GPR42

Functionⁱ

Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.1 Publication

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 19630535

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G protein-coupled receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 19630535

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G-protein coupled receptor 42
Gene namesⁱ	Name:GPR42 Synonyms:GPR42P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126251.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4500 GPR42
MIMⁱ	603822 gene
neXtProtⁱ	NX_O15529

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 19	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	20 – 40	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	41 – 47	Cytoplasmic	7
Transmembraneⁱ	48 – 68	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	69 – 90	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	91 – 111	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	112 – 132	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	133 – 153	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	154 – 178	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	179 – 199	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	200 – 222	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	223 – 243	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	244 – 258	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	259 – 279	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	280 – 346	CytoplasmicSequence analysisAdd BLAST	67

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2866
Open Targets More...OpenTargetsⁱ	ENSG00000126251

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069570	1 – 346	G-protein coupled receptor 42Add BLAST		346

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	O15529
PRIDEⁱ	O15529
ProteomicsDBⁱ	48735

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000126251 Expressed in 20 organ(s), highest expression level in blood
ExpressionAtlasⁱ	O15529 baseline and differential
Genevisibleⁱ	O15529 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044681

HPAⁱ

HPA044681

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	O15529, 74 interactors
STRINGⁱ	9606.ENSP00000410925

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15529
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IITC Eukaryota ENOG4111Q82 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148955
HOGENOMⁱ	HOG000026778
HOVERGENⁱ	HBG051811
InParanoidⁱ	O15529
KEGG Orthology (KO) More...KOⁱ	K04326
OMAⁱ	SSSIFHC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EX2
PhylomeDBⁱ	O15529
TreeFamⁱ	TF350010

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR013312 GPR40-rel_orph
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01904 GPR40FAMILY
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O15529-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV 
        60         70         80         90        100
DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY 
       110        120        130        140        150
LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV 
       160        170        180        190        200
YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI LLPVRLEMAV VLFVVPLIIT 
       210        220        230        240        250
SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI 
       260        270        280        290        300
CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 
       310        320        330        340 
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN

Length:346

Mass (Da):38,695

Last modified:January 1, 1998 - v1

Checksum:ⁱ03F6742DA4B798D0

GO

Polymorphismⁱ

Was originally thought to be a pseudogene due to the presence of a Trp at position 174 which prevents activation by short chain fatty acids, such as propionate (PubMed:12496283). However, the inactivating Trp-174 that differentiate GPR42 from the homologous functional G-protein-coupled receptor FFAR3 is most probably polymorphic for both genes in the human population. The frequency of the active allele of GPR42, with Arg at position 174, is estimated to 61%. Moreover, the 5 other amino acid differences at positions 44, 45, 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the human population (PubMed:19630535).2 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_062860	44	R → Q1 PublicationCorresponds to variant dbSNP:rs878906072Ensembl.	1
Natural variantⁱVAR_033468	45	C → R1 PublicationCorresponds to variant dbSNP:rs423385Ensembl.	1
Natural variantⁱVAR_062861	174	W → R Common polymorphism; restores responses to propionate. 2 PublicationsCorresponds to variant dbSNP:rs424241Ensembl.	1
Natural variantⁱVAR_033469	227	V → L1 PublicationCorresponds to variant dbSNP:rs403989Ensembl.	1
Natural variantⁱVAR_033470	256	V → A1 PublicationCorresponds to variant dbSNP:rs424715Ensembl.	1
Natural variantⁱVAR_062862	346	N → S1 PublicationCorresponds to variant dbSNP:rs381478Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF024689 Genomic DNA Translation: AAB86712.1 AC002511 Genomic DNA Translation: AAB67885.1
PIRⁱ	JC5716
NCBI Reference Sequences More...RefSeqⁱ	NP_001335124.1, NM_001348195.1

Genome annotation databases

Ensemblⁱ	ENST00000454971; ENSP00000410925; ENSG00000126251 ENST00000597214; ENSP00000473212; ENSG00000126251
GeneIDⁱ	2866
KEGGⁱ	hsa:2866
UCSC genome browser More...UCSCⁱ	uc021usn.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15529	G-protein coupled receptor		HUMAN		346	UniRef100_O15529

Protein	Similar proteins		Species	Score	Length	Source
O15529	Free fatty acid receptor 3		HUMAN		346	UniRef90_O14843
GPR42 isoform 1		PONAB		346
FFAR3 isoform 1		PANTR		346
Uncharacterized protein		GORGO		346
G-protein coupled receptor 41		MACFA		346
+44

Protein	Similar proteins		Species	Score	Length	Source
O15529	Free fatty acid receptor 3		MOUSE		319	UniRef50_Q3UFD7
Free fatty acid receptor 3		RAT		319
Free fatty acid receptor 3		HUMAN		346
free fatty acid receptor 3		MESAU		319
Proteinase-activated receptor		CRIGR		350
+128

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF024689 Genomic DNA Translation: AAB86712.1 AC002511 Genomic DNA Translation: AAB67885.1
PIRⁱ	JC5716
RefSeqⁱ	NP_001335124.1, NM_001348195.1

3D structure databases

ProteinModelPortalⁱ	O15529
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O15529, 74 interactors
STRINGⁱ	9606.ENSP00000410925

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Proteomic databases

PaxDbⁱ	O15529
PRIDEⁱ	O15529
ProteomicsDBⁱ	48735

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000454971; ENSP00000410925; ENSG00000126251 ENST00000597214; ENSP00000473212; ENSG00000126251
GeneIDⁱ	2866
KEGGⁱ	hsa:2866
UCSCⁱ	uc021usn.2 human

Organism-specific databases

CTDⁱ	2866
DisGeNETⁱ	2866
EuPathDBⁱ	HostDB:ENSG00000126251.6
GeneCardsⁱ	GPR42
H-InvDBⁱ	HIX0040157
HGNCⁱ	HGNC:4500 GPR42
HPAⁱ	HPA044681
MIMⁱ	603822 gene
neXtProtⁱ	NX_O15529
OpenTargetsⁱ	ENSG00000126251
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IITC Eukaryota ENOG4111Q82 LUCA
GeneTreeⁱ	ENSGT00920000148955
HOGENOMⁱ	HOG000026778
HOVERGENⁱ	HBG051811
InParanoidⁱ	O15529
KOⁱ	K04326
OMAⁱ	SSSIFHC
OrthoDBⁱ	EOG091G0EX2
PhylomeDBⁱ	O15529
TreeFamⁱ	TF350010

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O15529
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126251 Expressed in 20 organ(s), highest expression level in blood
ExpressionAtlasⁱ	O15529 baseline and differential
Genevisibleⁱ	O15529 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR013312 GPR40-rel_orph
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01904 GPR40FAMILY
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPR42_HUMAN
Accessionⁱ	O15529Primary (citable) accession number: O15529
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O15529 (GPR42_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

G-protein coupled receptor 42

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ