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Protein

High affinity copper uptake protein 1

Gene

SLC31A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: Reactome
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processCopper transport, Ion transport, Transport
LigandCopper

Enzyme and pathway databases

ReactomeiR-HSA-425410 Metal ion SLC transporters

Protein family/group databases

TCDBi1.A.56.1.2 the copper transporter (ctr) family

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name:
hCTR1
Solute carrier family 31 member 1
Gene namesi
Name:SLC31A1
Synonyms:COPT1, CTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136868.10
HGNCiHGNC:11016 SLC31A1
MIMi603085 gene
neXtProtiNX_O15431

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61ExtracellularSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 132CytoplasmicSequence analysisAdd BLAST50
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 156ExtracellularSequence analysis3
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 190CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1317
OpenTargetsiENSG00000136868
PharmGKBiPA118

Chemistry databases

DrugBankiDB00958 Carboplatin
DB00515 Cisplatin
DB00526 Oxaliplatin

Polymorphism and mutation databases

BioMutaiSLC31A1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950401 – 190High affinity copper uptake protein 1Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi27O-linked (GalNAc...) threonine1 Publication1
Modified residuei114PhosphothreonineCombined sources1

Post-translational modificationi

O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO15431
MaxQBiO15431
PaxDbiO15431
PeptideAtlasiO15431
PRIDEiO15431
ProteomicsDBi48657

PTM databases

iPTMnetiO15431
PhosphoSitePlusiO15431

Expressioni

Gene expression databases

BgeeiENSG00000136868 Expressed in 205 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_SLC31A1
ExpressionAtlasiO15431 baseline and differential
GenevisibleiO15431 HS

Organism-specific databases

HPAiHPA013810

Interactioni

Subunit structurei

Homotrimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-15571835,EBI-15571835

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107712, 14 interactors
DIPiDIP-48727N
STRINGi9606.ENSP00000363329

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO15431
SMRiO15431
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386 Eukaryota
ENOG4111I8D LUCA
GeneTreeiENSGT00530000063415
HOGENOMiHOG000195393
HOVERGENiHBG065767
InParanoidiO15431
KOiK14686
OMAiFFFSWKK
OrthoDBiEOG091G0VVR
PhylomeDBiO15431
TreeFamiTF315142

Family and domain databases

InterProiView protein in InterPro
IPR007274 Cop_transporter
PANTHERiPTHR12483 PTHR12483, 1 hit
PfamiView protein in Pfam
PF04145 Ctr, 1 hit

Sequencei

Sequence statusi: Complete.

O15431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG
60 70 80 90 100
FKNVELLFSG LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS
110 120 130 140 150
IRYNSMPVPG PNGTILMETH KTVGQQMLSF PHLLQTVLHI IQVVISYFLM
160 170 180 190
LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA VVVDITEHCH
Length:190
Mass (Da):21,091
Last modified:January 1, 1998 - v1
Checksum:i1E08FBAB72A9C014
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168A → G in BAD96586 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02933825P → A. Corresponds to variant dbSNP:rs2233915Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83460 mRNA Translation: AAB66306.1
AK222866 mRNA Translation: BAD96586.1
AK292511 mRNA Translation: BAF85200.1
AL831843 mRNA Translation: CAD38549.1
AL449305 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87357.1
BC013611 mRNA Translation: AAH13611.1
CCDSiCCDS6789.1
RefSeqiNP_001850.1, NM_001859.3
UniGeneiHs.532315

Genome annotation databases

EnsembliENST00000374212; ENSP00000363329; ENSG00000136868
GeneIDi1317
KEGGihsa:1317
UCSCiuc004bgu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83460 mRNA Translation: AAB66306.1
AK222866 mRNA Translation: BAD96586.1
AK292511 mRNA Translation: BAF85200.1
AL831843 mRNA Translation: CAD38549.1
AL449305 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87357.1
BC013611 mRNA Translation: AAH13611.1
CCDSiCCDS6789.1
RefSeqiNP_001850.1, NM_001859.3
UniGeneiHs.532315

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LS2NMR-A64-87[»]
2LS3NMR-A132-157[»]
2LS4NMR-A156-179[»]
ProteinModelPortaliO15431
SMRiO15431
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107712, 14 interactors
DIPiDIP-48727N
STRINGi9606.ENSP00000363329

Chemistry databases

DrugBankiDB00958 Carboplatin
DB00515 Cisplatin
DB00526 Oxaliplatin

Protein family/group databases

TCDBi1.A.56.1.2 the copper transporter (ctr) family

PTM databases

iPTMnetiO15431
PhosphoSitePlusiO15431

Polymorphism and mutation databases

BioMutaiSLC31A1

Proteomic databases

EPDiO15431
MaxQBiO15431
PaxDbiO15431
PeptideAtlasiO15431
PRIDEiO15431
ProteomicsDBi48657

Protocols and materials databases

DNASUi1317
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374212; ENSP00000363329; ENSG00000136868
GeneIDi1317
KEGGihsa:1317
UCSCiuc004bgu.4 human

Organism-specific databases

CTDi1317
DisGeNETi1317
EuPathDBiHostDB:ENSG00000136868.10
GeneCardsiSLC31A1
HGNCiHGNC:11016 SLC31A1
HPAiHPA013810
MIMi603085 gene
neXtProtiNX_O15431
OpenTargetsiENSG00000136868
PharmGKBiPA118
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3386 Eukaryota
ENOG4111I8D LUCA
GeneTreeiENSGT00530000063415
HOGENOMiHOG000195393
HOVERGENiHBG065767
InParanoidiO15431
KOiK14686
OMAiFFFSWKK
OrthoDBiEOG091G0VVR
PhylomeDBiO15431
TreeFamiTF315142

Enzyme and pathway databases

ReactomeiR-HSA-425410 Metal ion SLC transporters

Miscellaneous databases

GeneWikiiSLC31A1
GenomeRNAii1317
PROiPR:O15431
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136868 Expressed in 205 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_SLC31A1
ExpressionAtlasiO15431 baseline and differential
GenevisibleiO15431 HS

Family and domain databases

InterProiView protein in InterPro
IPR007274 Cop_transporter
PANTHERiPTHR12483 PTHR12483, 1 hit
PfamiView protein in Pfam
PF04145 Ctr, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPT1_HUMAN
AccessioniPrimary (citable) accession number: O15431
Secondary accession number(s): A8K8Z6, Q53GR5, Q5T1M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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