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Protein

C-C motif chemokine 16

Gene

CCL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemoattractant activity Source: UniProtKB
  • chemokine activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 16
Alternative name(s):
Chemokine CC-4
Short name:
HCC-4
Chemokine LEC
IL-10-inducible chemokine
LCC-1
Liver-expressed chemokine
Lymphocyte and monocyte chemoattractant
Short name:
LMC
Monotactin-1
Short name:
MTN-1
NCC-4
Small-inducible cytokine A16
Gene namesi
Name:CCL16
Synonyms:ILINCK, NCC4, SCYA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000275152.4
HGNCiHGNC:10614 CCL16
MIMi601394 gene
neXtProtiNX_O15467

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6360
OpenTargetsiENSG00000275152
PharmGKBiPA35547

Polymorphism and mutation databases

BioMutaiCCL16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000520924 – 120C-C motif chemokine 16Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 60By similarity
Disulfide bondi38 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO15467
PeptideAtlasiO15467
PRIDEiO15467
ProteomicsDBi48683
TopDownProteomicsiO15467

Expressioni

Tissue specificityi

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Inductioni

By IL10/interleukin-10.

Gene expression databases

BgeeiENSG00000275152 Expressed in 71 organ(s), highest expression level in liver
CleanExiHS_CCL16
ExpressionAtlasiO15467 baseline and differential
GenevisibleiO15467 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCL5P135012EBI-12204739,EBI-2848366

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5831N
IntActiO15467, 2 interactors
STRINGi9606.ENSP00000293275

Structurei

Secondary structure

1120
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO15467
SMRiO15467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J14J Eukaryota
ENOG41119S1 LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
InParanoidiO15467
KOiK21093
OMAiKKNREVC
OrthoDBiEOG091G14Y2
PhylomeDBiO15467
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O15467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL
60 70 80 90 100
VVGYRKALNC HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN
110 120
LSTVKIITAK NGQPQLLNSQ
Length:120
Mass (Da):13,600
Last modified:January 1, 1998 - v1
Checksum:i373D73016134D894
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUE5A0A087WUE5_HUMAN
C-C motif chemokine
CCL16
95Annotation score:
A0A087WUU4A0A087WUU4_HUMAN
C-C motif chemokine 16
CCL16
53Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91746 mRNA Translation: AAC05587.1
AB007454 mRNA Translation: BAA24057.1
AF088219 Genomic DNA Translation: AAC63330.1
AF055467 mRNA Translation: AAC28844.1
AB018249 Genomic DNA Translation: BAA35138.1
AF039954 Genomic DNA Translation: AAC97450.1
AF039955 mRNA Translation: AAC97451.1
BC099662 mRNA Translation: AAH99662.1
CCDSiCCDS11303.1
PIRiJE0177
RefSeqiNP_004581.1, NM_004590.3
XP_005258077.1, XM_005258020.4
UniGeneiHs.10458

Genome annotation databases

EnsembliENST00000611905; ENSP00000478024; ENSG00000275152
ENST00000621559; ENSP00000482168; ENSG00000275095
GeneIDi6360
KEGGihsa:6360
UCSCiuc002hkl.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL16 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91746 mRNA Translation: AAC05587.1
AB007454 mRNA Translation: BAA24057.1
AF088219 Genomic DNA Translation: AAC63330.1
AF055467 mRNA Translation: AAC28844.1
AB018249 Genomic DNA Translation: BAA35138.1
AF039954 Genomic DNA Translation: AAC97450.1
AF039955 mRNA Translation: AAC97451.1
BC099662 mRNA Translation: AAH99662.1
CCDSiCCDS11303.1
PIRiJE0177
RefSeqiNP_004581.1, NM_004590.3
XP_005258077.1, XM_005258020.4
UniGeneiHs.10458

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LTLX-ray1.45A/B24-120[»]
ProteinModelPortaliO15467
SMRiO15467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5831N
IntActiO15467, 2 interactors
STRINGi9606.ENSP00000293275

Polymorphism and mutation databases

BioMutaiCCL16

Proteomic databases

PaxDbiO15467
PeptideAtlasiO15467
PRIDEiO15467
ProteomicsDBi48683
TopDownProteomicsiO15467

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611905; ENSP00000478024; ENSG00000275152
ENST00000621559; ENSP00000482168; ENSG00000275095
GeneIDi6360
KEGGihsa:6360
UCSCiuc002hkl.4 human

Organism-specific databases

CTDi6360
DisGeNETi6360
EuPathDBiHostDB:ENSG00000275152.4
GeneCardsiCCL16
HGNCiHGNC:10614 CCL16
MIMi601394 gene
neXtProtiNX_O15467
OpenTargetsiENSG00000275152
PharmGKBiPA35547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J14J Eukaryota
ENOG41119S1 LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
InParanoidiO15467
KOiK21093
OMAiKKNREVC
OrthoDBiEOG091G14Y2
PhylomeDBiO15467
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GenomeRNAii6360
PROiPR:O15467
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000275152 Expressed in 71 organ(s), highest expression level in liver
CleanExiHS_CCL16
ExpressionAtlasiO15467 baseline and differential
GenevisibleiO15467 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL16_HUMAN
AccessioniPrimary (citable) accession number: O15467
Secondary accession number(s): Q4KKU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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