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Protein

Prolyl 4-hydroxylase subunit alpha-2

Gene

P4HA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi430IronPROSITE-ProRule annotation1
Metal bindingi432IronPROSITE-ProRule annotation1
Metal bindingi501IronPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei5112-oxoglutaratePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • peptidyl-proline hydroxylation to 4-hydroxy-L-proline Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding, Vitamin C

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.11.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814 Collagen biosynthesis and modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolyl 4-hydroxylase subunit alpha-2 (EC:1.14.11.2)
Short name:
4-PH alpha-2
Alternative name(s):
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P4HA2
ORF Names:UNQ290/PRO330
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000072682.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8547 P4HA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600608 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopia 25, autosomal dominant (MYP25)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.
See also OMIM:617238
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_074026140Q → R in MYP25. 1 PublicationCorresponds to variant dbSNP:rs764211125EnsemblClinVar.1
Natural variantiVAR_074027150I → V in MYP25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs771208496Ensembl.1
Natural variantiVAR_074028291E → K in MYP25; decreases protein abundance. 1 PublicationCorresponds to variant dbSNP:rs758872875EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8974

MalaCards human disease database

More...
MalaCardsi
P4HA2
MIMi617238 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000072682

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32875

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5640

Drug and drug target database

More...
DrugBanki
DB00172 L-Proline
DB00139 Succinic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
P4HA2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002272622 – 535Prolyl 4-hydroxylase subunit alpha-2Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei480N6-succinyllysineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15460

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15460

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15460

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15460

PeptideAtlas

More...
PeptideAtlasi
O15460

PRoteomics IDEntifications database

More...
PRIDEi
O15460

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48680
48681 [O15460-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15460

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15460

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000072682 Expressed in 211 organ(s), highest expression level in tibia

CleanEx database of gene expression profiles

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CleanExi
HS_P4HA2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15460 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15460 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB062557
HPA016997
HPA027824

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two alpha-2 chains and two beta chains (the beta chain is the multi-functional PDI).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-10182841,EBI-741101

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114464, 96 interactors

Protein interaction database and analysis system

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IntActi
O15460, 21 interactors

Molecular INTeraction database

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MINTi
O15460

STRING: functional protein association networks

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STRINGi
9606.ENSP00000166534

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1535
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EVLX-ray1.87A163-257[»]
6EVMX-ray2.00A163-257[»]
6EVNX-ray1.48A163-257[»]
6EVOX-ray1.55A163-257[»]
6EVPX-ray1.68A163-257[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O15460

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15460

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati207 – 240TPRAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini412 – 520Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST109

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P4HA family.Curated

Keywords - Domaini

Signal, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1591 Eukaryota
ENOG410XS5J LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230465

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006834

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15460

KEGG Orthology (KO)

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KOi
K00472

Identification of Orthologs from Complete Genome Data

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OMAi
HHGNRTP

Database of Orthologous Groups

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OrthoDBi
391515at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15460

TreeFam database of animal gene trees

More...
TreeFami
TF313393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR006620 Pro_4_hyd_alph
IPR013547 Pro_4_hyd_alph_N
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13640 2OG-FeII_Oxy_3, 1 hit
PF08336 P4Ha_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00702 P4Hc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51471 FE2OG_OXY, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform IIb (identifier: O15460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV
60 70 80 90 100
EEAKLSKIKS WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL
110 120 130 140 150
EDLVLQDSAA GFIANLSVQR QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI
160 170 180 190 200
SRGELPGTKY QAMLSVDDCF GMGRSAYNEG DYYHTVLWME QVLKQLDAGE
210 220 230 240 250
EATTTKSQVL DYLSYAVFQL GDLHRALELT RRLLSLDPSH ERAGGNLRYF
260 270 280 290 300
EQLLEEEREK TLTNQTEAEL ATPEGIYERP VDYLPERDVY ESLCRGEGVK
310 320 330 340 350
LTPRRQKRLF CRYHHGNRAP QLLIAPFKEE DEWDSPHIVR YYDVMSDEEI
360 370 380 390 400
ERIKEIAKPK LARATVRDPK TGVLTVASYR VSKSSWLEED DDPVVARVNR
410 420 430 440 450
RMQHITGLTV KTAELLQVAN YGVGGQYEPH FDFSRNDERD TFKHLGTGNR
460 470 480 490 500
VATFLNYMSD VEAGGATVFP DLGAAIWPKK GTAVFWYNLL RSGEGDYRTR
510 520 530
HAACPVLVGC KWVSNKWFHE RGQEFLRPCG STEVD
Length:535
Mass (Da):60,902
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD04467B098F63CF
GO
Isoform IIa (identifier: O15460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-451: NDERDTFKHLGTGNRV → RPFDSGLKTEGNRL

Show »
Length:533
Mass (Da):60,633
Checksum:i8C875AD482B0DBD2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXE0A8MXE0_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
167Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENX0E7ENX0_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JX45C9JX45_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
153Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERI1E7ERI1_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
184Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCP0C9JCP0_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPI9E7EPI9_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIG4C9JIG4_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JN43C9JN43_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFJ1C9JFJ1_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA2
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074026140Q → R in MYP25. 1 PublicationCorresponds to variant dbSNP:rs764211125EnsemblClinVar.1
Natural variantiVAR_074027150I → V in MYP25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs771208496Ensembl.1
Natural variantiVAR_074028291E → K in MYP25; decreases protein abundance. 1 PublicationCorresponds to variant dbSNP:rs758872875EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004506436 – 451NDERD…TGNRV → RPFDSGLKTEGNRL in isoform IIa. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U90441 mRNA Translation: AAB71339.1
AJ314859 Genomic DNA Translation: CAC85688.1
AJ314859 Genomic DNA Translation: CAC85689.1
AY358970 mRNA Translation: AAQ89329.1
CH471062 Genomic DNA Translation: EAW62341.1
CH471062 Genomic DNA Translation: EAW62342.1
CH471062 Genomic DNA Translation: EAW62343.1
CH471062 Genomic DNA Translation: EAW62346.1
BC035813 mRNA Translation: AAH35813.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34230.1 [O15460-2]
CCDS4151.1 [O15460-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001017973.1, NM_001017973.1 [O15460-2]
NP_001017974.1, NM_001017974.1 [O15460-2]
NP_001136070.1, NM_001142598.1 [O15460-2]
NP_001136071.1, NM_001142599.1 [O15460-1]
NP_004190.1, NM_004199.2 [O15460-1]
XP_005272173.1, XM_005272116.4 [O15460-1]
XP_005272174.1, XM_005272117.4 [O15460-1]
XP_005272175.1, XM_005272118.4 [O15460-1]
XP_005272176.1, XM_005272119.4 [O15460-1]
XP_005272177.1, XM_005272120.4 [O15460-1]
XP_006714791.1, XM_006714728.3 [O15460-1]
XP_006714792.1, XM_006714729.3 [O15460-2]
XP_006714793.1, XM_006714730.3 [O15460-2]
XP_016865500.1, XM_017010011.1 [O15460-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.519568
Hs.659712

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000166534; ENSP00000166534; ENSG00000072682 [O15460-1]
ENST00000360568; ENSP00000353772; ENSG00000072682 [O15460-2]
ENST00000379086; ENSP00000368379; ENSG00000072682 [O15460-2]
ENST00000379100; ENSP00000368394; ENSG00000072682 [O15460-2]
ENST00000379104; ENSP00000368398; ENSG00000072682 [O15460-1]
ENST00000401867; ENSP00000384999; ENSG00000072682 [O15460-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8974

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8974

UCSC genome browser

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UCSCi
uc003kwg.4 human [O15460-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90441 mRNA Translation: AAB71339.1
AJ314859 Genomic DNA Translation: CAC85688.1
AJ314859 Genomic DNA Translation: CAC85689.1
AY358970 mRNA Translation: AAQ89329.1
CH471062 Genomic DNA Translation: EAW62341.1
CH471062 Genomic DNA Translation: EAW62342.1
CH471062 Genomic DNA Translation: EAW62343.1
CH471062 Genomic DNA Translation: EAW62346.1
BC035813 mRNA Translation: AAH35813.1
CCDSiCCDS34230.1 [O15460-2]
CCDS4151.1 [O15460-1]
RefSeqiNP_001017973.1, NM_001017973.1 [O15460-2]
NP_001017974.1, NM_001017974.1 [O15460-2]
NP_001136070.1, NM_001142598.1 [O15460-2]
NP_001136071.1, NM_001142599.1 [O15460-1]
NP_004190.1, NM_004199.2 [O15460-1]
XP_005272173.1, XM_005272116.4 [O15460-1]
XP_005272174.1, XM_005272117.4 [O15460-1]
XP_005272175.1, XM_005272118.4 [O15460-1]
XP_005272176.1, XM_005272119.4 [O15460-1]
XP_005272177.1, XM_005272120.4 [O15460-1]
XP_006714791.1, XM_006714728.3 [O15460-1]
XP_006714792.1, XM_006714729.3 [O15460-2]
XP_006714793.1, XM_006714730.3 [O15460-2]
XP_016865500.1, XM_017010011.1 [O15460-2]
UniGeneiHs.519568
Hs.659712

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EVLX-ray1.87A163-257[»]
6EVMX-ray2.00A163-257[»]
6EVNX-ray1.48A163-257[»]
6EVOX-ray1.55A163-257[»]
6EVPX-ray1.68A163-257[»]
ProteinModelPortaliO15460
SMRiO15460
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114464, 96 interactors
IntActiO15460, 21 interactors
MINTiO15460
STRINGi9606.ENSP00000166534

Chemistry databases

ChEMBLiCHEMBL5640
DrugBankiDB00172 L-Proline
DB00139 Succinic acid

PTM databases

iPTMnetiO15460
PhosphoSitePlusiO15460

Polymorphism and mutation databases

BioMutaiP4HA2

Proteomic databases

EPDiO15460
jPOSTiO15460
MaxQBiO15460
PaxDbiO15460
PeptideAtlasiO15460
PRIDEiO15460
ProteomicsDBi48680
48681 [O15460-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8974
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000166534; ENSP00000166534; ENSG00000072682 [O15460-1]
ENST00000360568; ENSP00000353772; ENSG00000072682 [O15460-2]
ENST00000379086; ENSP00000368379; ENSG00000072682 [O15460-2]
ENST00000379100; ENSP00000368394; ENSG00000072682 [O15460-2]
ENST00000379104; ENSP00000368398; ENSG00000072682 [O15460-1]
ENST00000401867; ENSP00000384999; ENSG00000072682 [O15460-1]
GeneIDi8974
KEGGihsa:8974
UCSCiuc003kwg.4 human [O15460-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8974
DisGeNETi8974
EuPathDBiHostDB:ENSG00000072682.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
P4HA2
HGNCiHGNC:8547 P4HA2
HPAiCAB062557
HPA016997
HPA027824
MalaCardsiP4HA2
MIMi600608 gene
617238 phenotype
neXtProtiNX_O15460
OpenTargetsiENSG00000072682
PharmGKBiPA32875

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1591 Eukaryota
ENOG410XS5J LUCA
GeneTreeiENSGT00940000157695
HOGENOMiHOG000230465
HOVERGENiHBG006834
InParanoidiO15460
KOiK00472
OMAiHHGNRTP
OrthoDBi391515at2759
PhylomeDBiO15460
TreeFamiTF313393

Enzyme and pathway databases

BRENDAi1.14.11.2 2681
ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
P4HA2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
P4HA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8974

Protein Ontology

More...
PROi
PR:O15460

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000072682 Expressed in 211 organ(s), highest expression level in tibia
CleanExiHS_P4HA2
ExpressionAtlasiO15460 baseline and differential
GenevisibleiO15460 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR006620 Pro_4_hyd_alph
IPR013547 Pro_4_hyd_alph_N
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13640 2OG-FeII_Oxy_3, 1 hit
PF08336 P4Ha_N, 1 hit
SMARTiView protein in SMART
SM00702 P4Hc, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS51471 FE2OG_OXY, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP4HA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15460
Secondary accession number(s): D3DQ85, D3DQ86, Q8WWN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 1, 1998
Last modified: January 16, 2019
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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