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UniProtKB - O15527 (OGG1_HUMAN)

Entry version 217 (10 Feb 2021)
Sequence version 2 (01 Dec 2000)
Previous versions | rss
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Protein

N-glycosylase/DNA lyase

Gene

OGG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. EC:4.2.99.18

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei149DNA5 Publications1
Binding sitei154DNA5 Publications1
Binding sitei204DNA5 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei249Schiff-base intermediate with DNA1 Publication1
Binding sitei2668-oxoguanine; via carbonyl oxygen1
Binding sitei2688-oxoguanine1
Binding sitei270DNA5 Publications1
Binding sitei287DNA5 Publications1
Binding sitei3158-oxoguanine1
Binding sitei3198-oxoguanine1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.2.23, 2681
4.2.99.18, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15527

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329, Cleavage of the damaged pyrimidine
R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331, Cleavage of the damaged purine
R-HSA-110357, Displacement of DNA glycosylase by APEX1
R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-9656255, Defective OGG1 Substrate Binding
R-HSA-9656256, Defective OGG1 Substrate Processing
R-HSA-9657050, Defective OGG1 Localization [O15527-4]

SIGNOR Signaling Network Open Resource

More...SIGNORi		O15527

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OGG1
Synonyms:MMH, MUTM, OGH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8125, OGG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601982, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15527

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114026.21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal cell carcinoma (RCC)
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionRenal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi249K → Q: Loss of activity. 1 Publication1
Mutagenesisi268D → E or Q: No effect on activity. 1 Publication1
Mutagenesisi268D → N: Decreases activity about 65-fold. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4968

MalaCards human disease database

More...MalaCardsi		OGG1
MIMi144700, phenotype

Open Targets

More...OpenTargetsi		ENSG00000114026

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		422526, Hereditary clear cell renal cell carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31912

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15527, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3396944

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		OGG1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000585911 – 345N-glycosylase/DNA lyaseAdd BLAST345

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15527

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15527

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15527

PeptideAtlas

More...PeptideAtlasi		O15527

PRoteomics IDEntifications database

More...PRIDEi		O15527

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48726 [O15527-1]
48727 [O15527-2]
48728 [O15527-3]
48729 [O15527-4]
48730 [O15527-5]
48731 [O15527-6]
48732 [O15527-7]
48733 [O15527-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15527

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15527

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114026, Expressed in stomach and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15527, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15527, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114026, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111018, 13 interactors

Protein interaction database and analysis system

More...IntActi		O15527, 5 interactors

Molecular INTeraction database

More...MINTi		O15527

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306561

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O15527

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15527, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15527

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O15527

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-1 OGG1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2875, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00640000091554

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027543_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15527

Identification of Orthologs from Complete Genome Data

More...OMAi		GYAQQYL

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15527

TreeFam database of animal gene trees

More...TreeFami		TF323702

Family and domain databases

Conserved Domains Database

More...CDDi		cd00056, ENDO3c, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1670.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011257, DNA_glycosylase
IPR003265, HhH-GPD_domain
IPR023170, HTH_base_excis_C
IPR004577, Ogg1
IPR012904, OGG_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00730, HhH-GPD, 1 hit
PF07934, OGG_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00478, ENDO3c, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48150, SSF48150, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00588, ogg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1A (identifier: O15527-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ 
        60         70         80         90        100
SPAHWSGVLA DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF 
       110        120        130        140        150
QLDVTLAQLY HHWGSVDSHF QEVAQKFQGV RLLRQDPIEC LFSFICSSNN 
       160        170        180        190        200
NIARITGMVE RLCQAFGPRL IQLDDVTYHG FPSLQALAGP EVEAHLRKLG 
       210        220        230        240        250
LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL CILPGVGTKV 
       260        270        280        290        300
ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 
       310        320        330        340 
NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG
Length:345
Mass (Da):38,782
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC284106ADEEC1FDD
GO
Isoform 1B (identifier: O15527-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → VSVPRCPP

Show »
Length:324
Mass (Da):36,433
Checksum:iFB6DAF62F162C353
GO
Isoform 1C (identifier: O15527-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → TPPSYRCCSV...VCTTRWGGGY

Show »
Length:410
Mass (Da):45,761
Checksum:iCA01660C056A09F0
GO
Isoform 2A (identifier: O15527-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → GLLGNAFDGH...HVMQASLLAL

Show »
Length:424
Mass (Da):47,237
Checksum:i0013B0F2D51FD316
GO
Isoform 2B (identifier: O15527-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-345: VADCICLMAL...RRKGSKGPEG → GLLGNAFDGH...HVMQASLLAL

Show »
Length:357
Mass (Da):39,729
Checksum:i0FAA63310FC13ADB
GO
Isoform 2C (identifier: O15527-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-195: EVEAH → PWQCI
     196-345: Missing.

Show »
Length:195
Mass (Da):22,210
Checksum:i16628F612964E282
GO
Isoform 2D (identifier: O15527-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → LCQVITTFMTFLGPHRLDQMPPEELQTSSSRLGGPPWQCI

Show »
Length:356
Mass (Da):40,095
Checksum:i40D1E4783F042C8F
GO
Isoform 2E (identifier: O15527-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → AGSDAS

Show »
Length:322
Mass (Da):36,085
Checksum:iE47B3CA5AE8CFABB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXZ1H7BXZ1_HUMAN
DNA-(apurinic or apyrimidinic site)...
OGG1
263Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1D7H7C1D7_HUMAN
N-glycosylase/DNA lyase
OGG1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1V7H7C1V7_HUMAN
N-glycosylase/DNA lyase
OGG1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZM3H7BZM3_HUMAN
N-glycosylase/DNA lyase
OGG1
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0A1H7C0A1_HUMAN
N-glycosylase/DNA lyase
OGG1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCZ9F8WCZ9_HUMAN
N-glycosylase/DNA lyase
OGG1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB84013 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47W → WW in CAA10351 (Ref. 9) Curated1
Sequence conflicti308G → E in CAA10351 (Ref. 9) Curated1
Sequence conflicti316A → ATPPSLQ in AAB81132 (PubMed:9207108).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02483112G → E Found in a kidney cancer sample; no effect on activity; abolishes mitochondrial localization. 1 PublicationCorresponds to variant dbSNP:rs772520254Ensembl.1
Natural variantiVAR_00951946R → Q Found in a clear cell renal cell carcinoma sample; somatic mutation; diminished activity. 1 PublicationCorresponds to variant dbSNP:rs104893751EnsemblClinVar.1
Natural variantiVAR_02483285A → S Found in a lung cancer sample. 1 PublicationCorresponds to variant dbSNP:rs17050550Ensembl.1
Natural variantiVAR_024833131R → Q Found in a lung cancer sample; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747638147Ensembl.1
Natural variantiVAR_009520154R → H Found in a gastric cancer sample; no effect on base-excision activity; alters substrate specificity and strongly increases mutagenic mis-repair. 3 PublicationsCorresponds to variant dbSNP:rs56053615Ensembl.1
Natural variantiVAR_014487229R → Q1 PublicationCorresponds to variant dbSNP:rs1805373Ensembl.1
Natural variantiVAR_024834232S → T Found in a kidney cancer sample. 1 Publication1
Natural variantiVAR_018890288A → V1 PublicationCorresponds to variant dbSNP:rs3219012Ensembl.1
Natural variantiVAR_014488320S → T. Corresponds to variant dbSNP:rs1801128Ensembl.1
Natural variantiVAR_018891322D → N1 PublicationCorresponds to variant dbSNP:rs3219014Ensembl.1
Natural variantiVAR_009521326S → C4 PublicationsCorresponds to variant dbSNP:rs1052133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003750191 – 195EVEAH → PWQCI in isoform 2C. Curated5
Alternative sequenceiVSP_003751196 – 345Missing in isoform 2C. CuratedAdd BLAST150
Alternative sequenceiVSP_003749250 – 345VADCI…KGPEG → GLLGNAFDGHQLLRPLIFCQ DHLREGPPIGRGDSQGEELE PQLPSSLSSIPYGFCDHCWT KDVDDPPLVTHPSPGSRDGH MTQAWPVKVVSPLATVIGHV MQASLLAL in isoform 2B. CuratedAdd BLAST96
Alternative sequenceiVSP_003746317 – 345VLFSA…KGPEG → VSVPRCPP in isoform 1B. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_003747317 – 345VLFSA…KGPEG → TPPSYRCCSVPTCANPAMLR SHQQSAERVPKGRKARWGTL DKEIPQAPSPPFPTSLSPSP PSLMLGRGLPVTTSKARHPQ IKQSVCTTRWGGGY in isoform 1C. CuratedAdd BLAST29
Alternative sequenceiVSP_003748317 – 345VLFSA…KGPEG → GLLGNAFDGHQLLRPLIFCQ DHLREGPPIGRGDSQGEELE PQLPSSLSSIPYGFCDHCWT KDVDDPPLVTHPSPGSRDGH MTQAWPVKVVSPLATVIGHV MQASLLAL in isoform 2A. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_003752317 – 345VLFSA…KGPEG → LCQVITTFMTFLGPHRLDQM PPEELQTSSSRLGGPPWQCI in isoform 2D. CuratedAdd BLAST29
Alternative sequenceiVSP_003753317 – 345VLFSA…KGPEG → AGSDAS in isoform 2E. CuratedAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U88527 mRNA Translation: AAB68614.1
U88620 mRNA Translation: AAB68615.1
U96710 mRNA Translation: AAB81132.1
Y13277 mRNA Translation: CAA73726.1
Y11731 mRNA Translation: CAA72414.1
AF003595 mRNA Translation: AAB61340.1
AB000410 mRNA Translation: BAA19103.1
AF026691 mRNA Translation: AAB84013.1 Different initiation.
Y11838 mRNA Translation: CAA72536.1
AJ131341 Genomic DNA Translation: CAA10351.1
AF088282 Genomic DNA Translation: AAD41680.1
AF088282 Genomic DNA Translation: AAD41681.1
AF088282 Genomic DNA Translation: AAD41682.1
AB019528 mRNA Translation: BAA76635.1
AB019529 mRNA Translation: BAA76636.1
AB019530 mRNA Translation: BAA76637.1
AB019531 mRNA Translation: BAA76638.1
AB019532 mRNA Translation: BAA76639.1
AK289858 mRNA Translation: BAF82547.1
AF521807 Genomic DNA Translation: AAM74236.1
AC022382 Genomic DNA No translation available.
BC000657 mRNA Translation: AAH00657.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2576.1 [O15527-4]
CCDS2577.1 [O15527-5]
CCDS2578.1 [O15527-6]
CCDS2579.1 [O15527-7]
CCDS2580.1 [O15527-3]
CCDS2581.1 [O15527-1]
CCDS43046.1 [O15527-2]
CCDS46742.1 [O15527-8]

Protein sequence database of the Protein Information Resource

More...PIRi		T45069

NCBI Reference Sequences

More...RefSeqi		NP_002533.1, NM_002542.5 [O15527-1]
NP_058212.1, NM_016819.3 [O15527-2]
NP_058213.1, NM_016820.3 [O15527-3]
NP_058214.1, NM_016821.2 [O15527-4]
NP_058434.1, NM_016826.2 [O15527-5]
NP_058436.1, NM_016827.2 [O15527-6]
NP_058437.1, NM_016828.2 [O15527-7]
NP_058438.1, NM_016829.2 [O15527-8]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302003; ENSP00000305584; ENSG00000114026 [O15527-3]
ENST00000302008; ENSP00000305527; ENSG00000114026 [O15527-7]
ENST00000302036; ENSP00000306561; ENSG00000114026 [O15527-4]
ENST00000339511; ENSP00000345520; ENSG00000114026 [O15527-2]
ENST00000344629; ENSP00000342851; ENSG00000114026 [O15527-1]
ENST00000349503; ENSP00000303132; ENSG00000114026 [O15527-5]
ENST00000383826; ENSP00000373337; ENSG00000114026 [O15527-6]
ENST00000449570; ENSP00000403598; ENSG00000114026 [O15527-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4968

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4968

UCSC genome browser

More...UCSCi		uc003bsh.4, human [O15527-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88527 mRNA Translation: AAB68614.1
U88620 mRNA Translation: AAB68615.1
U96710 mRNA Translation: AAB81132.1
Y13277 mRNA Translation: CAA73726.1
Y11731 mRNA Translation: CAA72414.1
AF003595 mRNA Translation: AAB61340.1
AB000410 mRNA Translation: BAA19103.1
AF026691 mRNA Translation: AAB84013.1 Different initiation.
Y11838 mRNA Translation: CAA72536.1
AJ131341 Genomic DNA Translation: CAA10351.1
AF088282 Genomic DNA Translation: AAD41680.1
AF088282 Genomic DNA Translation: AAD41681.1
AF088282 Genomic DNA Translation: AAD41682.1
AB019528 mRNA Translation: BAA76635.1
AB019529 mRNA Translation: BAA76636.1
AB019530 mRNA Translation: BAA76637.1
AB019531 mRNA Translation: BAA76638.1
AB019532 mRNA Translation: BAA76639.1
AK289858 mRNA Translation: BAF82547.1
AF521807 Genomic DNA Translation: AAM74236.1
AC022382 Genomic DNA No translation available.
BC000657 mRNA Translation: AAH00657.1
CCDSiCCDS2576.1 [O15527-4]
CCDS2577.1 [O15527-5]
CCDS2578.1 [O15527-6]
CCDS2579.1 [O15527-7]
CCDS2580.1 [O15527-3]
CCDS2581.1 [O15527-1]
CCDS43046.1 [O15527-2]
CCDS46742.1 [O15527-8]
PIRiT45069
RefSeqiNP_002533.1, NM_002542.5 [O15527-1]
NP_058212.1, NM_016819.3 [O15527-2]
NP_058213.1, NM_016820.3 [O15527-3]
NP_058214.1, NM_016821.2 [O15527-4]
NP_058434.1, NM_016826.2 [O15527-5]
NP_058436.1, NM_016827.2 [O15527-6]
NP_058437.1, NM_016828.2 [O15527-7]
NP_058438.1, NM_016829.2 [O15527-8]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EBMX-ray2.10A12-325[»]
1FN7X-ray2.60A12-325[»]
1HU0X-ray2.35A12-327[»]
1KO9X-ray2.15A1-345[»]
1LWVX-ray2.30A12-327[»]
1LWWX-ray2.10A12-327[»]
1LWYX-ray2.01A12-327[»]
1M3HX-ray2.05A12-325[»]
1M3QX-ray1.90A12-325[»]
1N39X-ray2.20A12-325[»]
1N3AX-ray2.20A12-325[»]
1N3CX-ray2.70A12-325[»]
1YQKX-ray2.50A12-327[»]
1YQLX-ray2.60A12-327[»]
1YQMX-ray2.50A12-327[»]
1YQRX-ray2.43A12-327[»]
2I5WX-ray2.60A12-323[»]
2NOBX-ray2.10A12-327[»]
2NOEX-ray2.20A12-327[»]
2NOFX-ray2.35A12-327[»]
2NOHX-ray2.01A12-327[»]
2NOIX-ray2.35A12-327[»]
2NOLX-ray2.57A12-327[»]
2NOZX-ray2.43A12-327[»]
2XHIX-ray1.55A1-345[»]
3IH7X-ray3.10A12-325[»]
3KTUX-ray2.30A12-325[»]
5AN4X-ray1.60A12-323[»]
6RLWX-ray2.00AAA/BBB/CCC/DDD/EEE11-327[»]
6W0MX-ray2.37A12-325[»]
6W0RX-ray2.35A12-323[»]
6W13X-ray2.38A12-325[»]
SMRiO15527
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111018, 13 interactors
IntActiO15527, 5 interactors
MINTiO15527
STRINGi9606.ENSP00000306561

Chemistry databases

BindingDBiO15527
ChEMBLiCHEMBL3396944

PTM databases

iPTMnetiO15527
PhosphoSitePlusiO15527

Genetic variation databases

BioMutaiOGG1

Proteomic databases

jPOSTiO15527
MassIVEiO15527
MaxQBiO15527
PeptideAtlasiO15527
PRIDEiO15527
ProteomicsDBi48726 [O15527-1]
48727 [O15527-2]
48728 [O15527-3]
48729 [O15527-4]
48730 [O15527-5]
48731 [O15527-6]
48732 [O15527-7]
48733 [O15527-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25518, 468 antibodies

The CPTC Antibody Portal

More...CPTCi		O15527, 1 antibody

The DNASU plasmid repository

More...DNASUi		4968

Genome annotation databases

EnsembliENST00000302003; ENSP00000305584; ENSG00000114026 [O15527-3]
ENST00000302008; ENSP00000305527; ENSG00000114026 [O15527-7]
ENST00000302036; ENSP00000306561; ENSG00000114026 [O15527-4]
ENST00000339511; ENSP00000345520; ENSG00000114026 [O15527-2]
ENST00000344629; ENSP00000342851; ENSG00000114026 [O15527-1]
ENST00000349503; ENSP00000303132; ENSG00000114026 [O15527-5]
ENST00000383826; ENSP00000373337; ENSG00000114026 [O15527-6]
ENST00000449570; ENSP00000403598; ENSG00000114026 [O15527-8]
GeneIDi4968
KEGGihsa:4968
UCSCiuc003bsh.4, human [O15527-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4968
DisGeNETi4968

GeneCards: human genes, protein and diseases

More...GeneCardsi		OGG1
HGNCiHGNC:8125, OGG1
HPAiENSG00000114026, Low tissue specificity
MalaCardsiOGG1
MIMi144700, phenotype
601982, gene
neXtProtiNX_O15527
OpenTargetsiENSG00000114026
Orphaneti422526, Hereditary clear cell renal cell carcinoma
PharmGKBiPA31912
VEuPathDBiHostDB:ENSG00000114026.21

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2875, Eukaryota
GeneTreeiENSGT00640000091554
HOGENOMiCLU_027543_1_1_1
InParanoidiO15527
OMAiGYAQQYL
PhylomeDBiO15527
TreeFamiTF323702

Enzyme and pathway databases

BRENDAi3.2.2.23, 2681
4.2.99.18, 2681
PathwayCommonsiO15527
ReactomeiR-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329, Cleavage of the damaged pyrimidine
R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331, Cleavage of the damaged purine
R-HSA-110357, Displacement of DNA glycosylase by APEX1
R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-9656255, Defective OGG1 Substrate Binding
R-HSA-9656256, Defective OGG1 Substrate Processing
R-HSA-9657050, Defective OGG1 Localization [O15527-4]
SIGNORiO15527

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4968, 10 hits in 881 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		OGG1, human
EvolutionaryTraceiO15527

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Oxoguanine_glycosylase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4968
PharosiO15527, Tbio

Protein Ontology

More...PROi		PR:O15527
RNActiO15527, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114026, Expressed in stomach and 234 other tissues
ExpressionAtlasiO15527, baseline and differential
GenevisibleiO15527, HS

Family and domain databases

CDDicd00056, ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
InterProiView protein in InterPro
IPR011257, DNA_glycosylase
IPR003265, HhH-GPD_domain
IPR023170, HTH_base_excis_C
IPR004577, Ogg1
IPR012904, OGG_N
PfamiView protein in Pfam
PF00730, HhH-GPD, 1 hit
PF07934, OGG_N, 1 hit
SMARTiView protein in SMART
SM00478, ENDO3c, 1 hit
SUPFAMiSSF48150, SSF48150, 1 hit
TIGRFAMsiTIGR00588, ogg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOGG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15527
Secondary accession number(s): A8K1E3
, O00390, O00670, O00705, O14876, O95488, P78554, Q9BW42, Q9UIK0, Q9UIK1, Q9UIK2, Q9UL34, Q9Y2C0, Q9Y2C1, Q9Y6C3, Q9Y6C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 10, 2021
This is version 217 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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