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UniProtKB - O15440 (MRP5_HUMAN)

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Protein

Multidrug resistance-associated protein 5

Gene

ABCC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi595 – 602ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1227 – 1234ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2142850 Hyaluronan biosynthesis and export
R-HSA-382556 ABC-family proteins mediated transport

Protein family/group databases

TCDBi3.A.1.208.15 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
pABC11
Gene namesi
Name:ABCC5
Synonyms:MRP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114770.16
HGNCiHGNC:56 ABCC5
MIMi605251 gene
neXtProtiNX_O15440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei179 – 199HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei219 – 239HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei317 – 337HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei400 – 420HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei434 – 454HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei608 – 628HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei848 – 868HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei917 – 937HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei997 – 1017HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1018 – 1038HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1104 – 1124HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1127 – 1147HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10057
OpenTargetsiENSG00000114770
PharmGKBiPA395

Chemistry databases

ChEMBLiCHEMBL2046258
DrugBankiDB00718 Adefovir Dipivoxil
DB00770 Alprostadil
DB01076 Atorvastatin
DB00515 Cisplatin
DB02527 Cyclic Adenosine Monophosphate
DB00917 Dinoprostone
DB00975 Dipyridamole
DB00544 Fluorouracil
DB00143 Glutathione
DB01033 Mercaptopurine
DB01032 Probenecid
DB01045 Rifampicin
DB00203 Sildenafil
DB01138 Sulfinpyrazone
DB00495 Zidovudine
GuidetoPHARMACOLOGYi783

Polymorphism and mutation databases

BioMutaiABCC5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933631 – 1437Multidrug resistance-associated protein 5Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei505PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi684N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1044N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1417N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO15440
MaxQBiO15440
PaxDbiO15440
PeptideAtlasiO15440
PRIDEiO15440
ProteomicsDBi48667
48668 [O15440-2]
48669 [O15440-3]
48670 [O15440-4]

PTM databases

iPTMnetiO15440
PhosphoSitePlusiO15440

Expressioni

Tissue specificityi

All isoforms are equally expressed in retina.1 Publication

Gene expression databases

BgeeiENSG00000114770
CleanExiHS_ABCC5
ExpressionAtlasiO15440 baseline and differential
GenevisibleiO15440 HS

Organism-specific databases

HPAiHPA044067
HPA052295

Interactioni

Protein-protein interaction databases

BioGridi115368, 13 interactors
IntActiO15440, 8 interactors
STRINGi9606.ENSP00000333926

Chemistry databases

BindingDBiO15440

Structurei

3D structure databases

ProteinModelPortaliO15440
SMRiO15440
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 459ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini562 – 783ABC transporter 1PROSITE-ProRule annotationAdd BLAST222
Domaini859 – 1155ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST297
Domaini1193 – 1427ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00880000137856
HOGENOMiHOG000116132
HOVERGENiHBG108314
InParanoidiO15440
KOiK05668
OMAiYPAMMFV
OrthoDBiEOG091G01TC
PhylomeDBiO15440
TreeFamiTF105202

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030238 ABCC5
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF196 PTHR24223:SF196, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL 
        60         70         80         90        100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 
       110        120        130        140        150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 
       160        170        180        190        200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM 
       210        220        230        240        250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL 
       260        270        280        290        300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 
       310        320        330        340        350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA 
       360        370        380        390        400
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS 
       410        420        430        440        450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT 
       460        470        480        490        500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 
       510        520        530        540        550
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL 
       560        570        580        590        600
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 
       610        620        630        640        650
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD 
       660        670        680        690        700
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY 
       710        720        730        740        750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC 
       760        770        780        790        800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET 
       810        820        830        840        850
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI 
       860        870        880        890        900
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 
       910        920        930        940        950
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE 
       960        970        980        990       1000
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV 
      1010       1020       1030       1040       1050
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF 
      1060       1070       1080       1090       1100
LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV 
      1110       1120       1130       1140       1150
RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA 
      1160       1170       1180       1190       1200
SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 
      1210       1220       1230       1240       1250
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC 
      1260       1270       1280       1290       1300
IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW 
      1310       1320       1330       1340       1350
DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI 
      1360       1370       1380       1390       1400
LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL 
      1410       1420       1430 
AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG
Length:1,437
Mass (Da):160,660
Last modified:December 1, 2000 - v2
Checksum:i00558076B3BB4C00
GO
Isoform 2 (identifier: O15440-2) [UniParc]FASTAAdd to basket
Also known as: SV1

The sequence of this isoform differs from the canonical sequence as follows:
     198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
     226-1437: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:225
Mass (Da):25,341
Checksum:i771FBD2C32E08B8C
GO
Isoform 3 (identifier: O15440-3) [UniParc]FASTAAdd to basket
Also known as: SV2

The sequence of this isoform differs from the canonical sequence as follows:
     198-212: AFMVKHLLEYTQATE → LAWCCQDLDLGGVSL
     213-225: Missing.
     226-1437: Missing.

Note: Predominant isoform in retinal pigment epithelium, bladder, and stomach.
Show »
Length:212
Mass (Da):23,988
Checksum:iD562C6FBF01922D1
GO
Isoform 4 (identifier: O15440-4) [UniParc]FASTAAdd to basket
Also known as: SV3

The sequence of this isoform differs from the canonical sequence as follows:
     198-208: AFMVKHLLEYT → NFQDGCILRSE
     209-225: Missing.
     226-1437: Missing.

Show »
Length:208
Mass (Da):23,677
Checksum:i3FF375FBCE128270
GO
Isoform 5 (identifier: O15440-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1033-1075: Missing.

Show »
Length:1,394
Mass (Da):155,732
Checksum:i5B11EC10EB9D07C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176R → P in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti400S → G in AAD04169 (PubMed:9827529).Curated1
Sequence conflicti581I → V in AAD37716 (PubMed:10438534).Curated1
Sequence conflicti1383T → N in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti1383T → N in BAA22887 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043397198 – 225AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_043398198 – 212AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_043399198 – 208AFMVKHLLEYT → NFQDGCILRSE in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_043400209 – 225Missing in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_043401213 – 225Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_043402226 – 1437Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST1212
Alternative sequenceiVSP_0553541033 – 1075Missing in isoform 5. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104942 mRNA Translation: AAD04169.1
AF146074 mRNA Translation: AAD37716.1
AB019002 mRNA Translation: BAA76608.1
U83661 mRNA Translation: AAB71758.2
AY754874 mRNA Translation: AAW82948.1
AY754875 mRNA Translation: AAW82949.1
AY754876 mRNA Translation: AAW82950.1
AY196484 mRNA Translation: AAO49801.1
AC068644 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78307.1
CH471052 Genomic DNA Translation: EAW78308.1
BC050744 mRNA Translation: AAH50744.1
BC140771 mRNA Translation: AAI40772.1
BC142719 mRNA Translation: AAI42720.1
AB005659 mRNA Translation: BAA22887.1
CCDSiCCDS33898.1 [O15440-4]
CCDS43176.1 [O15440-1]
PIRiJC5667
RefSeqiNP_001018881.1, NM_001023587.2 [O15440-4]
NP_001306961.1, NM_001320032.1
NP_005679.2, NM_005688.3 [O15440-1]
XP_005247115.1, XM_005247058.4 [O15440-1]
XP_005247116.1, XM_005247059.4 [O15440-1]
XP_011510616.1, XM_011512314.1 [O15440-1]
XP_016860982.1, XM_017005493.1 [O15440-4]
XP_016860983.1, XM_017005494.1 [O15440-4]
UniGeneiHs.368563
Hs.732645
Hs.743953

Genome annotation databases

EnsembliENST00000265586; ENSP00000265586; ENSG00000114770 [O15440-5]
ENST00000334444; ENSP00000333926; ENSG00000114770 [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770 [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770 [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770 [O15440-3]
GeneIDi10057
KEGGihsa:10057
UCSCiuc003fmg.4 human [O15440-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMRP5_HUMAN
AccessioniPrimary (citable) accession number: O15440
Secondary accession number(s): B9EIQ2
, O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: June 20, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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