UniProtKB - O15492 (RGS16_HUMAN)
Protein
Regulator of G-protein signaling 16
Gene
RGS16
Organism
Homo sapiens (Human)
Status
Functioni
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).By similarity2 Publications
GO - Molecular functioni
- calmodulin binding Source: ProtInc
- GTPase activator activity Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: UniProtKB
- negative regulation of signal transduction Source: UniProtKB-KW
- positive regulation of GTPase activity Source: UniProtKB
- regulation of G protein-coupled receptor signaling pathway Source: ProtInc
- visual perception Source: ProtInc
Keywordsi
Molecular function | GTPase activation, Signal transduction inhibitor |
Enzyme and pathway databases
PathwayCommonsi | O15492 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events |
SIGNORi | O15492 |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 16Short name: RGS16 Alternative name(s): A28-RGS14P Retinal-specific RGS Short name: RGS-r Short name: hRGS-r Retinally abundant regulator of G-protein signaling |
Gene namesi | Name:RGS16 Synonyms:RGSR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9997, RGS16 |
MIMi | 602514, gene |
neXtProti | NX_O15492 |
VEuPathDBi | HostDB:ENSG00000143333.6 |
Subcellular locationi
Other locations
- Membrane By similarity; Lipid-anchor By similarity
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: CACAO
- intrinsic component of membrane Source: UniProtKB
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 168 | Y → F: 30% decrease in GAP activity. 1 Publication | 1 | |
Mutagenesisi | 177 | Y → F: No effect on GAP activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6004 |
OpenTargetsi | ENSG00000143333 |
PharmGKBi | PA34367 |
Miscellaneous databases
Pharosi | O15492, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3707469 |
Genetic variation databases
BioMutai | RGS16 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204221 | 1 – 202 | Regulator of G-protein signaling 16Add BLAST | 202 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 12 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 168 | Phosphotyrosine; by EGFR1 Publication | 1 | |
Modified residuei | 177 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Palmitoylated on Cys-2 and/or Cys-12.By similarity
Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.1 Publication
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
MassIVEi | O15492 |
PaxDbi | O15492 |
PeptideAtlasi | O15492 |
PRIDEi | O15492 |
ProteomicsDBi | 48695 |
PTM databases
iPTMneti | O15492 |
PhosphoSitePlusi | O15492 |
SwissPalmi | O15492 |
Expressioni
Tissue specificityi
Abundantly expressed in retina with lower levels of expression in most other tissues.
Gene expression databases
Bgeei | ENSG00000143333, Expressed in lateral nuclear group of thalamus and 189 other tissues |
Genevisiblei | O15492, HS |
Organism-specific databases
HPAi | ENSG00000143333, Tissue enhanced (thyroid) |
Interactioni
Subunit structurei
Interacts with GNAI1 and GNAQ (PubMed:18434541).
Interacts with GNAI2, GNAI3 and GNAO1 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- calmodulin binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 111936, 14 interactors |
DIPi | DIP-59094N |
IntActi | O15492, 3 interactors |
STRINGi | 9606.ENSP00000356529 |
Chemistry databases
BindingDBi | O15492 |
Miscellaneous databases
RNActi | O15492, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O15492 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15492 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 181 | RGSPROSITE-ProRule annotationAdd BLAST | 117 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000154304 |
HOGENOMi | CLU_059863_3_0_1 |
InParanoidi | O15492 |
OMAi | MCRTLAT |
OrthoDBi | 1296189at2759 |
PhylomeDBi | O15492 |
TreeFami | TF315837 |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
IDEALi | IID00607 |
InterProi | View protein in InterPro IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
i Sequence
Sequence statusi: Complete.
O15492-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK
60 70 80 90 100
ENRNFSEDVL GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE
110 120 130 140 150
FKKIRSATKL ASRAHQIFEE FICSEAPKEV NIDHETHELT RMNLQTATAT
160 170 180 190 200
CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL AAQASAASAT LSSCSLDEPS
HT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | F → S in AAC16912 (PubMed:9223279).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046528 | 137 | H → R7 PublicationsCorresponds to variant dbSNP:rs1144566Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70426 mRNA Translation: AAC16912.1 U94829 mRNA Translation: AAC52040.1 AF009356 Genomic DNA Translation: AAC39642.1 AF493937 mRNA Translation: AAM12651.1 BT006638 mRNA Translation: AAP35284.1 AK311880 mRNA Translation: BAG34821.1 AL353778 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91129.1 BC006243 mRNA Translation: AAH06243.1 |
CCDSi | CCDS1348.1 |
RefSeqi | NP_002919.3, NM_002928.3 |
Genome annotation databases
Ensembli | ENST00000367558; ENSP00000356529; ENSG00000143333 |
GeneIDi | 6004 |
KEGGi | hsa:6004 |
UCSCi | uc001gpl.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70426 mRNA Translation: AAC16912.1 U94829 mRNA Translation: AAC52040.1 AF009356 Genomic DNA Translation: AAC39642.1 AF493937 mRNA Translation: AAM12651.1 BT006638 mRNA Translation: AAP35284.1 AK311880 mRNA Translation: BAG34821.1 AL353778 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91129.1 BC006243 mRNA Translation: AAH06243.1 |
CCDSi | CCDS1348.1 |
RefSeqi | NP_002919.3, NM_002928.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BT2 | X-ray | 1.90 | A/B/C/D/E | 53-190 | [»] | |
2IK8 | X-ray | 2.71 | B/D | 53-190 | [»] | |
SMRi | O15492 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111936, 14 interactors |
DIPi | DIP-59094N |
IntActi | O15492, 3 interactors |
STRINGi | 9606.ENSP00000356529 |
Chemistry databases
BindingDBi | O15492 |
ChEMBLi | CHEMBL3707469 |
PTM databases
iPTMneti | O15492 |
PhosphoSitePlusi | O15492 |
SwissPalmi | O15492 |
Genetic variation databases
BioMutai | RGS16 |
Proteomic databases
MassIVEi | O15492 |
PaxDbi | O15492 |
PeptideAtlasi | O15492 |
PRIDEi | O15492 |
ProteomicsDBi | 48695 |
Protocols and materials databases
Antibodypediai | 34439, 334 antibodies |
DNASUi | 6004 |
Genome annotation databases
Ensembli | ENST00000367558; ENSP00000356529; ENSG00000143333 |
GeneIDi | 6004 |
KEGGi | hsa:6004 |
UCSCi | uc001gpl.5, human |
Organism-specific databases
CTDi | 6004 |
DisGeNETi | 6004 |
GeneCardsi | RGS16 |
HGNCi | HGNC:9997, RGS16 |
HPAi | ENSG00000143333, Tissue enhanced (thyroid) |
MIMi | 602514, gene |
neXtProti | NX_O15492 |
OpenTargetsi | ENSG00000143333 |
PharmGKBi | PA34367 |
VEuPathDBi | HostDB:ENSG00000143333.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000154304 |
HOGENOMi | CLU_059863_3_0_1 |
InParanoidi | O15492 |
OMAi | MCRTLAT |
OrthoDBi | 1296189at2759 |
PhylomeDBi | O15492 |
TreeFami | TF315837 |
Enzyme and pathway databases
PathwayCommonsi | O15492 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events |
SIGNORi | O15492 |
Miscellaneous databases
BioGRID-ORCSi | 6004, 3 hits in 988 CRISPR screens |
EvolutionaryTracei | O15492 |
GeneWikii | RGS16 |
GenomeRNAii | 6004 |
Pharosi | O15492, Tbio |
PROi | PR:O15492 |
RNActi | O15492, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143333, Expressed in lateral nuclear group of thalamus and 189 other tissues |
Genevisiblei | O15492, HS |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
IDEALi | IID00607 |
InterProi | View protein in InterPro IPR016137, RGS IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS16_HUMAN | |
Accessioni | O15492Primary (citable) accession number: O15492 Secondary accession number(s): B2R4M4, Q5VYN9, Q99701 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 11, 2011 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references