SLC31A2

Functionⁱ

Involved in low-affinity copper uptake.Curated

GO - Molecular functionⁱ

copper ion transmembrane transporter activity
Source: ProtInc
Traceable author statementⁱ
- 9207117

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular copper ion homeostasis Source: Ensembl
copper ion transport
Source: ProtInc
Traceable author statementⁱ
- 9207117
regulation of copper ion transmembrane transport Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Copper transport, Ion transport, Transport
Ligand	Copper

Protein family/group databases

TCDBⁱ	1.A.56.1.9 the copper transporter (ctr) family

TCDBⁱ

1.A.56.1.9 the copper transporter (ctr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable low affinity copper uptake protein 2 Alternative name(s): Copper transporter 2 Short name: hCTR2 Solute carrier family 31 member 2
Gene namesⁱ	Name:SLC31A2 Synonyms:COPT2, CTR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136867.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11017 SLC31A2
MIMⁱ	603088 gene
neXtProtⁱ	NX_O15432

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	23 – 43	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	94 – 114	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	120 – 140	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1318
Open Targets More...OpenTargetsⁱ	ENSG00000136867
PharmGKBⁱ	PA35886

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00958 Carboplatin DB00515 Cisplatin

DrugBankⁱ

DB00958 Carboplatin
DB00515 Cisplatin

Polymorphism and mutation databases

BioMutaⁱ	SLC31A2

BioMutaⁱ

SLC31A2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000195043	1 – 143	Probable low affinity copper uptake protein 2Add BLAST		143

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	77	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O15432
PeptideAtlas More...PeptideAtlasⁱ	O15432
PRIDEⁱ	O15432
ProteomicsDBⁱ	48658

PTM databases

iPTMnetⁱ	O15432
PhosphoSitePlusⁱ	O15432

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000136867 Expressed in 216 organ(s), highest expression level in saliva-secreting gland
CleanExⁱ	HS_SLC31A2
ExpressionAtlasⁱ	O15432 baseline and differential
Genevisibleⁱ	O15432 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014861

HPAⁱ

HPA014861

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107713, 6 interactors
IntActⁱ	O15432, 1 interactor
STRINGⁱ	9606.ENSP00000259392

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15432
SMRⁱ	O15432
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3386 Eukaryota ENOG4111I8D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063415
HOGENOMⁱ	HOG000195393
HOVERGENⁱ	HBG106679
InParanoidⁱ	O15432
KEGG Orthology (KO) More...KOⁱ	K14687
OMAⁱ	HFIFSDK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VVR
PhylomeDBⁱ	O15432
TreeFamⁱ	TF315142

Family and domain databases

InterProⁱ	View protein in InterPro IPR007274 Cop_transporter
PANTHERⁱ	PTHR12483 PTHR12483, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04145 Ctr, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O15432-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL 
        60         70         80         90        100
LNQVLVNLPT SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH 
       110        120        130        140 
VIQVVIGYFI MLAVMSYNTW IFLGVVLGSA VGYYLAYPLL STA

Length:143

Mass (Da):15,681

Last modified:January 1, 1998 - v1

Checksum:ⁱ0145EE8BE623443E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F2Z3D2	F2Z3D2_HUMAN		Probable low affinity copper uptake... Probable low affinity copper uptake protein 2	SLC31A2	73	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U83461 mRNA Translation: AAB66307.1 BC026252 mRNA Translation: AAH26252.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6788.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001851.1, NM_001860.2
UniGeneⁱ	Hs.24030

Genome annotation databases

Ensemblⁱ	ENST00000259392; ENSP00000259392; ENSG00000136867
GeneIDⁱ	1318
KEGGⁱ	hsa:1318

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15432	SLC31A2 protein (Fragment)		HUMAN		143	UniRef100_O15432
SLC31A2 isoform 2		PANTR		143
SLC31A2 isoform 2		PONAB		143
Uncharacterized protein		PANPA		143

Protein	Similar proteins		Species	Score	Length	Source
O15432	SLC31A2 protein (Fragment)		HUMAN		143	UniRef90_O15432
SLC31A2 isoform 2		PANTR		143
SLC31A2 isoform 2		PONAB		143
Uncharacterized protein		PANPA		143
Solute carrier family 31 member 2		SAIBB		144
+39

Protein	Similar proteins		Species	Score	Length	Source
O15432	SLC31A2 protein (Fragment)		HUMAN		143	UniRef50_O15432
SLC31A2 isoform 2		PANTR		143
SLC31A2 isoform 2		PONAB		143
Uncharacterized protein		PANPA		143
Solute carrier family 31 member 2		GORGO		144
+132

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U83461 mRNA Translation: AAB66307.1 BC026252 mRNA Translation: AAH26252.1
CCDSⁱ	CCDS6788.1
RefSeqⁱ	NP_001851.1, NM_001860.2
UniGeneⁱ	Hs.24030

3D structure databases

ProteinModelPortalⁱ	O15432
SMRⁱ	O15432
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107713, 6 interactors
IntActⁱ	O15432, 1 interactor
STRINGⁱ	9606.ENSP00000259392

Chemistry databases

DrugBankⁱ	DB00958 Carboplatin DB00515 Cisplatin

DrugBankⁱ

DB00958 Carboplatin
DB00515 Cisplatin

Protein family/group databases

TCDBⁱ	1.A.56.1.9 the copper transporter (ctr) family

TCDBⁱ

1.A.56.1.9 the copper transporter (ctr) family

PTM databases

iPTMnetⁱ	O15432
PhosphoSitePlusⁱ	O15432

Polymorphism and mutation databases

BioMutaⁱ	SLC31A2

BioMutaⁱ

SLC31A2

Proteomic databases

PaxDbⁱ	O15432
PeptideAtlasⁱ	O15432
PRIDEⁱ	O15432
ProteomicsDBⁱ	48658

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1318
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000259392; ENSP00000259392; ENSG00000136867
GeneIDⁱ	1318
KEGGⁱ	hsa:1318

Organism-specific databases

CTDⁱ	1318
DisGeNETⁱ	1318
EuPathDBⁱ	HostDB:ENSG00000136867.10
GeneCardsⁱ	SLC31A2
HGNCⁱ	HGNC:11017 SLC31A2
HPAⁱ	HPA014861
MIMⁱ	603088 gene
neXtProtⁱ	NX_O15432
OpenTargetsⁱ	ENSG00000136867
PharmGKBⁱ	PA35886
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3386 Eukaryota ENOG4111I8D LUCA
GeneTreeⁱ	ENSGT00530000063415
HOGENOMⁱ	HOG000195393
HOVERGENⁱ	HBG106679
InParanoidⁱ	O15432
KOⁱ	K14687
OMAⁱ	HFIFSDK
OrthoDBⁱ	EOG091G0VVR
PhylomeDBⁱ	O15432
TreeFamⁱ	TF315142

Miscellaneous databases

GeneWikiⁱ	SLC31A2
GenomeRNAiⁱ	1318
Protein Ontology More...PROⁱ	PR:O15432
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136867 Expressed in 216 organ(s), highest expression level in saliva-secreting gland
CleanExⁱ	HS_SLC31A2
ExpressionAtlasⁱ	O15432 baseline and differential
Genevisibleⁱ	O15432 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007274 Cop_transporter
PANTHERⁱ	PTHR12483 PTHR12483, 1 hit
Pfamⁱ	View protein in Pfam PF04145 Ctr, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COPT2_HUMAN
Accessionⁱ	O15432Primary (citable) accession number: O15432
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	January 1, 1998
	Last modified:	September 12, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - O15432 (COPT2_HUMAN)

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Probable low affinity copper uptake protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endosome

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ