UniProtKB - O15432 (COPT2_HUMAN)
Protein
Probable low affinity copper uptake protein 2
Gene
SLC31A2
Organism
Homo sapiens (Human)
Status
Functioni
Involved in low-affinity copper uptake.Curated
GO - Molecular functioni
- copper ion transmembrane transporter activity Source: ProtInc
GO - Biological processi
- cellular copper ion homeostasis Source: GO_Central
- copper ion transport Source: ProtInc
- regulation of copper ion transmembrane transport Source: Ensembl
Keywordsi
Biological process | Copper transport, Ion transport, Transport |
Ligand | Copper |
Enzyme and pathway databases
PathwayCommonsi | O15432 |
Protein family/group databases
TCDBi | 1.A.56.1.9, the copper transporter (ctr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Probable low affinity copper uptake protein 2Alternative name(s): Copper transporter 2 Short name: hCTR2 Solute carrier family 31 member 2 |
Gene namesi | Name:SLC31A2 Synonyms:COPT2, CTR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11017, SLC31A2 |
MIMi | 603088, gene |
neXtProti | NX_O15432 |
VEuPathDBi | HostDB:ENSG00000136867.10 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endosome
- late endosome Source: Ensembl
- recycling endosome Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 23 – 43 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 94 – 114 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1318 |
OpenTargetsi | ENSG00000136867 |
PharmGKBi | PA35886 |
Miscellaneous databases
Pharosi | O15432, Tbio |
Chemistry databases
DrugBanki | DB00958, Carboplatin DB00515, Cisplatin DB09130, Copper |
Genetic variation databases
BioMutai | SLC31A2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195043 | 1 – 143 | Probable low affinity copper uptake protein 2Add BLAST | 143 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | O15432 |
PaxDbi | O15432 |
PeptideAtlasi | O15432 |
PRIDEi | O15432 |
ProteomicsDBi | 48658 |
PTM databases
iPTMneti | O15432 |
PhosphoSitePlusi | O15432 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000136867, Expressed in saliva-secreting gland and 230 other tissues |
ExpressionAtlasi | O15432, baseline and differential |
Genevisiblei | O15432, HS |
Organism-specific databases
HPAi | ENSG00000136867, Tissue enhanced (blood, salivary gland) |
Interactioni
Binary interactionsi
O15432
With | #Exp. | IntAct |
---|---|---|
BNIP3 [Q12983] | 3 | EBI-17867220,EBI-749464 |
Protein-protein interaction databases
BioGRIDi | 107713, 8 interactors |
IntActi | O15432, 5 interactors |
MINTi | O15432 |
STRINGi | 9606.ENSP00000259392 |
Miscellaneous databases
RNActi | O15432, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3386, Eukaryota |
GeneTreei | ENSGT00940000159996 |
HOGENOMi | CLU_079690_2_1_1 |
InParanoidi | O15432 |
OMAi | FWNVHSP |
OrthoDBi | 1389393at2759 |
PhylomeDBi | O15432 |
TreeFami | TF315142 |
Family and domain databases
InterProi | View protein in InterPro IPR007274, Cop_transporter |
PANTHERi | PTHR12483, PTHR12483, 1 hit |
Pfami | View protein in Pfam PF04145, Ctr, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O15432-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL
60 70 80 90 100
LNQVLVNLPT SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH
110 120 130 140
VIQVVIGYFI MLAVMSYNTW IFLGVVLGSA VGYYLAYPLL STA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF2Z3D2 | F2Z3D2_HUMAN | Probable low affinity copper uptake... | SLC31A2 | 73 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83461 mRNA Translation: AAB66307.1 BC026252 mRNA Translation: AAH26252.1 |
CCDSi | CCDS6788.1 |
RefSeqi | NP_001851.1, NM_001860.2 |
Genome annotation databases
Ensembli | ENST00000259392; ENSP00000259392; ENSG00000136867 |
GeneIDi | 1318 |
KEGGi | hsa:1318 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83461 mRNA Translation: AAB66307.1 BC026252 mRNA Translation: AAH26252.1 |
CCDSi | CCDS6788.1 |
RefSeqi | NP_001851.1, NM_001860.2 |
3D structure databases
SMRi | O15432 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107713, 8 interactors |
IntActi | O15432, 5 interactors |
MINTi | O15432 |
STRINGi | 9606.ENSP00000259392 |
Chemistry databases
DrugBanki | DB00958, Carboplatin DB00515, Cisplatin DB09130, Copper |
Protein family/group databases
TCDBi | 1.A.56.1.9, the copper transporter (ctr) family |
PTM databases
iPTMneti | O15432 |
PhosphoSitePlusi | O15432 |
Genetic variation databases
BioMutai | SLC31A2 |
Proteomic databases
MassIVEi | O15432 |
PaxDbi | O15432 |
PeptideAtlasi | O15432 |
PRIDEi | O15432 |
ProteomicsDBi | 48658 |
Protocols and materials databases
Antibodypediai | 3100, 111 antibodies |
CPTCi | O15432, 3 antibodies |
DNASUi | 1318 |
Genome annotation databases
Ensembli | ENST00000259392; ENSP00000259392; ENSG00000136867 |
GeneIDi | 1318 |
KEGGi | hsa:1318 |
Organism-specific databases
CTDi | 1318 |
DisGeNETi | 1318 |
GeneCardsi | SLC31A2 |
HGNCi | HGNC:11017, SLC31A2 |
HPAi | ENSG00000136867, Tissue enhanced (blood, salivary gland) |
MIMi | 603088, gene |
neXtProti | NX_O15432 |
OpenTargetsi | ENSG00000136867 |
PharmGKBi | PA35886 |
VEuPathDBi | HostDB:ENSG00000136867.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3386, Eukaryota |
GeneTreei | ENSGT00940000159996 |
HOGENOMi | CLU_079690_2_1_1 |
InParanoidi | O15432 |
OMAi | FWNVHSP |
OrthoDBi | 1389393at2759 |
PhylomeDBi | O15432 |
TreeFami | TF315142 |
Enzyme and pathway databases
PathwayCommonsi | O15432 |
Miscellaneous databases
BioGRID-ORCSi | 1318, 12 hits in 874 CRISPR screens |
GeneWikii | SLC31A2 |
GenomeRNAii | 1318 |
Pharosi | O15432, Tbio |
PROi | PR:O15432 |
RNActi | O15432, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136867, Expressed in saliva-secreting gland and 230 other tissues |
ExpressionAtlasi | O15432, baseline and differential |
Genevisiblei | O15432, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007274, Cop_transporter |
PANTHERi | PTHR12483, PTHR12483, 1 hit |
Pfami | View protein in Pfam PF04145, Ctr, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COPT2_HUMAN | |
Accessioni | O15432Primary (citable) accession number: O15432 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM