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UniProtKB - O15409 (FOXP2_HUMAN)

Entry version 204 (23 Feb 2022)
Sequence version 2 (05 Dec 2001)
Previous versions | rss
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Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri346 – 371C2H2-typeAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi504 – 594Fork-headPROSITE-ProRule annotationAdd BLAST91

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15409

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O15409

SIGNOR Signaling Network Open Resource

More...SIGNORi		O15409

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Forkhead box protein P2
Alternative name(s):
CAG repeat protein 44
Trinucleotide repeat-containing gene 10 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOXP2
Synonyms:CAGH44, TNRC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13875, FOXP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605317, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15409

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000128573

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Speech-language disorder 1 (SPCH1)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012278553R → H in SPCH1; reduced interaction with TBR1. 2 PublicationsCorresponds to variant dbSNP:rs121908377EnsemblClinVar.1
A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		93986

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		FOXP2

MalaCards human disease database

More...MalaCardsi		FOXP2
MIMi602081, phenotype

Open Targets

More...OpenTargetsi		ENSG00000128573

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		251061, 7q31 microdeletion syndrome
209908, Childhood apraxia of speech

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28242

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15409, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FOXP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000918791 – 715Forkhead box protein P2Add BLAST715

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15409

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15409

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15409

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15409

PeptideAtlas

More...PeptideAtlasi		O15409

PRoteomics IDEntifications database

More...PRIDEi		O15409

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48644 [O15409-1]
48645 [O15409-2]
48646 [O15409-4]
48647 [O15409-5]
48648 [O15409-6]
48649 [O15409-7]
48650 [O15409-8]
48651 [O15409-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15409

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15409

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128573, Expressed in stomach and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15409, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15409, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128573, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding.

Interacts with CTBP1 (By similarity).

Interacts with FOXP1 (PubMed:26647308). Isoform 1 and isoform 3 interact with TBR1 (PubMed:25232744, PubMed:30250039).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125073, 39 interactors

Database of interacting proteins

More...DIPi		DIP-29004N

Protein interaction database and analysis system

More...IntActi		O15409, 30 interactors

Molecular INTeraction database

More...MINTi		O15409

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386200

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15409, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15409

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O15409

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni281 – 339DisorderedSequence analysisAdd BLAST59
Regioni388 – 409Leucine-zipperAdd BLAST22
Regioni422 – 426CTBP1-bindingBy similarity5
Regioni438 – 465DisorderedSequence analysisAdd BLAST28
Regioni649 – 668DisorderedSequence analysisAdd BLAST20
Regioni678 – 715DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi288 – 327Polar residuesSequence analysisAdd BLAST40
Compositional biasi650 – 665Polar residuesSequence analysisAdd BLAST16
Compositional biasi701 – 715Acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 371C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4385, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155480

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_2557677_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15409

Identification of Orthologs from Complete Genome Data

More...OMAi		XHLNNEH

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15409

TreeFam database of animal gene trees

More...TreeFami		TF326978

Family and domain databases

Conserved Domains Database

More...CDDi		cd00059, FH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00429

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001766, Fork_head_dom
IPR032354, FOXP-CC
IPR030456, TF_fork_head_CS_2
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00250, Forkhead, 1 hit
PF16159, FOXP-CC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00053, FORKHEAD

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00339, FH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00658, FORK_HEAD_2, 1 hit
PS50039, FORK_HEAD_3, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15409-1) [UniParc]FASTAAdd to basket
Also known as: I

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL 
        60         70         80         90        100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT 
       110        120        130        140        150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL 
       160        170        180        190        200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHPGKQAKEQ 
       210        220        230        240        250
QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG LISIPPGQAA 
       260        270        280        290        300
LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT 
       310        320        330        340        350
SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW 
       360        370        380        390        400
PGCESICEDF GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE 
       410        420        430        440        450
RLQAMMTHLH MRPSEPKPSP KPLNLVSSVT MSKNMLETSP QSLPQTPTTP 
       460        470        480        490        500
TAPVTPITQG PSVITPASVP NVGAIRRRHS DKYNIPMSSE IAPNYEFYKN 
       510        520        530        540        550
ADVRPPFTYA TLIRQAIMES SDRQLTLNEI YSWFTRTFAY FRRNAATWKN 
       560        570        580        590        600
AVRHNLSLHK CFVRVENVKG AVWTVDEVEY QKRRSQKITG SPTLVKNIPT 
       610        620        630        640        650
SLGYGAALNA SLQAALAESS LPLLSNPGLI NNASSGLLQA VHEDLNGSLD 
       660        670        680        690        700
HIDSNGNSSP GCSPQPHIHS IHVKEEPVIA EDEDCPMSLV TTANHSPELE 
       710 
DDREIEEEPL SEDLE
Length:715
Mass (Da):79,919
Last modified:December 5, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F9FBDB6D90516E0
GO
Isoform 2 (identifier: O15409-3)
Also known as: II
Sequence is not available
Length:–
Mass (Da):–
Isoform 3 (identifier: O15409-2) [UniParc]FASTAAdd to basket
Also known as: III, IV

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:623
Mass (Da):70,104
Checksum:iF78EA67F33A3AE05
GO
Isoform 4 (identifier: O15409-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA

Show »
Length:740
Mass (Da):82,565
Checksum:i423EC421368FCD94
GO
Isoform 5 (identifier: O15409-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA
     133-143: QQLQEFYKKQQ → VMWVTCFGVLA
     144-715: Missing.

Show »
Length:168
Mass (Da):18,315
Checksum:i61B297B4D64BC670
GO
Isoform 6 (identifier: O15409-6) [UniParc]FASTAAdd to basket
Also known as: FOXP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     423-432: LNLVSSVTMS → VSAYCFINSK
     433-715: Missing.

Show »
Length:432
Mass (Da):48,764
Checksum:i42BC7890ACAF498C
GO
Isoform 7 (identifier: O15409-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-715: Missing.

Show »
Length:365
Mass (Da):40,969
Checksum:i0B052282E2E30771
GO
Isoform 8 (identifier: O15409-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: V → P
     88-715: Missing.

Show »
Length:87
Mass (Da):9,377
Checksum:i624274B876E062E4
GO
Isoform 9 (identifier: O15409-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-132: Q → QDFLDSGLENFRAALEKN

Show »
Length:732
Mass (Da):81,840
Checksum:i8B72F946ABD821EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUV4A8MUV4_HUMAN
Forkhead box protein P2
FOXP2
694Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q0PRL4Q0PRL4_HUMAN
Forkhead box P2 variant 3
FOXP2
530Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQE0A0A0U1RQE0_HUMAN
Forkhead box protein P2
FOXP2
589Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQM2A0A0U1RQM2_HUMAN
Forkhead box protein P2
FOXP2
716Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQR8A0A0U1RQR8_HUMAN
Forkhead box protein P2
FOXP2
698Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQY3A0A0U1RQY3_HUMAN
Forkhead box protein P2
FOXP2
712Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N6B5Q8N6B5_HUMAN
Forkhead box P2, isoform CRA_d
FOXP2 hCG_1813384
456Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q75MZ5Q75MZ5_HUMAN
Forkhead box P2, isoform CRA_a
FOXP2 hCG_1813384
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQE6A0A0U1RQE6_HUMAN
Forkhead box protein P2
FOXP2
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MTU2A8MTU2_HUMAN
Forkhead box protein P2
FOXP2
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29A → V in AAM60762 (PubMed:12189486).Curated1
Sequence conflicti134Q → H in AAB91439 (PubMed:9225980).Curated1
Sequence conflicti290 – 304DLTTN…TSSNT → EEFPVQGPAAVCAGL in AAB91439 (PubMed:9225980).CuratedAdd BLAST15
Sequence conflicti414S → L in AAM60766 (PubMed:12189486).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012278553R → H in SPCH1; reduced interaction with TBR1. 2 PublicationsCorresponds to variant dbSNP:rs121908377EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0015581 – 92Missing in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_01153286Q → QELLPETKLCICGHSSGDGH PHNTFA in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_01153387V → P in isoform 8. 1 Publication1
Alternative sequenceiVSP_01153488 – 715Missing in isoform 8. 1 PublicationAdd BLAST628
Alternative sequenceiVSP_043464132Q → QDFLDSGLENFRAALEKN in isoform 9. 1 Publication1
Alternative sequenceiVSP_011535133 – 143QQLQEFYKKQQ → VMWVTCFGVLA in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_011536144 – 715Missing in isoform 5. 1 PublicationAdd BLAST572
Alternative sequenceiVSP_011537366 – 715Missing in isoform 7. 1 PublicationAdd BLAST350
Alternative sequenceiVSP_011538423 – 432LNLVSSVTMS → VSAYCFINSK in isoform 6. 1 Publication10
Alternative sequenceiVSP_011539433 – 715Missing in isoform 6. 1 PublicationAdd BLAST283

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF337817 mRNA Translation: AAL10762.1
AF467252 mRNA Translation: AAM60762.1
AF467253 mRNA Translation: AAM60763.1
AF467254 mRNA Translation: AAM60764.1
AF467255 mRNA Translation: AAM60765.1
AF467256 mRNA Translation: AAM60766.1
AF467257 mRNA Translation: AAM60767.1
AF493430 mRNA Translation: AAM13672.1
AY144615 mRNA Translation: AAN60016.1
AK131266 mRNA Translation: BAD18444.1 Sequence problems.
AK296957 mRNA Translation: BAG59501.1
AC003992 Genomic DNA Translation: AAS07399.1
AC020606 Genomic DNA Translation: AAS07502.1
AC073626 Genomic DNA No translation available.
AC074000 Genomic DNA No translation available.
AC092148 Genomic DNA No translation available.
AC092606 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24367.1
CH236947 Genomic DNA Translation: EAL24369.1
CH471070 Genomic DNA Translation: EAW83484.1
CH471070 Genomic DNA Translation: EAW83486.1
BC126104 mRNA Translation: AAI26105.1
BC143866 mRNA Translation: AAI43867.1
U80741 mRNA Translation: AAB91439.1
AF515031 Genomic DNA Translation: AAN03389.1
AF515032 Genomic DNA Translation: AAN03390.1
AF515033 Genomic DNA Translation: AAN03391.1
AF515034 Genomic DNA Translation: AAN03392.1
AF515035 Genomic DNA Translation: AAN03393.1
AF515036 Genomic DNA Translation: AAN03394.1
AF515037 Genomic DNA Translation: AAN03395.1
AF515038 Genomic DNA Translation: AAN03396.1
AF515039 Genomic DNA Translation: AAN03397.1
AF515040 Genomic DNA Translation: AAN03398.1
AF515041 Genomic DNA Translation: AAN03399.1
AF515042 Genomic DNA Translation: AAN03400.1
AF515043 Genomic DNA Translation: AAN03401.1
AF515044 Genomic DNA Translation: AAN03402.1
AF515045 Genomic DNA Translation: AAN03403.1
AF515046 Genomic DNA Translation: AAN03404.1
AF515047 Genomic DNA Translation: AAN03405.1
AF515048 Genomic DNA Translation: AAN03406.1
AF515049 Genomic DNA Translation: AAN03407.1
AF515050 Genomic DNA Translation: AAN03408.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43635.1 [O15409-4]
CCDS55154.1 [O15409-9]
CCDS5760.1 [O15409-1]
CCDS5761.2 [O15409-6]

NCBI Reference Sequences

More...RefSeqi		NP_001166237.1, NM_001172766.2
NP_001166238.1, NM_001172767.2
NP_055306.1, NM_014491.3 [O15409-1]
NP_683696.2, NM_148898.3 [O15409-4]
NP_683697.2, NM_148899.3 [O15409-6]
NP_683698.2, NM_148900.3 [O15409-9]
XP_016868290.1, XM_017012801.1 [O15409-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000350908; ENSP00000265436; ENSG00000128573
ENST00000360232; ENSP00000353367; ENSG00000128573 [O15409-6]
ENST00000378237; ENSP00000367482; ENSG00000128573 [O15409-7]
ENST00000393489; ENSP00000377129; ENSG00000128573 [O15409-8]
ENST00000393494; ENSP00000377132; ENSG00000128573
ENST00000403559; ENSP00000385069; ENSG00000128573 [O15409-9]
ENST00000408937; ENSP00000386200; ENSG00000128573 [O15409-4]
ENST00000412402; ENSP00000405470; ENSG00000128573 [O15409-8]
ENST00000441290; ENSP00000416825; ENSG00000128573 [O15409-8]
ENST00000635109; ENSP00000489457; ENSG00000128573 [O15409-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		93986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:93986

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000350908.9; ENSP00000265436.7; NM_014491.4; NP_055306.1

UCSC genome browser

More...UCSCi		uc003vgx.3, human [O15409-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Talking heads - Issue 51 of October 2004

Wikipedia

FOXP2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337817 mRNA Translation: AAL10762.1
AF467252 mRNA Translation: AAM60762.1
AF467253 mRNA Translation: AAM60763.1
AF467254 mRNA Translation: AAM60764.1
AF467255 mRNA Translation: AAM60765.1
AF467256 mRNA Translation: AAM60766.1
AF467257 mRNA Translation: AAM60767.1
AF493430 mRNA Translation: AAM13672.1
AY144615 mRNA Translation: AAN60016.1
AK131266 mRNA Translation: BAD18444.1 Sequence problems.
AK296957 mRNA Translation: BAG59501.1
AC003992 Genomic DNA Translation: AAS07399.1
AC020606 Genomic DNA Translation: AAS07502.1
AC073626 Genomic DNA No translation available.
AC074000 Genomic DNA No translation available.
AC092148 Genomic DNA No translation available.
AC092606 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24367.1
CH236947 Genomic DNA Translation: EAL24369.1
CH471070 Genomic DNA Translation: EAW83484.1
CH471070 Genomic DNA Translation: EAW83486.1
BC126104 mRNA Translation: AAI26105.1
BC143866 mRNA Translation: AAI43867.1
U80741 mRNA Translation: AAB91439.1
AF515031 Genomic DNA Translation: AAN03389.1
AF515032 Genomic DNA Translation: AAN03390.1
AF515033 Genomic DNA Translation: AAN03391.1
AF515034 Genomic DNA Translation: AAN03392.1
AF515035 Genomic DNA Translation: AAN03393.1
AF515036 Genomic DNA Translation: AAN03394.1
AF515037 Genomic DNA Translation: AAN03395.1
AF515038 Genomic DNA Translation: AAN03396.1
AF515039 Genomic DNA Translation: AAN03397.1
AF515040 Genomic DNA Translation: AAN03398.1
AF515041 Genomic DNA Translation: AAN03399.1
AF515042 Genomic DNA Translation: AAN03400.1
AF515043 Genomic DNA Translation: AAN03401.1
AF515044 Genomic DNA Translation: AAN03402.1
AF515045 Genomic DNA Translation: AAN03403.1
AF515046 Genomic DNA Translation: AAN03404.1
AF515047 Genomic DNA Translation: AAN03405.1
AF515048 Genomic DNA Translation: AAN03406.1
AF515049 Genomic DNA Translation: AAN03407.1
AF515050 Genomic DNA Translation: AAN03408.1
CCDSiCCDS43635.1 [O15409-4]
CCDS55154.1 [O15409-9]
CCDS5760.1 [O15409-1]
CCDS5761.2 [O15409-6]
RefSeqiNP_001166237.1, NM_001172766.2
NP_001166238.1, NM_001172767.2
NP_055306.1, NM_014491.3 [O15409-1]
NP_683696.2, NM_148898.3 [O15409-4]
NP_683697.2, NM_148899.3 [O15409-6]
NP_683698.2, NM_148900.3 [O15409-9]
XP_016868290.1, XM_017012801.1 [O15409-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A07X-ray1.90F/G/H/I/J/K502-594[»]
2AS5X-ray2.70F/G502-594[»]
SMRiO15409
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125073, 39 interactors
DIPiDIP-29004N
IntActiO15409, 30 interactors
MINTiO15409
STRINGi9606.ENSP00000386200

PTM databases

iPTMnetiO15409
PhosphoSitePlusiO15409

Genetic variation databases

BioMutaiFOXP2

Proteomic databases

jPOSTiO15409
MassIVEiO15409
MaxQBiO15409
PaxDbiO15409
PeptideAtlasiO15409
PRIDEiO15409
ProteomicsDBi48644 [O15409-1]
48645 [O15409-2]
48646 [O15409-4]
48647 [O15409-5]
48648 [O15409-6]
48649 [O15409-7]
48650 [O15409-8]
48651 [O15409-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		672, 473 antibodies from 40 providers

The DNASU plasmid repository

More...DNASUi		93986

Genome annotation databases

EnsembliENST00000350908; ENSP00000265436; ENSG00000128573
ENST00000360232; ENSP00000353367; ENSG00000128573 [O15409-6]
ENST00000378237; ENSP00000367482; ENSG00000128573 [O15409-7]
ENST00000393489; ENSP00000377129; ENSG00000128573 [O15409-8]
ENST00000393494; ENSP00000377132; ENSG00000128573
ENST00000403559; ENSP00000385069; ENSG00000128573 [O15409-9]
ENST00000408937; ENSP00000386200; ENSG00000128573 [O15409-4]
ENST00000412402; ENSP00000405470; ENSG00000128573 [O15409-8]
ENST00000441290; ENSP00000416825; ENSG00000128573 [O15409-8]
ENST00000635109; ENSP00000489457; ENSG00000128573 [O15409-8]
GeneIDi93986
KEGGihsa:93986
MANE-SelectiENST00000350908.9; ENSP00000265436.7; NM_014491.4; NP_055306.1
UCSCiuc003vgx.3, human [O15409-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		93986
DisGeNETi93986

GeneCards: human genes, protein and diseases

More...GeneCardsi		FOXP2
GeneReviewsiFOXP2
HGNCiHGNC:13875, FOXP2
HPAiENSG00000128573, Low tissue specificity
MalaCardsiFOXP2
MIMi602081, phenotype
605317, gene
neXtProtiNX_O15409
OpenTargetsiENSG00000128573
Orphaneti251061, 7q31 microdeletion syndrome
209908, Childhood apraxia of speech
PharmGKBiPA28242
VEuPathDBiHostDB:ENSG00000128573

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4385, Eukaryota
GeneTreeiENSGT00940000155480
HOGENOMiCLU_2557677_0_0_1
InParanoidiO15409
OMAiXHLNNEH
PhylomeDBiO15409
TreeFamiTF326978

Enzyme and pathway databases

PathwayCommonsiO15409
SignaLinkiO15409
SIGNORiO15409

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		93986, 13 hits in 1061 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FOXP2, human
EvolutionaryTraceiO15409

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FOXP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		93986
PharosiO15409, Tbio

Protein Ontology

More...PROi		PR:O15409
RNActiO15409, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000128573, Expressed in stomach and 199 other tissues
ExpressionAtlasiO15409, baseline and differential
GenevisibleiO15409, HS

Family and domain databases

CDDicd00059, FH, 1 hit
Gene3Di1.10.10.10, 1 hit
IDEALiIID00429
InterProiView protein in InterPro
IPR001766, Fork_head_dom
IPR032354, FOXP-CC
IPR030456, TF_fork_head_CS_2
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250, Forkhead, 1 hit
PF16159, FOXP-CC, 1 hit
PRINTSiPR00053, FORKHEAD
SMARTiView protein in SMART
SM00339, FH, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658, FORK_HEAD_2, 1 hit
PS50039, FORK_HEAD_3, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOXP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15409
Secondary accession number(s): A0AUV6
, A4D0U8, A6NNW4, B4DLD9, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: February 23, 2022
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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