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Protein

Actin-related protein 2/3 complex subunit 5

Gene

ARPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-6798695 Neutrophil degranulation
R-HSA-8856828 Clathrin-mediated endocytosis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O15511

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARPC5
Synonyms:ARC16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162704.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:708 ARPC5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604227 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15511

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10092

Open Targets

More...
OpenTargetsi
ENSG00000162704

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25003

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARPC5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001240542 – 151Actin-related protein 2/3 complex subunit 5Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15511

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15511

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15511

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15511

PeptideAtlas

More...
PeptideAtlasi
O15511

PRoteomics IDEntifications database

More...
PRIDEi
O15511

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48703
48704 [O15511-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O15511-1 [O15511-1]
O15511-2 [O15511-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
O15511

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
O15511

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162704 Expressed in 234 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
HS_ARPC5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15511 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15511 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022013
HPA031972

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115399, 61 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O15511

Database of interacting proteins

More...
DIPi
DIP-33144N

Protein interaction database and analysis system

More...
IntActi
O15511, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352918

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15511

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15511

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3380 Eukaryota
ENOG4111FGV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000197215

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050583

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15511

KEGG Orthology (KO)

More...
KOi
K05754

Identification of Orthologs from Complete Genome Data

More...
OMAi
GCIVRAM

Database of Orthologous Groups

More...
OrthoDBi
1565115at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15511

TreeFam database of animal gene trees

More...
TreeFami
TF319716

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006789 ARPC5
IPR036743 ARPC5_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12644 PTHR12644, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04699 P16-Arc, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039096 p16-ARC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69103 SSF69103, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,320
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF050B11774EA6E66
GO
Isoform 2 (identifier: O15511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-48: Q → HSIT

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):16,631
Checksum:i0FF22E5126BDC54A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALC0B1ALC0_HUMAN
Actin-related protein 2/3 complex s...
ARPC5
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02402848Q → HSIT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF006088 mRNA Translation: AAB64193.1
AF017807 mRNA Translation: AAB70561.1
AL137800 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91163.1
BC057237 mRNA Translation: AAH57237.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1357.1 [O15511-1]
CCDS58050.1 [O15511-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001257368.1, NM_001270439.1 [O15511-2]
NP_005708.1, NM_005717.3 [O15511-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.518609

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294742; ENSP00000294742; ENSG00000162704 [O15511-2]
ENST00000359856; ENSP00000352918; ENSG00000162704 [O15511-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10092

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10092

UCSC genome browser

More...
UCSCi
uc021pgb.3 human [O15511-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006088 mRNA Translation: AAB64193.1
AF017807 mRNA Translation: AAB70561.1
AL137800 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91163.1
BC057237 mRNA Translation: AAH57237.1
CCDSiCCDS1357.1 [O15511-1]
CCDS58050.1 [O15511-2]
RefSeqiNP_001257368.1, NM_001270439.1 [O15511-2]
NP_005708.1, NM_005717.3 [O15511-1]
UniGeneiHs.518609

3D structure databases

ProteinModelPortaliO15511
SMRiO15511
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115399, 61 interactors
CORUMiO15511
DIPiDIP-33144N
IntActiO15511, 27 interactors
STRINGi9606.ENSP00000352918

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

PTM databases

iPTMnetiO15511
PhosphoSitePlusiO15511

Polymorphism and mutation databases

BioMutaiARPC5

2D gel databases

OGPiO15511
SWISS-2DPAGEiO15511

Proteomic databases

EPDiO15511
jPOSTiO15511
MaxQBiO15511
PaxDbiO15511
PeptideAtlasiO15511
PRIDEiO15511
ProteomicsDBi48703
48704 [O15511-2]
TopDownProteomicsiO15511-1 [O15511-1]
O15511-2 [O15511-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10092
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294742; ENSP00000294742; ENSG00000162704 [O15511-2]
ENST00000359856; ENSP00000352918; ENSG00000162704 [O15511-1]
GeneIDi10092
KEGGihsa:10092
UCSCiuc021pgb.3 human [O15511-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10092
DisGeNETi10092
EuPathDBiHostDB:ENSG00000162704.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARPC5
HGNCiHGNC:708 ARPC5
HPAiHPA022013
HPA031972
MIMi604227 gene
neXtProtiNX_O15511
OpenTargetsiENSG00000162704
PharmGKBiPA25003

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3380 Eukaryota
ENOG4111FGV LUCA
GeneTreeiENSGT00940000154654
HOGENOMiHOG000197215
HOVERGENiHBG050583
InParanoidiO15511
KOiK05754
OMAiGCIVRAM
OrthoDBi1565115at2759
PhylomeDBiO15511
TreeFamiTF319716

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-6798695 Neutrophil degranulation
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiO15511

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARPC5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARPC5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10092

Protein Ontology

More...
PROi
PR:O15511

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162704 Expressed in 234 organ(s), highest expression level in bone marrow
CleanExiHS_ARPC5
ExpressionAtlasiO15511 baseline and differential
GenevisibleiO15511 HS

Family and domain databases

Gene3Di1.25.40.190, 1 hit
InterProiView protein in InterPro
IPR006789 ARPC5
IPR036743 ARPC5_sf
PANTHERiPTHR12644 PTHR12644, 1 hit
PfamiView protein in Pfam
PF04699 P16-Arc, 1 hit
PIRSFiPIRSF039096 p16-ARC, 1 hit
SUPFAMiSSF69103 SSF69103, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARPC5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15511
Secondary accession number(s): A6NEC4, Q6PG42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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