UniProtKB - O15527 (OGG1_HUMAN)
N-glycosylase/DNA lyase
OGG1
Functioni
Catalytic activityi
- The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. EC:4.2.99.18
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 149 | DNA5 Publications | 1 | |
Binding sitei | 154 | DNA5 Publications | 1 | |
Binding sitei | 204 | DNA5 Publications | 1 | |
Active sitei | 249 | Schiff-base intermediate with DNA1 Publication | 1 | |
Binding sitei | 266 | 8-oxoguanine; via carbonyl oxygen | 1 | |
Binding sitei | 268 | 8-oxoguanine | 1 | |
Binding sitei | 270 | DNA5 Publications | 1 | |
Binding sitei | 287 | DNA5 Publications | 1 | |
Binding sitei | 315 | 8-oxoguanine | 1 | |
Binding sitei | 319 | 8-oxoguanine | 1 |
GO - Molecular functioni
- 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity Source: CACAO
- class I DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKB-EC
- damaged DNA binding Source: UniProtKB
- endonuclease activity Source: ProtInc
- microtubule binding Source: Ensembl
- oxidized purine DNA binding Source: UniProtKB
- oxidized purine nucleobase lesion DNA N-glycosylase activity Source: Reactome
GO - Biological processi
- acute inflammatory response Source: Ensembl
- aging Source: Ensembl
- base-excision repair Source: ProtInc
- base-excision repair, AP site formation Source: GO_Central
- cellular response to cadmium ion Source: Ensembl
- cellular response to DNA damage stimulus Source: MGI
- depurination Source: Reactome
- depyrimidination Source: Reactome
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of double-strand break repair via single-strand annealing Source: MGI
- nucleotide-excision repair, DNA incision Source: MGI
- regulation of transcription, DNA-templated Source: UniProtKB
- response to drug Source: Ensembl
- response to estradiol Source: Ensembl
- response to ethanol Source: Ensembl
- response to folic acid Source: Ensembl
- response to light stimulus Source: Ensembl
- response to oxidative stress Source: UniProtKB
- response to radiation Source: UniProtKB
Keywordsi
Molecular function | Glycosidase, Hydrolase, Lyase, Multifunctional enzyme |
Biological process | DNA damage, DNA repair |
Enzyme and pathway databases
BRENDAi | 3.2.2.23, 2681 4.2.99.18, 2681 |
PathwayCommonsi | O15527 |
Reactomei | R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329, Cleavage of the damaged pyrimidine R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-110357, Displacement of DNA glycosylase by APEX1 R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-9656255, Defective OGG1 Substrate Binding R-HSA-9656256, Defective OGG1 Substrate Processing R-HSA-9657050, Defective OGG1 Localization [O15527-4] |
SIGNORi | O15527 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:OGG1 Synonyms:MMH, MUTM, OGH1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8125, OGG1 |
MIMi | 601982, gene |
neXtProti | NX_O15527 |
VEuPathDBi | HostDB:ENSG00000114026.21 |
Subcellular locationi
Nucleus
- nucleoplasm 1 Publication
- Nucleus speckle 1 Publication
- Nucleus matrix 1 Publication
Note: Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
Nucleus
Mitochondrion
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nuclear matrix Source: UniProtKB
- nuclear speck Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: MGI
Other locations
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Renal cell carcinoma (RCC)
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 249 | K → Q: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 268 | D → E or Q: No effect on activity. 1 Publication | 1 | |
Mutagenesisi | 268 | D → N: Decreases activity about 65-fold. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4968 |
MalaCardsi | OGG1 |
MIMi | 144700, phenotype |
OpenTargetsi | ENSG00000114026 |
Orphaneti | 422526, Hereditary clear cell renal cell carcinoma |
PharmGKBi | PA31912 |
Miscellaneous databases
Pharosi | O15527, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3396944 |
Genetic variation databases
BioMutai | OGG1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058591 | 1 – 345 | N-glycosylase/DNA lyaseAdd BLAST | 345 |
Proteomic databases
jPOSTi | O15527 |
MassIVEi | O15527 |
MaxQBi | O15527 |
PeptideAtlasi | O15527 |
PRIDEi | O15527 |
ProteomicsDBi | 48726 [O15527-1] 48727 [O15527-2] 48728 [O15527-3] 48729 [O15527-4] 48730 [O15527-5] 48731 [O15527-6] 48732 [O15527-7] 48733 [O15527-8] |
PTM databases
iPTMneti | O15527 |
PhosphoSitePlusi | O15527 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000114026, Expressed in stomach and 234 other tissues |
ExpressionAtlasi | O15527, baseline and differential |
Genevisiblei | O15527, HS |
Organism-specific databases
HPAi | ENSG00000114026, Low tissue specificity |
Interactioni
GO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111018, 13 interactors |
IntActi | O15527, 5 interactors |
MINTi | O15527 |
STRINGi | 9606.ENSP00000306561 |
Chemistry databases
BindingDBi | O15527 |
Miscellaneous databases
RNActi | O15527, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O15527 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15527 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2875, Eukaryota |
GeneTreei | ENSGT00640000091554 |
HOGENOMi | CLU_027543_1_1_1 |
InParanoidi | O15527 |
OMAi | GYAQQYL |
PhylomeDBi | O15527 |
TreeFami | TF323702 |
Family and domain databases
CDDi | cd00056, ENDO3c, 1 hit |
Gene3Di | 1.10.1670.10, 2 hits |
InterProi | View protein in InterPro IPR011257, DNA_glycosylase IPR003265, HhH-GPD_domain IPR023170, HTH_base_excis_C IPR004577, Ogg1 IPR012904, OGG_N |
Pfami | View protein in Pfam PF00730, HhH-GPD, 1 hit PF07934, OGG_N, 1 hit |
SMARTi | View protein in SMART SM00478, ENDO3c, 1 hit |
SUPFAMi | SSF48150, SSF48150, 1 hit |
TIGRFAMsi | TIGR00588, ogg, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ
60 70 80 90 100
SPAHWSGVLA DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF
110 120 130 140 150
QLDVTLAQLY HHWGSVDSHF QEVAQKFQGV RLLRQDPIEC LFSFICSSNN
160 170 180 190 200
NIARITGMVE RLCQAFGPRL IQLDDVTYHG FPSLQALAGP EVEAHLRKLG
210 220 230 240 250
LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL CILPGVGTKV
260 270 280 290 300
ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG
310 320 330 340
NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG
The sequence of this isoform differs from the canonical sequence as follows:
317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → VSVPRCPP
The sequence of this isoform differs from the canonical sequence as follows:
317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → TPPSYRCCSV...VCTTRWGGGY
The sequence of this isoform differs from the canonical sequence as follows:
317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → GLLGNAFDGH...HVMQASLLAL
The sequence of this isoform differs from the canonical sequence as follows:
250-345: VADCICLMAL...RRKGSKGPEG → GLLGNAFDGH...HVMQASLLAL
The sequence of this isoform differs from the canonical sequence as follows:
191-195: EVEAH → PWQCI
196-345: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → LCQVITTFMTFLGPHRLDQMPPEELQTSSSRLGGPPWQCI
The sequence of this isoform differs from the canonical sequence as follows:
317-345: VLFSADLRQSRHAQEPPAKRRKGSKGPEG → AGSDAS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BXZ1 | H7BXZ1_HUMAN | DNA-(apurinic or apyrimidinic site)... | OGG1 | 263 | Annotation score: | ||
H7C1D7 | H7C1D7_HUMAN | N-glycosylase/DNA lyase | OGG1 | 128 | Annotation score: | ||
H7C1V7 | H7C1V7_HUMAN | N-glycosylase/DNA lyase | OGG1 | 132 | Annotation score: | ||
H7BZM3 | H7BZM3_HUMAN | N-glycosylase/DNA lyase | OGG1 | 222 | Annotation score: | ||
H7C0A1 | H7C0A1_HUMAN | N-glycosylase/DNA lyase | OGG1 | 168 | Annotation score: | ||
F8WCZ9 | F8WCZ9_HUMAN | N-glycosylase/DNA lyase | OGG1 | 52 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | W → WW in CAA10351 (Ref. 9) Curated | 1 | |
Sequence conflicti | 308 | G → E in CAA10351 (Ref. 9) Curated | 1 | |
Sequence conflicti | 316 | A → ATPPSLQ in AAB81132 (PubMed:9207108).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024831 | 12 | G → E Found in a kidney cancer sample; no effect on activity; abolishes mitochondrial localization. 1 PublicationCorresponds to variant dbSNP:rs772520254Ensembl. | 1 | |
Natural variantiVAR_009519 | 46 | R → Q Found in a clear cell renal cell carcinoma sample; somatic mutation; diminished activity. 1 PublicationCorresponds to variant dbSNP:rs104893751EnsemblClinVar. | 1 | |
Natural variantiVAR_024832 | 85 | A → S Found in a lung cancer sample. 1 PublicationCorresponds to variant dbSNP:rs17050550Ensembl. | 1 | |
Natural variantiVAR_024833 | 131 | R → Q Found in a lung cancer sample; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs747638147Ensembl. | 1 | |
Natural variantiVAR_009520 | 154 | R → H Found in a gastric cancer sample; no effect on base-excision activity; alters substrate specificity and strongly increases mutagenic mis-repair. 3 PublicationsCorresponds to variant dbSNP:rs56053615Ensembl. | 1 | |
Natural variantiVAR_014487 | 229 | R → Q1 PublicationCorresponds to variant dbSNP:rs1805373Ensembl. | 1 | |
Natural variantiVAR_024834 | 232 | S → T Found in a kidney cancer sample. 1 Publication | 1 | |
Natural variantiVAR_018890 | 288 | A → V1 PublicationCorresponds to variant dbSNP:rs3219012Ensembl. | 1 | |
Natural variantiVAR_014488 | 320 | S → T. Corresponds to variant dbSNP:rs1801128Ensembl. | 1 | |
Natural variantiVAR_018891 | 322 | D → N1 PublicationCorresponds to variant dbSNP:rs3219014Ensembl. | 1 | |
Natural variantiVAR_009521 | 326 | S → C4 PublicationsCorresponds to variant dbSNP:rs1052133Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003750 | 191 – 195 | EVEAH → PWQCI in isoform 2C. Curated | 5 | |
Alternative sequenceiVSP_003751 | 196 – 345 | Missing in isoform 2C. CuratedAdd BLAST | 150 | |
Alternative sequenceiVSP_003749 | 250 – 345 | VADCI…KGPEG → GLLGNAFDGHQLLRPLIFCQ DHLREGPPIGRGDSQGEELE PQLPSSLSSIPYGFCDHCWT KDVDDPPLVTHPSPGSRDGH MTQAWPVKVVSPLATVIGHV MQASLLAL in isoform 2B. CuratedAdd BLAST | 96 | |
Alternative sequenceiVSP_003746 | 317 – 345 | VLFSA…KGPEG → VSVPRCPP in isoform 1B. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_003747 | 317 – 345 | VLFSA…KGPEG → TPPSYRCCSVPTCANPAMLR SHQQSAERVPKGRKARWGTL DKEIPQAPSPPFPTSLSPSP PSLMLGRGLPVTTSKARHPQ IKQSVCTTRWGGGY in isoform 1C. CuratedAdd BLAST | 29 | |
Alternative sequenceiVSP_003748 | 317 – 345 | VLFSA…KGPEG → GLLGNAFDGHQLLRPLIFCQ DHLREGPPIGRGDSQGEELE PQLPSSLSSIPYGFCDHCWT KDVDDPPLVTHPSPGSRDGH MTQAWPVKVVSPLATVIGHV MQASLLAL in isoform 2A. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_003752 | 317 – 345 | VLFSA…KGPEG → LCQVITTFMTFLGPHRLDQM PPEELQTSSSRLGGPPWQCI in isoform 2D. CuratedAdd BLAST | 29 | |
Alternative sequenceiVSP_003753 | 317 – 345 | VLFSA…KGPEG → AGSDAS in isoform 2E. CuratedAdd BLAST | 29 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EBM | X-ray | 2.10 | A | 12-325 | [»] | |
1FN7 | X-ray | 2.60 | A | 12-325 | [»] | |
1HU0 | X-ray | 2.35 | A | 12-327 | [»] | |
1KO9 | X-ray | 2.15 | A | 1-345 | [»] | |
1LWV | X-ray | 2.30 | A | 12-327 | [»] | |
1LWW | X-ray | 2.10 | A | 12-327 | [»] | |
1LWY | X-ray | 2.01 | A | 12-327 | [»] | |
1M3H | X-ray | 2.05 | A | 12-325 | [»] | |
1M3Q | X-ray | 1.90 | A | 12-325 | [»] | |
1N39 | X-ray | 2.20 | A | 12-325 | [»] | |
1N3A | X-ray | 2.20 | A | 12-325 | [»] | |
1N3C | X-ray | 2.70 | A | 12-325 | [»] | |
1YQK | X-ray | 2.50 | A | 12-327 | [»] | |
1YQL | X-ray | 2.60 | A | 12-327 | [»] | |
1YQM | X-ray | 2.50 | A | 12-327 | [»] | |
1YQR | X-ray | 2.43 | A | 12-327 | [»] | |
2I5W | X-ray | 2.60 | A | 12-323 | [»] | |
2NOB | X-ray | 2.10 | A | 12-327 | [»] | |
2NOE | X-ray | 2.20 | A | 12-327 | [»] | |
2NOF | X-ray | 2.35 | A | 12-327 | [»] | |
2NOH | X-ray | 2.01 | A | 12-327 | [»] | |
2NOI | X-ray | 2.35 | A | 12-327 | [»] | |
2NOL | X-ray | 2.57 | A | 12-327 | [»] | |
2NOZ | X-ray | 2.43 | A | 12-327 | [»] | |
2XHI | X-ray | 1.55 | A | 1-345 | [»] | |
3IH7 | X-ray | 3.10 | A | 12-325 | [»] | |
3KTU | X-ray | 2.30 | A | 12-325 | [»] | |
5AN4 | X-ray | 1.60 | A | 12-323 | [»] | |
6RLW | X-ray | 2.00 | AAA/BBB/CCC/DDD/EEE | 11-327 | [»] | |
6W0M | X-ray | 2.37 | A | 12-325 | [»] | |
6W0R | X-ray | 2.35 | A | 12-323 | [»] | |
6W13 | X-ray | 2.38 | A | 12-325 | [»] | |
SMRi | O15527 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111018, 13 interactors |
IntActi | O15527, 5 interactors |
MINTi | O15527 |
STRINGi | 9606.ENSP00000306561 |
Chemistry databases
BindingDBi | O15527 |
ChEMBLi | CHEMBL3396944 |
PTM databases
iPTMneti | O15527 |
PhosphoSitePlusi | O15527 |
Genetic variation databases
BioMutai | OGG1 |
Proteomic databases
jPOSTi | O15527 |
MassIVEi | O15527 |
MaxQBi | O15527 |
PeptideAtlasi | O15527 |
PRIDEi | O15527 |
ProteomicsDBi | 48726 [O15527-1] 48727 [O15527-2] 48728 [O15527-3] 48729 [O15527-4] 48730 [O15527-5] 48731 [O15527-6] 48732 [O15527-7] 48733 [O15527-8] |
Protocols and materials databases
Antibodypediai | 25518, 468 antibodies |
CPTCi | O15527, 1 antibody |
DNASUi | 4968 |
Genome annotation databases
Organism-specific databases
CTDi | 4968 |
DisGeNETi | 4968 |
GeneCardsi | OGG1 |
HGNCi | HGNC:8125, OGG1 |
HPAi | ENSG00000114026, Low tissue specificity |
MalaCardsi | OGG1 |
MIMi | 144700, phenotype 601982, gene |
neXtProti | NX_O15527 |
OpenTargetsi | ENSG00000114026 |
Orphaneti | 422526, Hereditary clear cell renal cell carcinoma |
PharmGKBi | PA31912 |
VEuPathDBi | HostDB:ENSG00000114026.21 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2875, Eukaryota |
GeneTreei | ENSGT00640000091554 |
HOGENOMi | CLU_027543_1_1_1 |
InParanoidi | O15527 |
OMAi | GYAQQYL |
PhylomeDBi | O15527 |
TreeFami | TF323702 |
Enzyme and pathway databases
BRENDAi | 3.2.2.23, 2681 4.2.99.18, 2681 |
PathwayCommonsi | O15527 |
Reactomei | R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110329, Cleavage of the damaged pyrimidine R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-110357, Displacement of DNA glycosylase by APEX1 R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-9656255, Defective OGG1 Substrate Binding R-HSA-9656256, Defective OGG1 Substrate Processing R-HSA-9657050, Defective OGG1 Localization [O15527-4] |
SIGNORi | O15527 |
Miscellaneous databases
BioGRID-ORCSi | 4968, 10 hits in 881 CRISPR screens |
ChiTaRSi | OGG1, human |
EvolutionaryTracei | O15527 |
GeneWikii | Oxoguanine_glycosylase |
GenomeRNAii | 4968 |
Pharosi | O15527, Tbio |
PROi | PR:O15527 |
RNActi | O15527, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114026, Expressed in stomach and 234 other tissues |
ExpressionAtlasi | O15527, baseline and differential |
Genevisiblei | O15527, HS |
Family and domain databases
CDDi | cd00056, ENDO3c, 1 hit |
Gene3Di | 1.10.1670.10, 2 hits |
InterProi | View protein in InterPro IPR011257, DNA_glycosylase IPR003265, HhH-GPD_domain IPR023170, HTH_base_excis_C IPR004577, Ogg1 IPR012904, OGG_N |
Pfami | View protein in Pfam PF00730, HhH-GPD, 1 hit PF07934, OGG_N, 1 hit |
SMARTi | View protein in SMART SM00478, ENDO3c, 1 hit |
SUPFAMi | SSF48150, SSF48150, 1 hit |
TIGRFAMsi | TIGR00588, ogg, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OGG1_HUMAN | |
Accessioni | O15527Primary (citable) accession number: O15527 Secondary accession number(s): A8K1E3 Q9Y6C4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 217 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families