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Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB
  • chemokine receptor binding Source: UniProtKB
  • hormone activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiO15444

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine TECK
Small-inducible cytokine A25
Thymus-expressed chemokine
Gene namesi
Name:CCL25
Synonyms:SCYA25, TECK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000131142.13
HGNCiHGNC:10624 CCL25
MIMi602565 gene
neXtProtiNX_O15444

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6370
OpenTargetsiENSG00000131142
PharmGKBiPA35556

Polymorphism and mutation databases

BioMutaiCCL25

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000523524 – 150C-C motif chemokine 25Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO15444
PRIDEiO15444
ProteomicsDBi48672
48673 [O15444-2]
48674 [O15444-3]

PTM databases

iPTMnetiO15444
PhosphoSitePlusiO15444

Expressioni

Tissue specificityi

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Gene expression databases

BgeeiENSG00000131142 Expressed in 59 organ(s), highest expression level in intestine
CleanExiHS_CCL25
ExpressionAtlasiO15444 baseline and differential
GenevisibleiO15444 HS

Organism-specific databases

HPAiHPA055883

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112273, 3 interactors
DIPiDIP-5883N
IntActiO15444, 10 interactors
MINTiO15444
STRINGi9606.ENSP00000375086

Structurei

3D structure databases

ProteinModelPortaliO15444
SMRiO15444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J09B Eukaryota
ENOG410Z7F2 LUCA
GeneTreeiENSGT00900000141238
HOGENOMiHOG000293281
HOVERGENiHBG050832
InParanoidiO15444
KOiK13072
OMAiCCLAYHR
PhylomeDBiO15444
TreeFamiTF353160

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15444-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR
60 70 80 90 100
IQEVSGSCNL PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL
110 120 130 140 150
HHNTQTFQAG PHAVKKLSSG NSKLSSSKFS NPISSSKRNV SLLISANSGL
Length:150
Mass (Da):16,609
Last modified:July 22, 2008 - v2
Checksum:i91D0810F137FBC7B
GO
Isoform 2 (identifier: O15444-2) [UniParc]FASTAAdd to basket
Also known as: TECKvar

The sequence of this isoform differs from the canonical sequence as follows:
     65-150: FYLPKRHRKV...SLLISANSGL → RPSCCKEVEFWKLQVIIIQV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:84
Mass (Da):9,496
Checksum:i11307E0137B394D4
GO
Isoform 3 (identifier: O15444-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: Missing.

Show »
Length:149
Mass (Da):16,538
Checksum:iAC5468E6EF71986E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JDZ7C9JDZ7_HUMAN
C-C motif chemokine 25
CCL25
150Annotation score:
F8VWI0F8VWI0_HUMAN
C-C motif chemokine 25
CCL25
84Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04451923T → A. Corresponds to variant dbSNP:rs960173Ensembl.1
Natural variantiVAR_044520101H → R. Corresponds to variant dbSNP:rs2032887Ensembl.1
Natural variantiVAR_044521104T → M1 PublicationCorresponds to variant dbSNP:rs1129763Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00106465 – 150FYLPK…ANSGL → RPSCCKEVEFWKLQVIIIQV in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_043199109Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86358 mRNA Translation: AAB69981.1
AB046579 mRNA Translation: BAB62257.1
AK292662 mRNA Translation: BAF85351.1
AC008946 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68952.1
BC130561 mRNA Translation: AAI30562.1
BC144463 mRNA Translation: AAI44464.1
CCDSiCCDS12194.1 [O15444-1]
CCDS56080.1 [O15444-3]
RefSeqiNP_001188288.1, NM_001201359.1 [O15444-3]
NP_005615.2, NM_005624.3 [O15444-1]
XP_011526479.1, XM_011528177.2 [O15444-1]
XP_016882609.1, XM_017027120.1 [O15444-1]
XP_016882610.1, XM_017027121.1 [O15444-1]
XP_016882611.1, XM_017027122.1 [O15444-3]
UniGeneiHs.310511

Genome annotation databases

EnsembliENST00000253451; ENSP00000253451; ENSG00000131142 [O15444-3]
ENST00000390669; ENSP00000375086; ENSG00000131142 [O15444-1]
GeneIDi6370
KEGGihsa:6370
UCSCiuc002mjc.5 human [O15444-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL25 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86358 mRNA Translation: AAB69981.1
AB046579 mRNA Translation: BAB62257.1
AK292662 mRNA Translation: BAF85351.1
AC008946 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68952.1
BC130561 mRNA Translation: AAI30562.1
BC144463 mRNA Translation: AAI44464.1
CCDSiCCDS12194.1 [O15444-1]
CCDS56080.1 [O15444-3]
RefSeqiNP_001188288.1, NM_001201359.1 [O15444-3]
NP_005615.2, NM_005624.3 [O15444-1]
XP_011526479.1, XM_011528177.2 [O15444-1]
XP_016882609.1, XM_017027120.1 [O15444-1]
XP_016882610.1, XM_017027121.1 [O15444-1]
XP_016882611.1, XM_017027122.1 [O15444-3]
UniGeneiHs.310511

3D structure databases

ProteinModelPortaliO15444
SMRiO15444
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112273, 3 interactors
DIPiDIP-5883N
IntActiO15444, 10 interactors
MINTiO15444
STRINGi9606.ENSP00000375086

PTM databases

iPTMnetiO15444
PhosphoSitePlusiO15444

Polymorphism and mutation databases

BioMutaiCCL25

Proteomic databases

PaxDbiO15444
PRIDEiO15444
ProteomicsDBi48672
48673 [O15444-2]
48674 [O15444-3]

Protocols and materials databases

DNASUi6370
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253451; ENSP00000253451; ENSG00000131142 [O15444-3]
ENST00000390669; ENSP00000375086; ENSG00000131142 [O15444-1]
GeneIDi6370
KEGGihsa:6370
UCSCiuc002mjc.5 human [O15444-1]

Organism-specific databases

CTDi6370
DisGeNETi6370
EuPathDBiHostDB:ENSG00000131142.13
GeneCardsiCCL25
H-InvDBiHIX0039931
HGNCiHGNC:10624 CCL25
HPAiHPA055883
MIMi602565 gene
neXtProtiNX_O15444
OpenTargetsiENSG00000131142
PharmGKBiPA35556
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J09B Eukaryota
ENOG410Z7F2 LUCA
GeneTreeiENSGT00900000141238
HOGENOMiHOG000293281
HOVERGENiHBG050832
InParanoidiO15444
KOiK13072
OMAiCCLAYHR
PhylomeDBiO15444
TreeFamiTF353160

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiO15444

Miscellaneous databases

GenomeRNAii6370
PROiPR:O15444
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131142 Expressed in 59 organ(s), highest expression level in intestine
CleanExiHS_CCL25
ExpressionAtlasiO15444 baseline and differential
GenevisibleiO15444 HS

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL25_HUMAN
AccessioniPrimary (citable) accession number: O15444
Secondary accession number(s): A1L4J4
, A6NI52, A8K9E7, B5MCA5, Q96KJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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