RGS16

Functionⁱ

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

calmodulin binding
Source: ProtInc
Traceable author statementⁱ
- 10747990
GTPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18434541

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G protein-coupled receptor signaling pathway Source: UniProtKB
negative regulation of signal transduction Source: UniProtKB-KW
positive regulation of GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18434541
regulation of G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10747990
visual perception
Source: ProtInc
Traceable author statementⁱ
- 9469939

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation, Signal transduction inhibitor

Molecular function

GTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	O15492

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 16 Short name: RGS16 Alternative name(s): A28-RGS14P Retinal-specific RGS Short name: RGS-r Short name: hRGS-r Retinally abundant regulator of G-protein signaling
Gene namesⁱ	Name:RGS16 Synonyms:RGSR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143333.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9997 RGS16
MIMⁱ	602514 gene
neXtProtⁱ	NX_O15492

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	168	Y → F: 30% decrease in GAP activity. 1 Publication		1
Mutagenesisⁱ	177	Y → F: No effect on GAP activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6004
Open Targets More...OpenTargetsⁱ	ENSG00000143333
PharmGKBⁱ	PA34367

Chemistry databases

ChEMBLⁱ	CHEMBL3707469

ChEMBLⁱ

CHEMBL3707469

Polymorphism and mutation databases

BioMutaⁱ	RGS16

BioMutaⁱ

RGS16

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204221	1 – 202	Regulator of G-protein signaling 16Add BLAST		202

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	S-palmitoyl cysteineBy similarity	1
Lipidationⁱ	12	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	168	Phosphotyrosine; by EGFR1 Publication	1
Modified residueⁱ	177	Phosphotyrosine1 Publication	1

Post-translational modificationⁱ

Palmitoylated on Cys-2 and/or Cys-12.By similarity

Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.1 Publication

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	O15492
PeptideAtlas More...PeptideAtlasⁱ	O15492
PRIDEⁱ	O15492
ProteomicsDBⁱ	48695

PTM databases

iPTMnetⁱ	O15492
PhosphoSitePlusⁱ	O15492
SwissPalmⁱ	O15492

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in retina with lower levels of expression in most other tissues.

Gene expression databases

Bgeeⁱ	ENSG00000143333 Expressed in 178 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExⁱ	HS_RGS16
Genevisibleⁱ	O15492 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053250 HPA055824

HPAⁱ

HPA053250
HPA055824

Interactionⁱ

Subunit structureⁱ

GO - Molecular functionⁱ

calmodulin binding
Source: ProtInc
Traceable author statementⁱ
- 10747990

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111936, 14 interactors
Database of interacting proteins More...DIPⁱ	DIP-59094N
IntActⁱ	O15492, 3 interactors
STRINGⁱ	9606.ENSP00000356529

Chemistry databases

BindingDBⁱ

O15492

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	53 – 62	Combined sources	10
Helixⁱ	66 – 70	Combined sources	5
Helixⁱ	73 – 85	Combined sources	13
Helixⁱ	89 – 101	Combined sources	13
Helixⁱ	107 – 121	Combined sources	15
Helixⁱ	134 – 143	Combined sources	10
Helixⁱ	144 – 146	Combined sources	3
Turnⁱ	149 – 152	Combined sources	4
Helixⁱ	153 – 165	Combined sources	13
Helixⁱ	167 – 173	Combined sources	7
Helixⁱ	175 – 186	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	O15492
SMRⁱ	O15492
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O15492

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	65 – 181	RGSPROSITE-ProRule annotationAdd BLAST		117

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	O15492
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	MCRTLAT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O15492
TreeFamⁱ	TF315837

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O15492-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK 
        60         70         80         90        100
ENRNFSEDVL GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE 
       110        120        130        140        150
FKKIRSATKL ASRAHQIFEE FICSEAPKEV NIDHETHELT RMNLQTATAT 
       160        170        180        190        200
CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL AAQASAASAT LSSCSLDEPS 

HT

Length:202

Mass (Da):22,749

Last modified:January 11, 2011 - v2

Checksum:ⁱ19B384E935F3E5D1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	42	F → S in AAC16912 (PubMed:9223279).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046528	137	H → R7 PublicationsCorresponds to variant dbSNP:rs1144566Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U70426 mRNA Translation: AAC16912.1 U94829 mRNA Translation: AAC52040.1 AF009356 Genomic DNA Translation: AAC39642.1 AF493937 mRNA Translation: AAM12651.1 BT006638 mRNA Translation: AAP35284.1 AK311880 mRNA Translation: BAG34821.1 AL353778 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91129.1 BC006243 mRNA Translation: AAH06243.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1348.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002919.3, NM_002928.3
UniGeneⁱ	Hs.413297

Genome annotation databases

Ensemblⁱ	ENST00000367558; ENSP00000356529; ENSG00000143333
GeneIDⁱ	6004
KEGGⁱ	hsa:6004
UCSC genome browser More...UCSCⁱ	uc001gpl.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15492	Regulator of G-protein signaling 16 (Fragment)		ESCRO		239	UniRef90_O15492
Uncharacterized protein		PROCO		202
RGS16 isoform 1		PONAB		202
Uncharacterized protein		NOMLE		202
RGS16 isoform 1		PANTR		202
+26

Protein	Similar proteins		Species	Score	Length	Source
O15492	Regulator of G-protein signaling 16		BOVIN		202	UniRef50_O15492
Regulator of G-protein signaling 16		PIG		200
Regulator of G-protein signaling 16 (Fragment)		ESCRO		239
Uncharacterized protein		NOMLE		202
RGS16 isoform 1		PANTR		202
+57

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U70426 mRNA Translation: AAC16912.1 U94829 mRNA Translation: AAC52040.1 AF009356 Genomic DNA Translation: AAC39642.1 AF493937 mRNA Translation: AAM12651.1 BT006638 mRNA Translation: AAP35284.1 AK311880 mRNA Translation: BAG34821.1 AL353778 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91129.1 BC006243 mRNA Translation: AAH06243.1
CCDSⁱ	CCDS1348.1
RefSeqⁱ	NP_002919.3, NM_002928.3
UniGeneⁱ	Hs.413297

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2BT2	X-ray	1.90	A/B/C/D/E	53-190	[»]
	2IK8	X-ray	2.71	B/D	53-190	[»]
ProteinModelPortalⁱ	O15492
SMRⁱ	O15492
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111936, 14 interactors
DIPⁱ	DIP-59094N
IntActⁱ	O15492, 3 interactors
STRINGⁱ	9606.ENSP00000356529

Chemistry databases

BindingDBⁱ	O15492
ChEMBLⁱ	CHEMBL3707469

PTM databases

iPTMnetⁱ	O15492
PhosphoSitePlusⁱ	O15492
SwissPalmⁱ	O15492

Polymorphism and mutation databases

BioMutaⁱ	RGS16

BioMutaⁱ

RGS16

Proteomic databases

PaxDbⁱ	O15492
PeptideAtlasⁱ	O15492
PRIDEⁱ	O15492
ProteomicsDBⁱ	48695

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6004
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367558; ENSP00000356529; ENSG00000143333
GeneIDⁱ	6004
KEGGⁱ	hsa:6004
UCSCⁱ	uc001gpl.5 human

Organism-specific databases

CTDⁱ	6004
DisGeNETⁱ	6004
EuPathDBⁱ	HostDB:ENSG00000143333.6
GeneCardsⁱ	RGS16
H-InvDBⁱ	HIX0001402
HGNCⁱ	HGNC:9997 RGS16
HPAⁱ	HPA053250 HPA055824
MIMⁱ	602514 gene
neXtProtⁱ	NX_O15492
OpenTargetsⁱ	ENSG00000143333
PharmGKBⁱ	PA34367
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	O15492
KOⁱ	K16449
OMAⁱ	MCRTLAT
OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O15492
TreeFamⁱ	TF315837

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	O15492

Miscellaneous databases

EvolutionaryTraceⁱ	O15492
GeneWikiⁱ	RGS16
GenomeRNAiⁱ	6004
Protein Ontology More...PROⁱ	PR:O15492
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143333 Expressed in 178 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExⁱ	HS_RGS16
Genevisibleⁱ	O15492 HS

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3
Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS16_HUMAN
Accessionⁱ	O15492Primary (citable) accession number: O15492 Secondary accession number(s): B2R4M4, Q5VYN9, Q99701
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O15492 (RGS16_HUMAN)

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Regulator of G-protein signaling 16

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ