ABCC5

Functionⁱ

Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561).

2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	595 – 602	ATP 1PROSITE-ProRule annotation		8
Nucleotide bindingⁱ	1227 – 1234	ATP 2PROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ABC-type xenobiotic transporter activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- "Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5."
  Reid G., Wielinga P., Zelcer N., De Haas M., Van Deemter L., Wijnholds J., Balzarini J., Borst P.
  Mol Pharmacol 63:1094-1103(2003) [PubMed] [Europe PMC] [Abstract]
- "The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates."
  Wielinga P., Hooijberg J.H., Gunnarsdottir S., Kathmann I., Reid G., Zelcer N., van der Born K., de Haas M., van der Heijden I., Kaspers G., Wijnholds J., Jansen G., Peters G., Borst P.
  Cancer Res 65:4425-4430(2005) [PubMed] [Europe PMC] [Abstract]
ATPase-coupled transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
ATP binding
Source: ProtInc
Traceable author statementⁱ
- Ref.10
  "cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line."
  Suzuki T., Nishio K., Sasaki H., Kurokawa H., Saito-Ohara F., Ikeuch T., Tanabe S., Terada M., Saijo N.
  Biochem. Biophys. Res. Commun. 238:790-794(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 492-1437 (ISOFORM 1).
efflux transmembrane transporter activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- Ref.4
  "Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs."
  Wijnholds J., Mol C.A.A.M., van Deemter L., de Haas M., Scheffer G.L., Baas F., Beijnen J.H., Scheper R.J., Hatse S., De Clercq E., Balzarini J., Borst P.
  Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
glutathione transmembrane transporter activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- Ref.4
  "Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs."
  Wijnholds J., Mol C.A.A.M., van Deemter L., de Haas M., Scheffer G.L., Baas F., Beijnen J.H., Scheper R.J., Hatse S., De Clercq E., Balzarini J., Borst P.
  Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
heme transmembrane transporter activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- Ref.15
  "Control of metazoan heme homeostasis by a conserved multidrug resistance protein."
  Korolnek T., Zhang J., Beardsley S., Scheffer G.L., Hamza I.
  Cell Metab. 19:1008-1019(2014) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION.
organic anion transmembrane transporter activity
Source: ProtInc
Traceable author statementⁱ
- Ref.1
  "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins."
  Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R., Kruh G.D.
  J. Natl. Cancer Inst. 90:1735-1741(1998) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
purine nucleotide transmembrane transporter activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- Ref.4
  "Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs."
  Wijnholds J., Mol C.A.A.M., van Deemter L., de Haas M., Scheffer G.L., Baas F., Beijnen J.H., Scheper R.J., Hatse S., De Clercq E., Balzarini J., Borst P.
  Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
xenobiotic transmembrane transporter activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- Ref.4
  "Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs."
  Wijnholds J., Mol C.A.A.M., van Deemter L., de Haas M., Scheffer G.L., Baas F., Beijnen J.H., Scheper R.J., Hatse S., De Clercq E., Balzarini J., Borst P.
  Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	7.6.2.3, 2681
PathwayCommonsⁱ	O15440
Reactomeⁱ	R-HSA-2142850, Hyaluronan biosynthesis and export R-HSA-382556, ABC-family proteins mediated transport

Protein family/group databases

TCDBⁱ	3.A.1.208.15, the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.208.15, the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Multidrug resistance-associated protein 5 Alternative name(s): ATP-binding cassette sub-family C member 5 Multi-specific organic anion transporter C Short name: MOAT-C SMRP pABC11
Gene namesⁱ	Name:ABCC5 Synonyms:MRP5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:56, ABCC5
MIMⁱ	605251, gene
neXtProtⁱ	NX_O15440
VEuPathDBⁱ	HostDB:ENSG00000114770.16

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	179 – 199	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	219 – 239	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	296 – 316	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	317 – 337	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	400 – 420	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	434 – 454	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	608 – 628	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	848 – 868	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	917 – 937	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	997 – 1017	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	1018 – 1038	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	1104 – 1124	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	1127 – 1147	HelicalPROSITE-ProRule annotationAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10057
Open Targets More...OpenTargetsⁱ	ENSG00000114770
PharmGKBⁱ	PA395

Miscellaneous databases

Pharosⁱ	O15440, Tchem

Pharosⁱ

O15440, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL2046258
Drug and drug target database More...DrugBankⁱ	DB00718, Adefovir dipivoxil DB00770, Alprostadil DB01076, Atorvastatin DB00515, Cisplatin DB11672, Curcumin DB14635, Curcumin sulfate DB02527, Cyclic adenosine monophosphate DB00917, Dinoprostone DB00975, Dipyridamole DB00544, Fluorouracil DB00143, Glutathione DB01033, Mercaptopurine DB01032, Probenecid DB01045, Rifampicin DB00203, Sildenafil DB01138, Sulfinpyrazone DB00495, Zidovudine
DrugCentral More...DrugCentralⁱ	O15440
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	783

Genetic variation databases

BioMutaⁱ	ABCC5

BioMutaⁱ

ABCC5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093363	1 – 1437	Multidrug resistance-associated protein 5Add BLAST		1437

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	19	PhosphoserineCombined sources	1
Modified residueⁱ	60	PhosphoserineCombined sources	1
Glycosylationⁱ	494	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	505	PhosphoserineCombined sources	1
Modified residueⁱ	509	PhosphoserineCombined sources	1
Modified residueⁱ	513	PhosphothreonineCombined sources	1
Glycosylationⁱ	636	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	684	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	890	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	897	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1044	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1329	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1417	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	O15440
jPOSTⁱ	O15440
MassIVEⁱ	O15440
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15440
PaxDbⁱ	O15440
PeptideAtlas More...PeptideAtlasⁱ	O15440
PRIDEⁱ	O15440
ProteomicsDBⁱ	48667 [O15440-1] 48668 [O15440-2] 48669 [O15440-3] 48670 [O15440-4] 69929

PTM databases

GlyGenⁱ	O15440, 8 sites
iPTMnetⁱ	O15440
PhosphoSitePlusⁱ	O15440

Expressionⁱ

Tissue specificityⁱ

All isoforms are equally expressed in retina.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000114770, Expressed in forebrain and 239 other tissues
ExpressionAtlasⁱ	O15440, baseline and differential
Genevisibleⁱ	O15440, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000114770, Low tissue specificity

HPAⁱ

ENSG00000114770, Low tissue specificity

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	115368, 18 interactors
IntActⁱ	O15440, 13 interactors
STRINGⁱ	9606.ENSP00000333926

Chemistry databases

BindingDBⁱ

O15440

Miscellaneous databases

RNActⁱ	O15440, protein

RNActⁱ

O15440, protein

Structureⁱ

3D structure databases

SMRⁱ	O15440
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	179 – 459	ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST	281
Domainⁱ	562 – 783	ABC transporter 1PROSITE-ProRule annotationAdd BLAST	222
Domainⁱ	859 – 1155	ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST	297
Domainⁱ	1193 – 1427	ABC transporter 2PROSITE-ProRule annotationAdd BLAST	235

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	15 – 41	DisorderedSequence analysisAdd BLAST	27
Regionⁱ	501 – 538	DisorderedSequence analysisAdd BLAST	38
Regionⁱ	794 – 827	DisorderedSequence analysisAdd BLAST	34

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	24 – 41	Basic and acidic residuesSequence analysisAdd BLAST		18
Compositional biasⁱ	799 – 827	Basic and acidic residuesSequence analysisAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0054, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155470
HOGENOMⁱ	CLU_000604_27_3_1
InParanoidⁱ	O15440
OMAⁱ	FVKFFGW
Database of Orthologous Groups More...OrthoDBⁱ	138195at2759
PhylomeDBⁱ	O15440
TreeFamⁱ	TF105202

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR030238, ABCC5 IPR027417, P-loop_NTPase
PANTHERⁱ	PTHR24223:SF196, PTHR24223:SF196, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382, AAA, 2 hits
SUPFAMⁱ	SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O15440-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL 
        60         70         80         90        100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 
       110        120        130        140        150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 
       160        170        180        190        200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM 
       210        220        230        240        250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL 
       260        270        280        290        300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 
       310        320        330        340        350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA 
       360        370        380        390        400
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS 
       410        420        430        440        450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT 
       460        470        480        490        500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 
       510        520        530        540        550
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL 
       560        570        580        590        600
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 
       610        620        630        640        650
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD 
       660        670        680        690        700
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY 
       710        720        730        740        750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC 
       760        770        780        790        800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET 
       810        820        830        840        850
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI 
       860        870        880        890        900
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 
       910        920        930        940        950
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE 
       960        970        980        990       1000
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV 
      1010       1020       1030       1040       1050
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF 
      1060       1070       1080       1090       1100
LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV 
      1110       1120       1130       1140       1150
RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA 
      1160       1170       1180       1190       1200
SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 
      1210       1220       1230       1240       1250
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC 
      1260       1270       1280       1290       1300
IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW 
      1310       1320       1330       1340       1350
DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI 
      1360       1370       1380       1390       1400
LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL 
      1410       1420       1430 
AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG

Length:1,437

Mass (Da):160,660

Last modified:December 1, 2000 - v2

Checksum:ⁱ00558076B3BB4C00

GO

Isoform 2 (identifier: O15440-2) [UniParc]FASTA Add to basket

Also known as: SV1

The sequence of this isoform differs from the canonical sequence as follows:
198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
226-1437: Missing.

« Hide

        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL 
        60         70         80         90        100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 
       110        120        130        140        150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 
       160        170        180        190        200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPPSF 
       210        220 
GDCSISAEVC GNRLHCTAIL LSCFT

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »

Length:225

Mass (Da):25,341

Checksum:ⁱ771FBD2C32E08B8C

GO

Isoform 3 (identifier: O15440-3) [UniParc]FASTA Add to basket

Also known as: SV2

The sequence of this isoform differs from the canonical sequence as follows:
     198-212: AFMVKHLLEYTQATE → LAWCCQDLDLGGVSL
     213-225: Missing.
     226-1437: Missing.

« Hide

        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL 
        60         70         80         90        100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 
       110        120        130        140        150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 
       160        170        180        190        200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPLAW 
       210 
CCQDLDLGGV SL

Note: Predominant isoform in retinal pigment epithelium, bladder, and stomach.Curated

Show »

Length:212

Mass (Da):23,988

Checksum:ⁱD562C6FBF01922D1

GO

Isoform 4 (identifier: O15440-4) [UniParc]FASTA Add to basket

Also known as: SV3

The sequence of this isoform differs from the canonical sequence as follows:
     198-208: AFMVKHLLEYT → NFQDGCILRSE
     209-225: Missing.
     226-1437: Missing.

« Hide

        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL 
        60         70         80         90        100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 
       110        120        130        140        150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 
       160        170        180        190        200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPNFQ 

DGCILRSE

Show »

Length:208

Mass (Da):23,677

Checksum:ⁱ3FF375FBCE128270

GO

Isoform 5 (identifier: O15440-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1033-1075: Missing.

« Hide

        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL 
        60         70         80         90        100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 
       110        120        130        140        150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 
       160        170        180        190        200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM 
       210        220        230        240        250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL 
       260        270        280        290        300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 
       310        320        330        340        350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA 
       360        370        380        390        400
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS 
       410        420        430        440        450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT 
       460        470        480        490        500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 
       510        520        530        540        550
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL 
       560        570        580        590        600
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 
       610        620        630        640        650
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD 
       660        670        680        690        700
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY 
       710        720        730        740        750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC 
       760        770        780        790        800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET 
       810        820        830        840        850
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI 
       860        870        880        890        900
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 
       910        920        930        940        950
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE 
       960        970        980        990       1000
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV 
      1010       1020       1030       1040       1050
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRYQELLDD NQAPFFLFTC 
      1060       1070       1080       1090       1100
AMRWLAVRLD LISIALITTT GLMIVLMHGQ IPPAYAGLAI SYAVQLTGLF 
      1110       1120       1130       1140       1150
QFTVRLASET EARFTSVERI NHYIKTLSLE APARIKNKAP SPDWPQEGEV 
      1160       1170       1180       1190       1200
TFENAEMRYR ENLPLVLKKV SFTIKPKEKI GIVGRTGSGK SSLGMALFRL 
      1210       1220       1230       1240       1250
VELSGGCIKI DGVRISDIGL ADLRSKLSII PQEPVLFSGT VRSNLDPFNQ 
      1260       1270       1280       1290       1300
YTEDQIWDAL ERTHMKECIA QLPLKLESEV MENGDNFSVG ERQLLCIARA 
      1310       1320       1330       1340       1350
LLRHCKILIL DEATAAMDTE TDLLIQETIR EAFADCTMLT IAHRLHTVLG 
      1360       1370       1380       1390 
SDRIMVLAQG QVVEFDTPSV LLSNDSSRFY AMFAAAENKV AVKG

Show »

Length:1,394

Mass (Da):155,732

Checksum:ⁱ5B11EC10EB9D07C9

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WCY8	F8WCY8_HUMAN	Multidrug resistance-associated pro... Multidrug resistance-associated protein 5	ABCC5	473	Annotation score:
C9JZL5	C9JZL5_HUMAN	Multidrug resistance-associated pro... Multidrug resistance-associated protein 5	ABCC5	147	Annotation score:
A5PKY6	A5PKY6_HUMAN	ABCC5 protein ABCC5 protein (Multidrug resistance-associated protein 5)	ABCC5	231	Annotation score:
E9PET4	E9PET4_HUMAN	Multidrug resistance-associated pro... Multidrug resistance-associated protein 5	ABCC5	53	Annotation score:
F8WDH3	F8WDH3_HUMAN	Multidrug resistance-associated pro... Multidrug resistance-associated protein 5	ABCC5	53	Annotation score:
H7C271	H7C271_HUMAN	Multidrug resistance-associated pro... Multidrug resistance-associated protein 5	ABCC5	70	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	176	R → P in BAA76608 (PubMed:10721709).Curated	1
Sequence conflictⁱ	400	S → G in AAD04169 (PubMed:9827529).Curated	1
Sequence conflictⁱ	581	I → V in AAD37716 (PubMed:10438534).Curated	1
Sequence conflictⁱ	1383	T → N in BAA76608 (PubMed:10721709).Curated	1
Sequence conflictⁱ	1383	T → N in BAA22887 (Ref. 8) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043397	198 – 225	AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2. 2 PublicationsAdd BLAST	28
Alternative sequenceⁱVSP_043398	198 – 212	AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_043399	198 – 208	AFMVKHLLEYT → NFQDGCILRSE in isoform 4. 1 PublicationAdd BLAST	11
Alternative sequenceⁱVSP_043400	209 – 225	Missing in isoform 4. 1 PublicationAdd BLAST	17
Alternative sequenceⁱVSP_043401	213 – 225	Missing in isoform 3. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_043402	226 – 1437	Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST	1212
Alternative sequenceⁱVSP_055354	1033 – 1075	Missing in isoform 5. 1 PublicationAdd BLAST	43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF104942 mRNA Translation: AAD04169.1 AF146074 mRNA Translation: AAD37716.1 AB019002 mRNA Translation: BAA76608.1 U83661 mRNA Translation: AAB71758.2 AY754874 mRNA Translation: AAW82948.1 AY754875 mRNA Translation: AAW82949.1 AY754876 mRNA Translation: AAW82950.1 AY196484 mRNA Translation: AAO49801.1 AC068644 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78307.1 CH471052 Genomic DNA Translation: EAW78308.1 BC050744 mRNA Translation: AAH50744.1 BC140771 mRNA Translation: AAI40772.1 BC142719 mRNA Translation: AAI42720.1 AB005659 mRNA Translation: BAA22887.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33898.1 [O15440-4] CCDS43176.1 [O15440-1]
PIRⁱ	JC5667
NCBI Reference Sequences More...RefSeqⁱ	NP_001018881.1, NM_001023587.2 [O15440-4] NP_001306961.1, NM_001320032.1 NP_005679.2, NM_005688.3 [O15440-1] XP_005247115.1, XM_005247058.4 [O15440-1] XP_005247116.1, XM_005247059.4 [O15440-1] XP_011510616.1, XM_011512314.1 [O15440-1] XP_016860982.1, XM_017005493.1 [O15440-4] XP_016860983.1, XM_017005494.1 [O15440-4]

Genome annotation databases

Ensemblⁱ	ENST00000265586; ENSP00000265586; ENSG00000114770 [O15440-5] ENST00000334444; ENSP00000333926; ENSG00000114770 [O15440-1] ENST00000382494; ENSP00000371934; ENSG00000114770 [O15440-4] ENST00000392579; ENSP00000376358; ENSG00000114770 [O15440-2] ENST00000443376; ENSP00000416840; ENSG00000114770 [O15440-3]
GeneIDⁱ	10057
KEGGⁱ	hsa:10057
UCSC genome browser More...UCSCⁱ	uc003fmg.4, human [O15440-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15440	ATP binding cassette subfamily C member 5		PANPA		1437	UniRef100_O15440
Multidrug resistance-associated protein 5 (Fragment)		HUMAN		147
ABCC5 isoform 12 (Fragment)		PANTR		147
+2
O15440-2	ABCC5 isoform 8		PANTR		225	UniRef100_A0A2J8M5A0
O15440-3	ABCC5 isoform 10		PANTR		212	UniRef100_A0A2J8M5A3
O15440-4	ATP binding cassette subfamily C member 5		PANTR		208	UniRef100_K7DP93
ATP binding cassette subfamily C member 5		PANPA		208
ATP binding cassette subfamily C member 5		GORGO		208
ABCC5 isoform 9		PANTR		208
O15440-5	ATP binding cassette subfamily C member 5		PANPA		1394	UniRef100_A0A2R9A5W3

Protein	Similar proteins		Species	Score	Length	Source
O15440	ATP binding cassette subfamily C member 5		PANPA		1437	UniRef90_O15440
Multidrug resistance-associated protein 5 (Fragment)		HUMAN		147
ABCC5 isoform 12 (Fragment)		PANTR		147
ATP binding cassette subfamily C member 5		AILME		1547
Uncharacterized protein		CALJA		1483
+346
O15440-2	ATP binding cassette subfamily C member 5		PAPAN		225	UniRef90_A0A2I3M5S1
ABCC5 isoform 9		PONAB		225
ATP binding cassette subfamily C member 5		CERAT		225
ATP binding cassette subfamily C member 5		MANLE		225
ATP binding cassette subfamily C member 5		MACNE		225
+4
O15440-3	ATP binding cassette subfamily C member 5		MACMU		207	UniRef90_A0A1D5Q6I6
ABCC5 isoform 10		PANTR		212
ABCC5 isoform 10		PONAB		212
Uncharacterized protein		CALJA		208
ATP binding cassette subfamily C member 5		AOTNA		208
+35
O15440-5	ATP binding cassette subfamily C member 5		GORGO		1241	UniRef90_G3QDT5
multidrug resistance-associated protein 5 isoform X1		PTEVA		1505
Multidrug resistance-associated protein 5		PTEAL		1445
ABCC5 isoform 2		PANTR		1394
ABCC5 isoform 2		PONAB		1394
+11

Protein	Similar proteins		Species	Score	Length	Source
O15440	ATP binding cassette subfamily C member 5		PANPA		1437	UniRef50_O15440
Multidrug resistance-associated protein 5 (Fragment)		HUMAN		147
ABCC5 isoform 12 (Fragment)		PANTR		147
ATP binding cassette subfamily C member 5		AILME		1547
Uncharacterized protein		CALJA		1483
+431
O15440-2	ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (Fragment)		DANRE		241	UniRef50_E9QGZ9
multidrug resistance-associated protein 5 isoform X4		MESAU		208
multidrug resistance-associated protein 5 isoform X3		PERMB		208
multidrug resistance-associated protein 5 isoform X5		ALLSI		206
ATP binding cassette subfamily C member 5		PIPKU		212
+43
O15440-3	ATP binding cassette subfamily C member 5		MACMU		210	UniRef50_A0A1D5R508
Uncharacterized protein		RHIBE		231
ABCC5 protein		HUMAN		231
ABCC5 isoform 7		PANTR		231
ATP binding cassette subfamily C member 5		GORGO		231
+139

Cross-referencesⁱ

Web resourcesⁱ

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF104942 mRNA Translation: AAD04169.1 AF146074 mRNA Translation: AAD37716.1 AB019002 mRNA Translation: BAA76608.1 U83661 mRNA Translation: AAB71758.2 AY754874 mRNA Translation: AAW82948.1 AY754875 mRNA Translation: AAW82949.1 AY754876 mRNA Translation: AAW82950.1 AY196484 mRNA Translation: AAO49801.1 AC068644 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78307.1 CH471052 Genomic DNA Translation: EAW78308.1 BC050744 mRNA Translation: AAH50744.1 BC140771 mRNA Translation: AAI40772.1 BC142719 mRNA Translation: AAI42720.1 AB005659 mRNA Translation: BAA22887.1
CCDSⁱ	CCDS33898.1 [O15440-4] CCDS43176.1 [O15440-1]
PIRⁱ	JC5667
RefSeqⁱ	NP_001018881.1, NM_001023587.2 [O15440-4] NP_001306961.1, NM_001320032.1 NP_005679.2, NM_005688.3 [O15440-1] XP_005247115.1, XM_005247058.4 [O15440-1] XP_005247116.1, XM_005247059.4 [O15440-1] XP_011510616.1, XM_011512314.1 [O15440-1] XP_016860982.1, XM_017005493.1 [O15440-4] XP_016860983.1, XM_017005494.1 [O15440-4]

3D structure databases

SMRⁱ	O15440
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115368, 18 interactors
IntActⁱ	O15440, 13 interactors
STRINGⁱ	9606.ENSP00000333926

Chemistry databases

BindingDBⁱ	O15440
ChEMBLⁱ	CHEMBL2046258
DrugBankⁱ	DB00718, Adefovir dipivoxil DB00770, Alprostadil DB01076, Atorvastatin DB00515, Cisplatin DB11672, Curcumin DB14635, Curcumin sulfate DB02527, Cyclic adenosine monophosphate DB00917, Dinoprostone DB00975, Dipyridamole DB00544, Fluorouracil DB00143, Glutathione DB01033, Mercaptopurine DB01032, Probenecid DB01045, Rifampicin DB00203, Sildenafil DB01138, Sulfinpyrazone DB00495, Zidovudine
DrugCentralⁱ	O15440
GuidetoPHARMACOLOGYⁱ	783

Protein family/group databases

TCDBⁱ	3.A.1.208.15, the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.208.15, the atp-binding cassette (abc) superfamily

PTM databases

GlyGenⁱ	O15440, 8 sites
iPTMnetⁱ	O15440
PhosphoSitePlusⁱ	O15440

Genetic variation databases

BioMutaⁱ	ABCC5

BioMutaⁱ

ABCC5

Proteomic databases

EPDⁱ	O15440
jPOSTⁱ	O15440
MassIVEⁱ	O15440
MaxQBⁱ	O15440
PaxDbⁱ	O15440
PeptideAtlasⁱ	O15440
PRIDEⁱ	O15440
ProteomicsDBⁱ	48667 [O15440-1] 48668 [O15440-2] 48669 [O15440-3] 48670 [O15440-4] 69929

Protocols and materials databases

Antibodypediaⁱ	18937, 399 antibodies
The DNASU plasmid repository More...DNASUⁱ	10057

Genome annotation databases

Ensemblⁱ	ENST00000265586; ENSP00000265586; ENSG00000114770 [O15440-5] ENST00000334444; ENSP00000333926; ENSG00000114770 [O15440-1] ENST00000382494; ENSP00000371934; ENSG00000114770 [O15440-4] ENST00000392579; ENSP00000376358; ENSG00000114770 [O15440-2] ENST00000443376; ENSP00000416840; ENSG00000114770 [O15440-3]
GeneIDⁱ	10057
KEGGⁱ	hsa:10057
UCSCⁱ	uc003fmg.4, human [O15440-1]

Organism-specific databases

CTDⁱ	10057
DisGeNETⁱ	10057
GeneCardsⁱ	ABCC5
HGNCⁱ	HGNC:56, ABCC5
HPAⁱ	ENSG00000114770, Low tissue specificity
MIMⁱ	605251, gene
neXtProtⁱ	NX_O15440
OpenTargetsⁱ	ENSG00000114770
PharmGKBⁱ	PA395
VEuPathDBⁱ	HostDB:ENSG00000114770.16
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0054, Eukaryota
GeneTreeⁱ	ENSGT00940000155470
HOGENOMⁱ	CLU_000604_27_3_1
InParanoidⁱ	O15440
OMAⁱ	FVKFFGW
OrthoDBⁱ	138195at2759
PhylomeDBⁱ	O15440
TreeFamⁱ	TF105202

Enzyme and pathway databases

BRENDAⁱ	7.6.2.3, 2681
PathwayCommonsⁱ	O15440
Reactomeⁱ	R-HSA-2142850, Hyaluronan biosynthesis and export R-HSA-382556, ABC-family proteins mediated transport

Miscellaneous databases

BioGRID-ORCSⁱ	10057, 7 hits in 997 CRISPR screens
ChiTaRSⁱ	ABCC5, human
GeneWikiⁱ	ABCC5
GenomeRNAiⁱ	10057
Pharosⁱ	O15440, Tchem
Protein Ontology More...PROⁱ	PR:O15440
RNActⁱ	O15440, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114770, Expressed in forebrain and 239 other tissues
ExpressionAtlasⁱ	O15440, baseline and differential
Genevisibleⁱ	O15440, HS

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR030238, ABCC5 IPR027417, P-loop_NTPase
PANTHERⁱ	PTHR24223:SF196, PTHR24223:SF196, 1 hit
Pfamⁱ	View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382, AAA, 2 hits
SUPFAMⁱ	SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MRP5_HUMAN
Accessionⁱ	O15440Primary (citable) accession number: O15440 Secondary accession number(s): B9EIQ2 Q9UQC3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	December 1, 2000
	Last modified:	June 2, 2021
	This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - O15440 (MRP5_HUMAN)

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Multidrug resistance-associated protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Golgi apparatus

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Endosome

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

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Chemistry databases

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PTM databases

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Proteomic databases

Protocols and materials databases

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Miscellaneous databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ