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Entry version 134 (13 Feb 2019)
Sequence version 3 (29 Apr 2008)
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Protein

Trinucleotide repeat-containing gene 18 protein

Gene

TNRC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 18 protein
Alternative name(s):
Long CAG trinucleotide repeat-containing gene 79 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC18
Synonyms:CAGL79, KIAA1856
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182095.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11962 TNRC18

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15417

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182095

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36649

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNRC18

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991421 – 2968Trinucleotide repeat-containing gene 18 proteinAdd BLAST2968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineCombined sources1
Modified residuei611PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1136PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei1857PhosphoserineCombined sources1
Modified residuei1863PhosphoserineCombined sources1
Modified residuei2146PhosphothreonineCombined sources1
Modified residuei2771PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15417

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15417

MaxQB - The MaxQuant DataBase

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MaxQBi
O15417

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15417

PeptideAtlas

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PeptideAtlasi
O15417

PRoteomics IDEntifications database

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PRIDEi
O15417

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48652
48653 [O15417-2]
48654 [O15417-3]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
O15417

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15417

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15417

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182095 Expressed in 200 organ(s), highest expression level in nasal cavity epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15417 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15417 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020730
HPA024251

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124158, 26 interactors

Protein interaction database and analysis system

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IntActi
O15417, 12 interactors

Molecular INTeraction database

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MINTi
O15417

STRING: functional protein association networks

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STRINGi
9606.ENSP00000395538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O15417

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15417

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2817 – 2962BAHPROSITE-ProRule annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili916 – 949Sequence analysisAdd BLAST34
Coiled coili1481 – 1516Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi326 – 506Pro-richAdd BLAST181
Compositional biasi968 – 1192Pro-richAdd BLAST225
Compositional biasi1828 – 1841Poly-GluAdd BLAST14
Compositional biasi2353 – 2437Pro-richAdd BLAST85
Compositional biasi2557 – 2681Ser-richAdd BLAST125

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUIV Eukaryota
ENOG410YZ4H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157099

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154656

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108592

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15417

Database of Orthologous Groups

More...
OrthoDBi
11077at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15417

TreeFam database of animal gene trees

More...
TreeFami
TF336007

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001025 BAH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01426 BAH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439 BAH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038 BAH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPA SGLPGPLPPG
60 70 80 90 100
KYMAGLNLHP HPGEAFLGSF VASGMGPSAS SHGSPVPLPS DLSFRSPTPS
110 120 130 140 150
NLPMVQLWAA HAHEGFSHLP SGLYPSYLHL NHLEPPSSGS PLLSQLGQPS
160 170 180 190 200
IFDTQKGQGP GGDGFYLPTA GAPGSLHSHA PSARTPGGGH SSGAPAKGSS
210 220 230 240 250
SRDGPAKERA GRGGEPPPLF GKKDPRARGE EASGPRGVVD LTQEARAEGR
260 270 280 290 300
QDRGPPRLAE RLSPFLAESK TKNAALQPSV LTMCNGGAGD VGLPALVAEA
310 320 330 340 350
GRGGAKEAAR QDEGARLLRR TETLLPGPRP CPSPLPPPPA PPKGPPAPPA
360 370 380 390 400
ATPAGVYTVF REQGREHRVV APTFVPSVEA FDERPGPIQI ASQARDARAR
410 420 430 440 450
EREAGRPGVL QAPPGSPRPL DRPEGLREKN SVIRSLKRPP PADAPTVRAT
460 470 480 490 500
RASPDPRAYV PAKELLKPEA DPRPCERAPR GPAGPAAQQA AKLFGLEPGR
510 520 530 540 550
PPPTGPEHKW KPFELGNFAA TQMAVLAAQH HHSRAEEEAA VVAASSSKKA
560 570 580 590 600
YLDPGAVLPR SAATCGRPVA DMHSAAHGSG EASAMQSLIK YSGSFARDAV
610 620 630 640 650
AVRPGGCGKK SPFGGLGTMK PEPAPTSAGA SRAQARLPHS GGPAAGGGRQ
660 670 680 690 700
LKRDPERPES AKAFGREGSG AQGEAEVRHP PVGIAVAVAR QKDSGGSGRL
710 720 730 740 750
GPGLVDQERS LSLSNVKGHG RADEDCVDDR ARHREERLLG ARLDRDQEKL
760 770 780 790 800
LRESKELADL ARLHPTSCAP NGLNPNLMVT GGPALAGSGR WSADPAAHLA
810 820 830 840 850
THPWLPRSGN ASMWLAGHPY GLGPPSLHQG MAPAFPPGLG GSLPSAYQFV
860 870 880 890 900
RDPQSGQLVV IPSDHLPHFA ELMERATVPP LWPALYPPGR SPLHHAQQLQ
910 920 930 940 950
LFSQQHFLRQ QEFLYLQQQA AQALELQRSA QLVQERLKAQ EHRAEMEEKG
960 970 980 990 1000
SKRGLEAAGK AGLATAGPGL LPRKPPGLAA GPAGTYGKAV SPPPSPRASP
1010 1020 1030 1040 1050
VAALKAKVIQ KLEDVSKPPA YAYPATPSSH PTSPPPASPP PTPGITRKEE
1060 1070 1080 1090 1100
APENVVEKKD LELEKEAPSP FQALFSDIPP RYPFQALPPH YGRPYPFLLQ
1110 1120 1130 1140 1150
PTAAADADGL APDVPLPADG PERLALSPED KPIRLSPSKI TEPLREGPEE
1160 1170 1180 1190 1200
EPLAEREVKA EVEDMDEGPT ELPPLESPLP LPAAEAMATP SPAGGCGGGL
1210 1220 1230 1240 1250
LEAQALSATG QSCAEPSECP DFVEGPEPRV DSPGRTEPCT AALDLGVQLT
1260 1270 1280 1290 1300
PETLVEAKEE PVEVPVAVPV VEAVPEEGLA QVAPSESQPT LEMSDCDVPA
1310 1320 1330 1340 1350
GEGQCPSLEP QEAVPVLGST CFLEEASSDQ FLPSLEDPLA GMNALAAAAE
1360 1370 1380 1390 1400
LPQARPLPSP GAAGAQALEK LEAAESLVLE QSFLHGITLL SEIAELELER
1410 1420 1430 1440 1450
RSQEMGGAER ALVARPSLES LLAAGSHMLR EVLDGPVVDP LKNLRLPREL
1460 1470 1480 1490 1500
KPNKKYSWMR KKEERMYAMK SSLEDMDALE LDFRMRLAEV QRQYKEKQRE
1510 1520 1530 1540 1550
LVKLQRRRDS EDRREEPHRS LARRGPGRPR KRTHAPSALS PPRKRGKSGH
1560 1570 1580 1590 1600
SSGKLSSKSL LTSDDYELGA GIRKRHKGSE EEHDALIGMG KARGRNQTWD
1610 1620 1630 1640 1650
EHEASSDFIS QLKIKKKKMA SDQEQLASKL DKALSLTKQD KLKSPFKFSD
1660 1670 1680 1690 1700
SAGGKSKTSG GCGRYLTPYD SLLGKNRKAL AKGLGLSLKS SREGKHKRAA
1710 1720 1730 1740 1750
KTRKMEVGFK ARGQPKSAHS PFASEVSSYS YNTDSEEDEE FLKDEWPAQG
1760 1770 1780 1790 1800
PSSSKLTPSL LCSMVAKNSK AAGGPKLTKR GLAAPRTLKP KPATSRKQPF
1810 1820 1830 1840 1850
CLLLREAEAR SSFSDSSEES FDQDESSEEE DEEEELEEED EASGGGYRLG
1860 1870 1880 1890 1900
ARERALSPGL EESGLGLLAR FAASALPSPT VGPSLSVVQL EAKQKARKKE
1910 1920 1930 1940 1950
ERQSLLGTEF EYTDSESEVK VRKRSPAGLL RPKKGLGEPG PSLAAPTPGA
1960 1970 1980 1990 2000
RGPDPSSPDK AKLAVEKGRK ARKLRGPKEP GFEAGPEASD DDLWTRRRSE
2010 2020 2030 2040 2050
RIFLHDASAA APAPVSTAPA TKTSRCAKGG PLSPRKDAGR AKDRKDPRKK
2060 2070 2080 2090 2100
KKGKEAGPGA GLPPPRAPAL PSEARAPHAS SLTAAKRSKA KAKGKEVKKE
2110 2120 2130 2140 2150
NRGKGGAVSK LMESMAAEED FEPNQDSSFS EDEHLPRGGA VERPLTPAPR
2160 2170 2180 2190 2200
SCIIDKDELK DGLRVLIPMD DKLLYAGHVQ TVHSPDIYRV VVEGERGNRP
2210 2220 2230 2240 2250
HIYCLEQLLQ EAIIDVRPAS TRFLPQGTRI AAYWSQQYRC LYPGTVVRGL
2260 2270 2280 2290 2300
LDLEDDGDLI TVEFDDGDTG RIPLSHIRLL PPDYKIQCAE PSPALLVPSA
2310 2320 2330 2340 2350
KRRSRKTSKD TGEGKDGGTA GSEEPGAKAR GRGRKPSAKA KGDRAATLEE
2360 2370 2380 2390 2400
GNPTDEVPST PLALEPSSTP GSKKSPPEPV DKRAKAPKAR PAPPQPSPAP
2410 2420 2430 2440 2450
PAFTSCPAPE PFAELPAPAT SLAPAPLITM PATRPKPKKA RAAEESGAKG
2460 2470 2480 2490 2500
PRRPGEEAEL LVKLDHEGVT SPKSKKAKEA LLLREDPGAG GWQEPKSLLS
2510 2520 2530 2540 2550
LGSYPPAAGS SEPKAPWPKA TDGDLAQEPG PGLTFEDSGN PKSPDKAQAE
2560 2570 2580 2590 2600
QDGAEESESS SSSSSGSSSS SSSSSSSGSE TEGEEEGDKN GDGGCGTGGR
2610 2620 2630 2640 2650
NCSAASSRAA SPASSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS
2660 2670 2680 2690 2700
SSSSSSSSSS SSSSSSSSSS STTDEDSSCS SDDEAAPAPT AGPSAQAALP
2710 2720 2730 2740 2750
TKATKQAGKA RPSAHSPGKK TPAPQPQAPP PQPTQPLQPK AQAGAKSRPK
2760 2770 2780 2790 2800
KREGVHLPTT KELAKRQRLP SVENRPKIAA FLPARQLWKW FGKPTQRRGM
2810 2820 2830 2840 2850
KGKARKLFYK AIVRGKEMIR IGDCAVFLSA GRPNLPYIGR IQSMWESWGN
2860 2870 2880 2890 2900
NMVVRVKWFY HPEETSPGKQ FHQGQHWDQK SSRSLPAALR VSSQRKDFME
2910 2920 2930 2940 2950
RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD SEGLYYLAGT
2960
YEPTTGMIFS TDGVPVLC
Length:2,968
Mass (Da):314,519
Last modified:April 29, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC83E5D7E3245740F
GO
Isoform 2 (identifier: O15417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2078-2256: HASSLTAAKR...VRGLLDLEDD → PPPPPPPPHP...GSASPPSGVA
     2257-2968: Missing.

Note: No experimental confirmation available. Dubious isoform produced through aberrant splice sites.
Show »
Length:2,256
Mass (Da):239,498
Checksum:i476F448917A3B6BE
GO
Isoform 3 (identifier: O15417-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1064: Missing.
     1403-1490: QEMGGAERAL...LDFRMRLAEV → PPQGLPPCMG...PSHYRKPQWC
     1491-2968: Missing.

Note: Incomplete sequence. No experimental confirmation available. Non-canonical intron-exon splice junction.
Show »
Length:414
Mass (Da):43,329
Checksum:i3BA1027E95500505
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVB4H9KVB4_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
2,968Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0N9H7C0N9_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXS9H7BXS9_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3U5H7C3U5_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MTZ4A8MTZ4_HUMAN
HCG96198, isoform CRA_d
TNRC18 hCG_96198
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C177H7C177_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9K1C9J9K1_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1255V → A in BAB55047 (PubMed:14702039).Curated1
Sequence conflicti1267A → G in BAB47485 (PubMed:11347906).Curated1
Sequence conflicti1343N → S in BAB55047 (PubMed:14702039).Curated1
Sequence conflicti2292S → P in AAB91447 (PubMed:9225980).Curated1
Sequence conflicti2411P → S in AAB91447 (PubMed:9225980).Curated1
Sequence conflicti2547A → V in AAB91447 (PubMed:9225980).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0427221193A → G. Corresponds to variant dbSNP:rs12671708Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331241 – 1064Missing in isoform 3. 1 PublicationAdd BLAST1064
Alternative sequenceiVSP_0331281403 – 1490QEMGG…RLAEV → PPQGLPPCMGQGSPMPAGLP DCARGPAPTLSGWPRLGEQS RVGLQPGVSVKGTRWRGPGT GPPWSKPSHYRKPQWC in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0331291491 – 2968Missing in isoform 3. 1 PublicationAdd BLAST1478
Alternative sequenceiVSP_0331262078 – 2256HASSL…DLEDD → PPPPPPPPHPPLPPPPLPPP PLPLRLPPLPPPPLPRPHPP PPPPLPPLLPPPQTRTLPAA RTMRQPPPPRLALPRRRRSP PRPPSRPARRGPRPTPQARR RPRPSPRRLLRSPHSLCSPR LRPGPRADPRRERASTSPPP RSWPSGSACRPWRTGPRSPP SCQPGSSGSGSASPPSGVA in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_0331272257 – 2968Missing in isoform 2. 1 PublicationAdd BLAST712

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC093376 Genomic DNA No translation available.
AC093620 Genomic DNA No translation available.
AK027341 mRNA Translation: BAB55047.1 Different initiation.
AB058759 mRNA Translation: BAB47485.1
U80753 mRNA Translation: AAB91447.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47534.1 [O15417-1]

NCBI Reference Sequences

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RefSeqi
NP_001073964.2, NM_001080495.2 [O15417-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.520638

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84629

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84629

UCSC genome browser

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UCSCi
uc003soi.5 human [O15417-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093376 Genomic DNA No translation available.
AC093620 Genomic DNA No translation available.
AK027341 mRNA Translation: BAB55047.1 Different initiation.
AB058759 mRNA Translation: BAB47485.1
U80753 mRNA Translation: AAB91447.1
CCDSiCCDS47534.1 [O15417-1]
RefSeqiNP_001073964.2, NM_001080495.2 [O15417-1]
UniGeneiHs.520638

3D structure databases

ProteinModelPortaliO15417
SMRiO15417
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124158, 26 interactors
IntActiO15417, 12 interactors
MINTiO15417
STRINGi9606.ENSP00000395538

PTM databases

CarbonylDBiO15417
iPTMnetiO15417
PhosphoSitePlusiO15417

Polymorphism and mutation databases

BioMutaiTNRC18

Proteomic databases

EPDiO15417
jPOSTiO15417
MaxQBiO15417
PaxDbiO15417
PeptideAtlasiO15417
PRIDEiO15417
ProteomicsDBi48652
48653 [O15417-2]
48654 [O15417-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1]
GeneIDi84629
KEGGihsa:84629
UCSCiuc003soi.5 human [O15417-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84629
EuPathDBiHostDB:ENSG00000182095.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TNRC18

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0200690
HGNCiHGNC:11962 TNRC18
HPAiHPA020730
HPA024251
neXtProtiNX_O15417
OpenTargetsiENSG00000182095
PharmGKBiPA36649

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUIV Eukaryota
ENOG410YZ4H LUCA
GeneTreeiENSGT00940000157099
HOGENOMiHOG000154656
HOVERGENiHBG108592
InParanoidiO15417
OrthoDBi11077at2759
PhylomeDBiO15417
TreeFamiTF336007

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNRC18 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84629

Protein Ontology

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PROi
PR:O15417

Gene expression databases

BgeeiENSG00000182095 Expressed in 200 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasiO15417 baseline and differential
GenevisibleiO15417 HS

Family and domain databases

InterProiView protein in InterPro
IPR001025 BAH_dom
PfamiView protein in Pfam
PF01426 BAH, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNC18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15417
Secondary accession number(s): A8MX41, Q96JH1, Q96K91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: April 29, 2008
Last modified: February 13, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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