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Entry version 147 (08 May 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Testis-specific protein TEX28

Gene

TEX28

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Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-specific protein TEX28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEX28
Synonyms:CXorf2
AND
Name:TEX28P1
AND
Name:TEX28P2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2563 TEX28
HGNC:33356 TEX28P1
HGNC:33357 TEX28P2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300092 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O15482

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei336 – 358HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1527

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405646

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TEX28

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001845941 – 410Testis-specific protein TEX28Add BLAST410

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15482

MaxQB - The MaxQuant DataBase

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MaxQBi
O15482

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O15482

PeptideAtlas

More...
PeptideAtlasi
O15482

PRoteomics IDEntifications database

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PRIDEi
O15482

ProteomicsDB human proteome resource

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ProteomicsDBi
48687

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15482

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15482

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000278057 Expressed in 10 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15482 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107907, 27 interactors

Protein interaction database and analysis system

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IntActi
O15482, 6 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000478834

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15482

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili93 – 128Sequence analysisAdd BLAST36
Coiled coili185 – 245Sequence analysisAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TEX28 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3850 Eukaryota
ENOG410Y9KV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049258

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15482

Identification of Orthologs from Complete Genome Data

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OMAi
MAYLSYE

Database of Orthologous Groups

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OrthoDBi
1258358at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O15482

TreeFam database of animal gene trees

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TreeFami
TF316292

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017387 Testis-specific_TEX28
IPR019394 TEX28/TMCC

The PANTHER Classification System

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PANTHERi
PTHR17613 PTHR17613, 1 hit
PTHR17613:SF10 PTHR17613:SF10, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF10267 Tmemb_cc2, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038100 Testis-specific_TEX28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O15482-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLKAEHTRS PSATLPSNVP SCRSLSSSED GPSGPSSLAD GGLAHNLQDS
60 70 80 90 100
VRHRILYLSE QLRVEKASRD GNTVSYLKLV SKADRHQVPH IQQAFEKVNQ
110 120 130 140 150
RASATIAQIE HRLHQCHQQL QELEEGCRPE GLLLMAESDP ANCEPPSEKA
160 170 180 190 200
LLSEPPEPGG EDGPVNLPHA SRPFILESRF QSLQQGTCLE TEDVAQQQNL
210 220 230 240 250
LLQKVKAELE EAKRFHISLQ ESYHSLKERS LTDLQLLLES LQEEKCRQAL
260 270 280 290 300
MEEQVNGRLQ GQLNEIYNLK HNLACSEERM AYLSYERAKE IWEITETFKS
310 320 330 340 350
RISKLEMLQQ VTQLEAAEHL QSRPPQMLFK FLSPRLSLAT VLLVFVSTLC
360 370 380 390 400
ACPSSLISSR LCTCTMLMLI GLGVLAWQRW RAIPATDWQE WVPSRCRLYS
410
KDSGPPADGP
Length:410
Mass (Da):46,131
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E455A761D52A660
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U93720 mRNA Translation: AAB71379.1
Z46936, AC092402 Genomic DNA Translation: CAI41959.1
Z68193, AC092402 Genomic DNA Translation: CAI43243.1
CH471172 Genomic DNA Translation: EAW72754.1
CH471172 Genomic DNA Translation: EAW72755.1
BC026183 mRNA Translation: AAH26183.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14744.2

NCBI Reference Sequences

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RefSeqi
NP_001192130.1, NM_001205201.1
NP_001577.1, NM_001586.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000610938; ENSP00000479148; ENSG00000278057
ENST00000617225; ENSP00000482010; ENSG00000278057
ENST00000619903; ENSP00000478834; ENSG00000278057

Database of genes from NCBI RefSeq genomes

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GeneIDi
1527

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1527

UCSC genome browser

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UCSCi
uc033fba.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93720 mRNA Translation: AAB71379.1
Z46936, AC092402 Genomic DNA Translation: CAI41959.1
Z68193, AC092402 Genomic DNA Translation: CAI43243.1
CH471172 Genomic DNA Translation: EAW72754.1
CH471172 Genomic DNA Translation: EAW72755.1
BC026183 mRNA Translation: AAH26183.1
CCDSiCCDS14744.2
RefSeqiNP_001192130.1, NM_001205201.1
NP_001577.1, NM_001586.2

3D structure databases

SMRiO15482
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107907, 27 interactors
IntActiO15482, 6 interactors
STRINGi9606.ENSP00000478834

PTM databases

iPTMnetiO15482
PhosphoSitePlusiO15482

Polymorphism and mutation databases

BioMutaiTEX28

Proteomic databases

EPDiO15482
MaxQBiO15482
PaxDbiO15482
PeptideAtlasiO15482
PRIDEiO15482
ProteomicsDBi48687

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1527
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610938; ENSP00000479148; ENSG00000278057
ENST00000617225; ENSP00000482010; ENSG00000278057
ENST00000619903; ENSP00000478834; ENSG00000278057
GeneIDi1527
KEGGihsa:1527
UCSCiuc033fba.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1527
DisGeNETi1527

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TEX28
TEX28P1
TEX28P2
HGNCiHGNC:2563 TEX28
HGNC:33356 TEX28P1
HGNC:33357 TEX28P2
MIMi300092 gene
neXtProtiNX_O15482
PharmGKBiPA162405646

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3850 Eukaryota
ENOG410Y9KV LUCA
GeneTreeiENSGT00940000162843
HOGENOMiHOG000049258
InParanoidiO15482
OMAiMAYLSYE
OrthoDBi1258358at2759
PhylomeDBiO15482
TreeFamiTF316292

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1527

Protein Ontology

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PROi
PR:O15482

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000278057 Expressed in 10 organ(s), highest expression level in right testis
GenevisibleiO15482 HS

Family and domain databases

InterProiView protein in InterPro
IPR017387 Testis-specific_TEX28
IPR019394 TEX28/TMCC
PANTHERiPTHR17613 PTHR17613, 1 hit
PTHR17613:SF10 PTHR17613:SF10, 1 hit
PfamiView protein in Pfam
PF10267 Tmemb_cc2, 2 hits
PIRSFiPIRSF038100 Testis-specific_TEX28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEX28_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15482
Secondary accession number(s): B1B1E8, D3DWW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 8, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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