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UniProtKB - O15457 (MSH4_HUMAN)

Protein

MutS protein homolog 4

Gene

MSH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi680 – 687ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: GO_Central
  • damaged DNA binding Source: GO_Central
  • DNA binding Source: ProtInc
  • DNA-dependent ATPase activity Source: GO_Central
  • mismatched DNA binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processMeiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-912446 Meiotic recombination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MutS protein homolog 4
Short name:
hMSH4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSH4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000057468.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:7327 MSH4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602105 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15457

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4438

Open Targets

More...OpenTargetsi		ENSG00000057468

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31135

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MSH4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001151971 – 936MutS protein homolog 4Add BLAST936

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15457

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15457

PeptideAtlas

More...PeptideAtlasi		O15457

PRoteomics IDEntifications database

More...PRIDEi		O15457

ProteomicsDB human proteome resource

More...ProteomicsDBi		48679

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15457

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15457

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis and ovary specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000057468 Expressed in 80 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...CleanExi		HS_MSH4

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15457 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer of MSH4 and MSH5.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110575, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O15457

Protein interaction database and analysis system

More...IntActi		O15457, 3 interactors

Molecular INTeraction database

More...MINTi		O15457

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263187

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O15457

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15457

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0220 Eukaryota
COG0249 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074897

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000290656

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG036910

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15457

KEGG Orthology (KO)

More...KOi		K08740

Identification of Orthologs from Complete Genome Data

More...OMAi		MREMAFI

Database of Orthologous Groups

More...OrthoDBi		138168at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15457

TreeFam database of animal gene trees

More...TreeFami		TF300572

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017261 DNA_mismatch_repair_MutS/MSH
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037677 DNA_mis_repair_Msh6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O15457-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRPEISSTS PSAPAVSPSS GETRSPQGPR YNFGLQETPQ SRPSVQVVSA 
        60         70         80         90        100
STCPGTSGAA GDRSSSSSSL PCPAPNSRPA QGSYFGNKRA YAENTVASNF 
       110        120        130        140        150
TFGASSSSAR DTNYPQTLKT PLSTGNPQRS GYKSWTPQVG YSASSSSAIS 
       160        170        180        190        200
AHSPSVIVAV VEGRGLARGE IGMASIDLKN PQIILSQFAD NTTYAKVITK 
       210        220        230        240        250
LKILSPLEII MSNTACAVGN STKLFTLITE NFKNVNFTTI QRKYFNETKG 
       260        270        280        290        300
LEYIEQLCIA EFSTVLMEVQ SKYYCLAAVA ALLKYVEFIQ NSVYAPKSLK 
       310        320        330        340        350
ICFQGSEQTA MIDSSSAQNL ELLINNQDYR NNHTLFGVLN YTKTPGGSRR 
       360        370        380        390        400
LRSNILEPLV DIETINMRLD CVQELLQDEE LFFGLQSVIS RFLDTEQLLS 
       410        420        430        440        450
VLVQIPKQDT VNAAESKITN LIYLKHTLEL VDPLKIAMKN CNTPLLRAYY 
       460        470        480        490        500
GSLEDKRFGI ILEKIKTVIN DDARYMKGCL NMRTQKCYAV RSNINEFLDI 
       510        520        530        540        550
ARRTYTEIVD DIAGMISQLG EKYSLPLRTS FSSARGFFIQ MTTDCIALPS 
       560        570        580        590        600
DQLPSEFIKI SKVKNSYSFT SADLIKMNER CQESLREIYH MTYMIVCKLL 
       610        620        630        640        650
SEIYEHIHCL YKLSDTVSML DMLLSFAHAC TLSDYVRPEF TDTLAIKQGW 
       660        670        680        690        700
HPILEKISAE KPIANNTYVT EGSNFLIITG PNMSGKSTYL KQIALCQIMA 
       710        720        730        740        750
QIGSYVPAEY SSFRIAKQIF TRISTDDDIE TNSSTFMKEM KEIAYILHNA 
       760        770        780        790        800
NDKSLILIDE LGRGTNTEEG IGICYAVCEY LLSLKAFTLF ATHFLELCHI 
       810        820        830        840        850
DALYPNVENM HFEVQHVKNT SRNKEAILYT YKLSKGLTEE KNYGLKAAEV 
       860        870        880        890        900
SSLPPSIVLD AKEITTQITR QILQNQRSTP EMERQRAVYH LATRLVQTAR 
       910        920        930 
NSQLDPDSLR IYLSNLKKKY KEDFPRTEQV PEKTEE
Length:936
Mass (Da):104,756
Last modified:April 30, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A82684379346441
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19 – 20SS → VV in AAB72039 (PubMed:9299235).Curated2
Sequence conflicti365I → V in AAH33030 (PubMed:15489334).Curated1
Sequence conflicti407K → E in AAB72039 (PubMed:9299235).Curated1
Sequence conflicti531F → L in AAB72039 (PubMed:9299235).Curated1
Sequence conflicti534A → V in AAB72039 (PubMed:9299235).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01883160A → V1 PublicationCorresponds to variant dbSNP:rs5745311Ensembl.1
Natural variantiVAR_01883290A → T1 PublicationCorresponds to variant dbSNP:rs5745324Ensembl.1
Natural variantiVAR_01883397A → T1 PublicationCorresponds to variant dbSNP:rs5745325Ensembl.1
Natural variantiVAR_018834162E → K1 PublicationCorresponds to variant dbSNP:rs5745329Ensembl.1
Natural variantiVAR_018835589Y → C1 PublicationCorresponds to variant dbSNP:rs5745459Ensembl.1
Natural variantiVAR_018836914S → N1 PublicationCorresponds to variant dbSNP:rs5745549Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U89293 mRNA Translation: AAB72039.1
AF104243 mRNA Translation: AAD17920.1
AY268350 Genomic DNA Translation: AAP03427.1
AL357314 Genomic DNA No translation available.
AL445464 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06392.1
BC033030 mRNA Translation: AAH33030.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS670.1

NCBI Reference Sequences

More...RefSeqi		NP_002431.2, NM_002440.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.216639

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263187; ENSP00000263187; ENSG00000057468

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4438

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4438

UCSC genome browser

More...UCSCi		uc001dhd.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89293 mRNA Translation: AAB72039.1
AF104243 mRNA Translation: AAD17920.1
AY268350 Genomic DNA Translation: AAP03427.1
AL357314 Genomic DNA No translation available.
AL445464 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06392.1
BC033030 mRNA Translation: AAH33030.1
CCDSiCCDS670.1
RefSeqiNP_002431.2, NM_002440.3
UniGeneiHs.216639

3D structure databases

ProteinModelPortaliO15457
SMRiO15457
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110575, 10 interactors
CORUMiO15457
IntActiO15457, 3 interactors
MINTiO15457
STRINGi9606.ENSP00000263187

PTM databases

iPTMnetiO15457
PhosphoSitePlusiO15457

Polymorphism and mutation databases

BioMutaiMSH4

Proteomic databases

EPDiO15457
PaxDbiO15457
PeptideAtlasiO15457
PRIDEiO15457
ProteomicsDBi48679

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		4438
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263187; ENSP00000263187; ENSG00000057468
GeneIDi4438
KEGGihsa:4438
UCSCiuc001dhd.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4438
DisGeNETi4438
EuPathDBiHostDB:ENSG00000057468.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		MSH4
HGNCiHGNC:7327 MSH4
MIMi602105 gene
neXtProtiNX_O15457
OpenTargetsiENSG00000057468
PharmGKBiPA31135

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0220 Eukaryota
COG0249 LUCA
GeneTreeiENSGT00550000074897
HOGENOMiHOG000290656
HOVERGENiHBG036910
InParanoidiO15457
KOiK08740
OMAiMREMAFI
OrthoDBi138168at2759
PhylomeDBiO15457
TreeFamiTF300572

Enzyme and pathway databases

ReactomeiR-HSA-912446 Meiotic recombination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MSH4 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MSH4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4438

Protein Ontology

More...PROi		PR:O15457

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000057468 Expressed in 80 organ(s), highest expression level in right testis
CleanExiHS_MSH4
GenevisibleiO15457 HS

Family and domain databases

Gene3Di3.30.420.110, 1 hit
InterProiView protein in InterPro
IPR017261 DNA_mismatch_repair_MutS/MSH
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit
PIRSFiPIRSF037677 DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSH4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15457
Secondary accession number(s): Q5T4U6, Q8NEB3, Q9UNP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 30, 2003
Last modified: January 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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