UniProtKB - O15417 (TNC18_HUMAN)
Trinucleotide repeat-containing gene 18 protein
TNRC18
Names & Taxonomyi
Protein namesi | Recommended name: Trinucleotide repeat-containing gene 18 proteinAlternative name(s): Long CAG trinucleotide repeat-containing gene 79 protein |
Gene namesi | Name:TNRC18 Synonyms:CAGL79, KIAA1856 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182095.14 |
HGNCi | HGNC:11962 TNRC18 |
neXtProti | NX_O15417 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: HPA
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000182095 |
PharmGKBi | PA36649 |
Polymorphism and mutation databases
BioMutai | TNRC18 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299142 | 1 – 2968 | Trinucleotide repeat-containing gene 18 proteinAdd BLAST | 2968 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 263 | PhosphoserineCombined sources | 1 | |
Modified residuei | 611 | PhosphoserineBy similarity | 1 | |
Cross-linki | 620 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1136 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1540 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1857 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1863 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2146 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2771 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O15417 |
jPOSTi | O15417 |
MaxQBi | O15417 |
PaxDbi | O15417 |
PeptideAtlasi | O15417 |
PRIDEi | O15417 |
ProteomicsDBi | 48652 48653 [O15417-2] 48654 [O15417-3] |
PTM databases
CarbonylDBi | O15417 |
iPTMneti | O15417 |
PhosphoSitePlusi | O15417 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182095 Expressed in 200 organ(s), highest expression level in nasal cavity epithelium |
ExpressionAtlasi | O15417 baseline and differential |
Genevisiblei | O15417 HS |
Organism-specific databases
HPAi | HPA020730 HPA024251 |
Interactioni
Protein-protein interaction databases
BioGridi | 124158, 26 interactors |
IntActi | O15417, 12 interactors |
MINTi | O15417 |
STRINGi | 9606.ENSP00000395538 |
Structurei
3D structure databases
ProteinModelPortali | O15417 |
SMRi | O15417 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2817 – 2962 | BAHPROSITE-ProRule annotationAdd BLAST | 146 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 916 – 949 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 1481 – 1516 | Sequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 326 – 506 | Pro-richAdd BLAST | 181 | |
Compositional biasi | 968 – 1192 | Pro-richAdd BLAST | 225 | |
Compositional biasi | 1828 – 1841 | Poly-GluAdd BLAST | 14 | |
Compositional biasi | 2353 – 2437 | Pro-richAdd BLAST | 85 | |
Compositional biasi | 2557 – 2681 | Ser-richAdd BLAST | 125 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG410IUIV Eukaryota ENOG410YZ4H LUCA |
GeneTreei | ENSGT00940000157099 |
HOGENOMi | HOG000154656 |
HOVERGENi | HBG108592 |
InParanoidi | O15417 |
OrthoDBi | 11077at2759 |
PhylomeDBi | O15417 |
TreeFami | TF336007 |
Family and domain databases
InterProi | View protein in InterPro IPR001025 BAH_dom |
Pfami | View protein in Pfam PF01426 BAH, 1 hit |
SMARTi | View protein in SMART SM00439 BAH, 1 hit |
PROSITEi | View protein in PROSITE PS51038 BAH, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPA SGLPGPLPPG
60 70 80 90 100
KYMAGLNLHP HPGEAFLGSF VASGMGPSAS SHGSPVPLPS DLSFRSPTPS
110 120 130 140 150
NLPMVQLWAA HAHEGFSHLP SGLYPSYLHL NHLEPPSSGS PLLSQLGQPS
160 170 180 190 200
IFDTQKGQGP GGDGFYLPTA GAPGSLHSHA PSARTPGGGH SSGAPAKGSS
210 220 230 240 250
SRDGPAKERA GRGGEPPPLF GKKDPRARGE EASGPRGVVD LTQEARAEGR
260 270 280 290 300
QDRGPPRLAE RLSPFLAESK TKNAALQPSV LTMCNGGAGD VGLPALVAEA
310 320 330 340 350
GRGGAKEAAR QDEGARLLRR TETLLPGPRP CPSPLPPPPA PPKGPPAPPA
360 370 380 390 400
ATPAGVYTVF REQGREHRVV APTFVPSVEA FDERPGPIQI ASQARDARAR
410 420 430 440 450
EREAGRPGVL QAPPGSPRPL DRPEGLREKN SVIRSLKRPP PADAPTVRAT
460 470 480 490 500
RASPDPRAYV PAKELLKPEA DPRPCERAPR GPAGPAAQQA AKLFGLEPGR
510 520 530 540 550
PPPTGPEHKW KPFELGNFAA TQMAVLAAQH HHSRAEEEAA VVAASSSKKA
560 570 580 590 600
YLDPGAVLPR SAATCGRPVA DMHSAAHGSG EASAMQSLIK YSGSFARDAV
610 620 630 640 650
AVRPGGCGKK SPFGGLGTMK PEPAPTSAGA SRAQARLPHS GGPAAGGGRQ
660 670 680 690 700
LKRDPERPES AKAFGREGSG AQGEAEVRHP PVGIAVAVAR QKDSGGSGRL
710 720 730 740 750
GPGLVDQERS LSLSNVKGHG RADEDCVDDR ARHREERLLG ARLDRDQEKL
760 770 780 790 800
LRESKELADL ARLHPTSCAP NGLNPNLMVT GGPALAGSGR WSADPAAHLA
810 820 830 840 850
THPWLPRSGN ASMWLAGHPY GLGPPSLHQG MAPAFPPGLG GSLPSAYQFV
860 870 880 890 900
RDPQSGQLVV IPSDHLPHFA ELMERATVPP LWPALYPPGR SPLHHAQQLQ
910 920 930 940 950
LFSQQHFLRQ QEFLYLQQQA AQALELQRSA QLVQERLKAQ EHRAEMEEKG
960 970 980 990 1000
SKRGLEAAGK AGLATAGPGL LPRKPPGLAA GPAGTYGKAV SPPPSPRASP
1010 1020 1030 1040 1050
VAALKAKVIQ KLEDVSKPPA YAYPATPSSH PTSPPPASPP PTPGITRKEE
1060 1070 1080 1090 1100
APENVVEKKD LELEKEAPSP FQALFSDIPP RYPFQALPPH YGRPYPFLLQ
1110 1120 1130 1140 1150
PTAAADADGL APDVPLPADG PERLALSPED KPIRLSPSKI TEPLREGPEE
1160 1170 1180 1190 1200
EPLAEREVKA EVEDMDEGPT ELPPLESPLP LPAAEAMATP SPAGGCGGGL
1210 1220 1230 1240 1250
LEAQALSATG QSCAEPSECP DFVEGPEPRV DSPGRTEPCT AALDLGVQLT
1260 1270 1280 1290 1300
PETLVEAKEE PVEVPVAVPV VEAVPEEGLA QVAPSESQPT LEMSDCDVPA
1310 1320 1330 1340 1350
GEGQCPSLEP QEAVPVLGST CFLEEASSDQ FLPSLEDPLA GMNALAAAAE
1360 1370 1380 1390 1400
LPQARPLPSP GAAGAQALEK LEAAESLVLE QSFLHGITLL SEIAELELER
1410 1420 1430 1440 1450
RSQEMGGAER ALVARPSLES LLAAGSHMLR EVLDGPVVDP LKNLRLPREL
1460 1470 1480 1490 1500
KPNKKYSWMR KKEERMYAMK SSLEDMDALE LDFRMRLAEV QRQYKEKQRE
1510 1520 1530 1540 1550
LVKLQRRRDS EDRREEPHRS LARRGPGRPR KRTHAPSALS PPRKRGKSGH
1560 1570 1580 1590 1600
SSGKLSSKSL LTSDDYELGA GIRKRHKGSE EEHDALIGMG KARGRNQTWD
1610 1620 1630 1640 1650
EHEASSDFIS QLKIKKKKMA SDQEQLASKL DKALSLTKQD KLKSPFKFSD
1660 1670 1680 1690 1700
SAGGKSKTSG GCGRYLTPYD SLLGKNRKAL AKGLGLSLKS SREGKHKRAA
1710 1720 1730 1740 1750
KTRKMEVGFK ARGQPKSAHS PFASEVSSYS YNTDSEEDEE FLKDEWPAQG
1760 1770 1780 1790 1800
PSSSKLTPSL LCSMVAKNSK AAGGPKLTKR GLAAPRTLKP KPATSRKQPF
1810 1820 1830 1840 1850
CLLLREAEAR SSFSDSSEES FDQDESSEEE DEEEELEEED EASGGGYRLG
1860 1870 1880 1890 1900
ARERALSPGL EESGLGLLAR FAASALPSPT VGPSLSVVQL EAKQKARKKE
1910 1920 1930 1940 1950
ERQSLLGTEF EYTDSESEVK VRKRSPAGLL RPKKGLGEPG PSLAAPTPGA
1960 1970 1980 1990 2000
RGPDPSSPDK AKLAVEKGRK ARKLRGPKEP GFEAGPEASD DDLWTRRRSE
2010 2020 2030 2040 2050
RIFLHDASAA APAPVSTAPA TKTSRCAKGG PLSPRKDAGR AKDRKDPRKK
2060 2070 2080 2090 2100
KKGKEAGPGA GLPPPRAPAL PSEARAPHAS SLTAAKRSKA KAKGKEVKKE
2110 2120 2130 2140 2150
NRGKGGAVSK LMESMAAEED FEPNQDSSFS EDEHLPRGGA VERPLTPAPR
2160 2170 2180 2190 2200
SCIIDKDELK DGLRVLIPMD DKLLYAGHVQ TVHSPDIYRV VVEGERGNRP
2210 2220 2230 2240 2250
HIYCLEQLLQ EAIIDVRPAS TRFLPQGTRI AAYWSQQYRC LYPGTVVRGL
2260 2270 2280 2290 2300
LDLEDDGDLI TVEFDDGDTG RIPLSHIRLL PPDYKIQCAE PSPALLVPSA
2310 2320 2330 2340 2350
KRRSRKTSKD TGEGKDGGTA GSEEPGAKAR GRGRKPSAKA KGDRAATLEE
2360 2370 2380 2390 2400
GNPTDEVPST PLALEPSSTP GSKKSPPEPV DKRAKAPKAR PAPPQPSPAP
2410 2420 2430 2440 2450
PAFTSCPAPE PFAELPAPAT SLAPAPLITM PATRPKPKKA RAAEESGAKG
2460 2470 2480 2490 2500
PRRPGEEAEL LVKLDHEGVT SPKSKKAKEA LLLREDPGAG GWQEPKSLLS
2510 2520 2530 2540 2550
LGSYPPAAGS SEPKAPWPKA TDGDLAQEPG PGLTFEDSGN PKSPDKAQAE
2560 2570 2580 2590 2600
QDGAEESESS SSSSSGSSSS SSSSSSSGSE TEGEEEGDKN GDGGCGTGGR
2610 2620 2630 2640 2650
NCSAASSRAA SPASSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS
2660 2670 2680 2690 2700
SSSSSSSSSS SSSSSSSSSS STTDEDSSCS SDDEAAPAPT AGPSAQAALP
2710 2720 2730 2740 2750
TKATKQAGKA RPSAHSPGKK TPAPQPQAPP PQPTQPLQPK AQAGAKSRPK
2760 2770 2780 2790 2800
KREGVHLPTT KELAKRQRLP SVENRPKIAA FLPARQLWKW FGKPTQRRGM
2810 2820 2830 2840 2850
KGKARKLFYK AIVRGKEMIR IGDCAVFLSA GRPNLPYIGR IQSMWESWGN
2860 2870 2880 2890 2900
NMVVRVKWFY HPEETSPGKQ FHQGQHWDQK SSRSLPAALR VSSQRKDFME
2910 2920 2930 2940 2950
RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD SEGLYYLAGT
2960
YEPTTGMIFS TDGVPVLC
The sequence of this isoform differs from the canonical sequence as follows:
2078-2256: HASSLTAAKR...VRGLLDLEDD → PPPPPPPPHP...GSASPPSGVA
2257-2968: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1064: Missing.
1403-1490: QEMGGAERAL...LDFRMRLAEV → PPQGLPPCMG...PSHYRKPQWC
1491-2968: Missing.
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH9KVB4 | H9KVB4_HUMAN | Trinucleotide repeat-containing gen... | TNRC18 | 2,968 | Annotation score: | ||
H7C0N9 | H7C0N9_HUMAN | Trinucleotide repeat-containing gen... | TNRC18 | 252 | Annotation score: | ||
H7C3U5 | H7C3U5_HUMAN | Trinucleotide repeat-containing gen... | TNRC18 | 308 | Annotation score: | ||
H7BXS9 | H7BXS9_HUMAN | Trinucleotide repeat-containing gen... | TNRC18 | 407 | Annotation score: | ||
A8MTZ4 | A8MTZ4_HUMAN | HCG96198, isoform CRA_d | TNRC18 hCG_96198 | 130 | Annotation score: | ||
H7C177 | H7C177_HUMAN | Trinucleotide repeat-containing gen... | TNRC18 | 192 | Annotation score: | ||
C9J9K1 | C9J9K1_HUMAN | Trinucleotide repeat-containing gen... | TNRC18 | 99 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1255 | V → A in BAB55047 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1267 | A → G in BAB47485 (PubMed:11347906).Curated | 1 | |
Sequence conflicti | 1343 | N → S in BAB55047 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2292 | S → P in AAB91447 (PubMed:9225980).Curated | 1 | |
Sequence conflicti | 2411 | P → S in AAB91447 (PubMed:9225980).Curated | 1 | |
Sequence conflicti | 2547 | A → V in AAB91447 (PubMed:9225980).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042722 | 1193 | A → G. Corresponds to variant dbSNP:rs12671708Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033124 | 1 – 1064 | Missing in isoform 3. 1 PublicationAdd BLAST | 1064 | |
Alternative sequenceiVSP_033128 | 1403 – 1490 | QEMGG…RLAEV → PPQGLPPCMGQGSPMPAGLP DCARGPAPTLSGWPRLGEQS RVGLQPGVSVKGTRWRGPGT GPPWSKPSHYRKPQWC in isoform 3. 1 PublicationAdd BLAST | 88 | |
Alternative sequenceiVSP_033129 | 1491 – 2968 | Missing in isoform 3. 1 PublicationAdd BLAST | 1478 | |
Alternative sequenceiVSP_033126 | 2078 – 2256 | HASSL…DLEDD → PPPPPPPPHPPLPPPPLPPP PLPLRLPPLPPPPLPRPHPP PPPPLPPLLPPPQTRTLPAA RTMRQPPPPRLALPRRRRSP PRPPSRPARRGPRPTPQARR RPRPSPRRLLRSPHSLCSPR LRPGPRADPRRERASTSPPP RSWPSGSACRPWRTGPRSPP SCQPGSSGSGSASPPSGVA in isoform 2. 1 PublicationAdd BLAST | 179 | |
Alternative sequenceiVSP_033127 | 2257 – 2968 | Missing in isoform 2. 1 PublicationAdd BLAST | 712 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093376 Genomic DNA No translation available. AC093620 Genomic DNA No translation available. AK027341 mRNA Translation: BAB55047.1 Different initiation. AB058759 mRNA Translation: BAB47485.1 U80753 mRNA Translation: AAB91447.1 |
CCDSi | CCDS47534.1 [O15417-1] |
RefSeqi | NP_001073964.2, NM_001080495.2 [O15417-1] |
UniGenei | Hs.520638 |
Genome annotation databases
Ensembli | ENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1] |
GeneIDi | 84629 |
KEGGi | hsa:84629 |
UCSCi | uc003soi.5 human [O15417-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093376 Genomic DNA No translation available. AC093620 Genomic DNA No translation available. AK027341 mRNA Translation: BAB55047.1 Different initiation. AB058759 mRNA Translation: BAB47485.1 U80753 mRNA Translation: AAB91447.1 |
CCDSi | CCDS47534.1 [O15417-1] |
RefSeqi | NP_001073964.2, NM_001080495.2 [O15417-1] |
UniGenei | Hs.520638 |
3D structure databases
ProteinModelPortali | O15417 |
SMRi | O15417 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 124158, 26 interactors |
IntActi | O15417, 12 interactors |
MINTi | O15417 |
STRINGi | 9606.ENSP00000395538 |
PTM databases
CarbonylDBi | O15417 |
iPTMneti | O15417 |
PhosphoSitePlusi | O15417 |
Polymorphism and mutation databases
BioMutai | TNRC18 |
Proteomic databases
EPDi | O15417 |
jPOSTi | O15417 |
MaxQBi | O15417 |
PaxDbi | O15417 |
PeptideAtlasi | O15417 |
PRIDEi | O15417 |
ProteomicsDBi | 48652 48653 [O15417-2] 48654 [O15417-3] |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000430969; ENSP00000395538; ENSG00000182095 [O15417-1] |
GeneIDi | 84629 |
KEGGi | hsa:84629 |
UCSCi | uc003soi.5 human [O15417-1] |
Organism-specific databases
CTDi | 84629 |
EuPathDBi | HostDB:ENSG00000182095.14 |
GeneCardsi | TNRC18 |
H-InvDBi | HIX0200690 |
HGNCi | HGNC:11962 TNRC18 |
HPAi | HPA020730 HPA024251 |
neXtProti | NX_O15417 |
OpenTargetsi | ENSG00000182095 |
PharmGKBi | PA36649 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IUIV Eukaryota ENOG410YZ4H LUCA |
GeneTreei | ENSGT00940000157099 |
HOGENOMi | HOG000154656 |
HOVERGENi | HBG108592 |
InParanoidi | O15417 |
OrthoDBi | 11077at2759 |
PhylomeDBi | O15417 |
TreeFami | TF336007 |
Miscellaneous databases
ChiTaRSi | TNRC18 human |
GenomeRNAii | 84629 |
PROi | PR:O15417 |
Gene expression databases
Bgeei | ENSG00000182095 Expressed in 200 organ(s), highest expression level in nasal cavity epithelium |
ExpressionAtlasi | O15417 baseline and differential |
Genevisiblei | O15417 HS |
Family and domain databases
InterProi | View protein in InterPro IPR001025 BAH_dom |
Pfami | View protein in Pfam PF01426 BAH, 1 hit |
SMARTi | View protein in SMART SM00439 BAH, 1 hit |
PROSITEi | View protein in PROSITE PS51038 BAH, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TNC18_HUMAN | |
Accessioni | O15417Primary (citable) accession number: O15417 Secondary accession number(s): A8MX41, Q96JH1, Q96K91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | April 29, 2008 | |
Last modified: | February 13, 2019 | |
This is version 134 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations