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UniProtKB - O15527 (OGG1_HUMAN)

Protein

N-glycosylase/DNA lyase

Gene

OGG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149DNA5 Publications1
Binding sitei154DNA5 Publications1
Binding sitei204DNA5 Publications1
Active sitei249Schiff-base intermediate with DNA1 Publication1
Binding sitei2668-oxoguanine; via carbonyl oxygen1
Binding sitei2688-oxoguanine1
Binding sitei270DNA5 Publications1
Binding sitei287DNA5 Publications1
Binding sitei3158-oxoguanine1
Binding sitei3198-oxoguanine1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.23 2681
4.2.99.18 2681
ReactomeiR-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-110357 Displacement of DNA glycosylase by APEX1
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
SIGNORiO15527

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:OGG1
Synonyms:MMH, MUTM, OGH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114026.21
HGNCiHGNC:8125 OGG1
MIMi601982 gene
neXtProtiNX_O15527

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Involvement in diseasei

Renal cell carcinoma (RCC)
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionRenal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
See also OMIM:144700

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi249K → Q: Loss of activity. 1 Publication1
Mutagenesisi268D → E or Q: No effect on activity. 1 Publication1
Mutagenesisi268D → N: Decreases activity about 65-fold. 1 Publication1

Organism-specific databases

DisGeNETi4968
MalaCardsiOGG1
MIMi144700 phenotype
OpenTargetsiENSG00000114026
PharmGKBiPA31912

Chemistry databases

ChEMBLiCHEMBL3396944

Polymorphism and mutation databases

BioMutaiOGG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585911 – 345N-glycosylase/DNA lyaseAdd BLAST345

Proteomic databases

EPDiO15527
MaxQBiO15527
PeptideAtlasiO15527
PRIDEiO15527
ProteomicsDBi48726
48727 [O15527-2]
48728 [O15527-3]
48729 [O15527-4]
48730 [O15527-5]
48731 [O15527-6]
48732 [O15527-7]
48733 [O15527-8]

PTM databases

iPTMnetiO15527
PhosphoSitePlusiO15527

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000114026 Expressed in 222 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiO15527 baseline and differential
GenevisibleiO15527 HS

Organism-specific databases

HPAiCAB047301
HPA027514

Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111018, 9 interactors
IntActiO15527, 4 interactors
MINTiO15527

Chemistry databases

BindingDBiO15527

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO15527
SMRiO15527
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15527

Family & Domainsi

Sequence similaritiesi

Belongs to the type-1 OGG1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00640000091554
HOVERGENiHBG001047
InParanoidiO15527
KOiK03660
OMAiEYAGYAQ
PhylomeDBiO15527
TreeFamiTF323702

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
InterProiView protein in InterPro
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
IPR004577 Ogg1
IPR012904 OGG_N
PfamiView protein in Pfam
PF00730 HhH-GPD, 1 hit
PF07934 OGG_N, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit
TIGRFAMsiTIGR00588 ogg, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1A (identifier: O15527-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ 
        60         70         80         90        100
SPAHWSGVLA DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF 
       110        120        130        140        150
QLDVTLAQLY HHWGSVDSHF QEVAQKFQGV RLLRQDPIEC LFSFICSSNN 
       160        170        180        190        200
NIARITGMVE RLCQAFGPRL IQLDDVTYHG FPSLQALAGP EVEAHLRKLG 
       210        220        230        240        250
LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL CILPGVGTKV 
       260        270        280        290        300
ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 
       310        320        330        340 
NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG
Length:345
Mass (Da):38,782
Last modified:December 1, 2000 - v2
Checksum:iC284106ADEEC1FDD
GO
Isoform 1B (identifier: O15527-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → VSVPRCPP

Show »
Length:324
Mass (Da):36,433
Checksum:iFB6DAF62F162C353
GO
Isoform 1C (identifier: O15527-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → TPPSYRCCSV...VCTTRWGGGY

Show »
Length:410
Mass (Da):45,761
Checksum:iCA01660C056A09F0
GO
Isoform 2A (identifier: O15527-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → GLLGNAFDGH...HVMQASLLAL

Show »
Length:424
Mass (Da):47,237
Checksum:i0013B0F2D51FD316
GO
Isoform 2B (identifier: O15527-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-345: VADCICLMAL...RRKGSKGPEG → GLLGNAFDGH...HVMQASLLAL

Show »
Length:357
Mass (Da):39,729
Checksum:i0FAA63310FC13ADB
GO
Isoform 2C (identifier: O15527-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-195: EVEAH → PWQCI
     196-345: Missing.

Show »
Length:195
Mass (Da):22,210
Checksum:i16628F612964E282
GO
Isoform 2D (identifier: O15527-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → LCQVITTFMTFLGPHRLDQMPPEELQTSSSRLGGPPWQCI

Show »
Length:356
Mass (Da):40,095
Checksum:i40D1E4783F042C8F
GO
Isoform 2E (identifier: O15527-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → AGSDAS

Show »
Length:322
Mass (Da):36,085
Checksum:iE47B3CA5AE8CFABB
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXZ1H7BXZ1_HUMAN
N-glycosylase/DNA lyase
OGG1
263Annotation score:
H7C1D7H7C1D7_HUMAN
N-glycosylase/DNA lyase
OGG1
128Annotation score:
H7BZM3H7BZM3_HUMAN
N-glycosylase/DNA lyase
OGG1
222Annotation score:
H7C0A1H7C0A1_HUMAN
N-glycosylase/DNA lyase
OGG1
168Annotation score:
F8WCZ9F8WCZ9_HUMAN
N-glycosylase/DNA lyase
OGG1
52Annotation score:
H7C1V7H7C1V7_HUMAN
N-glycosylase/DNA lyase
OGG1
132Annotation score:

Sequence cautioni

The sequence AAB84013 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47W → WW in CAA10351 (Ref. 9) Curated1
Sequence conflicti308G → E in CAA10351 (Ref. 9) Curated1
Sequence conflicti316A → ATPPSLQ in AAB81132 (PubMed:9207108).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02483112G → E Found in a kidney cancer sample; no effect on activity; abolishes mitochondrial localization. 1 PublicationCorresponds to variant dbSNP:rs772520254Ensembl.1
Natural variantiVAR_00951946R → Q Found in a clear cell renal cell carcinoma sample; somatic mutation; diminished activity. 1 PublicationCorresponds to variant dbSNP:rs104893751EnsemblClinVar.1
Natural variantiVAR_02483285A → S Found in a lung cancer sample. 1 PublicationCorresponds to variant dbSNP:rs17050550Ensembl.1
Natural variantiVAR_024833131R → Q Found in a lung cancer sample; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747638147Ensembl.1
Natural variantiVAR_009520154R → H Found in a gastric cancer sample; no effect on base-excision activity; alters substrate specificity and strongly increases mutagenic mis-repair. 3 PublicationsCorresponds to variant dbSNP:rs56053615Ensembl.1
Natural variantiVAR_014487229R → Q1 PublicationCorresponds to variant dbSNP:rs1805373Ensembl.1
Natural variantiVAR_024834232S → T Found in a kidney cancer sample. 1 Publication1
Natural variantiVAR_018890288A → V1 PublicationCorresponds to variant dbSNP:rs3219012Ensembl.1
Natural variantiVAR_014488320S → T. Corresponds to variant dbSNP:rs1801128Ensembl.1
Natural variantiVAR_018891322D → N1 PublicationCorresponds to variant dbSNP:rs3219014Ensembl.1
Natural variantiVAR_009521326S → C Common polymorphism in the Japanese population. 4 PublicationsCorresponds to variant dbSNP:rs1052133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003750191 – 195EVEAH → PWQCI in isoform 2C. Curated5
Alternative sequenceiVSP_003751196 – 345Missing in isoform 2C. CuratedAdd BLAST150
Alternative sequenceiVSP_003749250 – 345VADCI…KGPEG → GLLGNAFDGHQLLRPLIFCQ DHLREGPPIGRGDSQGEELE PQLPSSLSSIPYGFCDHCWT KDVDDPPLVTHPSPGSRDGH MTQAWPVKVVSPLATVIGHV MQASLLAL in isoform 2B. CuratedAdd BLAST96
Alternative sequenceiVSP_003746317 – 345VLFSA…KGPEG → VSVPRCPP in isoform 1B. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_003747317 – 345VLFSA…KGPEG → TPPSYRCCSVPTCANPAMLR SHQQSAERVPKGRKARWGTL DKEIPQAPSPPFPTSLSPSP PSLMLGRGLPVTTSKARHPQ IKQSVCTTRWGGGY in isoform 1C. CuratedAdd BLAST29
Alternative sequenceiVSP_003748317 – 345VLFSA…KGPEG → GLLGNAFDGHQLLRPLIFCQ DHLREGPPIGRGDSQGEELE PQLPSSLSSIPYGFCDHCWT KDVDDPPLVTHPSPGSRDGH MTQAWPVKVVSPLATVIGHV MQASLLAL in isoform 2A. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_003752317 – 345VLFSA…KGPEG → LCQVITTFMTFLGPHRLDQM PPEELQTSSSRLGGPPWQCI in isoform 2D. CuratedAdd BLAST29
Alternative sequenceiVSP_003753317 – 345VLFSA…KGPEG → AGSDAS in isoform 2E. CuratedAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88527 mRNA Translation: AAB68614.1
U88620 mRNA Translation: AAB68615.1
U96710 mRNA Translation: AAB81132.1
Y13277 mRNA Translation: CAA73726.1
Y11731 mRNA Translation: CAA72414.1
AF003595 mRNA Translation: AAB61340.1
AB000410 mRNA Translation: BAA19103.1
AF026691 mRNA Translation: AAB84013.1 Different initiation.
Y11838 mRNA Translation: CAA72536.1
AJ131341 Genomic DNA Translation: CAA10351.1
AF088282 Genomic DNA Translation: AAD41680.1
AF088282 Genomic DNA Translation: AAD41681.1
AF088282 Genomic DNA Translation: AAD41682.1
AB019528 mRNA Translation: BAA76635.1
AB019529 mRNA Translation: BAA76636.1
AB019530 mRNA Translation: BAA76637.1
AB019531 mRNA Translation: BAA76638.1
AB019532 mRNA Translation: BAA76639.1
AK289858 mRNA Translation: BAF82547.1
AF521807 Genomic DNA Translation: AAM74236.1
AC022382 Genomic DNA No translation available.
BC000657 mRNA Translation: AAH00657.1
CCDSiCCDS2576.1 [O15527-4]
CCDS2577.1 [O15527-5]
CCDS2578.1 [O15527-6]
CCDS2579.1 [O15527-7]
CCDS2580.1 [O15527-3]
CCDS2581.1 [O15527-1]
CCDS43046.1 [O15527-2]
CCDS46742.1 [O15527-8]
PIRiT45069
RefSeqiNP_002533.1, NM_002542.5 [O15527-1]
NP_058212.1, NM_016819.3 [O15527-2]
NP_058213.1, NM_016820.3 [O15527-3]
NP_058214.1, NM_016821.2 [O15527-4]
NP_058434.1, NM_016826.2 [O15527-5]
NP_058436.1, NM_016827.2 [O15527-6]
NP_058437.1, NM_016828.2 [O15527-7]
NP_058438.1, NM_016829.2 [O15527-8]
UniGeneiHs.380271

Genome annotation databases

EnsembliENST00000302003; ENSP00000305584; ENSG00000114026 [O15527-3]
ENST00000302008; ENSP00000305527; ENSG00000114026 [O15527-7]
ENST00000302036; ENSP00000306561; ENSG00000114026 [O15527-4]
ENST00000339511; ENSP00000345520; ENSG00000114026 [O15527-2]
ENST00000344629; ENSP00000342851; ENSG00000114026 [O15527-1]
ENST00000349503; ENSP00000303132; ENSG00000114026 [O15527-5]
ENST00000383826; ENSP00000373337; ENSG00000114026 [O15527-6]
ENST00000449570; ENSP00000403598; ENSG00000114026 [O15527-8]
GeneIDi4968
KEGGihsa:4968
UCSCiuc003bsh.4 human [O15527-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88527 mRNA Translation: AAB68614.1
U88620 mRNA Translation: AAB68615.1
U96710 mRNA Translation: AAB81132.1
Y13277 mRNA Translation: CAA73726.1
Y11731 mRNA Translation: CAA72414.1
AF003595 mRNA Translation: AAB61340.1
AB000410 mRNA Translation: BAA19103.1
AF026691 mRNA Translation: AAB84013.1 Different initiation.
Y11838 mRNA Translation: CAA72536.1
AJ131341 Genomic DNA Translation: CAA10351.1
AF088282 Genomic DNA Translation: AAD41680.1
AF088282 Genomic DNA Translation: AAD41681.1
AF088282 Genomic DNA Translation: AAD41682.1
AB019528 mRNA Translation: BAA76635.1
AB019529 mRNA Translation: BAA76636.1
AB019530 mRNA Translation: BAA76637.1
AB019531 mRNA Translation: BAA76638.1
AB019532 mRNA Translation: BAA76639.1
AK289858 mRNA Translation: BAF82547.1
AF521807 Genomic DNA Translation: AAM74236.1
AC022382 Genomic DNA No translation available.
BC000657 mRNA Translation: AAH00657.1
CCDSiCCDS2576.1 [O15527-4]
CCDS2577.1 [O15527-5]
CCDS2578.1 [O15527-6]
CCDS2579.1 [O15527-7]
CCDS2580.1 [O15527-3]
CCDS2581.1 [O15527-1]
CCDS43046.1 [O15527-2]
CCDS46742.1 [O15527-8]
PIRiT45069
RefSeqiNP_002533.1, NM_002542.5 [O15527-1]
NP_058212.1, NM_016819.3 [O15527-2]
NP_058213.1, NM_016820.3 [O15527-3]
NP_058214.1, NM_016821.2 [O15527-4]
NP_058434.1, NM_016826.2 [O15527-5]
NP_058436.1, NM_016827.2 [O15527-6]
NP_058437.1, NM_016828.2 [O15527-7]
NP_058438.1, NM_016829.2 [O15527-8]
UniGeneiHs.380271

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EBMX-ray2.10A12-325[»]
1FN7X-ray2.60A12-325[»]
1HU0X-ray2.35A12-327[»]
1KO9X-ray2.15A1-345[»]
1LWVX-ray2.30A12-327[»]
1LWWX-ray2.10A12-327[»]
1LWYX-ray2.01A12-327[»]
1M3HX-ray2.05A12-325[»]
1M3QX-ray1.90A12-325[»]
1N39X-ray2.20A12-325[»]
1N3AX-ray2.20A12-325[»]
1N3CX-ray2.70A12-325[»]
1YQKX-ray2.50A12-327[»]
1YQLX-ray2.60A12-327[»]
1YQMX-ray2.50A12-327[»]
1YQRX-ray2.43A12-327[»]
2I5WX-ray2.60A12-323[»]
2NOBX-ray2.10A12-327[»]
2NOEX-ray2.20A12-327[»]
2NOFX-ray2.35A12-327[»]
2NOHX-ray2.01A12-327[»]
2NOIX-ray2.35A12-327[»]
2NOLX-ray2.57A12-327[»]
2NOZX-ray2.43A12-327[»]
2XHIX-ray1.55A1-345[»]
3IH7X-ray3.10A12-325[»]
3KTUX-ray2.30A12-325[»]
5AN4X-ray1.60A12-323[»]
ProteinModelPortaliO15527
SMRiO15527
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111018, 9 interactors
IntActiO15527, 4 interactors
MINTiO15527

Chemistry databases

BindingDBiO15527
ChEMBLiCHEMBL3396944

PTM databases

iPTMnetiO15527
PhosphoSitePlusiO15527

Polymorphism and mutation databases

BioMutaiOGG1

Proteomic databases

EPDiO15527
MaxQBiO15527
PeptideAtlasiO15527
PRIDEiO15527
ProteomicsDBi48726
48727 [O15527-2]
48728 [O15527-3]
48729 [O15527-4]
48730 [O15527-5]
48731 [O15527-6]
48732 [O15527-7]
48733 [O15527-8]

Protocols and materials databases

DNASUi4968
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302003; ENSP00000305584; ENSG00000114026 [O15527-3]
ENST00000302008; ENSP00000305527; ENSG00000114026 [O15527-7]
ENST00000302036; ENSP00000306561; ENSG00000114026 [O15527-4]
ENST00000339511; ENSP00000345520; ENSG00000114026 [O15527-2]
ENST00000344629; ENSP00000342851; ENSG00000114026 [O15527-1]
ENST00000349503; ENSP00000303132; ENSG00000114026 [O15527-5]
ENST00000383826; ENSP00000373337; ENSG00000114026 [O15527-6]
ENST00000449570; ENSP00000403598; ENSG00000114026 [O15527-8]
GeneIDi4968
KEGGihsa:4968
UCSCiuc003bsh.4 human [O15527-1]

Organism-specific databases

CTDi4968
DisGeNETi4968
EuPathDBiHostDB:ENSG00000114026.21
GeneCardsiOGG1
HGNCiHGNC:8125 OGG1
HPAiCAB047301
HPA027514
MalaCardsiOGG1
MIMi144700 phenotype
601982 gene
neXtProtiNX_O15527
OpenTargetsiENSG00000114026
PharmGKBiPA31912
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00640000091554
HOVERGENiHBG001047
InParanoidiO15527
KOiK03660
OMAiEYAGYAQ
PhylomeDBiO15527
TreeFamiTF323702

Enzyme and pathway databases

BRENDAi3.2.2.23 2681
4.2.99.18 2681
ReactomeiR-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-110357 Displacement of DNA glycosylase by APEX1
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
SIGNORiO15527

Miscellaneous databases

ChiTaRSiOGG1 human
EvolutionaryTraceiO15527
GeneWikiiOxoguanine_glycosylase
GenomeRNAii4968
PROiPR:O15527
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114026 Expressed in 222 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiO15527 baseline and differential
GenevisibleiO15527 HS

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
InterProiView protein in InterPro
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
IPR004577 Ogg1
IPR012904 OGG_N
PfamiView protein in Pfam
PF00730 HhH-GPD, 1 hit
PF07934 OGG_N, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit
TIGRFAMsiTIGR00588 ogg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOGG1_HUMAN
AccessioniPrimary (citable) accession number: O15527
Secondary accession number(s): A8K1E3
, O00390, O00670, O00705, O14876, O95488, P78554, Q9BW42, Q9UIK0, Q9UIK1, Q9UIK2, Q9UL34, Q9Y2C0, Q9Y2C1, Q9Y6C3, Q9Y6C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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