UniProtKB - O15529 (GPR42_HUMAN)
Protein
G-protein coupled receptor 42
Gene
GPR42
Organism
Homo sapiens (Human)
Status
Functioni
Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 42 |
Gene namesi | Name:GPR42 Synonyms:GPR42P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126251.6 |
HGNCi | HGNC:4500 GPR42 |
MIMi | 603822 gene |
neXtProti | NX_O15529 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 40 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 41 – 47 | Cytoplasmic | 7 | |
Transmembranei | 48 – 68 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 69 – 90 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 91 – 111 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 112 – 132 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 133 – 153 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 154 – 178 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 179 – 199 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 200 – 222 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 223 – 243 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 258 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 259 – 279 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 280 – 346 | CytoplasmicSequence analysisAdd BLAST | 67 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2866 |
OpenTargetsi | ENSG00000126251 |
Polymorphism and mutation databases
BioMutai | GPR42 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069570 | 1 – 346 | G-protein coupled receptor 42Add BLAST | 346 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | O15529 |
PRIDEi | O15529 |
ProteomicsDBi | 48735 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126251 Expressed in 20 organ(s), highest expression level in blood |
ExpressionAtlasi | O15529 baseline and differential |
Genevisiblei | O15529 HS |
Organism-specific databases
HPAi | HPA044681 |
Interactioni
Protein-protein interaction databases
IntActi | O15529, 74 interactors |
STRINGi | 9606.ENSP00000410925 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IITC Eukaryota ENOG4111Q82 LUCA |
GeneTreei | ENSGT00940000153898 |
HOGENOMi | HOG000026778 |
HOVERGENi | HBG051811 |
InParanoidi | O15529 |
KOi | K04326 |
OMAi | SSSIFHC |
OrthoDBi | 1129026at2759 |
PhylomeDBi | O15529 |
TreeFami | TF350010 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR013312 GPR40-rel_orph |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01904 GPR40FAMILY |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O15529-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV
60 70 80 90 100
DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY
110 120 130 140 150
LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV
160 170 180 190 200
YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI LLPVRLEMAV VLFVVPLIIT
210 220 230 240 250
SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI
260 270 280 290 300
CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ
310 320 330 340
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN
Polymorphismi
Was originally thought to be a pseudogene due to the presence of a Trp at position 174 which prevents activation by short chain fatty acids, such as propionate (PubMed:12496283). However, the inactivating Trp-174 that differentiate GPR42 from the homologous functional G-protein-coupled receptor FFAR3 is most probably polymorphic for both genes in the human population. The frequency of the active allele of GPR42, with Arg at position 174, is estimated to 61%. Moreover, the 5 other amino acid differences at positions 44, 45, 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the human population (PubMed:19630535).2 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062860 | 44 | R → Q1 PublicationCorresponds to variant dbSNP:rs878906072Ensembl. | 1 | |
Natural variantiVAR_033468 | 45 | C → R1 PublicationCorresponds to variant dbSNP:rs423385Ensembl. | 1 | |
Natural variantiVAR_062861 | 174 | W → R Common polymorphism; restores responses to propionate. 2 PublicationsCorresponds to variant dbSNP:rs424241Ensembl. | 1 | |
Natural variantiVAR_033469 | 227 | V → L1 PublicationCorresponds to variant dbSNP:rs403989Ensembl. | 1 | |
Natural variantiVAR_033470 | 256 | V → A1 PublicationCorresponds to variant dbSNP:rs424715Ensembl. | 1 | |
Natural variantiVAR_062862 | 346 | N → S1 PublicationCorresponds to variant dbSNP:rs381478Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024689 Genomic DNA Translation: AAB86712.1 AC002511 Genomic DNA Translation: AAB67885.1 |
PIRi | JC5716 |
RefSeqi | NP_001335124.1, NM_001348195.1 |
Genome annotation databases
Ensembli | ENST00000454971; ENSP00000410925; ENSG00000126251 ENST00000597214; ENSP00000473212; ENSG00000126251 |
GeneIDi | 2866 |
KEGGi | hsa:2866 |
UCSCi | uc021usn.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024689 Genomic DNA Translation: AAB86712.1 AC002511 Genomic DNA Translation: AAB67885.1 |
PIRi | JC5716 |
RefSeqi | NP_001335124.1, NM_001348195.1 |
3D structure databases
ProteinModelPortali | O15529 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | O15529, 74 interactors |
STRINGi | 9606.ENSP00000410925 |
Protein family/group databases
GPCRDBi | Search... |
Polymorphism and mutation databases
BioMutai | GPR42 |
Proteomic databases
PaxDbi | O15529 |
PRIDEi | O15529 |
ProteomicsDBi | 48735 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000454971; ENSP00000410925; ENSG00000126251 ENST00000597214; ENSP00000473212; ENSG00000126251 |
GeneIDi | 2866 |
KEGGi | hsa:2866 |
UCSCi | uc021usn.2 human |
Organism-specific databases
CTDi | 2866 |
DisGeNETi | 2866 |
EuPathDBi | HostDB:ENSG00000126251.6 |
GeneCardsi | GPR42 |
H-InvDBi | HIX0040157 |
HGNCi | HGNC:4500 GPR42 |
HPAi | HPA044681 |
MIMi | 603822 gene |
neXtProti | NX_O15529 |
OpenTargetsi | ENSG00000126251 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IITC Eukaryota ENOG4111Q82 LUCA |
GeneTreei | ENSGT00940000153898 |
HOGENOMi | HOG000026778 |
HOVERGENi | HBG051811 |
InParanoidi | O15529 |
KOi | K04326 |
OMAi | SSSIFHC |
OrthoDBi | 1129026at2759 |
PhylomeDBi | O15529 |
TreeFami | TF350010 |
Miscellaneous databases
GenomeRNAii | 2866 |
PROi | PR:O15529 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126251 Expressed in 20 organ(s), highest expression level in blood |
ExpressionAtlasi | O15529 baseline and differential |
Genevisiblei | O15529 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR013312 GPR40-rel_orph |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01904 GPR40FAMILY |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | GPR42_HUMAN | |
Accessioni | O15529Primary (citable) accession number: O15529 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | January 16, 2019 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries