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Protein

ATP-dependent RNA helicase DDX3Y

Gene

DDX3Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 205ATPPROSITE-ProRule annotation8
Nucleotide bindingi222 – 229ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.13 2681

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX3Y (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 3, Y-chromosomal
Gene namesi
Name:DDX3Y
Synonyms:DBY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000067048.16
HGNCiHGNC:2699 DDX3Y
MIMi400010 gene
neXtProtiNX_O15523

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.

Organism-specific databases

DisGeNETi8653
GeneReviewsiDDX3Y
MalaCardsiDDX3Y
OpenTargetsiENSG00000067048
Orphaneti1646 Partial chromosome Y deletion
PharmGKBiPA27168

Polymorphism and mutation databases

BioMutaiDDX3Y

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000550112 – 660ATP-dependent RNA helicase DDX3YAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei55N6-acetyllysineBy similarity1
Modified residuei85PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei100Omega-N-methylarginineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei103PhosphotyrosineBy similarity1
Modified residuei109Omega-N-methylarginineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei181PhosphoserineBy similarity1
Cross-linki213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei454PhosphoserineBy similarity1
Modified residuei590Omega-N-methylarginineBy similarity1
Modified residuei592PhosphoserineBy similarity1
Modified residuei603PhosphoserineBy similarity1
Modified residuei615Omega-N-methylarginineBy similarity1
Modified residuei630Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15523
MaxQBiO15523
PaxDbiO15523
PeptideAtlasiO15523
PRIDEiO15523
ProteomicsDBi48723

PTM databases

iPTMnetiO15523
PhosphoSitePlusiO15523
SwissPalmiO15523

Expressioni

Tissue specificityi

Testis-specific. Expressed predominantly in spermatogonia.1 Publication

Gene expression databases

BgeeiENSG00000067048 Expressed in 198 organ(s), highest expression level in sperm
CleanExiHS_DDX3Y
ExpressionAtlasiO15523 baseline and differential
GenevisibleiO15523 HS

Organism-specific databases

HPAiHPA005631

Interactioni

Subunit structurei

May interact with TDRD3.

Protein-protein interaction databases

BioGridi114204, 40 interactors
ELMiO15523
IntActiO15523, 18 interactors
STRINGi9606.ENSP00000336725

Structurei

3D structure databases

ProteinModelPortaliO15523
SMRiO15523
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 401Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST193
Domaini412 – 573Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi178 – 206Q motifAdd BLAST29
Motifi345 – 348DEAD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0335 Eukaryota
ENOG410XNTI LUCA
GeneTreeiENSGT00930000150917
HOGENOMiHOG000268804
HOVERGENiHBG015893
InParanoidiO15523
KOiK17642
OMAiSYAGMQP
OrthoDBiEOG091G04U3
PhylomeDBiO15523
TreeFamiTF300364

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15523-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSHVVVKNDP ELDQQLANLD LNSEKQSGGA STASKGRYIP PHLRNREASK
60 70 80 90 100
GFHDKDSSGW SCSKDKDAYS SFGSRDSRGK PGYFSERGSG SRGRFDDRGR
110 120 130 140 150
SDYDGIGNRE RPGFGRFERS GHSRWCDKSV EDDWSKPLPP SERLEQELFS
160 170 180 190 200
GGNTGINFEK YDDIPVEATG SNCPPHIENF SDIDMGEIIM GNIELTRYTR
210 220 230 240 250
PTPVQKHAIP IIKGKRDLMA CAQTGSGKTA AFLLPILSQI YTDGPGEALK
260 270 280 290 300
AVKENGRYGR RKQYPISLVL APTRELAVQI YEEARKFSYR SRVRPCVVYG
310 320 330 340 350
GADIGQQIRD LERGCHLLVA TPGRLVDMME RGKIGLDFCK YLVLDEADRM
360 370 380 390 400
LDMGFEPQIR RIVEQDTMPP KGVRHTMMFS ATFPKEIQML ARDFLDEYIF
410 420 430 440 450
LAVGRVGSTS ENITQKVVWV EDLDKRSFLL DILGATGSDS LTLVFVETKK
460 470 480 490 500
GADSLEDFLY HEGYACTSIH GDRSQRDREE ALHQFRSGKS PILVATAVAA
510 520 530 540 550
RGLDISNVRH VINFDLPSDI EEYVHRIGRT GRVGNLGLAT SFFNEKNMNI
560 570 580 590 600
TKDLLDLLVE AKQEVPSWLE NMAYEHHYKG GSRGRSKSNR FSGGFGARDY
610 620 630 640 650
RQSSGSSSSG FGASRGSSSR SGGGGYGNSR GFGGGGYGGF YNSDGYGGNY
660
NSQGVDWWGN
Length:660
Mass (Da):73,154
Last modified:August 16, 2005 - v2
Checksum:i0C370E9367952AB6
GO
Isoform 2 (identifier: O15523-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MSHVVVKNDPELDQQ → MEIGRPRKDTWK

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):72,931
Checksum:iD31DEC552AAF75DB
GO
Isoform 3 (identifier: O15523-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-291: FSYRS → VKYSF
     292-660: Missing.

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):32,416
Checksum:iB8B67E2C8E5C208B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J081C9J081_HUMAN
ATP-dependent RNA helicase DDX3Y
DDX3Y
250Annotation score:
C9J8G5C9J8G5_HUMAN
ATP-dependent RNA helicase DDX3Y
DDX3Y
224Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46R → K in AAC51832 (PubMed:9381176).Curated1
Sequence conflicti46R → K in AAC51831 (PubMed:9381176).Curated1
Sequence conflicti219M → V in AAC51832 (PubMed:9381176).Curated1
Sequence conflicti219M → V in AAC51831 (PubMed:9381176).Curated1
Sequence conflicti628N → D in AAC51832 (PubMed:9381176).Curated1
Sequence conflicti628N → D in AAC51831 (PubMed:9381176).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0554561 – 15MSHVV…ELDQQ → MEIGRPRKDTWK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_055457287 – 291FSYRS → VKYSF in isoform 3. 1 Publication5
Alternative sequenceiVSP_055458292 – 660Missing in isoform 3. 1 PublicationAdd BLAST369

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000985 mRNA Translation: AAC51832.1
AF000984 mRNA Translation: AAC51831.1
AK296366 mRNA Translation: BAG59041.1
AK302172 mRNA Translation: BAG63539.1
AC004474 Genomic DNA No translation available.
BC034942 mRNA Translation: AAH34942.1
CCDSiCCDS14782.1 [O15523-1]
RefSeqiNP_001116137.1, NM_001122665.3 [O15523-1]
NP_001289481.1, NM_001302552.2 [O15523-2]
NP_004651.2, NM_004660.4 [O15523-1]
UniGeneiHs.99120

Genome annotation databases

EnsembliENST00000336079; ENSP00000336725; ENSG00000067048 [O15523-1]
ENST00000360160; ENSP00000353284; ENSG00000067048 [O15523-1]
GeneIDi8653
KEGGihsa:8653
UCSCiuc004fsu.2 human [O15523-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000985 mRNA Translation: AAC51832.1
AF000984 mRNA Translation: AAC51831.1
AK296366 mRNA Translation: BAG59041.1
AK302172 mRNA Translation: BAG63539.1
AC004474 Genomic DNA No translation available.
BC034942 mRNA Translation: AAH34942.1
CCDSiCCDS14782.1 [O15523-1]
RefSeqiNP_001116137.1, NM_001122665.3 [O15523-1]
NP_001289481.1, NM_001302552.2 [O15523-2]
NP_004651.2, NM_004660.4 [O15523-1]
UniGeneiHs.99120

3D structure databases

ProteinModelPortaliO15523
SMRiO15523
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114204, 40 interactors
ELMiO15523
IntActiO15523, 18 interactors
STRINGi9606.ENSP00000336725

PTM databases

iPTMnetiO15523
PhosphoSitePlusiO15523
SwissPalmiO15523

Polymorphism and mutation databases

BioMutaiDDX3Y

Proteomic databases

EPDiO15523
MaxQBiO15523
PaxDbiO15523
PeptideAtlasiO15523
PRIDEiO15523
ProteomicsDBi48723

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336079; ENSP00000336725; ENSG00000067048 [O15523-1]
ENST00000360160; ENSP00000353284; ENSG00000067048 [O15523-1]
GeneIDi8653
KEGGihsa:8653
UCSCiuc004fsu.2 human [O15523-1]

Organism-specific databases

CTDi8653
DisGeNETi8653
EuPathDBiHostDB:ENSG00000067048.16
GeneCardsiDDX3Y
GeneReviewsiDDX3Y
HGNCiHGNC:2699 DDX3Y
HPAiHPA005631
MalaCardsiDDX3Y
MIMi400010 gene
neXtProtiNX_O15523
OpenTargetsiENSG00000067048
Orphaneti1646 Partial chromosome Y deletion
PharmGKBiPA27168
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0335 Eukaryota
ENOG410XNTI LUCA
GeneTreeiENSGT00930000150917
HOGENOMiHOG000268804
HOVERGENiHBG015893
InParanoidiO15523
KOiK17642
OMAiSYAGMQP
OrthoDBiEOG091G04U3
PhylomeDBiO15523
TreeFamiTF300364

Enzyme and pathway databases

BRENDAi3.6.4.13 2681

Miscellaneous databases

ChiTaRSiDDX3Y human
GeneWikiiDDX3Y
GenomeRNAii8653
PROiPR:O15523
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067048 Expressed in 198 organ(s), highest expression level in sperm
CleanExiHS_DDX3Y
ExpressionAtlasiO15523 baseline and differential
GenevisibleiO15523 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDX3Y_HUMAN
AccessioniPrimary (citable) accession number: O15523
Secondary accession number(s): B4DK29, B4DXX7, Q8IYV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 16, 2005
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
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