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Protein

Group 10 secretory phospholipase A2

Gene

PLA2G10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.2 Publications

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Calcium; via carbonyl oxygen1
Metal bindingi70Calcium; via carbonyl oxygen1
Metal bindingi72Calcium; via carbonyl oxygen1
Active sitei881 Publication1
Metal bindingi89Calcium1
Active sitei1331 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.4 2681
ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Chemistry databases

SwissLipidsiSLP:000001084

Names & Taxonomyi

Protein namesi
Recommended name:
Group 10 secretory phospholipase A2 (EC:3.1.1.4)
Alternative name(s):
Group X secretory phospholipase A2
Short name:
GX sPLA2
Short name:
sPLA2-X
Phosphatidylcholine 2-acylhydrolase 10
Gene namesi
Name:PLA2G10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000069764.9
HGNCiHGNC:9029 PLA2G10
MIMi603603 gene
neXtProtiNX_O15496

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8399
OpenTargetsiENSG00000069764
PharmGKBiPA33360

Chemistry databases

ChEMBLiCHEMBL4342
GuidetoPHARMACOLOGYi1422

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
PropeptideiPRO_000002276432 – 42Sequence analysisAdd BLAST11
ChainiPRO_000002276543 – 165Group 10 secretory phospholipase A2Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 1111 Publication
Disulfide bondi67 ↔ 1571 Publication
Disulfide bondi69 ↔ 851 Publication
Disulfide bondi84 ↔ 1391 Publication
Disulfide bondi90 ↔ 1641 Publication
Disulfide bondi91 ↔ 1321 Publication
Disulfide bondi100 ↔ 1251 Publication
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 1301 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15496
PeptideAtlasiO15496
PRIDEiO15496
ProteomicsDBi48696

PTM databases

iPTMnetiO15496

Expressioni

Tissue specificityi

Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.1 Publication

Gene expression databases

BgeeiENSG00000069764 Expressed in 101 organ(s), highest expression level in sigmoid colon
CleanExiHS_PLA2G10
ExpressionAtlasiO15496 baseline and differential
GenevisibleiO15496 HS

Organism-specific databases

HPAiHPA041893

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
INCA1Q0VD864EBI-726466,EBI-6509505

Protein-protein interaction databases

BioGridi113987, 57 interactors
IntActiO15496, 48 interactors
STRINGi9606.ENSP00000393847

Chemistry databases

BindingDBiO15496

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO15496
SMRiO15496
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15496

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiO15496
KOiK01047
OMAiEIAYCLA
OrthoDBiEOG091G0UZ3
PhylomeDBiO15496
TreeFamiTF319283

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O15496-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPLPVCLPI MLLLLLPSLL LLLLLPGPGS GEASRILRVH RRGILELAGT
60 70 80 90 100
VGCVGPRTPI AYMKYGCFCG LGGHGQPRDA IDWCCHGHDC CYTRAEEAGC
110 120 130 140 150
SPKTERYSWQ CVNQSVLCGP AENKCQELLC KCDQEIANCL AQTEYNLKYL
160
FYPQFLCEPD SPKCD
Length:165
Mass (Da):18,153
Last modified:June 16, 2009 - v3
Checksum:iAD197A164319F102
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRW4H3BRW4_HUMAN
Phospholipase A(2)
PLA2G10 hCG_1746186
130Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95301 mRNA Translation: AAB64410.1
CR456885 mRNA Translation: CAG33166.1
AC009167 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85104.1
BC069539 mRNA Translation: AAH69539.1
BC106731 mRNA Translation: AAI06732.1
BC106732 mRNA Translation: AAI06733.1
BC111804 mRNA Translation: AAI11805.1
CCDSiCCDS10555.1
RefSeqiNP_003552.1, NM_003561.2
UniGeneiHs.567366

Genome annotation databases

EnsembliENST00000438167; ENSP00000393847; ENSG00000069764
ENST00000621727; ENSP00000479397; ENSG00000276870
GeneIDi8399
KEGGihsa:8399
UCSCiuc002dcq.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95301 mRNA Translation: AAB64410.1
CR456885 mRNA Translation: CAG33166.1
AC009167 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85104.1
BC069539 mRNA Translation: AAH69539.1
BC106731 mRNA Translation: AAI06732.1
BC106732 mRNA Translation: AAI06733.1
BC111804 mRNA Translation: AAI11805.1
CCDSiCCDS10555.1
RefSeqiNP_003552.1, NM_003561.2
UniGeneiHs.567366

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LE6X-ray1.97A/B/C43-165[»]
1LE7X-ray2.09A/B43-165[»]
4UY1X-ray2.20A/B43-165[»]
5G3MX-ray1.85A/B43-165[»]
5OW8X-ray1.90A/B43-165[»]
5OWCX-ray1.75A/B43-164[»]
6G5JX-ray1.85A/B1-165[»]
ProteinModelPortaliO15496
SMRiO15496
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113987, 57 interactors
IntActiO15496, 48 interactors
STRINGi9606.ENSP00000393847

Chemistry databases

BindingDBiO15496
ChEMBLiCHEMBL4342
GuidetoPHARMACOLOGYi1422
SwissLipidsiSLP:000001084

PTM databases

iPTMnetiO15496

Proteomic databases

PaxDbiO15496
PeptideAtlasiO15496
PRIDEiO15496
ProteomicsDBi48696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438167; ENSP00000393847; ENSG00000069764
ENST00000621727; ENSP00000479397; ENSG00000276870
GeneIDi8399
KEGGihsa:8399
UCSCiuc002dcq.4 human

Organism-specific databases

CTDi8399
DisGeNETi8399
EuPathDBiHostDB:ENSG00000069764.9
GeneCardsiPLA2G10
H-InvDBiHIX0026959
HGNCiHGNC:9029 PLA2G10
HPAiHPA041893
MIMi603603 gene
neXtProtiNX_O15496
OpenTargetsiENSG00000069764
PharmGKBiPA33360
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiO15496
KOiK01047
OMAiEIAYCLA
OrthoDBiEOG091G0UZ3
PhylomeDBiO15496
TreeFamiTF319283

Enzyme and pathway databases

BRENDAi3.1.1.4 2681
ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Miscellaneous databases

EvolutionaryTraceiO15496
GeneWikiiPLA2G10
GenomeRNAii8399
PROiPR:O15496
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069764 Expressed in 101 organ(s), highest expression level in sigmoid colon
CleanExiHS_PLA2G10
ExpressionAtlasiO15496 baseline and differential
GenevisibleiO15496 HS

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA2GX_HUMAN
AccessioniPrimary (citable) accession number: O15496
Secondary accession number(s): Q14DU3, Q6NT23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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