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Protein

Multidrug resistance-associated protein 4

Gene

ABCC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be an organic anion pump relevant to cellular detoxification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi445 – 452ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1075 – 1082ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-382556 ABC-family proteins mediated transport

Protein family/group databases

TCDBi3.A.1.208.7 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 4
Alternative name(s):
ATP-binding cassette sub-family C member 4
MRP/cMOAT-related ABC transporter
Multi-specific organic anion transporter B
Short name:
MOAT-B
Gene namesi
Name:ABCC4
Synonyms:MRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000125257.13
HGNCiHGNC:55 ABCC4
MIMi605250 gene
neXtProtiNX_O15439

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 113HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei136 – 156HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei207 – 227HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei228 – 248HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei328 – 348HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei351 – 371HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei440 – 460HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei710 – 730HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei771 – 791HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei836 – 856HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei858 – 878HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei954 – 974HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei977 – 997HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1038 – 1058HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10257
OpenTargetsiENSG00000125257
PharmGKBiPA397

Chemistry databases

ChEMBLiCHEMBL1743128
DrugBankiDB00718 Adefovir Dipivoxil
DB00770 Alprostadil
DB01076 Atorvastatin
DB01327 Cefazolin
DB00482 Celecoxib
DB02659 Cholic Acid
DB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB00586 Diclofenac
DB00917 Dinoprostone
DB00975 Dipyridamole
DB00544 Fluorouracil
DB00712 Flurbiprofen
DB00158 Folic Acid
DB08884 Gadoxetic acid
DB00143 Glutathione
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB00709 Lamivudine
DB00814 Meloxicam
DB01033 Mercaptopurine
DB00563 Methotrexate
DB00731 Nateglinide
DB00198 Oseltamivir
DB01032 Probenecid
DB00533 Rofecoxib
DB01098 Rosuvastatin
DB00203 Sildenafil
DB00398 Sorafenib
DB01138 Sulfinpyrazone
DB01268 Sunitinib
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00352 Tioguanine
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
DB00495 Zidovudine
GuidetoPHARMACOLOGYi782

Polymorphism and mutation databases

BioMutaiABCC4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933621 – 1325Multidrug resistance-associated protein 4Add BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei646PhosphothreonineCombined sources1
Modified residuei648PhosphothreonineCombined sources1
Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei664PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Glycosylationi690N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1309N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO15439
MaxQBiO15439
PaxDbiO15439
PeptideAtlasiO15439
PRIDEiO15439
ProteomicsDBi48664
48665 [O15439-2]
48666 [O15439-3]

PTM databases

iPTMnetiO15439
PhosphoSitePlusiO15439
SwissPalmiO15439

Expressioni

Tissue specificityi

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Gene expression databases

BgeeiENSG00000125257 Expressed in 184 organ(s), highest expression level in caput epididymis
CleanExiHS_ABCC4
ExpressionAtlasiO15439 baseline and differential
GenevisibleiO15439 HS

Organism-specific databases

HPAiHPA002476

Interactioni

Subunit structurei

Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).1 Publication

Protein-protein interaction databases

BioGridi115551, 25 interactors
IntActiO15439, 6 interactors
MINTiO15439
STRINGi9606.ENSP00000366084

Chemistry databases

BindingDBiO15439

Structurei

3D structure databases

ProteinModelPortaliO15439
SMRiO15439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 377ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST286
Domaini410 – 633ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini714 – 1005ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST292
Domaini1041 – 1274ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1322 – 1325PDZ-binding4

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00880000137856
HOVERGENiHBG108314
InParanoidiO15439
KOiK05673
OMAiIFYKMVQ
OrthoDBiEOG091G00IN
PhylomeDBiO15439
TreeFamiTF105202

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030240 ABCC4
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF237 PTHR24223:SF237, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE
60 70 80 90 100
DRSQHLGEEL QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL
110 120 130 140 150
IEESAKVIQP IFLGKIINYF ENYDPMDSVA LNTAYAYATV LTFCTLILAI
160 170 180 190 200
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNMAMGKTT TGQIVNLLSN
210 220 230 240 250
DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG MAVLIILLPL
260 270 280 290 300
QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT
310 320 330 340 350
NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR
360 370 380 390 400
VFVAVTLYGA VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR
410 420 430 440 450
QLPSDGKKMV HVQDFTAFWD KASETPTLQG LSFTVRPGEL LAVVGPVGAG
460 470 480 490 500
KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ QPWVFSGTLR SNILFGKKYE
510 520 530 540 550
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK ARVNLARAVY
560 570 580 590 600
QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA
610 620 630 640 650
SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR
660 670 680 690 700
NRTFSESSVW SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA
710 720 730 740 750
YKNYFRAGAH WIVFIFLILL NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN
760 770 780 790 800
GGGNVTEKLD LNWYLGIYSG LTVATVLFGI ARSLLVFYVL VNSSQTLHNK
810 820 830 840 850
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF LDFIQTLLQV
860 870 880 890 900
VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV
910 920 930 940 950
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV
960 970 980 990 1000
RLDAICAMFV IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS
1010 1020 1030 1040 1050
AEVENMMISV ERVIEYTDLE KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY
1060 1070 1080 1090 1100
SPGGPLVLKH LTALIKSQEK VGIVGRTGAG KSSLISALFR LSEPEGKIWI
1110 1120 1130 1140 1150
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWNAL
1160 1170 1180 1190 1200
QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII
1210 1220 1230 1240 1250
DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG
1260 1270 1280 1290 1300
RLKEYDEPYV LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI
1310 1320
GHTDHMVTNT SNGQPSTLTI FETAL
Length:1,325
Mass (Da):149,527
Last modified:September 23, 2008 - v3
Checksum:iBF2D53136B78C0BA
GO
Isoform 2 (identifier: O15439-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     679-725: Missing.

Show »
Length:1,278
Mass (Da):144,201
Checksum:i1B51AE7536A136E8
GO
Isoform 3 (identifier: O15439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):96,841
Checksum:iA254809A2F5CE133
GO
Isoform 4 (identifier: O15439-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-177: Missing.
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.
Show »
Length:784
Mass (Da):88,138
Checksum:i2835B9C2A12E164D
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6V8A0A2R8Y6V8_HUMAN
Multidrug resistance-associated pro...
ABCC4
800Annotation score:
A0A2R8YDC1A0A2R8YDC1_HUMAN
Multidrug resistance-associated pro...
ABCC4
669Annotation score:
Q8IWU1Q8IWU1_HUMAN
ATP-binding cassette subfamily C me...
ABCC4 hCG_2039665
39Annotation score:
A0A2R8YDG7A0A2R8YDG7_HUMAN
Multidrug resistance-associated pro...
ABCC4
52Annotation score:
A0A2R8Y5Z3A0A2R8Y5Z3_HUMAN
Multidrug resistance-associated pro...
ABCC4
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti703N → S in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti757E → G in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti893E → G in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti1139N → K in AAC27076 (PubMed:9661885).Curated1
Sequence conflicti1302H → D in AAB71757 (PubMed:9270026).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04644518L → I2 PublicationsCorresponds to variant dbSNP:rs11568681Ensembl.1
Natural variantiVAR_02912178P → A. Corresponds to variant dbSNP:rs11568689Ensembl.1
Natural variantiVAR_046446171C → G. Corresponds to variant dbSNP:rs4148460Ensembl.1
Natural variantiVAR_020241184M → T. Corresponds to variant dbSNP:rs45454092Ensembl.1
Natural variantiVAR_020242187G → W Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568658Ensembl.1
Natural variantiVAR_046447293K → E. Corresponds to variant dbSNP:rs11568684Ensembl.1
Natural variantiVAR_022072304K → N Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs2274407Ensembl.1
Natural variantiVAR_046448356T → M. Corresponds to variant dbSNP:rs11568701Ensembl.1
Natural variantiVAR_029122403P → L. Corresponds to variant dbSNP:rs11568705Ensembl.1
Natural variantiVAR_029123487G → E Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568668Ensembl.1
Natural variantiVAR_020243498K → E. Corresponds to variant dbSNP:rs11568669Ensembl.1
Natural variantiVAR_045684556Y → C 40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type. 1 PublicationCorresponds to variant dbSNP:rs753414892Ensembl.1
Natural variantiVAR_029124625I → M. Corresponds to variant dbSNP:rs11568699Ensembl.1
Natural variantiVAR_029125667P → L. Corresponds to variant dbSNP:rs11568697Ensembl.1
Natural variantiVAR_020244744M → V. Corresponds to variant dbSNP:rs9282570Ensembl.1
Natural variantiVAR_022073757E → K 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs3765534Ensembl.1
Natural variantiVAR_045685776V → I 20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type. 1 PublicationCorresponds to variant dbSNP:rs146708960Ensembl.1
Natural variantiVAR_045686820R → I Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568659Ensembl.1
Natural variantiVAR_045687854V → F Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568694Ensembl.1
Natural variantiVAR_020245860V → M. Corresponds to variant dbSNP:rs45477596Ensembl.1
Natural variantiVAR_045688866I → V Transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs139970608Ensembl.1
Natural variantiVAR_020246900V → L. Corresponds to variant dbSNP:rs45504892Ensembl.1
Natural variantiVAR_0291261142T → M 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 1 PublicationCorresponds to variant dbSNP:rs11568644Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057413103 – 177Missing in isoform 4. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_035426679 – 725Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_043283846 – 859TLLQV…SVAVA → RWDLAVLSWLVSNS in isoform 3 and isoform 4. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_043284860 – 1325Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST466

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071202 mRNA Translation: AAC27076.1
AY081219 mRNA Translation: AAL88745.1
AY207008 mRNA Translation: AAO37649.1
AF541977 mRNA Translation: AAN17334.1
AK296247 mRNA Translation: BAH12293.1
AL139381 Genomic DNA No translation available.
AL157818 Genomic DNA No translation available.
AL356257 Genomic DNA No translation available.
AL359750 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08951.1
CH471085 Genomic DNA Translation: EAX08950.1
BC041560 mRNA Translation: AAH41560.1
U83660 mRNA Translation: AAB71757.1
CCDSiCCDS45061.1 [O15439-3]
CCDS76643.1 [O15439-4]
CCDS86356.1 [O15439-2]
CCDS9474.1 [O15439-1]
RefSeqiNP_001098985.1, NM_001105515.2 [O15439-3]
NP_001288758.1, NM_001301829.1 [O15439-2]
NP_001288759.1, NM_001301830.1 [O15439-4]
NP_005836.2, NM_005845.4 [O15439-1]
UniGeneiHs.508423

Genome annotation databases

EnsembliENST00000376887; ENSP00000366084; ENSG00000125257 [O15439-1]
ENST00000536256; ENSP00000442024; ENSG00000125257 [O15439-4]
ENST00000629385; ENSP00000487081; ENSG00000125257 [O15439-3]
ENST00000645237; ENSP00000494609; ENSG00000125257 [O15439-1]
ENST00000646439; ENSP00000494751; ENSG00000125257 [O15439-2]
GeneIDi10257
KEGGihsa:10257
UCSCiuc001vmd.5 human [O15439-1]
uc010tih.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071202 mRNA Translation: AAC27076.1
AY081219 mRNA Translation: AAL88745.1
AY207008 mRNA Translation: AAO37649.1
AF541977 mRNA Translation: AAN17334.1
AK296247 mRNA Translation: BAH12293.1
AL139381 Genomic DNA No translation available.
AL157818 Genomic DNA No translation available.
AL356257 Genomic DNA No translation available.
AL359750 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08951.1
CH471085 Genomic DNA Translation: EAX08950.1
BC041560 mRNA Translation: AAH41560.1
U83660 mRNA Translation: AAB71757.1
CCDSiCCDS45061.1 [O15439-3]
CCDS76643.1 [O15439-4]
CCDS86356.1 [O15439-2]
CCDS9474.1 [O15439-1]
RefSeqiNP_001098985.1, NM_001105515.2 [O15439-3]
NP_001288758.1, NM_001301829.1 [O15439-2]
NP_001288759.1, NM_001301830.1 [O15439-4]
NP_005836.2, NM_005845.4 [O15439-1]
UniGeneiHs.508423

3D structure databases

ProteinModelPortaliO15439
SMRiO15439
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115551, 25 interactors
IntActiO15439, 6 interactors
MINTiO15439
STRINGi9606.ENSP00000366084

Chemistry databases

BindingDBiO15439
ChEMBLiCHEMBL1743128
DrugBankiDB00718 Adefovir Dipivoxil
DB00770 Alprostadil
DB01076 Atorvastatin
DB01327 Cefazolin
DB00482 Celecoxib
DB02659 Cholic Acid
DB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB00586 Diclofenac
DB00917 Dinoprostone
DB00975 Dipyridamole
DB00544 Fluorouracil
DB00712 Flurbiprofen
DB00158 Folic Acid
DB08884 Gadoxetic acid
DB00143 Glutathione
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB00709 Lamivudine
DB00814 Meloxicam
DB01033 Mercaptopurine
DB00563 Methotrexate
DB00731 Nateglinide
DB00198 Oseltamivir
DB01032 Probenecid
DB00533 Rofecoxib
DB01098 Rosuvastatin
DB00203 Sildenafil
DB00398 Sorafenib
DB01138 Sulfinpyrazone
DB01268 Sunitinib
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00352 Tioguanine
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
DB00495 Zidovudine
GuidetoPHARMACOLOGYi782

Protein family/group databases

TCDBi3.A.1.208.7 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiO15439
PhosphoSitePlusiO15439
SwissPalmiO15439

Polymorphism and mutation databases

BioMutaiABCC4

Proteomic databases

EPDiO15439
MaxQBiO15439
PaxDbiO15439
PeptideAtlasiO15439
PRIDEiO15439
ProteomicsDBi48664
48665 [O15439-2]
48666 [O15439-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376887; ENSP00000366084; ENSG00000125257 [O15439-1]
ENST00000536256; ENSP00000442024; ENSG00000125257 [O15439-4]
ENST00000629385; ENSP00000487081; ENSG00000125257 [O15439-3]
ENST00000645237; ENSP00000494609; ENSG00000125257 [O15439-1]
ENST00000646439; ENSP00000494751; ENSG00000125257 [O15439-2]
GeneIDi10257
KEGGihsa:10257
UCSCiuc001vmd.5 human [O15439-1]
uc010tih.2 human

Organism-specific databases

CTDi10257
DisGeNETi10257
EuPathDBiHostDB:ENSG00000125257.13
GeneCardsiABCC4
HGNCiHGNC:55 ABCC4
HPAiHPA002476
MIMi605250 gene
neXtProtiNX_O15439
OpenTargetsiENSG00000125257
PharmGKBiPA397
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00880000137856
HOVERGENiHBG108314
InParanoidiO15439
KOiK05673
OMAiIFYKMVQ
OrthoDBiEOG091G00IN
PhylomeDBiO15439
TreeFamiTF105202

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-382556 ABC-family proteins mediated transport

Miscellaneous databases

ChiTaRSiABCC4 human
GeneWikiiABCC4
GenomeRNAii10257
PROiPR:O15439
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125257 Expressed in 184 organ(s), highest expression level in caput epididymis
CleanExiHS_ABCC4
ExpressionAtlasiO15439 baseline and differential
GenevisibleiO15439 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030240 ABCC4
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF237 PTHR24223:SF237, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMRP4_HUMAN
AccessioniPrimary (citable) accession number: O15439
Secondary accession number(s): A9Z1Z7
, B7Z3Q7, Q8IVZ4, Q8IZN6, Q8NEW8, Q9Y6J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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