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Entry version 193 (16 Oct 2019)
Sequence version 3 (23 Sep 2008)
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Protein

Multidrug resistance-associated protein 4

Gene

ABCC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be an organic anion pump relevant to cellular detoxification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi445 – 452ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1075 – 1082ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-382556 ABC-family proteins mediated transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.7 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 4
Alternative name(s):
ATP-binding cassette sub-family C member 4
MRP/cMOAT-related ABC transporter
Multi-specific organic anion transporter B
Short name:
MOAT-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC4
Synonyms:MRP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:55 ABCC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605250 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15439

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei93 – 113HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei136 – 156HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei207 – 227HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei228 – 248HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei328 – 348HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei351 – 371HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei440 – 460HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei710 – 730HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei771 – 791HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei836 – 856HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei858 – 878HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei954 – 974HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei977 – 997HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1038 – 1058HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10257

Open Targets

More...
OpenTargetsi
ENSG00000125257

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA397

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O15439

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743128

Drug and drug target database

More...
DrugBanki
DB00718 Adefovir dipivoxil
DB00770 Alprostadil
DB01076 Atorvastatin
DB00171 ATP
DB01327 Cefazolin
DB00482 Celecoxib
DB02659 Cholic Acid
DB00286 Conjugated estrogens
DB02527 Cyclic adenosine monophosphate
DB09213 Dexibuprofen
DB00586 Diclofenac
DB00917 Dinoprostone
DB00975 Dipyridamole
DB13146 Fluciclovine (18F)
DB00544 Fluorouracil
DB00712 Flurbiprofen
DB00158 Folic acid
DB08884 Gadoxetic acid
DB00143 Glutathione
DB01050 Ibuprofen
DB00328 Indometacin
DB01009 Ketoprofen
DB00709 Lamivudine
DB00814 Meloxicam
DB01033 Mercaptopurine
DB00563 Methotrexate
DB00731 Nateglinide
DB00198 Oseltamivir
DB01032 Probenecid
DB00481 Raloxifene
DB00533 Rofecoxib
DB01098 Rosuvastatin
DB12332 Rucaparib
DB00203 Sildenafil
DB00398 Sorafenib
DB01138 Sulfinpyrazone
DB01268 Sunitinib
DB04348 Taurocholic Acid
DB14126 Tenofovir
DB09299 Tenofovir alafenamide
DB00300 Tenofovir disoproxil
DB00352 Tioguanine
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
DB00495 Zidovudine

DrugCentral

More...
DrugCentrali
O15439

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
782

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCC4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933621 – 1325Multidrug resistance-associated protein 4Add BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei646PhosphothreonineCombined sources1
Modified residuei648PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei664PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Glycosylationi690N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1309N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15439

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15439

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O15439

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15439

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15439

PeptideAtlas

More...
PeptideAtlasi
O15439

PRoteomics IDEntifications database

More...
PRIDEi
O15439

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
48664 [O15439-1]
48665 [O15439-2]
48666 [O15439-3]
6540

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15439

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15439

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O15439

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125257 Expressed in 184 organ(s), highest expression level in caput epididymis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15439 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15439 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002476

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MPP1Q0001310EBI-4319622,EBI-711788

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115551, 27 interactors

Protein interaction database and analysis system

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IntActi
O15439, 17 interactors

Molecular INTeraction database

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MINTi
O15439

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366084

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15439

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15439

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 377ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST286
Domaini410 – 633ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini714 – 1005ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST292
Domaini1041 – 1274ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1322 – 1325PDZ-binding4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153931

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15439

KEGG Orthology (KO)

More...
KOi
K05673

Identification of Orthologs from Complete Genome Data

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OMAi
MRVVKYF

Database of Orthologous Groups

More...
OrthoDBi
926074at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15439

TreeFam database of animal gene trees

More...
TreeFami
TF105202

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030240 ABCC4
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24223:SF393 PTHR24223:SF393, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE
60 70 80 90 100
DRSQHLGEEL QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL
110 120 130 140 150
IEESAKVIQP IFLGKIINYF ENYDPMDSVA LNTAYAYATV LTFCTLILAI
160 170 180 190 200
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNMAMGKTT TGQIVNLLSN
210 220 230 240 250
DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG MAVLIILLPL
260 270 280 290 300
QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT
310 320 330 340 350
NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR
360 370 380 390 400
VFVAVTLYGA VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR
410 420 430 440 450
QLPSDGKKMV HVQDFTAFWD KASETPTLQG LSFTVRPGEL LAVVGPVGAG
460 470 480 490 500
KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ QPWVFSGTLR SNILFGKKYE
510 520 530 540 550
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK ARVNLARAVY
560 570 580 590 600
QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA
610 620 630 640 650
SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR
660 670 680 690 700
NRTFSESSVW SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA
710 720 730 740 750
YKNYFRAGAH WIVFIFLILL NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN
760 770 780 790 800
GGGNVTEKLD LNWYLGIYSG LTVATVLFGI ARSLLVFYVL VNSSQTLHNK
810 820 830 840 850
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF LDFIQTLLQV
860 870 880 890 900
VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV
910 920 930 940 950
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV
960 970 980 990 1000
RLDAICAMFV IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS
1010 1020 1030 1040 1050
AEVENMMISV ERVIEYTDLE KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY
1060 1070 1080 1090 1100
SPGGPLVLKH LTALIKSQEK VGIVGRTGAG KSSLISALFR LSEPEGKIWI
1110 1120 1130 1140 1150
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWNAL
1160 1170 1180 1190 1200
QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII
1210 1220 1230 1240 1250
DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG
1260 1270 1280 1290 1300
RLKEYDEPYV LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI
1310 1320
GHTDHMVTNT SNGQPSTLTI FETAL
Length:1,325
Mass (Da):149,527
Last modified:September 23, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF2D53136B78C0BA
GO
Isoform 2 (identifier: O15439-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     679-725: Missing.

Show »
Length:1,278
Mass (Da):144,201
Checksum:i1B51AE7536A136E8
GO
Isoform 3 (identifier: O15439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):96,841
Checksum:iA254809A2F5CE133
GO
Isoform 4 (identifier: O15439-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-177: Missing.
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.
Show »
Length:784
Mass (Da):88,138
Checksum:i2835B9C2A12E164D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YDC1A0A2R8YDC1_HUMAN
Multidrug resistance-associated pro...
ABCC4
669Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6V8A0A2R8Y6V8_HUMAN
Multidrug resistance-associated pro...
ABCC4
800Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IWU1Q8IWU1_HUMAN
ATP-binding cassette subfamily C me...
ABCC4 hCG_2039665
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDG7A0A2R8YDG7_HUMAN
Multidrug resistance-associated pro...
ABCC4
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5Z3A0A2R8Y5Z3_HUMAN
Multidrug resistance-associated pro...
ABCC4
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti703N → S in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti757E → G in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti893E → G in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti1139N → K in AAC27076 (PubMed:9661885).Curated1
Sequence conflicti1302H → D in AAB71757 (PubMed:9270026).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04644518L → I2 PublicationsCorresponds to variant dbSNP:rs11568681Ensembl.1
Natural variantiVAR_02912178P → A. Corresponds to variant dbSNP:rs11568689Ensembl.1
Natural variantiVAR_046446171C → G. Corresponds to variant dbSNP:rs4148460Ensembl.1
Natural variantiVAR_020241184M → T. Corresponds to variant dbSNP:rs45454092Ensembl.1
Natural variantiVAR_020242187G → W Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568658Ensembl.1
Natural variantiVAR_046447293K → E. Corresponds to variant dbSNP:rs11568684Ensembl.1
Natural variantiVAR_022072304K → N Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs2274407Ensembl.1
Natural variantiVAR_046448356T → M. Corresponds to variant dbSNP:rs11568701Ensembl.1
Natural variantiVAR_029122403P → L. Corresponds to variant dbSNP:rs11568705Ensembl.1
Natural variantiVAR_029123487G → E Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568668Ensembl.1
Natural variantiVAR_020243498K → E. Corresponds to variant dbSNP:rs11568669Ensembl.1
Natural variantiVAR_045684556Y → C 40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type. 1 PublicationCorresponds to variant dbSNP:rs753414892Ensembl.1
Natural variantiVAR_029124625I → M. Corresponds to variant dbSNP:rs11568699Ensembl.1
Natural variantiVAR_029125667P → L. Corresponds to variant dbSNP:rs11568697Ensembl.1
Natural variantiVAR_020244744M → V. Corresponds to variant dbSNP:rs9282570Ensembl.1
Natural variantiVAR_022073757E → K 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs3765534Ensembl.1
Natural variantiVAR_045685776V → I 20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type. 1 PublicationCorresponds to variant dbSNP:rs146708960Ensembl.1
Natural variantiVAR_045686820R → I Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568659Ensembl.1
Natural variantiVAR_045687854V → F Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568694Ensembl.1
Natural variantiVAR_020245860V → M. Corresponds to variant dbSNP:rs45477596Ensembl.1
Natural variantiVAR_045688866I → V Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs139970608Ensembl.1
Natural variantiVAR_020246900V → L. Corresponds to variant dbSNP:rs45504892Ensembl.1
Natural variantiVAR_0291261142T → M 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568644Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057413103 – 177Missing in isoform 4. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_035426679 – 725Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_043283846 – 859TLLQV…SVAVA → RWDLAVLSWLVSNS in isoform 3 and isoform 4. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_043284860 – 1325Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST466

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF071202 mRNA Translation: AAC27076.1
AY081219 mRNA Translation: AAL88745.1
AY207008 mRNA Translation: AAO37649.1
AF541977 mRNA Translation: AAN17334.1
AK296247 mRNA Translation: BAH12293.1
AL139381 Genomic DNA No translation available.
AL157818 Genomic DNA No translation available.
AL356257 Genomic DNA No translation available.
AL359750 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08951.1
CH471085 Genomic DNA Translation: EAX08950.1
BC041560 mRNA Translation: AAH41560.1
U83660 mRNA Translation: AAB71757.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45061.1 [O15439-3]
CCDS76643.1 [O15439-4]
CCDS86356.1 [O15439-2]
CCDS9474.1 [O15439-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001098985.1, NM_001105515.2 [O15439-3]
NP_001288758.1, NM_001301829.1 [O15439-2]
NP_001288759.1, NM_001301830.1 [O15439-4]
NP_005836.2, NM_005845.4 [O15439-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000536256; ENSP00000442024; ENSG00000125257 [O15439-4]
ENST00000629385; ENSP00000487081; ENSG00000125257 [O15439-3]
ENST00000645237; ENSP00000494609; ENSG00000125257 [O15439-1]
ENST00000646439; ENSP00000494751; ENSG00000125257 [O15439-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10257

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10257

UCSC genome browser

More...
UCSCi
uc001vmd.5 human [O15439-1]
uc010tih.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071202 mRNA Translation: AAC27076.1
AY081219 mRNA Translation: AAL88745.1
AY207008 mRNA Translation: AAO37649.1
AF541977 mRNA Translation: AAN17334.1
AK296247 mRNA Translation: BAH12293.1
AL139381 Genomic DNA No translation available.
AL157818 Genomic DNA No translation available.
AL356257 Genomic DNA No translation available.
AL359750 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08951.1
CH471085 Genomic DNA Translation: EAX08950.1
BC041560 mRNA Translation: AAH41560.1
U83660 mRNA Translation: AAB71757.1
CCDSiCCDS45061.1 [O15439-3]
CCDS76643.1 [O15439-4]
CCDS86356.1 [O15439-2]
CCDS9474.1 [O15439-1]
RefSeqiNP_001098985.1, NM_001105515.2 [O15439-3]
NP_001288758.1, NM_001301829.1 [O15439-2]
NP_001288759.1, NM_001301830.1 [O15439-4]
NP_005836.2, NM_005845.4 [O15439-1]

3D structure databases

SMRiO15439
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115551, 27 interactors
IntActiO15439, 17 interactors
MINTiO15439
STRINGi9606.ENSP00000366084

Chemistry databases

BindingDBiO15439
ChEMBLiCHEMBL1743128
DrugBankiDB00718 Adefovir dipivoxil
DB00770 Alprostadil
DB01076 Atorvastatin
DB00171 ATP
DB01327 Cefazolin
DB00482 Celecoxib
DB02659 Cholic Acid
DB00286 Conjugated estrogens
DB02527 Cyclic adenosine monophosphate
DB09213 Dexibuprofen
DB00586 Diclofenac
DB00917 Dinoprostone
DB00975 Dipyridamole
DB13146 Fluciclovine (18F)
DB00544 Fluorouracil
DB00712 Flurbiprofen
DB00158 Folic acid
DB08884 Gadoxetic acid
DB00143 Glutathione
DB01050 Ibuprofen
DB00328 Indometacin
DB01009 Ketoprofen
DB00709 Lamivudine
DB00814 Meloxicam
DB01033 Mercaptopurine
DB00563 Methotrexate
DB00731 Nateglinide
DB00198 Oseltamivir
DB01032 Probenecid
DB00481 Raloxifene
DB00533 Rofecoxib
DB01098 Rosuvastatin
DB12332 Rucaparib
DB00203 Sildenafil
DB00398 Sorafenib
DB01138 Sulfinpyrazone
DB01268 Sunitinib
DB04348 Taurocholic Acid
DB14126 Tenofovir
DB09299 Tenofovir alafenamide
DB00300 Tenofovir disoproxil
DB00352 Tioguanine
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
DB00495 Zidovudine
DrugCentraliO15439
GuidetoPHARMACOLOGYi782

Protein family/group databases

TCDBi3.A.1.208.7 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiO15439
PhosphoSitePlusiO15439
SwissPalmiO15439

Polymorphism and mutation databases

BioMutaiABCC4

Proteomic databases

EPDiO15439
jPOSTiO15439
MassIVEiO15439
MaxQBiO15439
PaxDbiO15439
PeptideAtlasiO15439
PRIDEiO15439
ProteomicsDBi48664 [O15439-1]
48665 [O15439-2]
48666 [O15439-3]
6540

Genome annotation databases

EnsembliENST00000536256; ENSP00000442024; ENSG00000125257 [O15439-4]
ENST00000629385; ENSP00000487081; ENSG00000125257 [O15439-3]
ENST00000645237; ENSP00000494609; ENSG00000125257 [O15439-1]
ENST00000646439; ENSP00000494751; ENSG00000125257 [O15439-2]
GeneIDi10257
KEGGihsa:10257
UCSCiuc001vmd.5 human [O15439-1]
uc010tih.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10257
DisGeNETi10257

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCC4
HGNCiHGNC:55 ABCC4
HPAiHPA002476
MIMi605250 gene
neXtProtiNX_O15439
OpenTargetsiENSG00000125257
PharmGKBiPA397

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000153931
InParanoidiO15439
KOiK05673
OMAiMRVVKYF
OrthoDBi926074at2759
PhylomeDBiO15439
TreeFamiTF105202

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-382556 ABC-family proteins mediated transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCC4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10257
PharosiO15439

Protein Ontology

More...
PROi
PR:O15439

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125257 Expressed in 184 organ(s), highest expression level in caput epididymis
ExpressionAtlasiO15439 baseline and differential
GenevisibleiO15439 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030240 ABCC4
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF393 PTHR24223:SF393, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15439
Secondary accession number(s): A9Z1Z7
, B7Z3Q7, Q8IVZ4, Q8IZN6, Q8NEW8, Q9Y6J2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: October 16, 2019
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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