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Protein

Fibroblast growth factor 10

Gene

FGF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.1 Publication

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: Reactome
  • chemoattractant activity Source: UniProtKB
  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • heparin binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
  • protein tyrosine kinase activity Source: Reactome
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • type 2 fibroblast growth factor receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiO15520
SIGNORiO15520

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene namesi
Name:FGF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000070193.4
HGNCiHGNC:3666 FGF10
MIMi602115 gene
neXtProtiNX_O15520

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Aplasia of lacrimal and salivary glands (ALSG)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.
See also OMIM:180920
Lacrimo-auriculo-dento-digital syndrome (LADDS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
See also OMIM:149730
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029888106C → F in LADDS. 1 PublicationCorresponds to variant dbSNP:rs104893885EnsemblClinVar.1
Natural variantiVAR_029889156I → R in LADDS. 1 PublicationCorresponds to variant dbSNP:rs104893886EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Lacrimo-auriculo-dento-digital syndrome

Organism-specific databases

DisGeNETi2255
MalaCardsiFGF10
MIMi149730 phenotype
180920 phenotype
OpenTargetsiENSG00000070193
Orphaneti86815 Aplasia of lacrimal and salivary glands
2363 Lacrimoauriculodentodigital syndrome
PharmGKBiPA28106

Polymorphism and mutation databases

BioMutaiFGF10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000000898138 – 208Fibroblast growth factor 10Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO15520
PaxDbiO15520
PeptideAtlasiO15520
PRIDEiO15520
ProteomicsDBi48721

PTM databases

iPTMnetiO15520
PhosphoSitePlusiO15520

Expressioni

Gene expression databases

BgeeiENSG00000070193
CleanExiHS_FGF10
ExpressionAtlasiO15520 baseline and differential
GenevisibleiO15520 HS

Organism-specific databases

HPAiCAB010315

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR2P218022EBI-1035684,EBI-1028658

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB
  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • type 2 fibroblast growth factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108546, 7 interactors
DIPiDIP-6037N
IntActiO15520, 4 interactors
STRINGi9606.ENSP00000264664

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi70 – 73Combined sources4
Beta strandi76 – 84Combined sources9
Beta strandi89 – 92Combined sources4
Beta strandi98 – 101Combined sources4
Beta strandi111 – 117Combined sources7
Beta strandi120 – 125Combined sources6
Turni126 – 129Combined sources4
Beta strandi130 – 134Combined sources5
Beta strandi138 – 145Combined sources8
Beta strandi150 – 156Combined sources7
Beta strandi162 – 171Combined sources10
Beta strandi174 – 177Combined sources4
Helixi189 – 191Combined sources3
Helixi197 – 199Combined sources3
Beta strandi201 – 205Combined sources5

3D structure databases

ProteinModelPortaliO15520
SMRiO15520
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15520

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 62Poly-SerAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiO15520
KOiK04358
OMAiSSIPVTC
OrthoDBiEOG091G0NAY
PhylomeDBiO15520
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028252 FGF10
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF21 PTHR11486:SF21, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT
60 70 80 90 100
NSSSSSFSSP SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG
110 120 130 140 150
TKKENCPYSI LEITSVEIGV VAVKAINSNY YLAMNKKGKL YGSKEFNNDC
160 170 180 190 200
KLKERIEENG YNTYASFNWQ HNGRQMYVAL NGKGAPRRGQ KTRRKNTSAH

FLPMVVHS
Length:208
Mass (Da):23,436
Last modified:January 1, 1998 - v1
Checksum:iC0A0705C108680B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43D → V in CAG46489 (Ref. 5) Curated1
Sequence conflicti120V → A in AAL05875 (Ref. 3) Curated1
Sequence conflicti134M → R in AAL05875 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029888106C → F in LADDS. 1 PublicationCorresponds to variant dbSNP:rs104893885EnsemblClinVar.1
Natural variantiVAR_029889156I → R in LADDS. 1 PublicationCorresponds to variant dbSNP:rs104893886EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002097 mRNA Translation: BAA22331.1
U67918 mRNA Translation: AAB61991.1
AF411527 mRNA Translation: AAL05875.1
GQ351295 mRNA Translation: ACU00617.1
CR541665 mRNA Translation: CAG46466.1
CR541688 mRNA Translation: CAG46489.1
AY604046 Genomic DNA Translation: AAS99733.1
CH471119 Genomic DNA Translation: EAW56075.1
BC069561 mRNA Translation: AAH69561.1
BC105021 mRNA Translation: AAI05022.1
BC105023 mRNA Translation: AAI05024.1
CCDSiCCDS3950.1
RefSeqiNP_004456.1, NM_004465.1
XP_005248321.1, XM_005248264.3
UniGeneiHs.248049
Hs.664499

Genome annotation databases

EnsembliENST00000264664; ENSP00000264664; ENSG00000070193
GeneIDi2255
KEGGihsa:2255
UCSCiuc003jog.2 human

Similar proteinsi

Entry informationi

Entry nameiFGF10_HUMAN
AccessioniPrimary (citable) accession number: O15520
Secondary accession number(s): C7FDY0
, Q6FHR3, Q6FHT6, Q96P59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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