UniProtKB - O15519 (CFLAR_HUMAN)
CASP8 and FADD-like apoptosis regulator
CFLAR
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: GO_Central
- cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: GO_Central
- death receptor binding Source: Ensembl
- enzyme activator activity Source: UniProtKB
- peptidase activator activity Source: Ensembl
- protease binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- apoptotic process Source: UniProtKB
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to epidermal growth factor stimulus Source: Ensembl
- cellular response to estradiol stimulus Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to insulin stimulus Source: Ensembl
- cellular response to nitric oxide Source: Ensembl
- negative regulation of apoptotic process Source: ProtInc
- negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
- negative regulation of cellular response to transforming growth factor beta stimulus Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
- negative regulation of hepatocyte apoptotic process Source: Ensembl
- negative regulation of myoblast fusion Source: BHF-UCL
- negative regulation of necroptotic process Source: Ensembl
- negative regulation of reactive oxygen species biosynthetic process Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of extracellular matrix organization Source: Ensembl
- positive regulation of glomerular mesangial cell proliferation Source: Ensembl
- positive regulation of hepatocyte proliferation Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
- regulation of necroptotic process Source: UniProtKB
- regulation of skeletal muscle satellite cell proliferation Source: BHF-UCL
- response to bacterium Source: Ensembl
- response to testosterone Source: Ensembl
- skeletal muscle atrophy Source: BHF-UCL
- skeletal muscle tissue development Source: BHF-UCL
- skeletal muscle tissue regeneration Source: BHF-UCL
- skeletal myofibril assembly Source: BHF-UCL
- viral process Source: UniProtKB-KW
- wound healing Source: BHF-UCL
Keywordsi
Biological process | Apoptosis, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | O15519 |
Reactomei | R-HSA-3371378, Regulation by c-FLIP [O15519-1] R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5218900, CASP8 activity is inhibited R-HSA-69416, Dimerization of procaspase-8 [O15519-2] R-HSA-75158, TRAIL signaling |
SignaLinki | O15519 |
SIGNORi | O15519 |
Protein family/group databases
MEROPSi | C14.971 |
Names & Taxonomyi
Protein namesi | Recommended name: CASP8 and FADD-like apoptosis regulatorAlternative name(s): Caspase homolog Short name: CASH Caspase-eight-related protein Short name: Casper Caspase-like apoptosis regulatory protein Short name: CLARP Cellular FLICE-like inhibitory protein Short name: c-FLIP FADD-like antiapoptotic molecule 1 Short name: FLAME-1 Inhibitor of FLICE Short name: I-FLICE MACH-related inducer of toxicity Short name: MRIT Usurpin Cleaved into the following 2 chains: |
Gene namesi | Name:CFLAR Synonyms:CASH, CASP8AP1, CLARP, MRIT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000003402.19 |
HGNCi | HGNC:1876, CFLAR |
MIMi | 603599, gene |
neXtProti | NX_O15519 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- ripoptosome Source: UniProtKB
Plasma Membrane
- CD95 death-inducing signaling complex Source: Ensembl
- death-inducing signaling complex Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- membrane raft Source: Ensembl
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 360 | Y → F: Decreases apoptosis-inducing activity. Reduces interaction with caspase-3 and proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 376 | D → N or A: Abolishes proteolytic processing. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8837 |
OpenTargetsi | ENSG00000003402 |
PharmGKBi | PA26425 |
Miscellaneous databases
Pharosi | O15519, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1955713 |
Polymorphism and mutation databases
BioMutai | CFLAR |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000004678 | 1 – 376 | CASP8 and FADD-like apoptosis regulator subunit p43Add BLAST | 376 | |
ChainiPRO_0000004679 | 377 – 480 | CASP8 and FADD-like apoptosis regulator subunit p121 PublicationAdd BLAST | 104 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 369 – 370 | Cleavage; by CASP8By similarity | 2 | |
Sitei | 376 – 377 | Cleavage; by CASP81 Publication | 2 |
Proteomic databases
EPDi | O15519 |
jPOSTi | O15519 |
MassIVEi | O15519 |
MaxQBi | O15519 |
PaxDbi | O15519 |
PeptideAtlasi | O15519 |
PRIDEi | O15519 |
ProteomicsDBi | 4369 48707 [O15519-1] 48708 [O15519-10] 48709 [O15519-11] 48710 [O15519-12] 48711 [O15519-13] 48712 [O15519-14] 48713 [O15519-2] 48714 [O15519-3] 48715 [O15519-4] 48716 [O15519-5] 48717 [O15519-6] 48718 [O15519-7] 48719 [O15519-8] 48720 [O15519-9] |
PTM databases
iPTMneti | O15519 |
PhosphoSitePlusi | O15519 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
ExpressionAtlasi | O15519, baseline and differential |
Genevisiblei | O15519, HS |
Organism-specific databases
HPAi | ENSG00000003402, Low tissue specificity |
Interactioni
Subunit structurei
TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (PubMed:9880531). A proteolytic fragment (p43) stays associated with the DISC (PubMed:9880531).
Also interacts with FADD, CASP8, CASP3, TRAF1, TRAF2 and Bcl-X(L) (in vitro) (PubMed:9326610, PubMed:9208847).
Interacts with RIPK1 (By similarity) (PubMed:9326610, PubMed:9208847, PubMed:9880531).
By similarity3 Publications(Microbial infection) Interacts with HBV protein X.
1 PublicationBinary interactionsi
Hide detailsO15519
With | #Exp. | IntAct |
---|---|---|
CASP10 [Q92851] | 3 | EBI-514941,EBI-495095 |
CASP8 [Q14790] | 9 | EBI-514941,EBI-78060 |
TRAF1 [Q13077] | 6 | EBI-514941,EBI-359224 |
Isoform 1 [O15519-1]
With | #Exp. | IntAct |
---|---|---|
CASP8 [Q14790] | 2 | EBI-4567563,EBI-78060 |
CASP8 - isoform 2 [Q14790-2] | 3 | EBI-4567563,EBI-15777741 |
MAP2K1 [Q02750] | 3 | EBI-4567563,EBI-492564 |
MAP2K7 [O14733] | 2 | EBI-4567563,EBI-492605 |
CASP8 and FADD-like apoptosis regulator subunit p43 (PRO_0000004678)
With | #Exp. | IntAct |
---|---|---|
CASP10 - isoform D [Q92851-4] | 3 | EBI-4478097,EBI-6621134 |
GO - Molecular functioni
- death receptor binding Source: Ensembl
- protease binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114364, 50 interactors |
CORUMi | O15519 |
DIPi | DIP-27629N |
IntActi | O15519, 31 interactors |
MINTi | O15519 |
STRINGi | 9606.ENSP00000312455 |
Miscellaneous databases
RNActi | O15519, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O15519 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15519 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 73 | DED 1PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 92 – 170 | DED 2PROSITE-ProRule annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 435 | Not proteolytically processed and involved in apoptosis inhibitionAdd BLAST | 435 | |
Regioni | 1 – 305 | Interaction with CASP8 propeptide2 PublicationsAdd BLAST | 305 | |
Regioni | 1 – 227 | Interaction with FADD2 PublicationsAdd BLAST | 227 | |
Regioni | 1 – 195 | Interaction with CASP82 PublicationsAdd BLAST | 195 | |
Regioni | 192 – 480 | Interaction with TRAF1 and TRAF21 PublicationAdd BLAST | 289 | |
Regioni | 192 – 435 | Interaction with CASP32 PublicationsAdd BLAST | 244 | |
Regioni | 217 – 480 | Interaction with CASP8 subunits p18 and p102 PublicationsAdd BLAST | 264 | |
Regioni | 263 – 358 | CaspaseAdd BLAST | 96 | |
Regioni | 370 – 480 | Interaction with CASP82 PublicationsAdd BLAST | 111 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00530000064199 |
HOGENOMi | CLU_1030405_0_0_1 |
InParanoidi | O15519 |
OMAi | VYDWNSR |
OrthoDBi | 939331at2759 |
PhylomeDBi | O15519 |
TreeFami | TF352765 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
s (15+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 15 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 15 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL
60 70 80 90 100
SVGDLAELLY RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI
110 120 130 140 150
GEDLDKSDVS SLIFLMKDYM GRGKISKEKS FLDLVVELEK LNLVAPDQLD
160 170 180 190 200
LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT SYRNVLQAAI QKSLKDPSNN
210 220 230 240 250
FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP EERYKMKSKP
260 270 280 290 300
LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
310 320 330 340 350
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG
360 370 380 390 400
KPKMFFIQNY VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD
410 420 430 440 450
FFWSLCTADM SLLEQSHSSP SLYLQCLSQK LRQERKRPLL DLHIELNGYM
460 470 480
YDWNSRVSAK EKYYVWLQHT LRKKLILSYT
The sequence of this isoform differs from the canonical sequence as follows:
1-96: Missing.
203-221: LHNGRSKEQRLKEQLGAQQ → E
436-480: KRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT → GTIPGSGITESKDMHFSSLGCILLDVL
The sequence of this isoform differs from the canonical sequence as follows:
203-237: Missing.
267-305: LRDTFTSLGY...FACMPEHRDY → CGVRGPAGGQ...ARAVHSSPRS
306-480: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
266-300: LLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP → NAHSWIFTLNSMATCMIGTAEFLPRRNIMFGCSTL
301-480: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
436-480: KRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT → GTIPGSGITESKDMHFSSLGCILLDVL
The sequence of this isoform differs from the canonical sequence as follows:
265-292: ELLRDTFTSLGYEVQKFLHLSMHGISQI → GWSAMAQSQLTAISTSQVQAILLPQPPE
293-480: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
203-480: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
436-480: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-96: Missing.
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MR92 | A0A0A0MR92_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 321 | Annotation score: | ||
E9PAP3 | E9PAP3_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 250 | Annotation score: | ||
F8WBH9 | F8WBH9_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 243 | Annotation score: | ||
C9J408 | C9J408_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 129 | Annotation score: | ||
C9J4Q0 | C9J4Q0_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 64 | Annotation score: | ||
C9JV51 | C9JV51_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 118 | Annotation score: | ||
M0QYM0 | M0QYM0_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 168 | Annotation score: | ||
M0R1A8 | M0R1A8_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 117 | Annotation score: | ||
M0QY57 | M0QY57_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 117 | Annotation score: | ||
C9JSU3 | C9JSU3_HUMAN | CASP8 and FADD-like apoptosis regul... | CFLAR | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 – 132 | SFL → ISW in AAC15825 (PubMed:9380701).Curated | 3 | |
Sequence conflicti | 130 – 132 | SFL → ISW in AAC15826 (PubMed:9380701).Curated | 3 | |
Sequence conflicti | 343 | D → E in AAC15825 (PubMed:9380701).Curated | 1 | |
Sequence conflicti | 364 | E → D in AAB99794 (Ref. 6) Curated | 1 | |
Sequence conflicti | 366 – 368 | QLE → PAG in AAC15825 (PubMed:9380701).Curated | 3 | |
Sequence conflicti | 369 | D → N in CAA74366 (PubMed:9289491).Curated | 1 | |
Sequence conflicti | 372 | L → F in AAB99793 (Ref. 6) Curated | 1 | |
Sequence conflicti | 373 – 374 | LE → WR in AAC15825 (PubMed:9380701).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048619 | 203 | L → I. Corresponds to variant dbSNP:rs13424615EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000825 | 1 – 245 | Missing in isoform 4. 1 PublicationAdd BLAST | 245 | |
Alternative sequenceiVSP_000824 | 1 – 96 | Missing in isoform 3, isoform 7 and isoform 15. 3 PublicationsAdd BLAST | 96 | |
Alternative sequenceiVSP_000826 | 2 – 30 | SAEVI…RDVAI → LERPPVCSKV in isoform 6. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_000831 | 203 – 480 | Missing in isoform 13. 1 PublicationAdd BLAST | 278 | |
Alternative sequenceiVSP_000830 | 203 – 237 | Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_000828 | 203 – 221 | LHNGR…LGAQQ → MITPYAHCPDLKILGNCSM in isoform 2. 4 PublicationsAdd BLAST | 19 | |
Alternative sequenceiVSP_000827 | 203 – 221 | LHNGR…LGAQQ → E in isoform 7. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_000829 | 222 – 480 | Missing in isoform 2. 4 PublicationsAdd BLAST | 259 | |
Alternative sequenceiVSP_000832 | 265 – 292 | ELLRD…GISQI → GWSAMAQSQLTAISTSQVQA ILLPQPPE in isoform 12. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_000834 | 266 – 300 | LLRDT…FACMP → NAHSWIFTLNSMATCMIGTA EFLPRRNIMFGCSTL in isoform 10. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_000836 | 267 – 305 | LRDTF…EHRDY → CGVRGPAGGQQPLGGGWASD EECGIQGSEARAVHSSPRS in isoform 9. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_000833 | 293 – 480 | Missing in isoform 12. 1 PublicationAdd BLAST | 188 | |
Alternative sequenceiVSP_000835 | 301 – 480 | Missing in isoform 10. 1 PublicationAdd BLAST | 180 | |
Alternative sequenceiVSP_000837 | 306 – 480 | Missing in isoform 9. 1 PublicationAdd BLAST | 175 | |
Alternative sequenceiVSP_000838 | 436 – 480 | KRPLL…ILSYT → GTIPGSGITESKDMHFSSLG CILLDVL in isoform 11, isoform 7 and isoform 3. 4 PublicationsAdd BLAST | 45 | |
Alternative sequenceiVSP_000839 | 436 – 480 | Missing in isoform 14. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_000840 | 449 – 480 | YMYDW…ILSYT → L in isoform 5. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_000841 | 453 – 480 | WNSRV…ILSYT → SLEHTGGRY in isoform 6. 1 PublicationAdd BLAST | 28 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2N5R | NMR | - | A | 62-73 | [»] | |
3H11 | X-ray | 1.90 | A | 209-480 | [»] | |
3H13 | X-ray | 2.20 | A | 209-480 | [»] | |
SMRi | O15519 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114364, 50 interactors |
CORUMi | O15519 |
DIPi | DIP-27629N |
IntActi | O15519, 31 interactors |
MINTi | O15519 |
STRINGi | 9606.ENSP00000312455 |
Chemistry databases
ChEMBLi | CHEMBL1955713 |
Protein family/group databases
MEROPSi | C14.971 |
PTM databases
iPTMneti | O15519 |
PhosphoSitePlusi | O15519 |
Polymorphism and mutation databases
BioMutai | CFLAR |
Proteomic databases
EPDi | O15519 |
jPOSTi | O15519 |
MassIVEi | O15519 |
MaxQBi | O15519 |
PaxDbi | O15519 |
PeptideAtlasi | O15519 |
PRIDEi | O15519 |
ProteomicsDBi | 4369 48707 [O15519-1] 48708 [O15519-10] 48709 [O15519-11] 48710 [O15519-12] 48711 [O15519-13] 48712 [O15519-14] 48713 [O15519-2] 48714 [O15519-3] 48715 [O15519-4] 48716 [O15519-5] 48717 [O15519-6] 48718 [O15519-7] 48719 [O15519-8] 48720 [O15519-9] |
Protocols and materials databases
Antibodypediai | 19934, 924 antibodies |
DNASUi | 8837 |
Genome annotation databases
Organism-specific databases
CTDi | 8837 |
DisGeNETi | 8837 |
EuPathDBi | HostDB:ENSG00000003402.19 |
GeneCardsi | CFLAR |
HGNCi | HGNC:1876, CFLAR |
HPAi | ENSG00000003402, Low tissue specificity |
MIMi | 603599, gene |
neXtProti | NX_O15519 |
OpenTargetsi | ENSG00000003402 |
PharmGKBi | PA26425 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00530000064199 |
HOGENOMi | CLU_1030405_0_0_1 |
InParanoidi | O15519 |
OMAi | VYDWNSR |
OrthoDBi | 939331at2759 |
PhylomeDBi | O15519 |
TreeFami | TF352765 |
Enzyme and pathway databases
PathwayCommonsi | O15519 |
Reactomei | R-HSA-3371378, Regulation by c-FLIP [O15519-1] R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5218900, CASP8 activity is inhibited R-HSA-69416, Dimerization of procaspase-8 [O15519-2] R-HSA-75158, TRAIL signaling |
SignaLinki | O15519 |
SIGNORi | O15519 |
Miscellaneous databases
BioGRID-ORCSi | 8837, 322 hits in 845 CRISPR screens |
ChiTaRSi | CFLAR, human |
EvolutionaryTracei | O15519 |
GeneWikii | CFLAR |
GenomeRNAii | 8837 |
Pharosi | O15519, Tbio |
PROi | PR:O15519 |
RNActi | O15519, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000003402, Expressed in lower esophagus muscularis layer and 240 other tissues |
ExpressionAtlasi | O15519, baseline and differential |
Genevisiblei | O15519, HS |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CFLAR_HUMAN | |
Accessioni | O15519Primary (citable) accession number: O15519 Secondary accession number(s): B4DJE0 Q9UEW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 205 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries