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Protein

Melanoma-associated antigen B2

Gene

MAGEB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

Keywordsi

Molecular functionTumor antigen
Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B2
Alternative name(s):
Cancer/testis antigen 3.2
Short name:
CT3.2
DSS-AHC critical interval MAGE superfamily 6
Short name:
DAM6
MAGE XP-2 antigen
MAGE-B2 antigen
Gene namesi
Name:MAGEB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000099399.5
HGNCiHGNC:6809 MAGEB2
MIMi300098 gene
neXtProtiNX_O15479

Pathology & Biotechi

Organism-specific databases

DisGeNETi4113
OpenTargetsiENSG00000099399
PharmGKBiPA30555

Polymorphism and mutation databases

BioMutaiMAGEB2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567131 – 319Melanoma-associated antigen B2Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15479
MaxQBiO15479
PaxDbiO15479
PeptideAtlasiO15479
PRIDEiO15479
ProteomicsDBi48684

PTM databases

iPTMnetiO15479
PhosphoSitePlusiO15479

Expressioni

Tissue specificityi

Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.

Gene expression databases

BgeeiENSG00000099399
CleanExiHS_MAGEB2
GenevisibleiO15479 HS

Organism-specific databases

HPAiHPA065224
HPA074544
HPA075519

Interactioni

Subunit structurei

Interacts with TRIM28.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPGRIP1Q96KN73EBI-1057615,EBI-1050213

Protein-protein interaction databases

BioGridi110287, 30 interactors
IntActiO15479, 46 interactors
MINTiO15479
STRINGi9606.ENSP00000368273

Structurei

3D structure databases

ProteinModelPortaliO15479
SMRiO15479
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 310MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiO15479
OMAiRFREHFP
OrthoDBiEOG091G0TJ0
PhylomeDBiO15479
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

O15479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA
60 70 80 90 100
SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS
110 120 130 140 150
TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP
160 170 180 190 200
EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR
210 220 230 240 250
RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK
260 270 280 290 300
DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP
310
CAFPTHYEEA LKDEEKAGV
Length:319
Mass (Da):35,277
Last modified:January 11, 2011 - v3
Checksum:iCF0BD27A832D5CBB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02767561E → KCombined sources3 PublicationsCorresponds to variant dbSNP:rs2529541Ensembl.1
Natural variantiVAR_027676318G → R. Corresponds to variant dbSNP:rs5972090Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA Translation: AAC23617.1
AF015766 mRNA Translation: AAD01565.1
AC005185 Genomic DNA Translation: AAD10635.1
BC026071 mRNA Translation: AAH26071.1
CCDSiCCDS14219.1
RefSeqiNP_002355.2, NM_002364.4
XP_011543814.1, XM_011545512.1
UniGeneiHs.113824

Genome annotation databases

EnsembliENST00000378988; ENSP00000368273; ENSG00000099399
GeneIDi4113
KEGGihsa:4113
UCSCiuc004dbz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAGB2_HUMAN
AccessioniPrimary (citable) accession number: O15479
Secondary accession number(s): O75860
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: July 18, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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