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UniProtKB - O15417 (TNC18_HUMAN)

Entry version 143 (17 Jun 2020)
Sequence version 3 (29 Apr 2008)
Previous versions | rss
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Protein

Trinucleotide repeat-containing gene 18 protein

Gene

TNRC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 18 protein
Alternative name(s):
Long CAG trinucleotide repeat-containing gene 79 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC18
Synonyms:CAGL79, KIAA1856
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000182095.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:11962 TNRC18

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15417

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000182095

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36649

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15417 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNRC18

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991421 – 2968Trinucleotide repeat-containing gene 18 proteinAdd BLAST2968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineCombined sources1
Modified residuei611PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1136PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei1857PhosphoserineCombined sources1
Modified residuei1863PhosphoserineCombined sources1
Modified residuei2146PhosphothreonineCombined sources1
Modified residuei2771PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15417

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15417

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15417

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15417

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15417

PeptideAtlas

More...PeptideAtlasi		O15417

PRoteomics IDEntifications database

More...PRIDEi		O15417

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48652 [O15417-1]
48653 [O15417-2]
48654 [O15417-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O15417

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15417

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15417

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182095 Expressed in nasal cavity epithelium and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15417 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15417 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182095 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124158, 28 interactors

Protein interaction database and analysis system

More...IntActi		O15417, 18 interactors

Molecular INTeraction database

More...MINTi		O15417

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000395538

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15417 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2817 – 2962BAHPROSITE-ProRule annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili916 – 949Sequence analysisAdd BLAST34
Coiled coili1481 – 1516Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi326 – 506Pro-richAdd BLAST181
Compositional biasi968 – 1192Pro-richAdd BLAST225
Compositional biasi1828 – 1841Poly-GluAdd BLAST14
Compositional biasi2353 – 2437Pro-richAdd BLAST85
Compositional biasi2557 – 2681Ser-richAdd BLAST125

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IUIV Eukaryota
ENOG410YZ4H LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157099

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15417

Database of Orthologous Groups

More...OrthoDBi		11077at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15417

TreeFam database of animal gene trees

More...TreeFami		TF336007

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001025 BAH_dom
IPR043151 BAH_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01426 BAH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00439 BAH, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51038 BAH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPA SGLPGPLPPG 
        60         70         80         90        100
KYMAGLNLHP HPGEAFLGSF VASGMGPSAS SHGSPVPLPS DLSFRSPTPS 
       110        120        130        140        150
NLPMVQLWAA HAHEGFSHLP SGLYPSYLHL NHLEPPSSGS PLLSQLGQPS 
       160        170        180        190        200
IFDTQKGQGP GGDGFYLPTA GAPGSLHSHA PSARTPGGGH SSGAPAKGSS 
       210        220        230        240        250
SRDGPAKERA GRGGEPPPLF GKKDPRARGE EASGPRGVVD LTQEARAEGR 
       260        270        280        290        300
QDRGPPRLAE RLSPFLAESK TKNAALQPSV LTMCNGGAGD VGLPALVAEA 
       310        320        330        340        350
GRGGAKEAAR QDEGARLLRR TETLLPGPRP CPSPLPPPPA PPKGPPAPPA 
       360        370        380        390        400
ATPAGVYTVF REQGREHRVV APTFVPSVEA FDERPGPIQI ASQARDARAR 
       410        420        430        440        450
EREAGRPGVL QAPPGSPRPL DRPEGLREKN SVIRSLKRPP PADAPTVRAT 
       460        470        480        490        500
RASPDPRAYV PAKELLKPEA DPRPCERAPR GPAGPAAQQA AKLFGLEPGR 
       510        520        530        540        550
PPPTGPEHKW KPFELGNFAA TQMAVLAAQH HHSRAEEEAA VVAASSSKKA 
       560        570        580        590        600
YLDPGAVLPR SAATCGRPVA DMHSAAHGSG EASAMQSLIK YSGSFARDAV 
       610        620        630        640        650
AVRPGGCGKK SPFGGLGTMK PEPAPTSAGA SRAQARLPHS GGPAAGGGRQ 
       660        670        680        690        700
LKRDPERPES AKAFGREGSG AQGEAEVRHP PVGIAVAVAR QKDSGGSGRL 
       710        720        730        740        750
GPGLVDQERS LSLSNVKGHG RADEDCVDDR ARHREERLLG ARLDRDQEKL 
       760        770        780        790        800
LRESKELADL ARLHPTSCAP NGLNPNLMVT GGPALAGSGR WSADPAAHLA 
       810        820        830        840        850
THPWLPRSGN ASMWLAGHPY GLGPPSLHQG MAPAFPPGLG GSLPSAYQFV 
       860        870        880        890        900
RDPQSGQLVV IPSDHLPHFA ELMERATVPP LWPALYPPGR SPLHHAQQLQ 
       910        920        930        940        950
LFSQQHFLRQ QEFLYLQQQA AQALELQRSA QLVQERLKAQ EHRAEMEEKG 
       960        970        980        990       1000
SKRGLEAAGK AGLATAGPGL LPRKPPGLAA GPAGTYGKAV SPPPSPRASP 
      1010       1020       1030       1040       1050
VAALKAKVIQ KLEDVSKPPA YAYPATPSSH PTSPPPASPP PTPGITRKEE 
      1060       1070       1080       1090       1100
APENVVEKKD LELEKEAPSP FQALFSDIPP RYPFQALPPH YGRPYPFLLQ 
      1110       1120       1130       1140       1150
PTAAADADGL APDVPLPADG PERLALSPED KPIRLSPSKI TEPLREGPEE 
      1160       1170       1180       1190       1200
EPLAEREVKA EVEDMDEGPT ELPPLESPLP LPAAEAMATP SPAGGCGGGL 
      1210       1220       1230       1240       1250
LEAQALSATG QSCAEPSECP DFVEGPEPRV DSPGRTEPCT AALDLGVQLT 
      1260       1270       1280       1290       1300
PETLVEAKEE PVEVPVAVPV VEAVPEEGLA QVAPSESQPT LEMSDCDVPA 
      1310       1320       1330       1340       1350
GEGQCPSLEP QEAVPVLGST CFLEEASSDQ FLPSLEDPLA GMNALAAAAE 
      1360       1370       1380       1390       1400
LPQARPLPSP GAAGAQALEK LEAAESLVLE QSFLHGITLL SEIAELELER 
      1410       1420       1430       1440       1450
RSQEMGGAER ALVARPSLES LLAAGSHMLR EVLDGPVVDP LKNLRLPREL 
      1460       1470       1480       1490       1500
KPNKKYSWMR KKEERMYAMK SSLEDMDALE LDFRMRLAEV QRQYKEKQRE 
      1510       1520       1530       1540       1550
LVKLQRRRDS EDRREEPHRS LARRGPGRPR KRTHAPSALS PPRKRGKSGH 
      1560       1570       1580       1590       1600
SSGKLSSKSL LTSDDYELGA GIRKRHKGSE EEHDALIGMG KARGRNQTWD 
      1610       1620       1630       1640       1650
EHEASSDFIS QLKIKKKKMA SDQEQLASKL DKALSLTKQD KLKSPFKFSD 
      1660       1670       1680       1690       1700
SAGGKSKTSG GCGRYLTPYD SLLGKNRKAL AKGLGLSLKS SREGKHKRAA 
      1710       1720       1730       1740       1750
KTRKMEVGFK ARGQPKSAHS PFASEVSSYS YNTDSEEDEE FLKDEWPAQG 
      1760       1770       1780       1790       1800
PSSSKLTPSL LCSMVAKNSK AAGGPKLTKR GLAAPRTLKP KPATSRKQPF 
      1810       1820       1830       1840       1850
CLLLREAEAR SSFSDSSEES FDQDESSEEE DEEEELEEED EASGGGYRLG 
      1860       1870       1880       1890       1900
ARERALSPGL EESGLGLLAR FAASALPSPT VGPSLSVVQL EAKQKARKKE 
      1910       1920       1930       1940       1950
ERQSLLGTEF EYTDSESEVK VRKRSPAGLL RPKKGLGEPG PSLAAPTPGA 
      1960       1970       1980       1990       2000
RGPDPSSPDK AKLAVEKGRK ARKLRGPKEP GFEAGPEASD DDLWTRRRSE 
      2010       2020       2030       2040       2050
RIFLHDASAA APAPVSTAPA TKTSRCAKGG PLSPRKDAGR AKDRKDPRKK 
      2060       2070       2080       2090       2100
KKGKEAGPGA GLPPPRAPAL PSEARAPHAS SLTAAKRSKA KAKGKEVKKE 
      2110       2120       2130       2140       2150
NRGKGGAVSK LMESMAAEED FEPNQDSSFS EDEHLPRGGA VERPLTPAPR 
      2160       2170       2180       2190       2200
SCIIDKDELK DGLRVLIPMD DKLLYAGHVQ TVHSPDIYRV VVEGERGNRP 
      2210       2220       2230       2240       2250
HIYCLEQLLQ EAIIDVRPAS TRFLPQGTRI AAYWSQQYRC LYPGTVVRGL 
      2260       2270       2280       2290       2300
LDLEDDGDLI TVEFDDGDTG RIPLSHIRLL PPDYKIQCAE PSPALLVPSA 
      2310       2320       2330       2340       2350
KRRSRKTSKD TGEGKDGGTA GSEEPGAKAR GRGRKPSAKA KGDRAATLEE 
      2360       2370       2380       2390       2400
GNPTDEVPST PLALEPSSTP GSKKSPPEPV DKRAKAPKAR PAPPQPSPAP 
      2410       2420       2430       2440       2450
PAFTSCPAPE PFAELPAPAT SLAPAPLITM PATRPKPKKA RAAEESGAKG 
      2460       2470       2480       2490       2500
PRRPGEEAEL LVKLDHEGVT SPKSKKAKEA LLLREDPGAG GWQEPKSLLS 
      2510       2520       2530       2540       2550
LGSYPPAAGS SEPKAPWPKA TDGDLAQEPG PGLTFEDSGN PKSPDKAQAE 
      2560       2570       2580       2590       2600
QDGAEESESS SSSSSGSSSS SSSSSSSGSE TEGEEEGDKN GDGGCGTGGR 
      2610       2620       2630       2640       2650
NCSAASSRAA SPASSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS 
      2660       2670       2680       2690       2700
SSSSSSSSSS SSSSSSSSSS STTDEDSSCS SDDEAAPAPT AGPSAQAALP 
      2710       2720       2730       2740       2750
TKATKQAGKA RPSAHSPGKK TPAPQPQAPP PQPTQPLQPK AQAGAKSRPK 
      2760       2770       2780       2790       2800
KREGVHLPTT KELAKRQRLP SVENRPKIAA FLPARQLWKW FGKPTQRRGM 
      2810       2820       2830       2840       2850
KGKARKLFYK AIVRGKEMIR IGDCAVFLSA GRPNLPYIGR IQSMWESWGN 
      2860       2870       2880       2890       2900
NMVVRVKWFY HPEETSPGKQ FHQGQHWDQK SSRSLPAALR VSSQRKDFME 
      2910       2920       2930       2940       2950
RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD SEGLYYLAGT 
      2960 
YEPTTGMIFS TDGVPVLC
Length:2,968
Mass (Da):314,519
Last modified:April 29, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC83E5D7E3245740F
GO
Isoform 2 (identifier: O15417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2078-2256: HASSLTAAKR...VRGLLDLEDD → PPPPPPPPHP...GSASPPSGVA
     2257-2968: Missing.

Note: Dubious isoform produced through aberrant splice sites.Curated
Show »
Length:2,256
Mass (Da):239,498
Checksum:i476F448917A3B6BE
GO
Isoform 3 (identifier: O15417-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1064: Missing.
     1403-1490: QEMGGAERAL...LDFRMRLAEV → PPQGLPPCMG...PSHYRKPQWC
     1491-2968: Missing.

Note: Incomplete sequence. Non-canonical intron-exon splice junction.Curated
Show »
Length:414
Mass (Da):43,329
Checksum:i3BA1027E95500505
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVB4H9KVB4_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
2,968Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXS9H7BXS9_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0N9H7C0N9_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C177H7C177_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9K1C9J9K1_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MTZ4A8MTZ4_HUMAN
HCG96198, isoform CRA_d
TNRC18 hCG_96198
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3U5H7C3U5_HUMAN
Trinucleotide repeat-containing gen...
TNRC18
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55047 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1255V → A in BAB55047 (PubMed:14702039).Curated1
Sequence conflicti1267A → G in BAB47485 (PubMed:11347906).Curated1
Sequence conflicti1343N → S in BAB55047 (PubMed:14702039).Curated1
Sequence conflicti2292S → P in AAB91447 (PubMed:9225980).Curated1
Sequence conflicti2411P → S in AAB91447 (PubMed:9225980).Curated1
Sequence conflicti2547A → V in AAB91447 (PubMed:9225980).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0427221193A → G. Corresponds to variant dbSNP:rs12671708Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0331241 – 1064Missing in isoform 3. 1 PublicationAdd BLAST1064
Alternative sequenceiVSP_0331281403 – 1490QEMGG…RLAEV → PPQGLPPCMGQGSPMPAGLP DCARGPAPTLSGWPRLGEQS RVGLQPGVSVKGTRWRGPGT GPPWSKPSHYRKPQWC in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0331291491 – 2968Missing in isoform 3. 1 PublicationAdd BLAST1478
Alternative sequenceiVSP_0331262078 – 2256HASSL…DLEDD → PPPPPPPPHPPLPPPPLPPP PLPLRLPPLPPPPLPRPHPP PPPPLPPLLPPPQTRTLPAA RTMRQPPPPRLALPRRRRSP PRPPSRPARRGPRPTPQARR RPRPSPRRLLRSPHSLCSPR LRPGPRADPRRERASTSPPP RSWPSGSACRPWRTGPRSPP SCQPGSSGSGSASPPSGVA in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_0331272257 – 2968Missing in isoform 2. 1 PublicationAdd BLAST712

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC093376 Genomic DNA No translation available.
AC093620 Genomic DNA No translation available.
AK027341 mRNA Translation: BAB55047.1 Different initiation.
AB058759 mRNA Translation: BAB47485.1
U80753 mRNA Translation: AAB91447.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47534.1 [O15417-1]

NCBI Reference Sequences

More...RefSeqi		NP_001073964.2, NM_001080495.2 [O15417-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84629

UCSC genome browser

More...UCSCi		uc003soi.5 human [O15417-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093376 Genomic DNA No translation available.
AC093620 Genomic DNA No translation available.
AK027341 mRNA Translation: BAB55047.1 Different initiation.
AB058759 mRNA Translation: BAB47485.1
U80753 mRNA Translation: AAB91447.1
CCDSiCCDS47534.1 [O15417-1]
RefSeqiNP_001073964.2, NM_001080495.2 [O15417-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124158, 28 interactors
IntActiO15417, 18 interactors
MINTiO15417
STRINGi9606.ENSP00000395538

PTM databases

CarbonylDBiO15417
iPTMnetiO15417
PhosphoSitePlusiO15417

Polymorphism and mutation databases

BioMutaiTNRC18

Proteomic databases

EPDiO15417
jPOSTiO15417
MassIVEiO15417
MaxQBiO15417
PaxDbiO15417
PeptideAtlasiO15417
PRIDEiO15417
ProteomicsDBi48652 [O15417-1]
48653 [O15417-2]
48654 [O15417-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43721 24 antibodies

Genome annotation databases

EnsembliENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1]
GeneIDi84629
KEGGihsa:84629
UCSCiuc003soi.5 human [O15417-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84629
EuPathDBiHostDB:ENSG00000182095.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNRC18
HGNCiHGNC:11962 TNRC18
HPAiENSG00000182095 Low tissue specificity
neXtProtiNX_O15417
OpenTargetsiENSG00000182095
PharmGKBiPA36649

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IUIV Eukaryota
ENOG410YZ4H LUCA
GeneTreeiENSGT00940000157099
InParanoidiO15417
OrthoDBi11077at2759
PhylomeDBiO15417
TreeFamiTF336007

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84629 9 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNRC18 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84629
PharosiO15417 Tdark

Protein Ontology

More...PROi		PR:O15417
RNActiO15417 protein

Gene expression databases

BgeeiENSG00000182095 Expressed in nasal cavity epithelium and 199 other tissues
ExpressionAtlasiO15417 baseline and differential
GenevisibleiO15417 HS

Family and domain databases

Gene3Di2.30.30.490, 1 hit
InterProiView protein in InterPro
IPR001025 BAH_dom
IPR043151 BAH_sf
PfamiView protein in Pfam
PF01426 BAH, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNC18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15417
Secondary accession number(s): A8MX41, Q96JH1, Q96K91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: April 29, 2008
Last modified: June 17, 2020
This is version 143 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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