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UniProtKB - O15440 (MRP5_HUMAN)

Entry version 189 (10 Feb 2021)
Sequence version 2 (01 Dec 2000)
Previous versions | rss
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Protein

Multidrug resistance-associated protein 5

Gene

ABCC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi595 – 602ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1227 – 1234ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15440

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2142850, Hyaluronan biosynthesis and export
R-HSA-382556, ABC-family proteins mediated transport

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.208.15, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
pABC11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC5
Synonyms:MRP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:56, ABCC5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605251, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15440

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114770.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei179 – 199HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei219 – 239HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei317 – 337HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei400 – 420HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei434 – 454HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei608 – 628HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei848 – 868HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei917 – 937HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei997 – 1017HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1018 – 1038HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1104 – 1124HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1127 – 1147HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10057

Open Targets

More...OpenTargetsi		ENSG00000114770

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA395

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15440, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2046258

Drug and drug target database

More...DrugBanki		DB00718, Adefovir dipivoxil
DB00770, Alprostadil
DB01076, Atorvastatin
DB00515, Cisplatin
DB11672, Curcumin
DB14635, Curcumin sulfate
DB02527, Cyclic adenosine monophosphate
DB00917, Dinoprostone
DB00975, Dipyridamole
DB00544, Fluorouracil
DB00143, Glutathione
DB01033, Mercaptopurine
DB01032, Probenecid
DB01045, Rifampicin
DB00203, Sildenafil
DB01138, Sulfinpyrazone
DB00495, Zidovudine

DrugCentral

More...DrugCentrali		O15440

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		783

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ABCC5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933631 – 1437Multidrug resistance-associated protein 5Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei505PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi684N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1044N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1417N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15440

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15440

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15440

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15440

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15440

PeptideAtlas

More...PeptideAtlasi		O15440

PRoteomics IDEntifications database

More...PRIDEi		O15440

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48667 [O15440-1]
48668 [O15440-2]
48669 [O15440-3]
48670 [O15440-4]
69929

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O15440, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15440

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15440

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

All isoforms are equally expressed in retina.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114770, Expressed in forebrain and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15440, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15440, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114770, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115368, 18 interactors

Protein interaction database and analysis system

More...IntActi		O15440, 13 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333926

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O15440

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15440, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15440

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini179 – 459ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini562 – 783ABC transporter 1PROSITE-ProRule annotationAdd BLAST222
Domaini859 – 1155ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST297
Domaini1193 – 1427ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0054, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_27_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15440

Identification of Orthologs from Complete Genome Data

More...OMAi		FVKFFGW

Database of Orthologous Groups

More...OrthoDBi		138195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15440

TreeFam database of animal gene trees

More...TreeFami		TF105202

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030238, ABCC5
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR24223:SF196, PTHR24223:SF196, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL 
        60         70         80         90        100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 
       110        120        130        140        150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 
       160        170        180        190        200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM 
       210        220        230        240        250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL 
       260        270        280        290        300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 
       310        320        330        340        350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA 
       360        370        380        390        400
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS 
       410        420        430        440        450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT 
       460        470        480        490        500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 
       510        520        530        540        550
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL 
       560        570        580        590        600
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 
       610        620        630        640        650
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD 
       660        670        680        690        700
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY 
       710        720        730        740        750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC 
       760        770        780        790        800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET 
       810        820        830        840        850
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI 
       860        870        880        890        900
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 
       910        920        930        940        950
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE 
       960        970        980        990       1000
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV 
      1010       1020       1030       1040       1050
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF 
      1060       1070       1080       1090       1100
LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV 
      1110       1120       1130       1140       1150
RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA 
      1160       1170       1180       1190       1200
SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 
      1210       1220       1230       1240       1250
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC 
      1260       1270       1280       1290       1300
IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW 
      1310       1320       1330       1340       1350
DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI 
      1360       1370       1380       1390       1400
LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL 
      1410       1420       1430 
AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG
Length:1,437
Mass (Da):160,660
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00558076B3BB4C00
GO
Isoform 2 (identifier: O15440-2) [UniParc]FASTAAdd to basket
Also known as: SV1

The sequence of this isoform differs from the canonical sequence as follows:
     198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
     226-1437: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:225
Mass (Da):25,341
Checksum:i771FBD2C32E08B8C
GO
Isoform 3 (identifier: O15440-3) [UniParc]FASTAAdd to basket
Also known as: SV2

The sequence of this isoform differs from the canonical sequence as follows:
     198-212: AFMVKHLLEYTQATE → LAWCCQDLDLGGVSL
     213-225: Missing.
     226-1437: Missing.

Note: Predominant isoform in retinal pigment epithelium, bladder, and stomach.Curated
Show »
Length:212
Mass (Da):23,988
Checksum:iD562C6FBF01922D1
GO
Isoform 4 (identifier: O15440-4) [UniParc]FASTAAdd to basket
Also known as: SV3

The sequence of this isoform differs from the canonical sequence as follows:
     198-208: AFMVKHLLEYT → NFQDGCILRSE
     209-225: Missing.
     226-1437: Missing.

Show »
Length:208
Mass (Da):23,677
Checksum:i3FF375FBCE128270
GO
Isoform 5 (identifier: O15440-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1033-1075: Missing.

Show »
Length:1,394
Mass (Da):155,732
Checksum:i5B11EC10EB9D07C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCY8F8WCY8_HUMAN
Multidrug resistance-associated pro...
ABCC5
473Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A5PKY6A5PKY6_HUMAN
ABCC5 protein
ABCC5
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZL5C9JZL5_HUMAN
Multidrug resistance-associated pro...
ABCC5
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PET4E9PET4_HUMAN
Multidrug resistance-associated pro...
ABCC5
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDH3F8WDH3_HUMAN
Multidrug resistance-associated pro...
ABCC5
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C271H7C271_HUMAN
Multidrug resistance-associated pro...
ABCC5
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176R → P in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti400S → G in AAD04169 (PubMed:9827529).Curated1
Sequence conflicti581I → V in AAD37716 (PubMed:10438534).Curated1
Sequence conflicti1383T → N in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti1383T → N in BAA22887 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043397198 – 225AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_043398198 – 212AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_043399198 – 208AFMVKHLLEYT → NFQDGCILRSE in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_043400209 – 225Missing in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_043401213 – 225Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_043402226 – 1437Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST1212
Alternative sequenceiVSP_0553541033 – 1075Missing in isoform 5. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF104942 mRNA Translation: AAD04169.1
AF146074 mRNA Translation: AAD37716.1
AB019002 mRNA Translation: BAA76608.1
U83661 mRNA Translation: AAB71758.2
AY754874 mRNA Translation: AAW82948.1
AY754875 mRNA Translation: AAW82949.1
AY754876 mRNA Translation: AAW82950.1
AY196484 mRNA Translation: AAO49801.1
AC068644 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78307.1
CH471052 Genomic DNA Translation: EAW78308.1
BC050744 mRNA Translation: AAH50744.1
BC140771 mRNA Translation: AAI40772.1
BC142719 mRNA Translation: AAI42720.1
AB005659 mRNA Translation: BAA22887.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33898.1 [O15440-4]
CCDS43176.1 [O15440-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5667

NCBI Reference Sequences

More...RefSeqi		NP_001018881.1, NM_001023587.2 [O15440-4]
NP_001306961.1, NM_001320032.1
NP_005679.2, NM_005688.3 [O15440-1]
XP_005247115.1, XM_005247058.4 [O15440-1]
XP_005247116.1, XM_005247059.4 [O15440-1]
XP_011510616.1, XM_011512314.1 [O15440-1]
XP_016860982.1, XM_017005493.1 [O15440-4]
XP_016860983.1, XM_017005494.1 [O15440-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265586; ENSP00000265586; ENSG00000114770 [O15440-5]
ENST00000334444; ENSP00000333926; ENSG00000114770 [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770 [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770 [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770 [O15440-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10057

UCSC genome browser

More...UCSCi		uc003fmg.4, human [O15440-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104942 mRNA Translation: AAD04169.1
AF146074 mRNA Translation: AAD37716.1
AB019002 mRNA Translation: BAA76608.1
U83661 mRNA Translation: AAB71758.2
AY754874 mRNA Translation: AAW82948.1
AY754875 mRNA Translation: AAW82949.1
AY754876 mRNA Translation: AAW82950.1
AY196484 mRNA Translation: AAO49801.1
AC068644 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78307.1
CH471052 Genomic DNA Translation: EAW78308.1
BC050744 mRNA Translation: AAH50744.1
BC140771 mRNA Translation: AAI40772.1
BC142719 mRNA Translation: AAI42720.1
AB005659 mRNA Translation: BAA22887.1
CCDSiCCDS33898.1 [O15440-4]
CCDS43176.1 [O15440-1]
PIRiJC5667
RefSeqiNP_001018881.1, NM_001023587.2 [O15440-4]
NP_001306961.1, NM_001320032.1
NP_005679.2, NM_005688.3 [O15440-1]
XP_005247115.1, XM_005247058.4 [O15440-1]
XP_005247116.1, XM_005247059.4 [O15440-1]
XP_011510616.1, XM_011512314.1 [O15440-1]
XP_016860982.1, XM_017005493.1 [O15440-4]
XP_016860983.1, XM_017005494.1 [O15440-4]

3D structure databases

SMRiO15440
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115368, 18 interactors
IntActiO15440, 13 interactors
STRINGi9606.ENSP00000333926

Chemistry databases

BindingDBiO15440
ChEMBLiCHEMBL2046258
DrugBankiDB00718, Adefovir dipivoxil
DB00770, Alprostadil
DB01076, Atorvastatin
DB00515, Cisplatin
DB11672, Curcumin
DB14635, Curcumin sulfate
DB02527, Cyclic adenosine monophosphate
DB00917, Dinoprostone
DB00975, Dipyridamole
DB00544, Fluorouracil
DB00143, Glutathione
DB01033, Mercaptopurine
DB01032, Probenecid
DB01045, Rifampicin
DB00203, Sildenafil
DB01138, Sulfinpyrazone
DB00495, Zidovudine
DrugCentraliO15440
GuidetoPHARMACOLOGYi783

Protein family/group databases

TCDBi3.A.1.208.15, the atp-binding cassette (abc) superfamily

PTM databases

GlyGeniO15440, 8 sites
iPTMnetiO15440
PhosphoSitePlusiO15440

Genetic variation databases

BioMutaiABCC5

Proteomic databases

EPDiO15440
jPOSTiO15440
MassIVEiO15440
MaxQBiO15440
PaxDbiO15440
PeptideAtlasiO15440
PRIDEiO15440
ProteomicsDBi48667 [O15440-1]
48668 [O15440-2]
48669 [O15440-3]
48670 [O15440-4]
69929

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18937, 389 antibodies

Genome annotation databases

EnsembliENST00000265586; ENSP00000265586; ENSG00000114770 [O15440-5]
ENST00000334444; ENSP00000333926; ENSG00000114770 [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770 [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770 [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770 [O15440-3]
GeneIDi10057
KEGGihsa:10057
UCSCiuc003fmg.4, human [O15440-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10057
DisGeNETi10057

GeneCards: human genes, protein and diseases

More...GeneCardsi		ABCC5
HGNCiHGNC:56, ABCC5
HPAiENSG00000114770, Low tissue specificity
MIMi605251, gene
neXtProtiNX_O15440
OpenTargetsiENSG00000114770
PharmGKBiPA395
VEuPathDBiHostDB:ENSG00000114770.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0054, Eukaryota
GeneTreeiENSGT00940000155470
HOGENOMiCLU_000604_27_3_1
InParanoidiO15440
OMAiFVKFFGW
OrthoDBi138195at2759
PhylomeDBiO15440
TreeFamiTF105202

Enzyme and pathway databases

PathwayCommonsiO15440
ReactomeiR-HSA-2142850, Hyaluronan biosynthesis and export
R-HSA-382556, ABC-family proteins mediated transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10057, 6 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABCC5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ABCC5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10057
PharosiO15440, Tchem

Protein Ontology

More...PROi		PR:O15440
RNActiO15440, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114770, Expressed in forebrain and 238 other tissues
ExpressionAtlasiO15440, baseline and differential
GenevisibleiO15440, HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030238, ABCC5
IPR027417, P-loop_NTPase
PANTHERiPTHR24223:SF196, PTHR24223:SF196, 1 hit
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15440
Secondary accession number(s): B9EIQ2
, O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: February 10, 2021
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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