MAGEB2

Functionⁱ

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

Keywordsⁱ

Molecular function	Tumor antigen
Biological process	Ubl conjugation pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Melanoma-associated antigen B2 Alternative name(s): Cancer/testis antigen 3.2 Short name: CT3.2 DSS-AHC critical interval MAGE superfamily 6 Short name: DAM6 MAGE XP-2 antigen MAGE-B2 antigen
Gene namesⁱ	Name:MAGEB2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000099399.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6809 MAGEB2
MIMⁱ	300098 gene
neXtProtⁱ	NX_O15479

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4113
Open Targets More...OpenTargetsⁱ	ENSG00000099399
PharmGKBⁱ	PA30555

Polymorphism and mutation databases

BioMutaⁱ	MAGEB2

BioMutaⁱ

MAGEB2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000156713	1 – 319	Melanoma-associated antigen B2Add BLAST		319

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	77	PhosphoserineCombined sources		1
Modified residueⁱ	105	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O15479
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15479
PaxDbⁱ	O15479
PeptideAtlas More...PeptideAtlasⁱ	O15479
PRIDEⁱ	O15479
ProteomicsDBⁱ	48684

PTM databases

iPTMnetⁱ	O15479
PhosphoSitePlusⁱ	O15479

Expressionⁱ

Tissue specificityⁱ

Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.

Gene expression databases

Bgeeⁱ	ENSG00000099399 Expressed in 26 organ(s), highest expression level in testis
CleanExⁱ	HS_MAGEB2
Genevisibleⁱ	O15479 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065224 HPA074544 HPA075519

HPAⁱ

HPA065224
HPA074544
HPA075519

Interactionⁱ

Subunit structureⁱ

Interacts with TRIM28.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RPGRIP1	Q96KN7	3	EBI-1057615,EBI-1050213

With

Entry

#Exp.

IntAct

Notes

RPGRIP1

Q96KN7

3

EBI-1057615,EBI-1050213

Protein-protein interaction databases

BioGridⁱ	110287, 30 interactors
IntActⁱ	O15479, 12 interactors
Molecular INTeraction database More...MINTⁱ	O15479
STRINGⁱ	9606.ENSP00000368273

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15479
SMRⁱ	O15479
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	111 – 310	MAGEPROSITE-ProRule annotationAdd BLAST		200

Phylogenomic databases

eggNOGⁱ	KOG4562 Eukaryota ENOG4111S70 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118824
HOGENOMⁱ	HOG000231161
HOVERGENⁱ	HBG006315
InParanoidⁱ	O15479
OMAⁱ	RFREHFP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TJ0
PhylomeDBⁱ	O15479
TreeFamⁱ	TF328505

Family and domain databases

InterProⁱ	View protein in InterPro IPR037445 MAGE IPR021072 MAGE_N IPR002190 MHD_dom
PANTHERⁱ	PTHR11736 PTHR11736, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01454 MAGE, 1 hit PF12440 MAGE_N, 1 hit
SMARTⁱ	View protein in SMART SM01373 MAGE, 1 hit SM01392 MAGE_N, 1 hit
PROSITEⁱ	View protein in PROSITE PS50838 MAGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O15479-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA 
        60         70         80         90        100
SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS 
       110        120        130        140        150
TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP 
       160        170        180        190        200
EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR 
       210        220        230        240        250
RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK 
       260        270        280        290        300
DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP 
       310 
CAFPTHYEEA LKDEEKAGV

Length:319

Mass (Da):35,277

Last modified:January 11, 2011 - v3

Checksum:ⁱCF0BD27A832D5CBB

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027675	61	E → KCombined sources3 PublicationsCorresponds to variant dbSNP:rs2529541Ensembl.		1
Natural variantⁱVAR_027676	318	G → R. Corresponds to variant dbSNP:rs5972090Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U93163 Genomic DNA Translation: AAC23617.1 AF015766 mRNA Translation: AAD01565.1 AC005185 Genomic DNA Translation: AAD10635.1 BC026071 mRNA Translation: AAH26071.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14219.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002355.2, NM_002364.4 XP_011543814.1, XM_011545512.1
UniGeneⁱ	Hs.113824

Genome annotation databases

Ensemblⁱ	ENST00000378988; ENSP00000368273; ENSG00000099399
GeneIDⁱ	4113
KEGGⁱ	hsa:4113
UCSC genome browser More...UCSCⁱ	uc004dbz.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O15479	cDNA, FLJ93871, highly similar to Homo sapiens melanoma antigen, family B, 2 (MAGEB2), mRNA		HUMAN		319	UniRef90_O15479
MAGE family member B2		NOMLE		307
UPI00020AB91B		NOMLE		320

Protein	Similar proteins		Species	Score	Length	Source
O15479	cDNA, FLJ93871, highly similar to Homo sapiens melanoma antigen, family B, 2 (MAGEB2), mRNA		HUMAN		319	UniRef50_O15479
MAGE family member B2		NOMLE		307
Melanoma-associated antigen B2		PANTR		319
MAGE family member B2		GORGO		319
MAGE family member B2		PANPA		319
+24

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U93163 Genomic DNA Translation: AAC23617.1 AF015766 mRNA Translation: AAD01565.1 AC005185 Genomic DNA Translation: AAD10635.1 BC026071 mRNA Translation: AAH26071.1
CCDSⁱ	CCDS14219.1
RefSeqⁱ	NP_002355.2, NM_002364.4 XP_011543814.1, XM_011545512.1
UniGeneⁱ	Hs.113824

3D structure databases

ProteinModelPortalⁱ	O15479
SMRⁱ	O15479
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110287, 30 interactors
IntActⁱ	O15479, 12 interactors
MINTⁱ	O15479
STRINGⁱ	9606.ENSP00000368273

PTM databases

iPTMnetⁱ	O15479
PhosphoSitePlusⁱ	O15479

Polymorphism and mutation databases

BioMutaⁱ	MAGEB2

BioMutaⁱ

MAGEB2

Proteomic databases

EPDⁱ	O15479
MaxQBⁱ	O15479
PaxDbⁱ	O15479
PeptideAtlasⁱ	O15479
PRIDEⁱ	O15479
ProteomicsDBⁱ	48684

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4113
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000378988; ENSP00000368273; ENSG00000099399
GeneIDⁱ	4113
KEGGⁱ	hsa:4113
UCSCⁱ	uc004dbz.4 human

Organism-specific databases

CTDⁱ	4113
DisGeNETⁱ	4113
EuPathDBⁱ	HostDB:ENSG00000099399.5
GeneCardsⁱ	MAGEB2
H-InvDBⁱ	HIX0016713
HGNCⁱ	HGNC:6809 MAGEB2
HPAⁱ	HPA065224 HPA074544 HPA075519
MIMⁱ	300098 gene
neXtProtⁱ	NX_O15479
OpenTargetsⁱ	ENSG00000099399
PharmGKBⁱ	PA30555
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4562 Eukaryota ENOG4111S70 LUCA
GeneTreeⁱ	ENSGT00760000118824
HOGENOMⁱ	HOG000231161
HOVERGENⁱ	HBG006315
InParanoidⁱ	O15479
OMAⁱ	RFREHFP
OrthoDBⁱ	EOG091G0TJ0
PhylomeDBⁱ	O15479
TreeFamⁱ	TF328505

Miscellaneous databases

GeneWikiⁱ	MAGEB2
GenomeRNAiⁱ	4113
Protein Ontology More...PROⁱ	PR:O15479
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000099399 Expressed in 26 organ(s), highest expression level in testis
CleanExⁱ	HS_MAGEB2
Genevisibleⁱ	O15479 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037445 MAGE IPR021072 MAGE_N IPR002190 MHD_dom
PANTHERⁱ	PTHR11736 PTHR11736, 1 hit
Pfamⁱ	View protein in Pfam PF01454 MAGE, 1 hit PF12440 MAGE_N, 1 hit
SMARTⁱ	View protein in SMART SM01373 MAGE, 1 hit SM01392 MAGE_N, 1 hit
PROSITEⁱ	View protein in PROSITE PS50838 MAGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MAGB2_HUMAN
Accessionⁱ	O15479Primary (citable) accession number: O15479 Secondary accession number(s): O75860
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	January 11, 2011
	Last modified:	September 12, 2018
	This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - O15479 (MAGB2_HUMAN)

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Melanoma-associated antigen B2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ