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Protein

Multidrug resistance-associated protein 5

Gene

ABCC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi595 – 602ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1227 – 1234ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATPase-coupled anion transmembrane transporter activity Source: Reactome
  • ATP binding Source: ProtInc
  • organic anion transmembrane transporter activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2142850 Hyaluronan biosynthesis and export
R-HSA-382556 ABC-family proteins mediated transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.15 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
pABC11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC5
Synonyms:MRP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000114770.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:56 ABCC5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605251 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15440

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei179 – 199HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei219 – 239HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei317 – 337HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei400 – 420HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei434 – 454HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei608 – 628HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei848 – 868HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei917 – 937HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei997 – 1017HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1018 – 1038HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1104 – 1124HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1127 – 1147HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10057

Open Targets

More...
OpenTargetsi
ENSG00000114770

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA395

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2046258

Drug and drug target database

More...
DrugBanki
DB00718 Adefovir Dipivoxil
DB00770 Alprostadil
DB01076 Atorvastatin
DB00515 Cisplatin
DB02527 Cyclic Adenosine Monophosphate
DB00917 Dinoprostone
DB00975 Dipyridamole
DB00544 Fluorouracil
DB00143 Glutathione
DB01033 Mercaptopurine
DB01032 Probenecid
DB01045 Rifampicin
DB00203 Sildenafil
DB01138 Sulfinpyrazone
DB00495 Zidovudine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
783

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCC5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933631 – 1437Multidrug resistance-associated protein 5Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei505PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi684N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1044N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1417N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15440

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15440

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15440

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15440

PeptideAtlas

More...
PeptideAtlasi
O15440

PRoteomics IDEntifications database

More...
PRIDEi
O15440

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48667
48668 [O15440-2]
48669 [O15440-3]
48670 [O15440-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15440

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15440

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

All isoforms are equally expressed in retina.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114770 Expressed in 226 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
HS_ABCC5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15440 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15440 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044067
HPA052295

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115368, 13 interactors

Protein interaction database and analysis system

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IntActi
O15440, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333926

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15440

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15440

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini179 – 459ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini562 – 783ABC transporter 1PROSITE-ProRule annotationAdd BLAST222
Domaini859 – 1155ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST297
Domaini1193 – 1427ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116132

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108314

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15440

KEGG Orthology (KO)

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KOi
K05668

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMVYNVI

Database of Orthologous Groups

More...
OrthoDBi
926074at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15440

TreeFam database of animal gene trees

More...
TreeFami
TF105202

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030238 ABCC5
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF196 PTHR24223:SF196, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL
60 70 80 90 100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP
110 120 130 140 150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE
160 170 180 190 200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM
210 220 230 240 250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL
260 270 280 290 300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
310 320 330 340 350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA
360 370 380 390 400
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS
410 420 430 440 450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT
460 470 480 490 500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD
510 520 530 540 550
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL
560 570 580 590 600
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG
610 620 630 640 650
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD
660 670 680 690 700
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY
710 720 730 740 750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC
760 770 780 790 800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET
810 820 830 840 850
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI
860 870 880 890 900
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS
910 920 930 940 950
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE
960 970 980 990 1000
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV
1010 1020 1030 1040 1050
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF
1060 1070 1080 1090 1100
LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV
1110 1120 1130 1140 1150
RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA
1160 1170 1180 1190 1200
SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM
1210 1220 1230 1240 1250
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC
1260 1270 1280 1290 1300
IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW
1310 1320 1330 1340 1350
DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI
1360 1370 1380 1390 1400
LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL
1410 1420 1430
AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG
Length:1,437
Mass (Da):160,660
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00558076B3BB4C00
GO
Isoform 2 (identifier: O15440-2) [UniParc]FASTAAdd to basket
Also known as: SV1

The sequence of this isoform differs from the canonical sequence as follows:
     198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
     226-1437: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:225
Mass (Da):25,341
Checksum:i771FBD2C32E08B8C
GO
Isoform 3 (identifier: O15440-3) [UniParc]FASTAAdd to basket
Also known as: SV2

The sequence of this isoform differs from the canonical sequence as follows:
     198-212: AFMVKHLLEYTQATE → LAWCCQDLDLGGVSL
     213-225: Missing.
     226-1437: Missing.

Note: Predominant isoform in retinal pigment epithelium, bladder, and stomach.
Show »
Length:212
Mass (Da):23,988
Checksum:iD562C6FBF01922D1
GO
Isoform 4 (identifier: O15440-4) [UniParc]FASTAAdd to basket
Also known as: SV3

The sequence of this isoform differs from the canonical sequence as follows:
     198-208: AFMVKHLLEYT → NFQDGCILRSE
     209-225: Missing.
     226-1437: Missing.

Show »
Length:208
Mass (Da):23,677
Checksum:i3FF375FBCE128270
GO
Isoform 5 (identifier: O15440-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1033-1075: Missing.

Show »
Length:1,394
Mass (Da):155,732
Checksum:i5B11EC10EB9D07C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCY8F8WCY8_HUMAN
Multidrug resistance-associated pro...
ABCC5
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZL5C9JZL5_HUMAN
Multidrug resistance-associated pro...
ABCC5
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A5PKY6A5PKY6_HUMAN
ABCC5 protein
ABCC5
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PET4E9PET4_HUMAN
Multidrug resistance-associated pro...
ABCC5
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDH3F8WDH3_HUMAN
Multidrug resistance-associated pro...
ABCC5
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C271H7C271_HUMAN
Multidrug resistance-associated pro...
ABCC5
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176R → P in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti400S → G in AAD04169 (PubMed:9827529).Curated1
Sequence conflicti581I → V in AAD37716 (PubMed:10438534).Curated1
Sequence conflicti1383T → N in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti1383T → N in BAA22887 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043397198 – 225AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_043398198 – 212AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_043399198 – 208AFMVKHLLEYT → NFQDGCILRSE in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_043400209 – 225Missing in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_043401213 – 225Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_043402226 – 1437Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST1212
Alternative sequenceiVSP_0553541033 – 1075Missing in isoform 5. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF104942 mRNA Translation: AAD04169.1
AF146074 mRNA Translation: AAD37716.1
AB019002 mRNA Translation: BAA76608.1
U83661 mRNA Translation: AAB71758.2
AY754874 mRNA Translation: AAW82948.1
AY754875 mRNA Translation: AAW82949.1
AY754876 mRNA Translation: AAW82950.1
AY196484 mRNA Translation: AAO49801.1
AC068644 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78307.1
CH471052 Genomic DNA Translation: EAW78308.1
BC050744 mRNA Translation: AAH50744.1
BC140771 mRNA Translation: AAI40772.1
BC142719 mRNA Translation: AAI42720.1
AB005659 mRNA Translation: BAA22887.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33898.1 [O15440-4]
CCDS43176.1 [O15440-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5667

NCBI Reference Sequences

More...
RefSeqi
NP_001018881.1, NM_001023587.2 [O15440-4]
NP_001306961.1, NM_001320032.1
NP_005679.2, NM_005688.3 [O15440-1]
XP_005247115.1, XM_005247058.4 [O15440-1]
XP_005247116.1, XM_005247059.4 [O15440-1]
XP_011510616.1, XM_011512314.1 [O15440-1]
XP_016860982.1, XM_017005493.1 [O15440-4]
XP_016860983.1, XM_017005494.1 [O15440-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.368563
Hs.732645
Hs.743953

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265586; ENSP00000265586; ENSG00000114770 [O15440-5]
ENST00000334444; ENSP00000333926; ENSG00000114770 [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770 [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770 [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770 [O15440-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10057

UCSC genome browser

More...
UCSCi
uc003fmg.4 human [O15440-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104942 mRNA Translation: AAD04169.1
AF146074 mRNA Translation: AAD37716.1
AB019002 mRNA Translation: BAA76608.1
U83661 mRNA Translation: AAB71758.2
AY754874 mRNA Translation: AAW82948.1
AY754875 mRNA Translation: AAW82949.1
AY754876 mRNA Translation: AAW82950.1
AY196484 mRNA Translation: AAO49801.1
AC068644 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78307.1
CH471052 Genomic DNA Translation: EAW78308.1
BC050744 mRNA Translation: AAH50744.1
BC140771 mRNA Translation: AAI40772.1
BC142719 mRNA Translation: AAI42720.1
AB005659 mRNA Translation: BAA22887.1
CCDSiCCDS33898.1 [O15440-4]
CCDS43176.1 [O15440-1]
PIRiJC5667
RefSeqiNP_001018881.1, NM_001023587.2 [O15440-4]
NP_001306961.1, NM_001320032.1
NP_005679.2, NM_005688.3 [O15440-1]
XP_005247115.1, XM_005247058.4 [O15440-1]
XP_005247116.1, XM_005247059.4 [O15440-1]
XP_011510616.1, XM_011512314.1 [O15440-1]
XP_016860982.1, XM_017005493.1 [O15440-4]
XP_016860983.1, XM_017005494.1 [O15440-4]
UniGeneiHs.368563
Hs.732645
Hs.743953

3D structure databases

ProteinModelPortaliO15440
SMRiO15440
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115368, 13 interactors
IntActiO15440, 8 interactors
STRINGi9606.ENSP00000333926

Chemistry databases

BindingDBiO15440
ChEMBLiCHEMBL2046258
DrugBankiDB00718 Adefovir Dipivoxil
DB00770 Alprostadil
DB01076 Atorvastatin
DB00515 Cisplatin
DB02527 Cyclic Adenosine Monophosphate
DB00917 Dinoprostone
DB00975 Dipyridamole
DB00544 Fluorouracil
DB00143 Glutathione
DB01033 Mercaptopurine
DB01032 Probenecid
DB01045 Rifampicin
DB00203 Sildenafil
DB01138 Sulfinpyrazone
DB00495 Zidovudine
GuidetoPHARMACOLOGYi783

Protein family/group databases

TCDBi3.A.1.208.15 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiO15440
PhosphoSitePlusiO15440

Polymorphism and mutation databases

BioMutaiABCC5

Proteomic databases

EPDiO15440
jPOSTiO15440
MaxQBiO15440
PaxDbiO15440
PeptideAtlasiO15440
PRIDEiO15440
ProteomicsDBi48667
48668 [O15440-2]
48669 [O15440-3]
48670 [O15440-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265586; ENSP00000265586; ENSG00000114770 [O15440-5]
ENST00000334444; ENSP00000333926; ENSG00000114770 [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770 [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770 [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770 [O15440-3]
GeneIDi10057
KEGGihsa:10057
UCSCiuc003fmg.4 human [O15440-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10057
DisGeNETi10057
EuPathDBiHostDB:ENSG00000114770.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCC5
HGNCiHGNC:56 ABCC5
HPAiHPA044067
HPA052295
MIMi605251 gene
neXtProtiNX_O15440
OpenTargetsiENSG00000114770
PharmGKBiPA395

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000155470
HOGENOMiHOG000116132
HOVERGENiHBG108314
InParanoidiO15440
KOiK05668
OMAiGMVYNVI
OrthoDBi926074at2759
PhylomeDBiO15440
TreeFamiTF105202

Enzyme and pathway databases

ReactomeiR-HSA-2142850 Hyaluronan biosynthesis and export
R-HSA-382556 ABC-family proteins mediated transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCC5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCC5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10057

Protein Ontology

More...
PROi
PR:O15440

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114770 Expressed in 226 organ(s), highest expression level in forebrain
CleanExiHS_ABCC5
ExpressionAtlasiO15440 baseline and differential
GenevisibleiO15440 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030238 ABCC5
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF196 PTHR24223:SF196, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15440
Secondary accession number(s): B9EIQ2
, O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: January 16, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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