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UniProtKB - O15499 (GSC2_HUMAN)
Protein
Homeobox protein goosecoid-2
Gene
GSC2
Organism
Homo sapiens (Human)
Status
Functioni
May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 126 – 185 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | O15499 |
SignaLinki | O15499 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein goosecoid-2Short name: GSC-2 Alternative name(s): Homeobox protein goosecoid-like Short name: GSC-L |
Gene namesi | Name:GSC2 Synonyms:GSCL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4613, GSC2 |
MIMi | 601845, gene |
neXtProti | NX_O15499 |
VEuPathDBi | HostDB:ENSG00000063515 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2928 |
OpenTargetsi | ENSG00000063515 |
PharmGKBi | PA162390265 |
Miscellaneous databases
Pharosi | O15499, Tbio |
Genetic variation databases
BioMutai | GSC2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048891 | 1 – 205 | Homeobox protein goosecoid-2Add BLAST | 205 |
Proteomic databases
MassIVEi | O15499 |
PaxDbi | O15499 |
PeptideAtlasi | O15499 |
PRIDEi | O15499 |
PTM databases
iPTMneti | O15499 |
PhosphoSitePlusi | O15499 |
Expressioni
Tissue specificityi
Detected in adult testis and pituitary, and in 9-10 week fetal tissue (thorax). Probably expressed in other tissues at low levels.
Developmental stagei
Expressed in early human development as well as in a limited number of adult tissues.
Gene expression databases
Bgeei | ENSG00000063515, Expressed in testis and 6 other tissues |
Genevisiblei | O15499, HS |
Organism-specific databases
HPAi | ENSG00000063515, Tissue enhanced (retina, testis) |
Interactioni
Binary interactionsi
O15499
Protein-protein interaction databases
BioGRIDi | 109183, 60 interactors |
IntActi | O15499, 57 interactors |
STRINGi | 9606.ENSP00000086933 |
Miscellaneous databases
RNActi | O15499, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 33 – 58 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 185 – 205 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000162536 |
HOGENOMi | CLU_122191_0_0_1 |
InParanoidi | O15499 |
OMAi | DTRFPWP |
OrthoDBi | 1270742at2759 |
PhylomeDBi | O15499 |
TreeFami | TF351613 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O15499-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAGGAAS RRGAGRPCPF SIEHILSSLP ERSLPARAAC PPQPAGRQSP
60 70 80 90 100
AKPEEPGAPE AAPCACCCCC GPRAAPCGPP EAAAGLGARL AWPLRLGPAV
110 120 130 140 150
PLSLGAPAGG SGALPGAVGP GSQRRTRRHR TIFSEEQLQA LEALFVQNQY
160 170 180 190 200
PDVSTRERLA GRIRLREERV EVWFKNRRAK WRHQKRASAS ARLLPGVKKS
PKGSC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008549 | 47 | R → C1 PublicationCorresponds to variant dbSNP:rs34341950Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U96402 Genomic DNA Translation: AAC39544.1 |
CCDSi | CCDS13757.1 |
RefSeqi | NP_005306.1, NM_005315.1 |
Genome annotation databases
Ensembli | ENST00000086933.3; ENSP00000086933.2; ENSG00000063515.3 |
GeneIDi | 2928 |
KEGGi | hsa:2928 |
MANE-Selecti | ENST00000086933.3; ENSP00000086933.2; NM_005315.2; NP_005306.1 |
UCSCi | uc011ags.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U96402 Genomic DNA Translation: AAC39544.1 |
CCDSi | CCDS13757.1 |
RefSeqi | NP_005306.1, NM_005315.1 |
3D structure databases
AlphaFoldDBi | O15499 |
SMRi | O15499 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109183, 60 interactors |
IntActi | O15499, 57 interactors |
STRINGi | 9606.ENSP00000086933 |
PTM databases
iPTMneti | O15499 |
PhosphoSitePlusi | O15499 |
Genetic variation databases
BioMutai | GSC2 |
Proteomic databases
MassIVEi | O15499 |
PaxDbi | O15499 |
PeptideAtlasi | O15499 |
PRIDEi | O15499 |
Protocols and materials databases
Antibodypediai | 7476, 72 antibodies from 21 providers |
DNASUi | 2928 |
Genome annotation databases
Ensembli | ENST00000086933.3; ENSP00000086933.2; ENSG00000063515.3 |
GeneIDi | 2928 |
KEGGi | hsa:2928 |
MANE-Selecti | ENST00000086933.3; ENSP00000086933.2; NM_005315.2; NP_005306.1 |
UCSCi | uc011ags.3, human |
Organism-specific databases
CTDi | 2928 |
DisGeNETi | 2928 |
GeneCardsi | GSC2 |
HGNCi | HGNC:4613, GSC2 |
HPAi | ENSG00000063515, Tissue enhanced (retina, testis) |
MIMi | 601845, gene |
neXtProti | NX_O15499 |
OpenTargetsi | ENSG00000063515 |
PharmGKBi | PA162390265 |
VEuPathDBi | HostDB:ENSG00000063515 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000162536 |
HOGENOMi | CLU_122191_0_0_1 |
InParanoidi | O15499 |
OMAi | DTRFPWP |
OrthoDBi | 1270742at2759 |
PhylomeDBi | O15499 |
TreeFami | TF351613 |
Enzyme and pathway databases
PathwayCommonsi | O15499 |
SignaLinki | O15499 |
Miscellaneous databases
BioGRID-ORCSi | 2928, 22 hits in 1085 CRISPR screens |
GenomeRNAii | 2928 |
Pharosi | O15499, Tbio |
PROi | PR:O15499 |
RNActi | O15499, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000063515, Expressed in testis and 6 other tissues |
Genevisiblei | O15499, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSC2_HUMAN | |
Accessioni | O15499Primary (citable) accession number: O15499 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families