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Protein

Homeobox protein Nkx-2.8

Gene

NKX2-8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi84 – 143HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.8
Alternative name(s):
Homeobox protein NK-2 homolog H
Gene namesi
Name:NKX2-8
Synonyms:NKX-2.8, NKX2G, NKX2H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000136327.6
HGNCiHGNC:16364 NKX2-8
MIMi603245 gene
neXtProtiNX_O15522

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26257
OpenTargetsiENSG00000136327
PharmGKBiPA38402

Polymorphism and mutation databases

BioMutaiNKX2-8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489431 – 239Homeobox protein Nkx-2.8Add BLAST239

Proteomic databases

EPDiO15522
PaxDbiO15522
PeptideAtlasiO15522
PRIDEiO15522
ProteomicsDBi48722

Expressioni

Gene expression databases

BgeeiENSG00000136327 Expressed in 42 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_NKX2-8
GenevisibleiO15522 HS

Organism-specific databases

HPAiHPA062879

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000258829

Structurei

3D structure databases

ProteinModelPortaliO15522
SMRiO15522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 187Poly-Gly6

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG006689
InParanoidiO15522
KOiK09347
OMAiYKMKRGR
OrthoDBiEOG091G0LZ2
PhylomeDBiO15522
TreeFamiTF351204

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O15522-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSGRLSFT VRSLLDLPEQ DAQHLPRREP EPRAPQPDPC AAWLDSERGH
60 70 80 90 100
YPSSDESSLE TSPPDSSQRP SARPASPGSD AEKRKKRRVL FSKAQTLELE
110 120 130 140 150
RRFRQQRYLS APEREQLASL LRLTPTQVKI WFQNHRYKLK RARAPGAAES
160 170 180 190 200
PDLAASAELH AAPGLLRRVV VPVLVRDGQP CGGGGGGEVG TAAAQEKCGA
210 220 230
PPAAACPLPG YPAFGPGSAL GLFPAYQHLA SPALVSWNW
Length:239
Mass (Da):25,866
Last modified:September 23, 2008 - v2
Checksum:iE227378CCD6E9D27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16D → G in AAC71081 (PubMed:9446603).Curated1
Sequence conflicti16D → G in AAC71082 (PubMed:9446603).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00375316D → A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000295 mRNA Translation: AAC71081.1
AF000297, AF000296 Genomic DNA Translation: AAC71082.1
AK313537 mRNA Translation: BAG36314.1
BC041090 mRNA Translation: AAH41090.1
CCDSiCCDS9660.1
RefSeqiNP_055175.2, NM_014360.3
UniGeneiHs.234763

Genome annotation databases

EnsembliENST00000258829; ENSP00000258829; ENSG00000136327
GeneIDi26257
KEGGihsa:26257
UCSCiuc001wtx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000295 mRNA Translation: AAC71081.1
AF000297, AF000296 Genomic DNA Translation: AAC71082.1
AK313537 mRNA Translation: BAG36314.1
BC041090 mRNA Translation: AAH41090.1
CCDSiCCDS9660.1
RefSeqiNP_055175.2, NM_014360.3
UniGeneiHs.234763

3D structure databases

ProteinModelPortaliO15522
SMRiO15522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000258829

Polymorphism and mutation databases

BioMutaiNKX2-8

Proteomic databases

EPDiO15522
PaxDbiO15522
PeptideAtlasiO15522
PRIDEiO15522
ProteomicsDBi48722

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258829; ENSP00000258829; ENSG00000136327
GeneIDi26257
KEGGihsa:26257
UCSCiuc001wtx.4 human

Organism-specific databases

CTDi26257
DisGeNETi26257
EuPathDBiHostDB:ENSG00000136327.6
GeneCardsiNKX2-8
H-InvDBiHIX0026629
HGNCiHGNC:16364 NKX2-8
HPAiHPA062879
MIMi603245 gene
neXtProtiNX_O15522
OpenTargetsiENSG00000136327
PharmGKBiPA38402
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG006689
InParanoidiO15522
KOiK09347
OMAiYKMKRGR
OrthoDBiEOG091G0LZ2
PhylomeDBiO15522
TreeFamiTF351204

Miscellaneous databases

GenomeRNAii26257
PROiPR:O15522
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136327 Expressed in 42 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_NKX2-8
GenevisibleiO15522 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKX28_HUMAN
AccessioniPrimary (citable) accession number: O15522
Secondary accession number(s): Q8IUT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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