UniProtKB - O15479 (MAGB2_HUMAN)
Protein
Melanoma-associated antigen B2
Gene
MAGEB2
Organism
Homo sapiens (Human)
Status
Functioni
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication
Keywordsi
Molecular function | Tumor antigen |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | O15479 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma-associated antigen B2Alternative name(s): Cancer/testis antigen 3.2 Short name: CT3.2 DSS-AHC critical interval MAGE superfamily 6 Short name: DAM6 MAGE XP-2 antigen MAGE-B2 antigen |
Gene namesi | Name:MAGEB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000099399.5 |
HGNCi | HGNC:6809, MAGEB2 |
MIMi | 300098, gene |
neXtProti | NX_O15479 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 4113 |
OpenTargetsi | ENSG00000099399 |
PharmGKBi | PA30555 |
Miscellaneous databases
Pharosi | O15479, Tbio |
Polymorphism and mutation databases
BioMutai | MAGEB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156713 | 1 – 319 | Melanoma-associated antigen B2Add BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 105 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O15479 |
jPOSTi | O15479 |
MassIVEi | O15479 |
MaxQBi | O15479 |
PaxDbi | O15479 |
PeptideAtlasi | O15479 |
PRIDEi | O15479 |
ProteomicsDBi | 48684 |
PTM databases
iPTMneti | O15479 |
PhosphoSitePlusi | O15479 |
Expressioni
Tissue specificityi
Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.
Gene expression databases
Bgeei | ENSG00000099399, Expressed in testis and 35 other tissues |
Genevisiblei | O15479, HS |
Organism-specific databases
HPAi | ENSG00000099399, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with TRIM28.
1 PublicationBinary interactionsi
Hide detailsO15479
Protein-protein interaction databases
BioGRIDi | 110287, 40 interactors |
IntActi | O15479, 20 interactors |
MINTi | O15479 |
STRINGi | 9606.ENSP00000368273 |
Miscellaneous databases
RNActi | O15479, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 111 – 310 | MAGEPROSITE-ProRule annotationAdd BLAST | 200 |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000155485 |
HOGENOMi | CLU_039582_1_0_1 |
InParanoidi | O15479 |
OMAi | GHTYTFN |
OrthoDBi | 1195799at2759 |
PhylomeDBi | O15479 |
TreeFami | TF328505 |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR021072, MAGE_N IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 1 hit |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit PF12440, MAGE_N, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit SM01392, MAGE_N, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
i Sequence
Sequence statusi: Complete.
O15479-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA
60 70 80 90 100
SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS
110 120 130 140 150
TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP
160 170 180 190 200
EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR
210 220 230 240 250
RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK
260 270 280 290 300
DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP
310
CAFPTHYEEA LKDEEKAGV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027675 | 61 | E → KCombined sources3 PublicationsCorresponds to variant dbSNP:rs2529541Ensembl. | 1 | |
Natural variantiVAR_027676 | 318 | G → R. Corresponds to variant dbSNP:rs5972090Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U93163 Genomic DNA Translation: AAC23617.1 AF015766 mRNA Translation: AAD01565.1 AC005185 Genomic DNA Translation: AAD10635.1 BC026071 mRNA Translation: AAH26071.1 |
CCDSi | CCDS14219.1 |
RefSeqi | NP_002355.2, NM_002364.4 XP_011543814.1, XM_011545512.1 |
Genome annotation databases
Ensembli | ENST00000378988; ENSP00000368273; ENSG00000099399 |
GeneIDi | 4113 |
KEGGi | hsa:4113 |
UCSCi | uc004dbz.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U93163 Genomic DNA Translation: AAC23617.1 AF015766 mRNA Translation: AAD01565.1 AC005185 Genomic DNA Translation: AAD10635.1 BC026071 mRNA Translation: AAH26071.1 |
CCDSi | CCDS14219.1 |
RefSeqi | NP_002355.2, NM_002364.4 XP_011543814.1, XM_011545512.1 |
3D structure databases
SMRi | O15479 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110287, 40 interactors |
IntActi | O15479, 20 interactors |
MINTi | O15479 |
STRINGi | 9606.ENSP00000368273 |
PTM databases
iPTMneti | O15479 |
PhosphoSitePlusi | O15479 |
Polymorphism and mutation databases
BioMutai | MAGEB2 |
Proteomic databases
EPDi | O15479 |
jPOSTi | O15479 |
MassIVEi | O15479 |
MaxQBi | O15479 |
PaxDbi | O15479 |
PeptideAtlasi | O15479 |
PRIDEi | O15479 |
ProteomicsDBi | 48684 |
Protocols and materials databases
Antibodypediai | 24654, 184 antibodies |
DNASUi | 4113 |
Genome annotation databases
Ensembli | ENST00000378988; ENSP00000368273; ENSG00000099399 |
GeneIDi | 4113 |
KEGGi | hsa:4113 |
UCSCi | uc004dbz.4, human |
Organism-specific databases
CTDi | 4113 |
DisGeNETi | 4113 |
EuPathDBi | HostDB:ENSG00000099399.5 |
GeneCardsi | MAGEB2 |
HGNCi | HGNC:6809, MAGEB2 |
HPAi | ENSG00000099399, Tissue enriched (testis) |
MIMi | 300098, gene |
neXtProti | NX_O15479 |
OpenTargetsi | ENSG00000099399 |
PharmGKBi | PA30555 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000155485 |
HOGENOMi | CLU_039582_1_0_1 |
InParanoidi | O15479 |
OMAi | GHTYTFN |
OrthoDBi | 1195799at2759 |
PhylomeDBi | O15479 |
TreeFami | TF328505 |
Enzyme and pathway databases
PathwayCommonsi | O15479 |
Miscellaneous databases
BioGRID-ORCSi | 4113, 1 hit in 471 CRISPR screens |
ChiTaRSi | MAGEB2, human |
GeneWikii | MAGEB2 |
GenomeRNAii | 4113 |
Pharosi | O15479, Tbio |
PROi | PR:O15479 |
RNActi | O15479, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000099399, Expressed in testis and 35 other tissues |
Genevisiblei | O15479, HS |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR021072, MAGE_N IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 1 hit |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit PF12440, MAGE_N, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit SM01392, MAGE_N, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGB2_HUMAN | |
Accessioni | O15479Primary (citable) accession number: O15479 Secondary accession number(s): O75860 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations