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UniProtKB - O15529 (GPR42_HUMAN)

Entry version 160 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
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Protein

G-protein coupled receptor 42

Gene

GPR42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15529

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor 42
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR42
Synonyms:GPR42P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4500, GPR42

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603822, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15529

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126251

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 47Cytoplasmic7
Transmembranei48 – 68Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini69 – 90ExtracellularSequence analysisAdd BLAST22
Transmembranei91 – 111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini112 – 132CytoplasmicSequence analysisAdd BLAST21
Transmembranei133 – 153Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini154 – 178ExtracellularSequence analysisAdd BLAST25
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 222CytoplasmicSequence analysisAdd BLAST23
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 258ExtracellularSequence analysisAdd BLAST15
Transmembranei259 – 279Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini280 – 346CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2866

Open Targets

More...OpenTargetsi		ENSG00000126251

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15529, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPR42

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000695701 – 346G-protein coupled receptor 42Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15529

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15529

PeptideAtlas

More...PeptideAtlasi		O15529

PRoteomics IDEntifications database

More...PRIDEi		O15529

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48735

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O15529, 1 site

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126251, Expressed in blood and 30 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15529, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15529, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126251, Tissue enhanced (adipose tissue, blood, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O15529
With#Exp.IntAct
ADIPOQ [Q15848]3EBI-18076404,EBI-10827839
ALOX5AP [P20292]3EBI-18076404,EBI-3904621
ANKRD46 - isoform 1 [Q86W74-2]3EBI-18076404,EBI-12109402
APOD [P05090]3EBI-18076404,EBI-715495
ATP13A1 - isoform C [Q9HD20-3]3EBI-18076404,EBI-12069500
ATP4B [P51164]3EBI-18076404,EBI-3904463
ATP6V0B [Q99437]3EBI-18076404,EBI-3904417
ATP6V0C [P27449]3EBI-18076404,EBI-721179
BNIP3 [Q12983]3EBI-18076404,EBI-749464
BTN2A2 [Q8WVV5]3EBI-18076404,EBI-8648738
CCDC167 [Q9P0B6]3EBI-18076404,EBI-9083477
CCL4L2 [Q8NHW4]3EBI-18076404,EBI-10271156
CD300C [Q08708]3EBI-18076404,EBI-3915344
CD79A [P11912]3EBI-18076404,EBI-7797864
CLEC2D - isoform 2 [Q9UHP7-3]3EBI-18076404,EBI-11749983
COMT [P21964]3EBI-18076404,EBI-372265
CTXN3 [Q4LDR2]3EBI-18076404,EBI-12019274
CXCL9 [Q07325]3EBI-18076404,EBI-3911467
DRAM1 [Q8N682]3EBI-18076404,EBI-10305400
EFNA5 [P52803]3EBI-18076404,EBI-1753674
EMP1 [P54849]3EBI-18076404,EBI-4319440
ERMP1 [Q7Z2K6]3EBI-18076404,EBI-10976398
FAM3C [Q92520]3EBI-18076404,EBI-2876774
FXYD3 - isoform 3 [Q14802-3]3EBI-18076404,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-18076404,EBI-713304
GJB2 [P29033]3EBI-18076404,EBI-3905204
GOSR2 [O14653]3EBI-18076404,EBI-4401517
GPR37L1 [O60883]3EBI-18076404,EBI-2927498
GYPC [P04921]3EBI-18076404,EBI-7797098
IER3IP1 [Q9Y5U9]3EBI-18076404,EBI-725665
IGFBP5 [P24593]3EBI-18076404,EBI-720480
IL1RL1 - isoform B [Q01638-2]3EBI-18076404,EBI-12838366
ITGAM [P11215]3EBI-18076404,EBI-2568251
JPH1 [Q9HDC5]3EBI-18076404,EBI-465137
KCNA1 [Q09470]3EBI-18076404,EBI-8286599
KLRG1 [Q96E93]3EBI-18076404,EBI-750770
LAT - isoform 2 [O43561-2]3EBI-18076404,EBI-8070286
LEPROTL1 [O95214]3EBI-18076404,EBI-750776
LHFPL5 [Q8TAF8]3EBI-18076404,EBI-2820517
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-18076404,EBI-12133176
LTC4S [Q16873]3EBI-18076404,EBI-12241118
MFSD5 [Q6N075]3EBI-18076404,EBI-3920969
MFSD6 [Q6ZSS7]3EBI-18076404,EBI-2858252
MGAM [O43451]3EBI-18076404,EBI-2829774
MS4A1 [P11836]3EBI-18076404,EBI-2808234
NDUFB11 [Q9NX14]3EBI-18076404,EBI-1246182
NINJ2 [Q9NZG7]3EBI-18076404,EBI-10317425
NRM [Q8IXM6]3EBI-18076404,EBI-10262547
NSG1 [P42857]3EBI-18076404,EBI-6380741
PAEP [P09466]3EBI-18076404,EBI-465167
PLP1 - isoform DM-20 [P60201-2]3EBI-18076404,EBI-12188331
PLPP1 [O14494]3EBI-18076404,EBI-2865290
PMP22 [Q01453]3EBI-18076404,EBI-2845982
PNLIPRP1 [P54315]3EBI-18076404,EBI-8652812
RPRM [Q9NS64]3EBI-18076404,EBI-1052363
RTP2 [Q5QGT7]3EBI-18076404,EBI-10244780
RUSF1 [Q96GQ5]3EBI-18076404,EBI-8636004
SCD [O00767]3EBI-18076404,EBI-2684237
SERINC1 [Q9NRX5]3EBI-18076404,EBI-2683145
SERP2 [Q8N6R1]3EBI-18076404,EBI-749270
SERTM1 [A2A2V5]3EBI-18076404,EBI-17284533
SLC30A2 [Q9BRI3]3EBI-18076404,EBI-8644112
SLC30A3 [Q99726]3EBI-18076404,EBI-10294651
SLC30A8 [Q8IWU4]3EBI-18076404,EBI-10262251
SLC35E4 [Q6ICL7]3EBI-18076404,EBI-12867720
SLC38A1 [Q9H2H9]3EBI-18076404,EBI-9978441
SLC38A7 [Q9NVC3]3EBI-18076404,EBI-10314552
SLC39A2 [Q9NP94]3EBI-18076404,EBI-12898013
SLC41A1 [Q8IVJ1]3EBI-18076404,EBI-12266234
SLC41A2 [Q96JW4]3EBI-18076404,EBI-10290130
SMCO4 [Q9NRQ5]3EBI-18076404,EBI-8640191
SMIM3 [Q9BZL3]3EBI-18076404,EBI-741850
STATH [P02808]3EBI-18076404,EBI-738687
STRIT1 [P0DN84]3EBI-18076404,EBI-12200293
STX8 [Q9UNK0]3EBI-18076404,EBI-727240
SYNDIG1 [Q9H7V2]3EBI-18076404,EBI-726331
SYNGR1 - isoform 1B [O43759-2]3EBI-18076404,EBI-12187159
TEX264 [Q9Y6I9]3EBI-18076404,EBI-10329860
TF [P02787]3EBI-18076404,EBI-714319
TM4SF4 [P48230]3EBI-18076404,EBI-8650934
TMBIM6 [P55061]3EBI-18076404,EBI-1045825
TMEM140 [Q9NV12]3EBI-18076404,EBI-2844246
TMEM147 [Q9BVK8]3EBI-18076404,EBI-348587
TMEM182 [Q6ZP80]3EBI-18076404,EBI-10255122
TMEM19 [Q96HH6]3EBI-18076404,EBI-741829
TMEM237 - isoform 2 [Q96Q45-2]3EBI-18076404,EBI-10982110
TMEM239 - isoform 2 [Q8WW34-2]3EBI-18076404,EBI-11528917
TMEM242 [Q9NWH2]3EBI-18076404,EBI-10315004
TMEM262 [E9PQX1]3EBI-18076404,EBI-17180389
TMEM30B [Q3MIR4]3EBI-18076404,EBI-9527107
TMEM60 [Q9H2L4]3EBI-18076404,EBI-2852148
TMEM65 [Q6PI78]3EBI-18076404,EBI-6656213
TREX1 - isoform 1 [Q9NSU2-1]3EBI-18076404,EBI-16746122
TSPO2 [Q5TGU0]3EBI-18076404,EBI-12195249
TUSC5 [A5PKU2]3EBI-18076404,EBI-11988865
YIF1A [O95070]3EBI-18076404,EBI-2799703
YIPF1 [Q9Y548]3EBI-18076404,EBI-7850136
YIPF2 [Q9BWQ6]3EBI-18076404,EBI-751204
YIPF4 [Q9BSR8]3EBI-18076404,EBI-751253
YIPF6 [Q96EC8]3EBI-18076404,EBI-751210
ZFPL1 [O95159]3EBI-18076404,EBI-718439

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O15529, 101 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000473212

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15529, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 346DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi309 – 329Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQGM, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203527

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15529

Identification of Orthologs from Complete Genome Data

More...OMAi		ISCFCYV

Database of Orthologous Groups

More...OrthoDBi		1129026at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15529

TreeFam database of animal gene trees

More...TreeFami		TF350010

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR013312, GPR40-rel_orph

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01904, GPR40FAMILY

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O15529-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV 
        60         70         80         90        100
DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY 
       110        120        130        140        150
LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV 
       160        170        180        190        200
YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI LLPVRLEMAV VLFVVPLIIT 
       210        220        230        240        250
SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI 
       260        270        280        290        300
CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 
       310        320        330        340 
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN
Length:346
Mass (Da):38,695
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03F6742DA4B798D0
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Was originally thought to be a pseudogene due to the presence of a Trp at position 174 which prevents activation by short chain fatty acids, such as propionate (PubMed:12496283). However, the inactivating Trp-174 that differentiate GPR42 from the homologous functional G-protein-coupled receptor FFAR3 is most probably polymorphic for both genes in the human population. The frequency of the active allele of GPR42, with Arg at position 174, is estimated to 61%. Moreover, the 5 other amino acid differences at positions 44, 45, 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the human population (PubMed:19630535).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06286044R → Q1 PublicationCorresponds to variant dbSNP:rs878906072Ensembl.1
Natural variantiVAR_03346845C → R1 PublicationCorresponds to variant dbSNP:rs423385Ensembl.1
Natural variantiVAR_062861174W → R Restores responses to propionate. 2 PublicationsCorresponds to variant dbSNP:rs424241Ensembl.1
Natural variantiVAR_033469227V → L1 PublicationCorresponds to variant dbSNP:rs403989Ensembl.1
Natural variantiVAR_033470256V → A1 PublicationCorresponds to variant dbSNP:rs424715Ensembl.1
Natural variantiVAR_062862346N → S1 PublicationCorresponds to variant dbSNP:rs381478Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF024689 Genomic DNA Translation: AAB86712.1
AC002511 Genomic DNA Translation: AAB67885.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC5716

NCBI Reference Sequences

More...RefSeqi		NP_001335124.1, NM_001348195.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000454971; ENSP00000410925; ENSG00000126251
ENST00000597214; ENSP00000473212; ENSG00000126251

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2866

UCSC genome browser

More...UCSCi		uc021usn.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024689 Genomic DNA Translation: AAB86712.1
AC002511 Genomic DNA Translation: AAB67885.1
PIRiJC5716
RefSeqiNP_001335124.1, NM_001348195.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiO15529, 101 interactors
STRINGi9606.ENSP00000473212

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniO15529, 1 site

Genetic variation databases

BioMutaiGPR42

Proteomic databases

MassIVEiO15529
PaxDbiO15529
PeptideAtlasiO15529
PRIDEiO15529
ProteomicsDBi48735

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		71522, 12 antibodies

The DNASU plasmid repository

More...DNASUi		2866

Genome annotation databases

EnsembliENST00000454971; ENSP00000410925; ENSG00000126251
ENST00000597214; ENSP00000473212; ENSG00000126251
GeneIDi2866
KEGGihsa:2866
UCSCiuc021usn.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2866
DisGeNETi2866

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPR42
HGNCiHGNC:4500, GPR42
HPAiENSG00000126251, Tissue enhanced (adipose tissue, blood, intestine)
MIMi603822, gene
neXtProtiNX_O15529
OpenTargetsiENSG00000126251
VEuPathDBiHostDB:ENSG00000126251

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQGM, Eukaryota
GeneTreeiENSGT00990000203527
HOGENOMiCLU_009579_8_4_1
InParanoidiO15529
OMAiISCFCYV
OrthoDBi1129026at2759
PhylomeDBiO15529
TreeFamiTF350010

Enzyme and pathway databases

PathwayCommonsiO15529

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2866, 0 hits in 40 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2866
PharosiO15529, Tdark

Protein Ontology

More...PROi		PR:O15529
RNActiO15529, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126251, Expressed in blood and 30 other tissues
ExpressionAtlasiO15529, baseline and differential
GenevisibleiO15529, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR013312, GPR40-rel_orph
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01904, GPR40FAMILY
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPR42_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15529
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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