Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G-protein coupled receptor 42

Gene

GPR42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 42
Gene namesi
Name:GPR42
Synonyms:GPR42P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000126251.6
HGNCiHGNC:4500 GPR42
MIMi603822 gene
neXtProtiNX_O15529

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 47Cytoplasmic7
Transmembranei48 – 68Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini69 – 90ExtracellularSequence analysisAdd BLAST22
Transmembranei91 – 111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini112 – 132CytoplasmicSequence analysisAdd BLAST21
Transmembranei133 – 153Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini154 – 178ExtracellularSequence analysisAdd BLAST25
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 222CytoplasmicSequence analysisAdd BLAST23
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 258ExtracellularSequence analysisAdd BLAST15
Transmembranei259 – 279Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini280 – 346CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2866
OpenTargetsiENSG00000126251

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695701 – 346G-protein coupled receptor 42Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO15529
PRIDEiO15529
ProteomicsDBi48735

Expressioni

Gene expression databases

BgeeiENSG00000126251 Expressed in 20 organ(s), highest expression level in blood
ExpressionAtlasiO15529 baseline and differential
GenevisibleiO15529 HS

Organism-specific databases

HPAiHPA044681

Interactioni

Protein-protein interaction databases

IntActiO15529, 74 interactors
STRINGi9606.ENSP00000410925

Structurei

3D structure databases

ProteinModelPortaliO15529
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IITC Eukaryota
ENOG4111Q82 LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000026778
HOVERGENiHBG051811
InParanoidiO15529
KOiK04326
OMAiSSSIFHC
OrthoDBiEOG091G0EX2
PhylomeDBiO15529
TreeFamiTF350010

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR013312 GPR40-rel_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01904 GPR40FAMILY
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O15529-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV
60 70 80 90 100
DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY
110 120 130 140 150
LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV
160 170 180 190 200
YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI LLPVRLEMAV VLFVVPLIIT
210 220 230 240 250
SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI
260 270 280 290 300
CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ
310 320 330 340
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN
Length:346
Mass (Da):38,695
Last modified:January 1, 1998 - v1
Checksum:i03F6742DA4B798D0
GO

Polymorphismi

Was originally thought to be a pseudogene due to the presence of a Trp at position 174 which prevents activation by short chain fatty acids, such as propionate (PubMed:12496283). However, the inactivating Trp-174 that differentiate GPR42 from the homologous functional G-protein-coupled receptor FFAR3 is most probably polymorphic for both genes in the human population. The frequency of the active allele of GPR42, with Arg at position 174, is estimated to 61%. Moreover, the 5 other amino acid differences at positions 44, 45, 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the human population (PubMed:19630535).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06286044R → Q1 PublicationCorresponds to variant dbSNP:rs878906072Ensembl.1
Natural variantiVAR_03346845C → R1 PublicationCorresponds to variant dbSNP:rs423385Ensembl.1
Natural variantiVAR_062861174W → R Common polymorphism; restores responses to propionate. 2 PublicationsCorresponds to variant dbSNP:rs424241Ensembl.1
Natural variantiVAR_033469227V → L1 PublicationCorresponds to variant dbSNP:rs403989Ensembl.1
Natural variantiVAR_033470256V → A1 PublicationCorresponds to variant dbSNP:rs424715Ensembl.1
Natural variantiVAR_062862346N → S1 PublicationCorresponds to variant dbSNP:rs381478Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024689 Genomic DNA Translation: AAB86712.1
AC002511 Genomic DNA Translation: AAB67885.1
PIRiJC5716
RefSeqiNP_001335124.1, NM_001348195.1

Genome annotation databases

EnsembliENST00000454971; ENSP00000410925; ENSG00000126251
ENST00000597214; ENSP00000473212; ENSG00000126251
GeneIDi2866
KEGGihsa:2866
UCSCiuc021usn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024689 Genomic DNA Translation: AAB86712.1
AC002511 Genomic DNA Translation: AAB67885.1
PIRiJC5716
RefSeqiNP_001335124.1, NM_001348195.1

3D structure databases

ProteinModelPortaliO15529
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO15529, 74 interactors
STRINGi9606.ENSP00000410925

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO15529
PRIDEiO15529
ProteomicsDBi48735

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454971; ENSP00000410925; ENSG00000126251
ENST00000597214; ENSP00000473212; ENSG00000126251
GeneIDi2866
KEGGihsa:2866
UCSCiuc021usn.2 human

Organism-specific databases

CTDi2866
DisGeNETi2866
EuPathDBiHostDB:ENSG00000126251.6
GeneCardsiGPR42
H-InvDBiHIX0040157
HGNCiHGNC:4500 GPR42
HPAiHPA044681
MIMi603822 gene
neXtProtiNX_O15529
OpenTargetsiENSG00000126251
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IITC Eukaryota
ENOG4111Q82 LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000026778
HOVERGENiHBG051811
InParanoidiO15529
KOiK04326
OMAiSSSIFHC
OrthoDBiEOG091G0EX2
PhylomeDBiO15529
TreeFamiTF350010

Miscellaneous databases

PROiPR:O15529
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126251 Expressed in 20 organ(s), highest expression level in blood
ExpressionAtlasiO15529 baseline and differential
GenevisibleiO15529 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR013312 GPR40-rel_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01904 GPR40FAMILY
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR42_HUMAN
AccessioniPrimary (citable) accession number: O15529
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again