UniProtKB - O15498 (YKT6_HUMAN)
Synaptobrevin homolog YKT6
YKT6
Functioni
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
2 PublicationsGO - Molecular functioni
- cadherin binding Source: BHF-UCL
- protein-cysteine S-palmitoyltransferase activity Source: HGNC-UCL
- SNAP receptor activity Source: HGNC-UCL
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: HGNC-UCL
- protein transport Source: UniProtKB-KW
- retrograde transport, endosome to Golgi Source: HGNC-UCL
- vesicle docking involved in exocytosis Source: HGNC-UCL
- vesicle targeting Source: HGNC-UCL
Keywordsi
Molecular function | Transferase |
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O15498 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811438, Intra-Golgi traffic R-HSA-8980692, RHOA GTPase cycle R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013423, RAC3 GTPase cycle |
SignaLinki | O15498 |
Protein family/group databases
TCDBi | 1.F.1.3.1, the synaptosomal vesicle fusion pore (svf-pore) family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:YKT6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16959, YKT6 |
MIMi | 606209, gene |
neXtProti | NX_O15498 |
VEuPathDBi | HostDB:ENSG00000106636 |
Subcellular locationi
Golgi apparatus
Cytoplasm and Cytosol
Other locations
Note: Probably cycles through vesicles between Golgi and endosomes.
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: HGNC-UCL
Endosome
- endosome Source: HGNC-UCL
Golgi apparatus
- Golgi apparatus Source: HGNC-UCL
- Golgi membrane Source: Reactome
Mitochondrion
- mitochondrion Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: HGNC-UCL
Other locations
- apical dendrite Source: Ensembl
- basal dendrite Source: Ensembl
- cytoplasm Source: BHF-UCL
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- neuronal cell body Source: Ensembl
- SNARE complex Source: HGNC-UCL
- transport vesicle Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 42 | F → E: Increases palmitoylation. Targeted to Golgi membranes. Targeted to Golgi and cytosol; when associated with S-194. Targeted to cytosol; when associated with S-195. 2 Publications | 1 | |
Mutagenesisi | 194 | C → S: Decreases palmitoylation by 55%. Prevents palmitoylation; when associated with S-195. Targeted to Golgi and cytosol; when associated with E-42. 2 Publications | 1 | |
Mutagenesisi | 195 | C → S: Prevents farnesylation. Targeted to cytosol; when associated with E-42. Decreases palmitoylation by 13%. Prevents palmitoylation; when associated with S-194. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 10652 |
OpenTargetsi | ENSG00000106636 |
PharmGKBi | PA145007308 |
Miscellaneous databases
Pharosi | O15498, Tbio |
Genetic variation databases
BioMutai | YKT6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280709 | 1 – 195 | Synaptobrevin homolog YKT6Add BLAST | 195 | |
PropeptideiPRO_0000396661 | 196 – 198 | Removed in mature formCurated | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 159 | PhosphoserineCombined sources | 1 | |
Lipidationi | 194 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 195 | Cysteine methyl esterCurated | 1 | |
Lipidationi | 195 | S-farnesyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, Phosphoprotein, PrenylationProteomic databases
EPDi | O15498 |
jPOSTi | O15498 |
MassIVEi | O15498 |
MaxQBi | O15498 |
PaxDbi | O15498 |
PeptideAtlasi | O15498 |
PRIDEi | O15498 |
ProteomicsDBi | 48697 [O15498-1] 4936 |
TopDownProteomicsi | O15498-1 [O15498-1] |
PTM databases
iPTMneti | O15498 |
PhosphoSitePlusi | O15498 |
SwissPalmi | O15498 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106636, Expressed in stromal cell of endometrium and 226 other tissues |
ExpressionAtlasi | O15498, baseline and differential |
Genevisiblei | O15498, HS |
Organism-specific databases
HPAi | ENSG00000106636, Low tissue specificity |
Interactioni
Subunit structurei
Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.
By similarityGO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 115895, 200 interactors |
IntActi | O15498, 38 interactors |
MINTi | O15498 |
STRINGi | 9606.ENSP00000223369 |
Miscellaneous databases
RNActi | O15498, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O15498 |
SMRi | O15498 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 126 | LonginPROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 138 – 198 | v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 61 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0861, Eukaryota |
GeneTreei | ENSGT00390000015164 |
HOGENOMi | CLU_074848_3_0_1 |
InParanoidi | O15498 |
OMAi | ITDHEYP |
PhylomeDBi | O15498 |
TreeFami | TF105606 |
Family and domain databases
CDDi | cd14824, Longin, 1 hit cd15867, R-SNARE_YKT6, 1 hit |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR045848, R-SNARE_YKT6 IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS50892, V_SNARE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLYSLSVLY KGEAKVVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER
60 70 80 90 100
SSKGTRASVK EQDYLCHVYV RNDSLAGVVI ADNEYPSRVA FTLLEKVLDE
110 120 130 140 150
FSKQVDRIDW PVGSPATIHY PALDGHLSRY QNPREADPMT KVQAELDETK
160 170 180 190
IILHNTMESL LERGEKLDDL VSKSEVLGTQ SKAFYKTARK QNSCCAIM
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A7I2V4L6 | A0A7I2V4L6_HUMAN | Synaptobrevin homolog YKT6 | YKT6 | 191 | Annotation score: | ||
A0A7I2V3A1 | A0A7I2V3A1_HUMAN | Synaptobrevin homolog YKT6 | YKT6 | 180 | Annotation score: | ||
A0A7I2V3V7 | A0A7I2V3V7_HUMAN | Synaptobrevin homolog YKT6 | YKT6 | 250 | Annotation score: | ||
H7C3K7 | H7C3K7_HUMAN | Synaptobrevin homolog YKT6 | YKT6 | 29 | Annotation score: | ||
A0A7I2V3S2 | A0A7I2V3S2_HUMAN | Synaptobrevin homolog YKT6 | YKT6 | 37 | Annotation score: | ||
A0A7I2V530 | A0A7I2V530_HUMAN | Synaptobrevin homolog YKT6 | YKT6 | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | D → N in CAG46805 (Ref. 4) Curated | 1 | |
Sequence conflicti | 138 | P → L in BAD97208 (Ref. 5) Curated | 1 | |
Sequence conflicti | 198 | M → I in CAG33270 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056071 | 154 – 187 | Missing in isoform 2. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U95735 mRNA Translation: AAB81131.1 BT007078 mRNA Translation: AAP35741.1 AK299158 mRNA Translation: BAG61206.1 CR456989 mRNA Translation: CAG33270.1 CR542008 mRNA Translation: CAG46805.1 AK223488 mRNA Translation: BAD97208.1 AC006454 Genomic DNA No translation available. BC007319 mRNA Translation: AAH07319.1 |
CCDSi | CCDS5482.1 [O15498-1] CCDS87497.1 [O15498-2] |
RefSeqi | NP_006546.1, NM_006555.3 [O15498-1] XP_016867171.1, XM_017011682.1 |
Genome annotation databases
Ensembli | ENST00000223369.3; ENSP00000223369.2; ENSG00000106636.9 ENST00000496112.5; ENSP00000420805.1; ENSG00000106636.9 [O15498-2] ENST00000679020.1; ENSP00000504623.1; ENSG00000106636.9 |
GeneIDi | 10652 |
KEGGi | hsa:10652 |
MANE-Selecti | ENST00000223369.3; ENSP00000223369.2; NM_006555.4; NP_006546.1 |
UCSCi | uc003tkm.4, human [O15498-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U95735 mRNA Translation: AAB81131.1 BT007078 mRNA Translation: AAP35741.1 AK299158 mRNA Translation: BAG61206.1 CR456989 mRNA Translation: CAG33270.1 CR542008 mRNA Translation: CAG46805.1 AK223488 mRNA Translation: BAD97208.1 AC006454 Genomic DNA No translation available. BC007319 mRNA Translation: AAH07319.1 |
CCDSi | CCDS5482.1 [O15498-1] CCDS87497.1 [O15498-2] |
RefSeqi | NP_006546.1, NM_006555.3 [O15498-1] XP_016867171.1, XM_017011682.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6J74 | X-ray | 3.21 | C | 1-198 | [»] | |
6J7F | X-ray | 2.88 | C | 1-195 | [»] | |
6J7X | X-ray | 2.75 | C | 1-198 | [»] | |
AlphaFoldDBi | O15498 | |||||
SMRi | O15498 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115895, 200 interactors |
IntActi | O15498, 38 interactors |
MINTi | O15498 |
STRINGi | 9606.ENSP00000223369 |
Protein family/group databases
TCDBi | 1.F.1.3.1, the synaptosomal vesicle fusion pore (svf-pore) family |
PTM databases
iPTMneti | O15498 |
PhosphoSitePlusi | O15498 |
SwissPalmi | O15498 |
Genetic variation databases
BioMutai | YKT6 |
Proteomic databases
EPDi | O15498 |
jPOSTi | O15498 |
MassIVEi | O15498 |
MaxQBi | O15498 |
PaxDbi | O15498 |
PeptideAtlasi | O15498 |
PRIDEi | O15498 |
ProteomicsDBi | 48697 [O15498-1] 4936 |
TopDownProteomicsi | O15498-1 [O15498-1] |
Protocols and materials databases
Antibodypediai | 27085, 66 antibodies from 17 providers |
DNASUi | 10652 |
Genome annotation databases
Ensembli | ENST00000223369.3; ENSP00000223369.2; ENSG00000106636.9 ENST00000496112.5; ENSP00000420805.1; ENSG00000106636.9 [O15498-2] ENST00000679020.1; ENSP00000504623.1; ENSG00000106636.9 |
GeneIDi | 10652 |
KEGGi | hsa:10652 |
MANE-Selecti | ENST00000223369.3; ENSP00000223369.2; NM_006555.4; NP_006546.1 |
UCSCi | uc003tkm.4, human [O15498-1] |
Organism-specific databases
CTDi | 10652 |
DisGeNETi | 10652 |
GeneCardsi | YKT6 |
HGNCi | HGNC:16959, YKT6 |
HPAi | ENSG00000106636, Low tissue specificity |
MIMi | 606209, gene |
neXtProti | NX_O15498 |
OpenTargetsi | ENSG00000106636 |
PharmGKBi | PA145007308 |
VEuPathDBi | HostDB:ENSG00000106636 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0861, Eukaryota |
GeneTreei | ENSGT00390000015164 |
HOGENOMi | CLU_074848_3_0_1 |
InParanoidi | O15498 |
OMAi | ITDHEYP |
PhylomeDBi | O15498 |
TreeFami | TF105606 |
Enzyme and pathway databases
PathwayCommonsi | O15498 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811438, Intra-Golgi traffic R-HSA-8980692, RHOA GTPase cycle R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013423, RAC3 GTPase cycle |
SignaLinki | O15498 |
Miscellaneous databases
BioGRID-ORCSi | 10652, 750 hits in 1086 CRISPR screens |
ChiTaRSi | YKT6, human |
GeneWikii | YKT6 |
GenomeRNAii | 10652 |
Pharosi | O15498, Tbio |
PROi | PR:O15498 |
RNActi | O15498, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106636, Expressed in stromal cell of endometrium and 226 other tissues |
ExpressionAtlasi | O15498, baseline and differential |
Genevisiblei | O15498, HS |
Family and domain databases
CDDi | cd14824, Longin, 1 hit cd15867, R-SNARE_YKT6, 1 hit |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR045848, R-SNARE_YKT6 IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS50892, V_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YKT6_HUMAN | |
Accessioni | O15498Primary (citable) accession number: O15498 Secondary accession number(s): B4DR94 Q6IB15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families