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Protein

Melanoma-associated antigen B2

Gene

MAGEB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen
Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen B2
Alternative name(s):
Cancer/testis antigen 3.2
Short name:
CT3.2
DSS-AHC critical interval MAGE superfamily 6
Short name:
DAM6
MAGE XP-2 antigen
MAGE-B2 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000099399.5

Human Gene Nomenclature Database

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HGNCi
HGNC:6809 MAGEB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300098 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15479

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4113

Open Targets

More...
OpenTargetsi
ENSG00000099399

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30555

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGEB2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567131 – 319Melanoma-associated antigen B2Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15479

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15479

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15479

PeptideAtlas

More...
PeptideAtlasi
O15479

PRoteomics IDEntifications database

More...
PRIDEi
O15479

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48684

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15479

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15479

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099399 Expressed in 26 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAGEB2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15479 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065224
HPA074544
HPA075519

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRIM28.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RPGRIP1Q96KN73EBI-1057615,EBI-1050213

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110287, 30 interactors

Protein interaction database and analysis system

More...
IntActi
O15479, 12 interactors

Molecular INTeraction database

More...
MINTi
O15479

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368273

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15479

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15479

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 310MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562 Eukaryota
ENOG4111S70 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155485

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231161

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006315

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15479

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHTYTFN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0TJ0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15479

TreeFam database of animal gene trees

More...
TreeFami
TF328505

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11736 PTHR11736, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838 MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O15479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA
60 70 80 90 100
SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS
110 120 130 140 150
TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP
160 170 180 190 200
EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR
210 220 230 240 250
RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK
260 270 280 290 300
DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP
310
CAFPTHYEEA LKDEEKAGV
Length:319
Mass (Da):35,277
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF0BD27A832D5CBB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02767561E → KCombined sources3 PublicationsCorresponds to variant dbSNP:rs2529541Ensembl.1
Natural variantiVAR_027676318G → R. Corresponds to variant dbSNP:rs5972090Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U93163 Genomic DNA Translation: AAC23617.1
AF015766 mRNA Translation: AAD01565.1
AC005185 Genomic DNA Translation: AAD10635.1
BC026071 mRNA Translation: AAH26071.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14219.1

NCBI Reference Sequences

More...
RefSeqi
NP_002355.2, NM_002364.4
XP_011543814.1, XM_011545512.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.113824

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378988; ENSP00000368273; ENSG00000099399

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4113

UCSC genome browser

More...
UCSCi
uc004dbz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA Translation: AAC23617.1
AF015766 mRNA Translation: AAD01565.1
AC005185 Genomic DNA Translation: AAD10635.1
BC026071 mRNA Translation: AAH26071.1
CCDSiCCDS14219.1
RefSeqiNP_002355.2, NM_002364.4
XP_011543814.1, XM_011545512.1
UniGeneiHs.113824

3D structure databases

ProteinModelPortaliO15479
SMRiO15479
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110287, 30 interactors
IntActiO15479, 12 interactors
MINTiO15479
STRINGi9606.ENSP00000368273

PTM databases

iPTMnetiO15479
PhosphoSitePlusiO15479

Polymorphism and mutation databases

BioMutaiMAGEB2

Proteomic databases

EPDiO15479
MaxQBiO15479
PaxDbiO15479
PeptideAtlasiO15479
PRIDEiO15479
ProteomicsDBi48684

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4113
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378988; ENSP00000368273; ENSG00000099399
GeneIDi4113
KEGGihsa:4113
UCSCiuc004dbz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4113
DisGeNETi4113
EuPathDBiHostDB:ENSG00000099399.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAGEB2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016713
HGNCiHGNC:6809 MAGEB2
HPAiHPA065224
HPA074544
HPA075519
MIMi300098 gene
neXtProtiNX_O15479
OpenTargetsiENSG00000099399
PharmGKBiPA30555

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00940000155485
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiO15479
OMAiGHTYTFN
OrthoDBiEOG091G0TJ0
PhylomeDBiO15479
TreeFamiTF328505

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAGEB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4113

Protein Ontology

More...
PROi
PR:O15479

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099399 Expressed in 26 organ(s), highest expression level in testis
CleanExiHS_MAGEB2
GenevisibleiO15479 HS

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15479
Secondary accession number(s): O75860
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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