000346979; ENSG00000179094 [O15534-4] |
GeneIDi | 5187 |
KEGGi | hsa:5187 |
UCSCi | uc002gkd.4 human [O15534-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF022991 mRNA Translation: AAC51765.1 AB002107 mRNA Translation: BAA22633.1 AF102137 Genomic DNA Translation: AAF15544.1 AB030817 Genomic DNA Translation: BAA94085.1 AB088477 mRNA Translation: BAC06326.2 Different initiation. AK295410 mRNA Translation: BAG58361.1 AC129492 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90090.1 CH471108 Genomic DNA Translation: EAW90091.1 BC137346 mRNA Translation: AAI37347.1 |
CCDSi | CCDS11131.1 [O15534-1] |
PIRi | T00018 |
RefSeqi | NP_002607.2, NM_002616.2 [O15534-1] XP_005256746.1, XM_005256689.1 [O15534-1] |
UniGenei | Hs.445534 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UL6 | model | - | A | 830-845 | [»] | |
ProteinModelPortali | O15534 | |||||
SMRi | O15534 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 111210, 46 interactors |
ComplexPortali | CPX-3221 Cry2-Per1 complex CPX-3222 Cry1-Per1 complex |
DIPi | DIP-56603N |
IntActi | O15534, 11 interactors |
MINTi | O15534 |
STRINGi | 9606.ENSP00000314420 |
PTM databases
iPTMneti | O15534 |
PhosphoSitePlusi | O15534 |
Polymorphism and mutation databases
BioMutai | PER1 |
Proteomic databases
EPDi | O15534 |
jPOSTi | O15534 |
PaxDbi | O15534 |
PeptideAtlasi | O15534 |
PRIDEi | O15534 |
ProteomicsDBi | 48743 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000317276; ENSP00000314420; ENSG00000179094 [O15534-1] ENST00000354903; ENSP00000346979; ENSG00000179094 [O15534-4] |
GeneIDi | 5187 |
KEGGi | hsa:5187 |
UCSCi | uc002gkd.4 human [O15534-1] |
Organism-specific databases
CTDi | 5187 |
DisGeNETi | 5187 |
EuPathDBi | HostDB:ENSG00000179094.13 |
GeneCardsi | PER1 |
H-InvDBi | HIX0039072 |
HGNCi | HGNC:8845 PER1 |
HPAi | HPA047947 HPA067064 |
MIMi | 602260 gene |
neXtProti | NX_O15534 |
OpenTargetsi | ENSG00000179094 |
PharmGKBi | PA33184 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IMRF Eukaryota ENOG410ZBUP LUCA |
GeneTreei | ENSGT00940000159217 |
HOGENOMi | HOG000231111 |
HOVERGENi | HBG008167 |
InParanoidi | O15534 |
KOi | K21944 |
OMAi | RHHQTPR |
OrthoDBi | 145617at2759 |
PhylomeDBi | O15534 |
TreeFami | TF318445 |
Enzyme and pathway databases
Reactomei | R-HSA-400253 Circadian Clock |
SIGNORi | O15534 |
Miscellaneous databases
ChiTaRSi | PER1 human |
GeneWikii | PER1 |
GenomeRNAii | 5187 |
PROi | PR:O15534 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179094 Expressed in 224 organ(s), highest expression level in right adrenal gland |
ExpressionAtlasi | O15534 baseline and differential |
Genevisiblei | O15534 HS |
Family and domain databases
CDDi | cd00130 PAS, 1 hit |
InterProi | View protein in InterPro IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013655 PAS_fold_3 IPR022728 Period_circadian-like_C |
Pfami | View protein in Pfam PF08447 PAS_3, 1 hit PF12114 Period_C, 1 hit |
SMARTi | View protein in SMART SM00091 PAS, 2 hits |
SUPFAMi | SSF55785 SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50112 PAS, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PER1_HUMAN | |
Accessioni | O15534Primary (citable) accession number: O15534 Secondary accession number(s): B2RPA8, B4DI49, D3DTR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | December 16, 2008 | |
Last modified: | February 13, 2019 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations