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Protein

Probable low affinity copper uptake protein 2

Gene

SLC31A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in low-affinity copper uptake.Curated

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCopper transport, Ion transport, Transport
LigandCopper

Protein family/group databases

TCDBi1.A.56.1.9 the copper transporter (ctr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low affinity copper uptake protein 2
Alternative name(s):
Copper transporter 2
Short name:
hCTR2
Solute carrier family 31 member 2
Gene namesi
Name:SLC31A2
Synonyms:COPT2, CTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136867.10
HGNCiHGNC:11017 SLC31A2
MIMi603088 gene
neXtProtiNX_O15432

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1318
OpenTargetsiENSG00000136867
PharmGKBiPA35886

Chemistry databases

DrugBankiDB00958 Carboplatin
DB00515 Cisplatin

Polymorphism and mutation databases

BioMutaiSLC31A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950431 – 143Probable low affinity copper uptake protein 2Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO15432
PeptideAtlasiO15432
PRIDEiO15432
ProteomicsDBi48658

PTM databases

iPTMnetiO15432
PhosphoSitePlusiO15432

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000136867 Expressed in 216 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_SLC31A2
ExpressionAtlasiO15432 baseline and differential
GenevisibleiO15432 HS

Organism-specific databases

HPAiHPA014861

Interactioni

Protein-protein interaction databases

BioGridi107713, 6 interactors
IntActiO15432, 1 interactor
STRINGi9606.ENSP00000259392

Structurei

3D structure databases

ProteinModelPortaliO15432
SMRiO15432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386 Eukaryota
ENOG4111I8D LUCA
GeneTreeiENSGT00530000063415
HOGENOMiHOG000195393
HOVERGENiHBG106679
InParanoidiO15432
KOiK14687
OMAiHFIFSDK
OrthoDBiEOG091G0VVR
PhylomeDBiO15432
TreeFamiTF315142

Family and domain databases

InterProiView protein in InterPro
IPR007274 Cop_transporter
PANTHERiPTHR12483 PTHR12483, 1 hit
PfamiView protein in Pfam
PF04145 Ctr, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O15432-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL
60 70 80 90 100
LNQVLVNLPT SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH
110 120 130 140
VIQVVIGYFI MLAVMSYNTW IFLGVVLGSA VGYYLAYPLL STA
Length:143
Mass (Da):15,681
Last modified:January 1, 1998 - v1
Checksum:i0145EE8BE623443E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z3D2F2Z3D2_HUMAN
Probable low affinity copper uptake...
SLC31A2
73Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83461 mRNA Translation: AAB66307.1
BC026252 mRNA Translation: AAH26252.1
CCDSiCCDS6788.1
RefSeqiNP_001851.1, NM_001860.2
UniGeneiHs.24030

Genome annotation databases

EnsembliENST00000259392; ENSP00000259392; ENSG00000136867
GeneIDi1318
KEGGihsa:1318

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83461 mRNA Translation: AAB66307.1
BC026252 mRNA Translation: AAH26252.1
CCDSiCCDS6788.1
RefSeqiNP_001851.1, NM_001860.2
UniGeneiHs.24030

3D structure databases

ProteinModelPortaliO15432
SMRiO15432
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107713, 6 interactors
IntActiO15432, 1 interactor
STRINGi9606.ENSP00000259392

Chemistry databases

DrugBankiDB00958 Carboplatin
DB00515 Cisplatin

Protein family/group databases

TCDBi1.A.56.1.9 the copper transporter (ctr) family

PTM databases

iPTMnetiO15432
PhosphoSitePlusiO15432

Polymorphism and mutation databases

BioMutaiSLC31A2

Proteomic databases

PaxDbiO15432
PeptideAtlasiO15432
PRIDEiO15432
ProteomicsDBi48658

Protocols and materials databases

DNASUi1318
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259392; ENSP00000259392; ENSG00000136867
GeneIDi1318
KEGGihsa:1318

Organism-specific databases

CTDi1318
DisGeNETi1318
EuPathDBiHostDB:ENSG00000136867.10
GeneCardsiSLC31A2
HGNCiHGNC:11017 SLC31A2
HPAiHPA014861
MIMi603088 gene
neXtProtiNX_O15432
OpenTargetsiENSG00000136867
PharmGKBiPA35886
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3386 Eukaryota
ENOG4111I8D LUCA
GeneTreeiENSGT00530000063415
HOGENOMiHOG000195393
HOVERGENiHBG106679
InParanoidiO15432
KOiK14687
OMAiHFIFSDK
OrthoDBiEOG091G0VVR
PhylomeDBiO15432
TreeFamiTF315142

Miscellaneous databases

GeneWikiiSLC31A2
GenomeRNAii1318
PROiPR:O15432
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136867 Expressed in 216 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_SLC31A2
ExpressionAtlasiO15432 baseline and differential
GenevisibleiO15432 HS

Family and domain databases

InterProiView protein in InterPro
IPR007274 Cop_transporter
PANTHERiPTHR12483 PTHR12483, 1 hit
PfamiView protein in Pfam
PF04145 Ctr, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPT2_HUMAN
AccessioniPrimary (citable) accession number: O15432
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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