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UniProtKB - O15417 (TNC18_HUMAN)

Protein

Trinucleotide repeat-containing gene 18 protein

Gene

TNRC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 18 protein
Alternative name(s):
Long CAG trinucleotide repeat-containing gene 79 protein
Gene namesi
Name:TNRC18
Synonyms:CAGL79, KIAA1856
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000182095.14
HGNCiHGNC:11962 TNRC18
neXtProtiNX_O15417

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182095
PharmGKBiPA36649

Polymorphism and mutation databases

BioMutaiTNRC18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991421 – 2968Trinucleotide repeat-containing gene 18 proteinAdd BLAST2968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineCombined sources1
Modified residuei611PhosphoserineBy similarity1
Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1136PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei1857PhosphoserineCombined sources1
Modified residuei1863PhosphoserineCombined sources1
Modified residuei2146PhosphothreonineCombined sources1
Modified residuei2771PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15417
MaxQBiO15417
PaxDbiO15417
PeptideAtlasiO15417
PRIDEiO15417
ProteomicsDBi48652
48653 [O15417-2]
48654 [O15417-3]

PTM databases

CarbonylDBiO15417
iPTMnetiO15417
PhosphoSitePlusiO15417

Expressioni

Gene expression databases

BgeeiENSG00000182095 Expressed in 200 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_TNRC18
ExpressionAtlasiO15417 baseline and differential
GenevisibleiO15417 HS

Organism-specific databases

HPAiHPA020730
HPA024251

Interactioni

Protein-protein interaction databases

BioGridi124158, 25 interactors
IntActiO15417, 11 interactors
MINTiO15417
STRINGi9606.ENSP00000395538

Structurei

3D structure databases

ProteinModelPortaliO15417
SMRiO15417
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2817 – 2962BAHPROSITE-ProRule annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili916 – 949Sequence analysisAdd BLAST34
Coiled coili1481 – 1516Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 506Pro-richAdd BLAST181
Compositional biasi968 – 1192Pro-richAdd BLAST225
Compositional biasi1828 – 1841Poly-GluAdd BLAST14
Compositional biasi2353 – 2437Pro-richAdd BLAST85
Compositional biasi2557 – 2681Ser-richAdd BLAST125

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IUIV Eukaryota
ENOG410YZ4H LUCA
GeneTreeiENSGT00530000063602
HOGENOMiHOG000154656
HOVERGENiHBG108592
InParanoidiO15417
OrthoDBiEOG091G0071
PhylomeDBiO15417
TreeFamiTF336007

Family and domain databases

InterProiView protein in InterPro
IPR001025 BAH_dom
PfamiView protein in Pfam
PF01426 BAH, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPA SGLPGPLPPG 
        60         70         80         90        100
KYMAGLNLHP HPGEAFLGSF VASGMGPSAS SHGSPVPLPS DLSFRSPTPS 
       110        120        130        140        150
NLPMVQLWAA HAHEGFSHLP SGLYPSYLHL NHLEPPSSGS PLLSQLGQPS 
       160        170        180        190        200
IFDTQKGQGP GGDGFYLPTA GAPGSLHSHA PSARTPGGGH SSGAPAKGSS 
       210        220        230        240        250
SRDGPAKERA GRGGEPPPLF GKKDPRARGE EASGPRGVVD LTQEARAEGR 
       260        270        280        290        300
QDRGPPRLAE RLSPFLAESK TKNAALQPSV LTMCNGGAGD VGLPALVAEA 
       310        320        330        340        350
GRGGAKEAAR QDEGARLLRR TETLLPGPRP CPSPLPPPPA PPKGPPAPPA 
       360        370        380        390        400
ATPAGVYTVF REQGREHRVV APTFVPSVEA FDERPGPIQI ASQARDARAR 
       410        420        430        440        450
EREAGRPGVL QAPPGSPRPL DRPEGLREKN SVIRSLKRPP PADAPTVRAT 
       460        470        480        490        500
RASPDPRAYV PAKELLKPEA DPRPCERAPR GPAGPAAQQA AKLFGLEPGR 
       510        520        530        540        550
PPPTGPEHKW KPFELGNFAA TQMAVLAAQH HHSRAEEEAA VVAASSSKKA 
       560        570        580        590        600
YLDPGAVLPR SAATCGRPVA DMHSAAHGSG EASAMQSLIK YSGSFARDAV 
       610        620        630        640        650
AVRPGGCGKK SPFGGLGTMK PEPAPTSAGA SRAQARLPHS GGPAAGGGRQ 
       660        670        680        690        700
LKRDPERPES AKAFGREGSG AQGEAEVRHP PVGIAVAVAR QKDSGGSGRL 
       710        720        730        740        750
GPGLVDQERS LSLSNVKGHG RADEDCVDDR ARHREERLLG ARLDRDQEKL 
       760        770        780        790        800
LRESKELADL ARLHPTSCAP NGLNPNLMVT GGPALAGSGR WSADPAAHLA 
       810        820        830        840        850
THPWLPRSGN ASMWLAGHPY GLGPPSLHQG MAPAFPPGLG GSLPSAYQFV 
       860        870        880        890        900
RDPQSGQLVV IPSDHLPHFA ELMERATVPP LWPALYPPGR SPLHHAQQLQ 
       910        920        930        940        950
LFSQQHFLRQ QEFLYLQQQA AQALELQRSA QLVQERLKAQ EHRAEMEEKG 
       960        970        980        990       1000
SKRGLEAAGK AGLATAGPGL LPRKPPGLAA GPAGTYGKAV SPPPSPRASP 
      1010       1020       1030       1040       1050
VAALKAKVIQ KLEDVSKPPA YAYPATPSSH PTSPPPASPP PTPGITRKEE 
      1060       1070       1080       1090       1100
APENVVEKKD LELEKEAPSP FQALFSDIPP RYPFQALPPH YGRPYPFLLQ 
      1110       1120       1130       1140       1150
PTAAADADGL APDVPLPADG PERLALSPED KPIRLSPSKI TEPLREGPEE 
      1160       1170       1180       1190       1200
EPLAEREVKA EVEDMDEGPT ELPPLESPLP LPAAEAMATP SPAGGCGGGL 
      1210       1220       1230       1240       1250
LEAQALSATG QSCAEPSECP DFVEGPEPRV DSPGRTEPCT AALDLGVQLT 
      1260       1270       1280       1290       1300
PETLVEAKEE PVEVPVAVPV VEAVPEEGLA QVAPSESQPT LEMSDCDVPA 
      1310       1320       1330       1340       1350
GEGQCPSLEP QEAVPVLGST CFLEEASSDQ FLPSLEDPLA GMNALAAAAE 
      1360       1370       1380       1390       1400
LPQARPLPSP GAAGAQALEK LEAAESLVLE QSFLHGITLL SEIAELELER 
      1410       1420       1430       1440       1450
RSQEMGGAER ALVARPSLES LLAAGSHMLR EVLDGPVVDP LKNLRLPREL 
      1460       1470       1480       1490       1500
KPNKKYSWMR KKEERMYAMK SSLEDMDALE LDFRMRLAEV QRQYKEKQRE 
      1510       1520       1530       1540       1550
LVKLQRRRDS EDRREEPHRS LARRGPGRPR KRTHAPSALS PPRKRGKSGH 
      1560       1570       1580       1590       1600
SSGKLSSKSL LTSDDYELGA GIRKRHKGSE EEHDALIGMG KARGRNQTWD 
      1610       1620       1630       1640       1650
EHEASSDFIS QLKIKKKKMA SDQEQLASKL DKALSLTKQD KLKSPFKFSD 
      1660       1670       1680       1690       1700
SAGGKSKTSG GCGRYLTPYD SLLGKNRKAL AKGLGLSLKS SREGKHKRAA 
      1710       1720       1730       1740       1750
KTRKMEVGFK ARGQPKSAHS PFASEVSSYS YNTDSEEDEE FLKDEWPAQG 
      1760       1770       1780       1790       1800
PSSSKLTPSL LCSMVAKNSK AAGGPKLTKR GLAAPRTLKP KPATSRKQPF 
      1810       1820       1830       1840       1850
CLLLREAEAR SSFSDSSEES FDQDESSEEE DEEEELEEED EASGGGYRLG 
      1860       1870       1880       1890       1900
ARERALSPGL EESGLGLLAR FAASALPSPT VGPSLSVVQL EAKQKARKKE 
      1910       1920       1930       1940       1950
ERQSLLGTEF EYTDSESEVK VRKRSPAGLL RPKKGLGEPG PSLAAPTPGA 
      1960       1970       1980       1990       2000
RGPDPSSPDK AKLAVEKGRK ARKLRGPKEP GFEAGPEASD DDLWTRRRSE 
      2010       2020       2030       2040       2050
RIFLHDASAA APAPVSTAPA TKTSRCAKGG PLSPRKDAGR AKDRKDPRKK 
      2060       2070       2080       2090       2100
KKGKEAGPGA GLPPPRAPAL PSEARAPHAS SLTAAKRSKA KAKGKEVKKE 
      2110       2120       2130       2140       2150
NRGKGGAVSK LMESMAAEED FEPNQDSSFS EDEHLPRGGA VERPLTPAPR 
      2160       2170       2180       2190       2200
SCIIDKDELK DGLRVLIPMD DKLLYAGHVQ TVHSPDIYRV VVEGERGNRP 
      2210       2220       2230       2240       2250
HIYCLEQLLQ EAIIDVRPAS TRFLPQGTRI AAYWSQQYRC LYPGTVVRGL 
      2260       2270       2280       2290       2300
LDLEDDGDLI TVEFDDGDTG RIPLSHIRLL PPDYKIQCAE PSPALLVPSA 
      2310       2320       2330       2340       2350
KRRSRKTSKD TGEGKDGGTA GSEEPGAKAR GRGRKPSAKA KGDRAATLEE 
      2360       2370       2380       2390       2400
GNPTDEVPST PLALEPSSTP GSKKSPPEPV DKRAKAPKAR PAPPQPSPAP 
      2410       2420       2430       2440       2450
PAFTSCPAPE PFAELPAPAT SLAPAPLITM PATRPKPKKA RAAEESGAKG 
      2460       2470       2480       2490       2500
PRRPGEEAEL LVKLDHEGVT SPKSKKAKEA LLLREDPGAG GWQEPKSLLS 
      2510       2520       2530       2540       2550
LGSYPPAAGS SEPKAPWPKA TDGDLAQEPG PGLTFEDSGN PKSPDKAQAE 
      2560       2570       2580       2590       2600
QDGAEESESS SSSSSGSSSS SSSSSSSGSE TEGEEEGDKN GDGGCGTGGR 
      2610       2620       2630       2640       2650
NCSAASSRAA SPASSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS 
      2660       2670       2680       2690       2700
SSSSSSSSSS SSSSSSSSSS STTDEDSSCS SDDEAAPAPT AGPSAQAALP 
      2710       2720       2730       2740       2750
TKATKQAGKA RPSAHSPGKK TPAPQPQAPP PQPTQPLQPK AQAGAKSRPK 
      2760       2770       2780       2790       2800
KREGVHLPTT KELAKRQRLP SVENRPKIAA FLPARQLWKW FGKPTQRRGM 
      2810       2820       2830       2840       2850
KGKARKLFYK AIVRGKEMIR IGDCAVFLSA GRPNLPYIGR IQSMWESWGN 
      2860       2870       2880       2890       2900
NMVVRVKWFY HPEETSPGKQ FHQGQHWDQK SSRSLPAALR VSSQRKDFME 
      2910       2920       2930       2940       2950
RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD SEGLYYLAGT 
      2960 
YEPTTGMIFS TDGVPVLC
Length:2,968
Mass (Da):314,519
Last modified:April 29, 2008 - v3
Checksum:iC83E5D7E3245740F
GO
Isoform 2 (identifier: O15417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2078-2256: HASSLTAAKR...VRGLLDLEDD → PPPPPPPPHP...GSASPPSGVA
     2257-2968: Missing.

Note: No experimental confirmation available. Dubious isoform produced through aberrant splice sites.
Show »
Length:2,256
Mass (Da):239,498
Checksum:i476F448917A3B6BE
GO
Isoform 3 (identifier: O15417-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1064: Missing.
     1403-1490: QEMGGAERAL...LDFRMRLAEV → PPQGLPPCMG...PSHYRKPQWC
     1491-2968: Missing.

Note: Incomplete sequence. No experimental confirmation available. Non-canonical intron-exon splice junction.
Show »
Length:414
Mass (Da):43,329
Checksum:i3BA1027E95500505
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVB4H9KVB4_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
2,968Annotation score:
H7C0N9H7C0N9_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
252Annotation score:
H7BXS9H7BXS9_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
407Annotation score:
H7C3U5H7C3U5_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
308Annotation score:
A8MTZ4A8MTZ4_HUMAN
HCG96198, isoform CRA_d
TNRC18 hCG_96198
130Annotation score:
H7C177H7C177_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
192Annotation score:
C9J9K1C9J9K1_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
99Annotation score:

Sequence cautioni

The sequence BAB55047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1255V → A in BAB55047 (PubMed:14702039).Curated1
Sequence conflicti1267A → G in BAB47485 (PubMed:11347906).Curated1
Sequence conflicti1343N → S in BAB55047 (PubMed:14702039).Curated1
Sequence conflicti2292S → P in AAB91447 (PubMed:9225980).Curated1
Sequence conflicti2411P → S in AAB91447 (PubMed:9225980).Curated1
Sequence conflicti2547A → V in AAB91447 (PubMed:9225980).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0427221193A → G. Corresponds to variant dbSNP:rs12671708Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0331241 – 1064Missing in isoform 3. 1 PublicationAdd BLAST1064
Alternative sequenceiVSP_0331281403 – 1490QEMGG…RLAEV → PPQGLPPCMGQGSPMPAGLP DCARGPAPTLSGWPRLGEQS RVGLQPGVSVKGTRWRGPGT GPPWSKPSHYRKPQWC in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0331291491 – 2968Missing in isoform 3. 1 PublicationAdd BLAST1478
Alternative sequenceiVSP_0331262078 – 2256HASSL…DLEDD → PPPPPPPPHPPLPPPPLPPP PLPLRLPPLPPPPLPRPHPP PPPPLPPLLPPPQTRTLPAA RTMRQPPPPRLALPRRRRSP PRPPSRPARRGPRPTPQARR RPRPSPRRLLRSPHSLCSPR LRPGPRADPRRERASTSPPP RSWPSGSACRPWRTGPRSPP SCQPGSSGSGSASPPSGVA in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_0331272257 – 2968Missing in isoform 2. 1 PublicationAdd BLAST712

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093376 Genomic DNA No translation available.
AC093620 Genomic DNA No translation available.
AK027341 mRNA Translation: BAB55047.1 Different initiation.
AB058759 mRNA Translation: BAB47485.1
U80753 mRNA Translation: AAB91447.1
CCDSiCCDS47534.1 [O15417-1]
RefSeqiNP_001073964.2, NM_001080495.2 [O15417-1]
UniGeneiHs.520638

Genome annotation databases

EnsembliENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1]
GeneIDi84629
KEGGihsa:84629
UCSCiuc003soi.5 human [O15417-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093376 Genomic DNA No translation available.
AC093620 Genomic DNA No translation available.
AK027341 mRNA Translation: BAB55047.1 Different initiation.
AB058759 mRNA Translation: BAB47485.1
U80753 mRNA Translation: AAB91447.1
CCDSiCCDS47534.1 [O15417-1]
RefSeqiNP_001073964.2, NM_001080495.2 [O15417-1]
UniGeneiHs.520638

3D structure databases

ProteinModelPortaliO15417
SMRiO15417
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124158, 25 interactors
IntActiO15417, 11 interactors
MINTiO15417
STRINGi9606.ENSP00000395538

PTM databases

CarbonylDBiO15417
iPTMnetiO15417
PhosphoSitePlusiO15417

Polymorphism and mutation databases

BioMutaiTNRC18

Proteomic databases

EPDiO15417
MaxQBiO15417
PaxDbiO15417
PeptideAtlasiO15417
PRIDEiO15417
ProteomicsDBi48652
48653 [O15417-2]
48654 [O15417-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1]
GeneIDi84629
KEGGihsa:84629
UCSCiuc003soi.5 human [O15417-1]

Organism-specific databases

CTDi84629
EuPathDBiHostDB:ENSG00000182095.14
GeneCardsiTNRC18
H-InvDBiHIX0200690
HGNCiHGNC:11962 TNRC18
HPAiHPA020730
HPA024251
neXtProtiNX_O15417
OpenTargetsiENSG00000182095
PharmGKBiPA36649
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUIV Eukaryota
ENOG410YZ4H LUCA
GeneTreeiENSGT00530000063602
HOGENOMiHOG000154656
HOVERGENiHBG108592
InParanoidiO15417
OrthoDBiEOG091G0071
PhylomeDBiO15417
TreeFamiTF336007

Miscellaneous databases

ChiTaRSiTNRC18 human
GenomeRNAii84629
PROiPR:O15417

Gene expression databases

BgeeiENSG00000182095 Expressed in 200 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_TNRC18
ExpressionAtlasiO15417 baseline and differential
GenevisibleiO15417 HS

Family and domain databases

InterProiView protein in InterPro
IPR001025 BAH_dom
PfamiView protein in Pfam
PF01426 BAH, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNC18_HUMAN
AccessioniPrimary (citable) accession number: O15417
Secondary accession number(s): A8MX41, Q96JH1, Q96K91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: April 29, 2008
Last modified: November 7, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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