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UniProtKB - O15444 (CCL25_HUMAN)

Entry version 162 (02 Jun 2021)
Sequence version 2 (22 Jul 2008)
Previous versions | rss
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Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15444

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		O15444

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine TECK
Small-inducible cytokine A25
Thymus-expressed chemokine
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCL25
Synonyms:SCYA25, TECK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10624, CCL25

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602565, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15444

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131142.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6370

Open Targets

More...OpenTargetsi		ENSG00000131142

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35556

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15444, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCL25

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000523524 – 150C-C motif chemokine 25Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15444

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15444

PeptideAtlas

More...PeptideAtlasi		O15444

PRoteomics IDEntifications database

More...PRIDEi		O15444

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48672 [O15444-1]
48673 [O15444-2]
48674 [O15444-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15444

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15444

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131142, Expressed in small intestine and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15444, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15444, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131142, Group enriched (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112273, 10 interactors

Database of interacting proteins

More...DIPi		DIP-5883N

Protein interaction database and analysis system

More...IntActi		O15444, 11 interactors

Molecular INTeraction database

More...MINTi		O15444

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000375086

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15444, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15444

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S8D1, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_113773_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15444

Identification of Orthologs from Complete Genome Data

More...OMAi		CLAYHHR

Database of Orthologous Groups

More...OrthoDBi		1542802at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15444

TreeFam database of animal gene trees

More...TreeFami		TF353160

Family and domain databases

Conserved Domains Database

More...CDDi		cd01119, Chemokine_CC_DCCL, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039809, Chemokine_b/g/d
IPR034133, Chemokine_CC_DCCL
IPR001811, Chemokine_IL8-like_dom
IPR036048, Interleukin_8-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR12015, PTHR12015, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00048, IL8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00199, SCY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54117, SSF54117, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15444-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR 
        60         70         80         90        100
IQEVSGSCNL PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL 
       110        120        130        140        150
HHNTQTFQAG PHAVKKLSSG NSKLSSSKFS NPISSSKRNV SLLISANSGL
Length:150
Mass (Da):16,609
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91D0810F137FBC7B
GO
Isoform 2 (identifier: O15444-2) [UniParc]FASTAAdd to basket
Also known as: TECKvar

The sequence of this isoform differs from the canonical sequence as follows:
     65-150: FYLPKRHRKV...SLLISANSGL → RPSCCKEVEFWKLQVIIIQV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:84
Mass (Da):9,496
Checksum:i11307E0137B394D4
GO
Isoform 3 (identifier: O15444-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: Missing.

Show »
Length:149
Mass (Da):16,538
Checksum:iAC5468E6EF71986E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JDZ7C9JDZ7_HUMAN
C-C motif chemokine 25
CCL25
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWI0F8VWI0_HUMAN
C-C motif chemokine 25
CCL25
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TBH2A0A7P0TBH2_HUMAN
C-C motif chemokine 25
CCL25
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04451923T → A. Corresponds to variant dbSNP:rs960173Ensembl.1
Natural variantiVAR_044520101H → R. Corresponds to variant dbSNP:rs2032887Ensembl.1
Natural variantiVAR_044521104T → M1 PublicationCorresponds to variant dbSNP:rs1129763Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00106465 – 150FYLPK…ANSGL → RPSCCKEVEFWKLQVIIIQV in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_043199109Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U86358 mRNA Translation: AAB69981.1
AB046579 mRNA Translation: BAB62257.1
AK292662 mRNA Translation: BAF85351.1
AC008946 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68952.1
BC130561 mRNA Translation: AAI30562.1
BC144463 mRNA Translation: AAI44464.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12194.1 [O15444-1]
CCDS56080.1 [O15444-3]

NCBI Reference Sequences

More...RefSeqi		NP_001188288.1, NM_001201359.1 [O15444-3]
NP_005615.2, NM_005624.3 [O15444-1]
XP_011526479.1, XM_011528177.2 [O15444-1]
XP_016882609.1, XM_017027120.1 [O15444-1]
XP_016882610.1, XM_017027121.1 [O15444-1]
XP_016882611.1, XM_017027122.1 [O15444-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000253451; ENSP00000253451; ENSG00000131142 [O15444-3]
ENST00000315626; ENSP00000324756; ENSG00000131142 [O15444-1]
ENST00000390669; ENSP00000375086; ENSG00000131142 [O15444-1]
ENST00000680450; ENSP00000506202; ENSG00000131142 [O15444-3]
ENST00000680506; ENSP00000505422; ENSG00000131142 [O15444-1]
ENST00000680646; ENSP00000504875; ENSG00000131142 [O15444-1]
ENST00000681526; ENSP00000505387; ENSG00000131142 [O15444-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6370

UCSC genome browser

More...UCSCi		uc002mjc.5, human [O15444-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CCL25 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86358 mRNA Translation: AAB69981.1
AB046579 mRNA Translation: BAB62257.1
AK292662 mRNA Translation: BAF85351.1
AC008946 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68952.1
BC130561 mRNA Translation: AAI30562.1
BC144463 mRNA Translation: AAI44464.1
CCDSiCCDS12194.1 [O15444-1]
CCDS56080.1 [O15444-3]
RefSeqiNP_001188288.1, NM_001201359.1 [O15444-3]
NP_005615.2, NM_005624.3 [O15444-1]
XP_011526479.1, XM_011528177.2 [O15444-1]
XP_016882609.1, XM_017027120.1 [O15444-1]
XP_016882610.1, XM_017027121.1 [O15444-1]
XP_016882611.1, XM_017027122.1 [O15444-3]

3D structure databases

SMRiO15444
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112273, 10 interactors
DIPiDIP-5883N
IntActiO15444, 11 interactors
MINTiO15444
STRINGi9606.ENSP00000375086

PTM databases

iPTMnetiO15444
PhosphoSitePlusiO15444

Genetic variation databases

BioMutaiCCL25

Proteomic databases

MassIVEiO15444
PaxDbiO15444
PeptideAtlasiO15444
PRIDEiO15444
ProteomicsDBi48672 [O15444-1]
48673 [O15444-2]
48674 [O15444-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24738, 402 antibodies

The DNASU plasmid repository

More...DNASUi		6370

Genome annotation databases

EnsembliENST00000253451; ENSP00000253451; ENSG00000131142 [O15444-3]
ENST00000315626; ENSP00000324756; ENSG00000131142 [O15444-1]
ENST00000390669; ENSP00000375086; ENSG00000131142 [O15444-1]
ENST00000680450; ENSP00000506202; ENSG00000131142 [O15444-3]
ENST00000680506; ENSP00000505422; ENSG00000131142 [O15444-1]
ENST00000680646; ENSP00000504875; ENSG00000131142 [O15444-1]
ENST00000681526; ENSP00000505387; ENSG00000131142 [O15444-3]
GeneIDi6370
KEGGihsa:6370
UCSCiuc002mjc.5, human [O15444-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6370
DisGeNETi6370

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCL25
HGNCiHGNC:10624, CCL25
HPAiENSG00000131142, Group enriched (intestine, lymphoid tissue)
MIMi602565, gene
neXtProtiNX_O15444
OpenTargetsiENSG00000131142
PharmGKBiPA35556
VEuPathDBiHostDB:ENSG00000131142.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S8D1, Eukaryota
GeneTreeiENSGT01030000234602
HOGENOMiCLU_113773_0_0_1
InParanoidiO15444
OMAiCLAYHHR
OrthoDBi1542802at2759
PhylomeDBiO15444
TreeFamiTF353160

Enzyme and pathway databases

PathwayCommonsiO15444
ReactomeiR-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
SIGNORiO15444

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6370, 7 hits in 983 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6370
PharosiO15444, Tbio

Protein Ontology

More...PROi		PR:O15444
RNActiO15444, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131142, Expressed in small intestine and 93 other tissues
ExpressionAtlasiO15444, baseline and differential
GenevisibleiO15444, HS

Family and domain databases

CDDicd01119, Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR039809, Chemokine_b/g/d
IPR034133, Chemokine_CC_DCCL
IPR001811, Chemokine_IL8-like_dom
IPR036048, Interleukin_8-like_sf
PANTHERiPTHR12015, PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048, IL8, 1 hit
SMARTiView protein in SMART
SM00199, SCY, 1 hit
SUPFAMiSSF54117, SSF54117, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCL25_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15444
Secondary accession number(s): A1L4J4
, A6NI52, A8K9E7, B5MCA5, Q96KJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 22, 2008
Last modified: June 2, 2021
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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