Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoporin-like protein 2

Gene

NUPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 25C3H1-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • nuclear export signal receptor activity Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA export from nucleus Source: Reactome
  • protein export from nucleus Source: GO_Central
  • viral process Source: Reactome

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin-like protein 2
Alternative name(s):
NLP-1
NUP42 homolog
Nucleoporin hCG1
Gene namesi
Name:NUPL2
Synonyms:CG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136243.16
HGNCiHGNC:17010 NUPL2
neXtProtiNX_O15504

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11097
OpenTargetsiENSG00000136243
PharmGKBiPA134990469

Polymorphism and mutation databases

BioMutaiNUPL2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048951 – 423Nucleoporin-like protein 2Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphoserineCombined sources1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO15504
MaxQBiO15504
PaxDbiO15504
PeptideAtlasiO15504
PRIDEiO15504
ProteomicsDBi48700
48701 [O15504-2]
48702 [O15504-3]

PTM databases

iPTMnetiO15504
PhosphoSitePlusiO15504

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000136243 Expressed in 217 organ(s), highest expression level in kidney
CleanExiHS_NUPL2
ExpressionAtlasiO15504 baseline and differential
GenevisibleiO15504 HS

Organism-specific databases

HPAiHPA049036
HPA057251

Interactioni

Subunit structurei

Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1. Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro. Interacts with the HIV-1 virus proteins Rev and Vpr. The interaction with HIV-1 Rev, a protein that mediates nuclear export of unspliced viral RNAs, suggests that its function may be bypassed by the HIV-1 virus.4 Publications

Protein-protein interaction databases

BioGridi116278, 23 interactors
CORUMiO15504
IntActiO15504, 20 interactors
MINTiO15504
STRINGi9606.ENSP00000258742

Structurei

3D structure databases

ProteinModelPortaliO15504
SMRiO15504
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 15FG 12
Repeati95 – 96FG 22
Repeati218 – 219FG 32
Repeati220 – 221FG 42
Repeati265 – 266FG 52
Repeati271 – 272FG 62
Repeati288 – 289FG 72
Repeati290 – 291FG 82
Repeati311 – 312FG 92
Repeati336 – 337FG 102
Repeati345 – 346FG 112
Repeati364 – 365FG 122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 170Interaction with HIV-1 VprAdd BLAST77
Regioni365 – 423Interaction with GLE11 PublicationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 378Ser-richAdd BLAST141

Domaini

The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 25C3H1-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIH3 Eukaryota
ENOG4111HKJ LUCA
GeneTreeiENSGT00390000000118
HOGENOMiHOG000113895
HOVERGENiHBG082070
InParanoidiO15504
KOiK14321
PhylomeDBiO15504
TreeFamiTF106503

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAICQFFLQG RCRFGDRCWN EHPGARGAGG GRQQPQQQPS GNNRRGWNTT
60 70 80 90 100
SQRYSNVIQP SSFSKSTPWG GSRDQEKPYF SSFDSGASTN RKEGFGLSEN
110 120 130 140 150
PFASLSPDEQ KDEKKLLEGI VKDMEVWESS GQWMFSVYSP VKKKPNISGF
160 170 180 190 200
TDISPEELRL EYHNFLTSNN LQSYLNSVQR LINQWRNRVN ELKSLNISTK
210 220 230 240 250
VALLSDVKDG VNQAAPAFGF GSSQAATFMS PGFPVNNSSS DNAQNFSFKT
260 270 280 290 300
NSGFAAASSG SPAGFGSSPA FGAAASTSSG ISTSAPAFGF GKPEVTSAAS
310 320 330 340 350
FSFKSPAASS FGSPGFSGLP ASLATGPVRA PVAPAFGGGS SVAGFGSPGS
360 370 380 390 400
HSHTAFSKPS SDTFGNSSIS TSLSASSSII ATDNVLFTPR DKLTVEELEQ
410 420
FQSKKFTLGK IPLKPPPLEL LNV
Length:423
Mass (Da):44,872
Last modified:January 1, 1998 - v1
Checksum:i6F8B95073312E999
GO
Isoform 2 (identifier: O15504-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-224: LSDVKDGVNQAAPAFGFGSSQ → KCLWKIYTHLSPKIYGPDCAL
     225-423: Missing.

Show »
Length:224
Mass (Da):25,542
Checksum:i2EBE880F1494052D
GO
Isoform 3 (identifier: O15504-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Show »
Length:195
Mass (Da):19,312
Checksum:i90FAD1990293952F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYA1C9JYA1_HUMAN
Nucleoporin-like protein 2
NUPL2
435Annotation score:
B4DT96B4DT96_HUMAN
Nucleoporin-like protein 2
NUPL2
155Annotation score:
F8WC66F8WC66_HUMAN
Nucleoporin-like protein 2
NUPL2
44Annotation score:
A0A087WZL5A0A087WZL5_HUMAN
Nucleoporin-like protein 2
NUPL2
83Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050572391D → N. Corresponds to variant dbSNP:rs13243961Ensembl.1
Natural variantiVAR_050573392K → N. Corresponds to variant dbSNP:rs34902971Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0164801 – 228Missing in isoform 3. 2 PublicationsAdd BLAST228
Alternative sequenceiVSP_016481204 – 224LSDVK…FGSSQ → KCLWKIYTHLSPKIYGPDCA L in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_016482225 – 423Missing in isoform 2. 2 PublicationsAdd BLAST199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97198 mRNA Translation: AAC33794.1
BT007409 mRNA Translation: AAP36077.1
AK298183 mRNA Translation: BAG60454.1
CH236948 Genomic DNA Translation: EAL24260.1
BC005327 mRNA Translation: AAH05327.1
BC039333 mRNA Translation: AAH39333.1
CCDSiCCDS5379.1 [O15504-1]
RefSeqiNP_031368.1, NM_007342.2 [O15504-1]
UniGeneiHs.408241

Genome annotation databases

EnsembliENST00000258742; ENSP00000258742; ENSG00000136243 [O15504-1]
ENST00000438012; ENSP00000415511; ENSG00000136243 [O15504-2]
GeneIDi11097
KEGGihsa:11097
UCSCiuc003svu.4 human [O15504-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97198 mRNA Translation: AAC33794.1
BT007409 mRNA Translation: AAP36077.1
AK298183 mRNA Translation: BAG60454.1
CH236948 Genomic DNA Translation: EAL24260.1
BC005327 mRNA Translation: AAH05327.1
BC039333 mRNA Translation: AAH39333.1
CCDSiCCDS5379.1 [O15504-1]
RefSeqiNP_031368.1, NM_007342.2 [O15504-1]
UniGeneiHs.408241

3D structure databases

ProteinModelPortaliO15504
SMRiO15504
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116278, 23 interactors
CORUMiO15504
IntActiO15504, 20 interactors
MINTiO15504
STRINGi9606.ENSP00000258742

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO15504
PhosphoSitePlusiO15504

Polymorphism and mutation databases

BioMutaiNUPL2

Proteomic databases

EPDiO15504
MaxQBiO15504
PaxDbiO15504
PeptideAtlasiO15504
PRIDEiO15504
ProteomicsDBi48700
48701 [O15504-2]
48702 [O15504-3]

Protocols and materials databases

DNASUi11097
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258742; ENSP00000258742; ENSG00000136243 [O15504-1]
ENST00000438012; ENSP00000415511; ENSG00000136243 [O15504-2]
GeneIDi11097
KEGGihsa:11097
UCSCiuc003svu.4 human [O15504-1]

Organism-specific databases

CTDi11097
DisGeNETi11097
EuPathDBiHostDB:ENSG00000136243.16
GeneCardsiNUPL2
HGNCiHGNC:17010 NUPL2
HPAiHPA049036
HPA057251
neXtProtiNX_O15504
OpenTargetsiENSG00000136243
PharmGKBiPA134990469
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIH3 Eukaryota
ENOG4111HKJ LUCA
GeneTreeiENSGT00390000000118
HOGENOMiHOG000113895
HOVERGENiHBG082070
InParanoidiO15504
KOiK14321
PhylomeDBiO15504
TreeFamiTF106503

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Miscellaneous databases

ChiTaRSiNUPL2 human
GeneWikiiNUPL2
GenomeRNAii11097
PROiPR:O15504

Gene expression databases

BgeeiENSG00000136243 Expressed in 217 organ(s), highest expression level in kidney
CleanExiHS_NUPL2
ExpressionAtlasiO15504 baseline and differential
GenevisibleiO15504 HS

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUPL2_HUMAN
AccessioniPrimary (citable) accession number: O15504
Secondary accession number(s): A4D143
, B4DP42, Q49AE7, Q9BS49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again