UniProtKB - O15440 (MRP5_HUMAN)
ATP-binding cassette sub-family C member 5
ABCC5
Functioni
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:15899835, PubMed:25964343, PubMed:17229149, PubMed:12695538, PubMed:12637526).
Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061).
Confers resistance to the antiviral agent PMEA (PubMed:12695538).
Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:15899835, PubMed:12435799, PubMed:12695538).
Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561).
May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity).
By similarity10 PublicationsMiscellaneous
Catalytic activityi
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H+ + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H+ + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H+ + N-acetyl-L-glutamate(out) + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H+ + N-acetyl-L-aspartate(out) + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (2S)-2-[5-amino-1-(β-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(β-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H+ + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) = ADP + H+ + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).4 Publications EC:7.6.2.2
Activity regulationi
Kineticsi
- KM=379 µM for cAMP1 Publication
- KM=2.1 µM for cGMP1 Publication
- KM=132 µM for cGMP1 Publication
- KM=1.0 mM for folate1 Publication
- KM=1 mM for N-[(S)-lactoyl]-L-phenylalanine1 Publication
- KM=1.9 mM for ZJ43 (glutamate analog)1 Publication
- KM=3.5 mM for N-acetylaspartylglutamate (NAAG)1 Publication
- KM=1.3 mM for methotrexate1 Publication
- Vmax=780 pmol/min/mg enzyme for methotrexate transport1 Publication
- Vmax=875 pmol/min/mg enzyme for folate transport1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 595 – 602 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1227 – 1234 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type xenobiotic transporter activity Source: UniProtKB
- ATPase-coupled inorganic anion transmembrane transporter activity Source: Reactome
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: ProtInc
- efflux transmembrane transporter activity Source: ARUK-UCL
- glutathione transmembrane transporter activity Source: ARUK-UCL
- heme transmembrane transporter activity Source: UniProtKB
- organic anion transmembrane transporter activity Source: Reactome
- purine nucleotide transmembrane transporter activity Source: ARUK-UCL
- xenobiotic transmembrane transporter activity Source: ARUK-UCL
GO - Biological processi
- cAMP transport Source: UniProtKB
- cGMP transport Source: UniProtKB
- export across plasma membrane Source: ARUK-UCL
- folate transmembrane transport Source: UniProtKB
- glutathione transmembrane transport Source: ARUK-UCL
- heme transmembrane transport Source: UniProtKB
- hyaluronan biosynthetic process Source: Reactome
- purine nucleotide transport Source: ARUK-UCL
- transmembrane transport Source: GO_Central
- transport across blood-brain barrier Source: ARUK-UCL
- xenobiotic transport Source: ARUK-UCL
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 7.6.2.3, 2681 |
PathwayCommonsi | O15440 |
Reactomei | R-HSA-2142850, Hyaluronan biosynthesis and export R-HSA-382556, ABC-family proteins mediated transport |
SignaLinki | O15440 |
Protein family/group databases
TCDBi | 3.A.1.208.15, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ABCC5 Synonyms:MRP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:56, ABCC5 |
MIMi | 605251, gene |
neXtProti | NX_O15440 |
VEuPathDBi | HostDB:ENSG00000114770 |
Subcellular locationi
Endosome
- Endosome membrane 1 Publication
Golgi apparatus
- Golgi apparatus lumen 1 Publication
Plasma membrane
- Basolateral cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- Apical cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- Cytoplasmic granule By similarity
Note: In most cells, routes to the basolateral plasma membrane, but in the brain capillary endothelial cells that form the blood-brain barrier, resides in the apical membrane.2 Publications
Endosome
- endosome membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi lumen Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: ARUK-UCL
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: ARUK-UCL
Other locations
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 179 – 199 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 219 – 239 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 296 – 316 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 317 – 337 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 400 – 420 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 434 – 454 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 608 – 628 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 848 – 868 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 917 – 937 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 997 – 1017 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1018 – 1038 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1104 – 1124 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1127 – 1147 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Endosome, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10057 |
OpenTargetsi | ENSG00000114770 |
PharmGKBi | PA395 |
Miscellaneous databases
Pharosi | O15440, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2046258 |
DrugBanki | DB00718, Adefovir dipivoxil DB00770, Alprostadil DB01076, Atorvastatin DB00515, Cisplatin DB11672, Curcumin DB14635, Curcumin sulfate DB02527, Cyclic adenosine monophosphate DB00917, Dinoprostone DB00975, Dipyridamole DB00544, Fluorouracil DB00143, Glutathione DB08818, Hyaluronic acid DB01033, Mercaptopurine DB01032, Probenecid DB01045, Rifampicin DB00203, Sildenafil DB01138, Sulfinpyrazone DB00495, Zidovudine |
DrugCentrali | O15440 |
GuidetoPHARMACOLOGYi | 783 |
Genetic variation databases
BioMutai | ABCC5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093363 | 1 – 1437 | ATP-binding cassette sub-family C member 5Add BLAST | 1437 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphoserineCombined sources | 1 | |
Modified residuei | 19 | PhosphoserineCombined sources | 1 | |
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 494 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 505 | PhosphoserineCombined sources | 1 | |
Modified residuei | 509 | PhosphoserineCombined sources | 1 | |
Modified residuei | 513 | PhosphothreonineCombined sources | 1 | |
Glycosylationi | 636 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 684 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 890 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 897 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1044 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1329 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | O15440 |
jPOSTi | O15440 |
MassIVEi | O15440 |
MaxQBi | O15440 |
PaxDbi | O15440 |
PeptideAtlasi | O15440 |
PRIDEi | O15440 |
ProteomicsDBi | 48667 [O15440-1] 48668 [O15440-2] 48669 [O15440-3] 48670 [O15440-4] 69929 |
PTM databases
GlyGeni | O15440, 8 sites |
iPTMneti | O15440 |
PhosphoSitePlusi | O15440 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000114770, Expressed in forebrain and 239 other tissues |
ExpressionAtlasi | O15440, baseline and differential |
Genevisiblei | O15440, HS |
Organism-specific databases
HPAi | ENSG00000114770, Tissue enhanced (choroid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115368, 31 interactors |
IntActi | O15440, 15 interactors |
MINTi | O15440 |
STRINGi | 9606.ENSP00000333926 |
Chemistry databases
BindingDBi | O15440 |
Miscellaneous databases
RNActi | O15440, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 179 – 459 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 281 | |
Domaini | 562 – 783 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 222 | |
Domaini | 859 – 1155 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 297 | |
Domaini | 1193 – 1427 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 41 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 501 – 538 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 794 – 827 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 41 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 799 – 827 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000155470 |
HOGENOMi | CLU_000604_27_3_1 |
InParanoidi | O15440 |
OMAi | FVKFFGW |
OrthoDBi | 138195at2759 |
PhylomeDBi | O15440 |
TreeFami | TF105202 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR030238, ABCC5 IPR027417, P-loop_NTPase |
PANTHERi | PTHR24223:SF196, PTHR24223:SF196, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL
60 70 80 90 100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP
110 120 130 140 150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE
160 170 180 190 200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM
210 220 230 240 250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL
260 270 280 290 300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
310 320 330 340 350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA
360 370 380 390 400
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS
410 420 430 440 450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT
460 470 480 490 500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD
510 520 530 540 550
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL
560 570 580 590 600
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG
610 620 630 640 650
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD
660 670 680 690 700
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY
710 720 730 740 750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC
760 770 780 790 800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET
810 820 830 840 850
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI
860 870 880 890 900
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS
910 920 930 940 950
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE
960 970 980 990 1000
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV
1010 1020 1030 1040 1050
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF
1060 1070 1080 1090 1100
LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV
1110 1120 1130 1140 1150
RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA
1160 1170 1180 1190 1200
SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM
1210 1220 1230 1240 1250
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC
1260 1270 1280 1290 1300
IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW
1310 1320 1330 1340 1350
DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI
1360 1370 1380 1390 1400
LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL
1410 1420 1430
AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG
The sequence of this isoform differs from the canonical sequence as follows:
198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
226-1437: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WCY8 | F8WCY8_HUMAN | ATP-binding cassette sub-family C m... | ABCC5 | 473 | Annotation score: | ||
C9JZL5 | C9JZL5_HUMAN | ATP-binding cassette sub-family C m... | ABCC5 | 147 | Annotation score: | ||
A5PKY6 | A5PKY6_HUMAN | ABCC5 protein | ABCC5 | 231 | Annotation score: | ||
E9PET4 | E9PET4_HUMAN | ATP-binding cassette sub-family C m... | ABCC5 | 53 | Annotation score: | ||
F8WDH3 | F8WDH3_HUMAN | ATP-binding cassette sub-family C m... | ABCC5 | 53 | Annotation score: | ||
H7C271 | H7C271_HUMAN | ATP-binding cassette sub-family C m... | ABCC5 | 70 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 176 | R → P in BAA76608 (PubMed:10721709).Curated | 1 | |
Sequence conflicti | 400 | S → G in AAD04169 (PubMed:9827529).Curated | 1 | |
Sequence conflicti | 581 | I → V in AAD37716 (PubMed:10438534).Curated | 1 | |
Sequence conflicti | 1383 | T → N in BAA76608 (PubMed:10721709).Curated | 1 | |
Sequence conflicti | 1383 | T → N in BAA22887 (Ref. 8) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043397 | 198 – 225 | AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2. 2 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_043398 | 198 – 212 | AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_043399 | 198 – 208 | AFMVKHLLEYT → NFQDGCILRSE in isoform 4. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_043400 | 209 – 225 | Missing in isoform 4. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_043401 | 213 – 225 | Missing in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_043402 | 226 – 1437 | Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 1212 | |
Alternative sequenceiVSP_055354 | 1033 – 1075 | Missing in isoform 5. 1 PublicationAdd BLAST | 43 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000265586.10; ENSP00000265586.6; ENSG00000114770.17 [O15440-5] ENST00000334444.11; ENSP00000333926.6; ENSG00000114770.17 ENST00000382494.6; ENSP00000371934.2; ENSG00000114770.17 [O15440-4] ENST00000392579.6; ENSP00000376358.2; ENSG00000114770.17 [O15440-2] ENST00000443376.5; ENSP00000416840.1; ENSG00000114770.17 [O15440-3] |
GeneIDi | 10057 |
KEGGi | hsa:10057 |
MANE-Selecti | ENST00000334444.11; ENSP00000333926.6; NM_005688.4; NP_005679.2 |
UCSCi | uc003fmg.4, human [O15440-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
ABCMdb Database for mutations in ABC proteins |
Sequence databases
3D structure databases
AlphaFoldDBi | O15440 |
SMRi | O15440 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115368, 31 interactors |
IntActi | O15440, 15 interactors |
MINTi | O15440 |
STRINGi | 9606.ENSP00000333926 |
Chemistry databases
BindingDBi | O15440 |
ChEMBLi | CHEMBL2046258 |
DrugBanki | DB00718, Adefovir dipivoxil DB00770, Alprostadil DB01076, Atorvastatin DB00515, Cisplatin DB11672, Curcumin DB14635, Curcumin sulfate DB02527, Cyclic adenosine monophosphate DB00917, Dinoprostone DB00975, Dipyridamole DB00544, Fluorouracil DB00143, Glutathione DB08818, Hyaluronic acid DB01033, Mercaptopurine DB01032, Probenecid DB01045, Rifampicin DB00203, Sildenafil DB01138, Sulfinpyrazone DB00495, Zidovudine |
DrugCentrali | O15440 |
GuidetoPHARMACOLOGYi | 783 |
Protein family/group databases
TCDBi | 3.A.1.208.15, the atp-binding cassette (abc) superfamily |
PTM databases
GlyGeni | O15440, 8 sites |
iPTMneti | O15440 |
PhosphoSitePlusi | O15440 |
Genetic variation databases
BioMutai | ABCC5 |
Proteomic databases
EPDi | O15440 |
jPOSTi | O15440 |
MassIVEi | O15440 |
MaxQBi | O15440 |
PaxDbi | O15440 |
PeptideAtlasi | O15440 |
PRIDEi | O15440 |
ProteomicsDBi | 48667 [O15440-1] 48668 [O15440-2] 48669 [O15440-3] 48670 [O15440-4] 69929 |
Protocols and materials databases
Antibodypediai | 18937, 407 antibodies from 38 providers |
DNASUi | 10057 |
Genome annotation databases
Ensembli | ENST00000265586.10; ENSP00000265586.6; ENSG00000114770.17 [O15440-5] ENST00000334444.11; ENSP00000333926.6; ENSG00000114770.17 ENST00000382494.6; ENSP00000371934.2; ENSG00000114770.17 [O15440-4] ENST00000392579.6; ENSP00000376358.2; ENSG00000114770.17 [O15440-2] ENST00000443376.5; ENSP00000416840.1; ENSG00000114770.17 [O15440-3] |
GeneIDi | 10057 |
KEGGi | hsa:10057 |
MANE-Selecti | ENST00000334444.11; ENSP00000333926.6; NM_005688.4; NP_005679.2 |
UCSCi | uc003fmg.4, human [O15440-1] |
Organism-specific databases
CTDi | 10057 |
DisGeNETi | 10057 |
GeneCardsi | ABCC5 |
HGNCi | HGNC:56, ABCC5 |
HPAi | ENSG00000114770, Tissue enhanced (choroid) |
MIMi | 605251, gene |
neXtProti | NX_O15440 |
OpenTargetsi | ENSG00000114770 |
PharmGKBi | PA395 |
VEuPathDBi | HostDB:ENSG00000114770 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000155470 |
HOGENOMi | CLU_000604_27_3_1 |
InParanoidi | O15440 |
OMAi | FVKFFGW |
OrthoDBi | 138195at2759 |
PhylomeDBi | O15440 |
TreeFami | TF105202 |
Enzyme and pathway databases
BRENDAi | 7.6.2.3, 2681 |
PathwayCommonsi | O15440 |
Reactomei | R-HSA-2142850, Hyaluronan biosynthesis and export R-HSA-382556, ABC-family proteins mediated transport |
SignaLinki | O15440 |
Miscellaneous databases
BioGRID-ORCSi | 10057, 9 hits in 1077 CRISPR screens |
ChiTaRSi | ABCC5, human |
GeneWikii | ABCC5 |
GenomeRNAii | 10057 |
Pharosi | O15440, Tchem |
PROi | PR:O15440 |
RNActi | O15440, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114770, Expressed in forebrain and 239 other tissues |
ExpressionAtlasi | O15440, baseline and differential |
Genevisiblei | O15440, HS |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR030238, ABCC5 IPR027417, P-loop_NTPase |
PANTHERi | PTHR24223:SF196, PTHR24223:SF196, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MRP5_HUMAN | |
Accessioni | O15440Primary (citable) accession number: O15440 Secondary accession number(s): B9EIQ2 Q9UQC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | December 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families