Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri346 – 371C2H2-typeAdd BLAST26
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi504 – 594Fork-headPROSITE-ProRule annotationAdd BLAST91

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O15409

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Forkhead box protein P2
Alternative name(s):
CAG repeat protein 44
Trinucleotide repeat-containing gene 10 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOXP2
Synonyms:CAGH44, TNRC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128573.23

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13875 FOXP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605317 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15409

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Speech-language disorder 1 (SPCH1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.
See also OMIM:602081
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012278553R → H in SPCH1. 1 PublicationCorresponds to variant dbSNP:rs121908377EnsemblClinVar.1
A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
93986

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
FOXP2

MalaCards human disease database

More...
MalaCardsi
FOXP2
MIMi602081 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000128573

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
251061 7q31 microdeletion syndrome
209908 Childhood apraxia of speech

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28242

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FOXP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000918791 – 715Forkhead box protein P2Add BLAST715

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15409

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15409

PeptideAtlas

More...
PeptideAtlasi
O15409

PRoteomics IDEntifications database

More...
PRIDEi
O15409

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48644
48645 [O15409-2]
48646 [O15409-4]
48647 [O15409-5]
48648 [O15409-6]
48649 [O15409-7]
48650 [O15409-8]
48651 [O15409-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15409

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15409

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128573 Expressed in 182 organ(s), highest expression level in stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15409 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15409 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000382
HPA000383
HPA001679

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (PubMed:26647308).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125073, 28 interactors

Database of interacting proteins

More...
DIPi
DIP-29004N

Protein interaction database and analysis system

More...
IntActi
O15409, 16 interactors

Molecular INTeraction database

More...
MINTi
O15409

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386200

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A07X-ray1.90F/G/H/I/J/K502-594[»]
2AS5X-ray2.70F/G502-594[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15409

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15409

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O15409

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni388 – 409Leucine-zipperAdd BLAST22
Regioni422 – 426CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 268Gln-richAdd BLAST216

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 371C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4385 Eukaryota
COG5025 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155480

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000092089

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051657

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15409

KEGG Orthology (KO)

More...
KOi
K09409

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHMDSNG

Database of Orthologous Groups

More...
OrthoDBi
836427at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15409

TreeFam database of animal gene trees

More...
TreeFami
TF326978

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00059 FH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00053 FORKHEAD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00339 FH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15409-1) [UniParc]FASTAAdd to basket
Also known as: I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHPGKQAKEQ
210 220 230 240 250
QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG LISIPPGQAA
260 270 280 290 300
LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT
310 320 330 340 350
SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW
360 370 380 390 400
PGCESICEDF GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE
410 420 430 440 450
RLQAMMTHLH MRPSEPKPSP KPLNLVSSVT MSKNMLETSP QSLPQTPTTP
460 470 480 490 500
TAPVTPITQG PSVITPASVP NVGAIRRRHS DKYNIPMSSE IAPNYEFYKN
510 520 530 540 550
ADVRPPFTYA TLIRQAIMES SDRQLTLNEI YSWFTRTFAY FRRNAATWKN
560 570 580 590 600
AVRHNLSLHK CFVRVENVKG AVWTVDEVEY QKRRSQKITG SPTLVKNIPT
610 620 630 640 650
SLGYGAALNA SLQAALAESS LPLLSNPGLI NNASSGLLQA VHEDLNGSLD
660 670 680 690 700
HIDSNGNSSP GCSPQPHIHS IHVKEEPVIA EDEDCPMSLV TTANHSPELE
710
DDREIEEEPL SEDLE
Length:715
Mass (Da):79,919
Last modified:December 5, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F9FBDB6D90516E0
GO
Isoform 2 (identifier: O15409-3)
Also known as: II
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: O15409-2) [UniParc]FASTAAdd to basket
Also known as: III, IV

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:623
Mass (Da):70,104
Checksum:iF78EA67F33A3AE05
GO
Isoform 4 (identifier: O15409-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA

Show »
Length:740
Mass (Da):82,565
Checksum:i423EC421368FCD94
GO
Isoform 5 (identifier: O15409-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA
     133-143: QQLQEFYKKQQ → VMWVTCFGVLA
     144-715: Missing.

Show »
Length:168
Mass (Da):18,315
Checksum:i61B297B4D64BC670
GO
Isoform 6 (identifier: O15409-6) [UniParc]FASTAAdd to basket
Also known as: FOXP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     423-432: LNLVSSVTMS → VSAYCFINSK
     433-715: Missing.

Show »
Length:432
Mass (Da):48,764
Checksum:i42BC7890ACAF498C
GO
Isoform 7 (identifier: O15409-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-715: Missing.

Show »
Length:365
Mass (Da):40,969
Checksum:i0B052282E2E30771
GO
Isoform 8 (identifier: O15409-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: V → P
     88-715: Missing.

Note: No experimental confirmation available.
Show »
Length:87
Mass (Da):9,377
Checksum:i624274B876E062E4
GO
Isoform 9 (identifier: O15409-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-132: Q → QDFLDSGLENFRAALEKN

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):81,840
Checksum:i8B72F946ABD821EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q0PRL4Q0PRL4_HUMAN
Forkhead box P2 variant 3
FOXP2
530Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MUV4A8MUV4_HUMAN
Forkhead box protein P2
FOXP2
694Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQM2A0A0U1RQM2_HUMAN
Forkhead box protein P2
FOXP2
716Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQR8A0A0U1RQR8_HUMAN
Forkhead box protein P2
FOXP2
698Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQE0A0A0U1RQE0_HUMAN
Forkhead box protein P2
FOXP2
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQY3A0A0U1RQY3_HUMAN
Forkhead box protein P2
FOXP2
712Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q75MZ5Q75MZ5_HUMAN
Forkhead box P2, isoform CRA_a
FOXP2 hCG_1813384
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N6B5Q8N6B5_HUMAN
Forkhead box P2, isoform CRA_d
FOXP2 hCG_1813384
456Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQP8C9JQP8_HUMAN
Forkhead box protein P2
FOXP2
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQE6A0A0U1RQE6_HUMAN
Forkhead box protein P2
FOXP2
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29A → V in AAM60762 (PubMed:12189486).Curated1
Sequence conflicti134Q → H in AAB91439 (PubMed:9225980).Curated1
Sequence conflicti290 – 304DLTTN…TSSNT → EEFPVQGPAAVCAGL in AAB91439 (PubMed:9225980).CuratedAdd BLAST15
Sequence conflicti414S → L in AAM60766 (PubMed:12189486).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012278553R → H in SPCH1. 1 PublicationCorresponds to variant dbSNP:rs121908377EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0015581 – 92Missing in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_01153286Q → QELLPETKLCICGHSSGDGH PHNTFA in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_01153387V → P in isoform 8. 1 Publication1
Alternative sequenceiVSP_01153488 – 715Missing in isoform 8. 1 PublicationAdd BLAST628
Alternative sequenceiVSP_043464132Q → QDFLDSGLENFRAALEKN in isoform 9. 1 Publication1
Alternative sequenceiVSP_011535133 – 143QQLQEFYKKQQ → VMWVTCFGVLA in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_011536144 – 715Missing in isoform 5. 1 PublicationAdd BLAST572
Alternative sequenceiVSP_011537366 – 715Missing in isoform 7. 1 PublicationAdd BLAST350
Alternative sequenceiVSP_011538423 – 432LNLVSSVTMS → VSAYCFINSK in isoform 6. 1 Publication10
Alternative sequenceiVSP_011539433 – 715Missing in isoform 6. 1 PublicationAdd BLAST283

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF337817 mRNA Translation: AAL10762.1
AF467252 mRNA Translation: AAM60762.1
AF467253 mRNA Translation: AAM60763.1
AF467254 mRNA Translation: AAM60764.1
AF467255 mRNA Translation: AAM60765.1
AF467256 mRNA Translation: AAM60766.1
AF467257 mRNA Translation: AAM60767.1
AF493430 mRNA Translation: AAM13672.1
AY144615 mRNA Translation: AAN60016.1
AK131266 mRNA Translation: BAD18444.1 Sequence problems.
AK296957 mRNA Translation: BAG59501.1
AC003992 Genomic DNA Translation: AAS07399.1
AC020606 Genomic DNA Translation: AAS07502.1
AC073626 Genomic DNA No translation available.
AC074000 Genomic DNA No translation available.
AC092148 Genomic DNA No translation available.
AC092606 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24367.1
CH236947 Genomic DNA Translation: EAL24369.1
CH471070 Genomic DNA Translation: EAW83484.1
CH471070 Genomic DNA Translation: EAW83486.1
BC126104 mRNA Translation: AAI26105.1
BC143866 mRNA Translation: AAI43867.1
U80741 mRNA Translation: AAB91439.1
AF515031 Genomic DNA Translation: AAN03389.1
AF515032 Genomic DNA Translation: AAN03390.1
AF515033 Genomic DNA Translation: AAN03391.1
AF515034 Genomic DNA Translation: AAN03392.1
AF515035 Genomic DNA Translation: AAN03393.1
AF515036 Genomic DNA Translation: AAN03394.1
AF515037 Genomic DNA Translation: AAN03395.1
AF515038 Genomic DNA Translation: AAN03396.1
AF515039 Genomic DNA Translation: AAN03397.1
AF515040 Genomic DNA Translation: AAN03398.1
AF515041 Genomic DNA Translation: AAN03399.1
AF515042 Genomic DNA Translation: AAN03400.1
AF515043 Genomic DNA Translation: AAN03401.1
AF515044 Genomic DNA Translation: AAN03402.1
AF515045 Genomic DNA Translation: AAN03403.1
AF515046 Genomic DNA Translation: AAN03404.1
AF515047 Genomic DNA Translation: AAN03405.1
AF515048 Genomic DNA Translation: AAN03406.1
AF515049 Genomic DNA Translation: AAN03407.1
AF515050 Genomic DNA Translation: AAN03408.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43635.1 [O15409-4]
CCDS55154.1 [O15409-9]
CCDS5760.1 [O15409-1]
CCDS5761.2 [O15409-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001166237.1, NM_001172766.2
NP_001166238.1, NM_001172767.2
NP_055306.1, NM_014491.3 [O15409-1]
NP_683696.2, NM_148898.3 [O15409-4]
NP_683697.2, NM_148899.3 [O15409-6]
NP_683698.2, NM_148900.3 [O15409-9]
XP_016868290.1, XM_017012801.1 [O15409-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.282787

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000350908; ENSP00000265436; ENSG00000128573 [O15409-1]
ENST00000360232; ENSP00000353367; ENSG00000128573 [O15409-6]
ENST00000378237; ENSP00000367482; ENSG00000128573 [O15409-7]
ENST00000393489; ENSP00000377129; ENSG00000128573 [O15409-2]
ENST00000393494; ENSP00000377132; ENSG00000128573 [O15409-1]
ENST00000403559; ENSP00000385069; ENSG00000128573 [O15409-9]
ENST00000408937; ENSP00000386200; ENSG00000128573 [O15409-4]
ENST00000412402; ENSP00000405470; ENSG00000128573 [O15409-8]
ENST00000441290; ENSP00000416825; ENSG00000128573 [O15409-8]
ENST00000635109; ENSP00000489457; ENSG00000128573 [O15409-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
93986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93986

UCSC genome browser

More...
UCSCi
uc003vgx.3 human [O15409-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Talking heads - Issue 51 of October 2004

Wikipedia

FOXP2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337817 mRNA Translation: AAL10762.1
AF467252 mRNA Translation: AAM60762.1
AF467253 mRNA Translation: AAM60763.1
AF467254 mRNA Translation: AAM60764.1
AF467255 mRNA Translation: AAM60765.1
AF467256 mRNA Translation: AAM60766.1
AF467257 mRNA Translation: AAM60767.1
AF493430 mRNA Translation: AAM13672.1
AY144615 mRNA Translation: AAN60016.1
AK131266 mRNA Translation: BAD18444.1 Sequence problems.
AK296957 mRNA Translation: BAG59501.1
AC003992 Genomic DNA Translation: AAS07399.1
AC020606 Genomic DNA Translation: AAS07502.1
AC073626 Genomic DNA No translation available.
AC074000 Genomic DNA No translation available.
AC092148 Genomic DNA No translation available.
AC092606 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24367.1
CH236947 Genomic DNA Translation: EAL24369.1
CH471070 Genomic DNA Translation: EAW83484.1
CH471070 Genomic DNA Translation: EAW83486.1
BC126104 mRNA Translation: AAI26105.1
BC143866 mRNA Translation: AAI43867.1
U80741 mRNA Translation: AAB91439.1
AF515031 Genomic DNA Translation: AAN03389.1
AF515032 Genomic DNA Translation: AAN03390.1
AF515033 Genomic DNA Translation: AAN03391.1
AF515034 Genomic DNA Translation: AAN03392.1
AF515035 Genomic DNA Translation: AAN03393.1
AF515036 Genomic DNA Translation: AAN03394.1
AF515037 Genomic DNA Translation: AAN03395.1
AF515038 Genomic DNA Translation: AAN03396.1
AF515039 Genomic DNA Translation: AAN03397.1
AF515040 Genomic DNA Translation: AAN03398.1
AF515041 Genomic DNA Translation: AAN03399.1
AF515042 Genomic DNA Translation: AAN03400.1
AF515043 Genomic DNA Translation: AAN03401.1
AF515044 Genomic DNA Translation: AAN03402.1
AF515045 Genomic DNA Translation: AAN03403.1
AF515046 Genomic DNA Translation: AAN03404.1
AF515047 Genomic DNA Translation: AAN03405.1
AF515048 Genomic DNA Translation: AAN03406.1
AF515049 Genomic DNA Translation: AAN03407.1
AF515050 Genomic DNA Translation: AAN03408.1
CCDSiCCDS43635.1 [O15409-4]
CCDS55154.1 [O15409-9]
CCDS5760.1 [O15409-1]
CCDS5761.2 [O15409-6]
RefSeqiNP_001166237.1, NM_001172766.2
NP_001166238.1, NM_001172767.2
NP_055306.1, NM_014491.3 [O15409-1]
NP_683696.2, NM_148898.3 [O15409-4]
NP_683697.2, NM_148899.3 [O15409-6]
NP_683698.2, NM_148900.3 [O15409-9]
XP_016868290.1, XM_017012801.1 [O15409-4]
UniGeneiHs.282787

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A07X-ray1.90F/G/H/I/J/K502-594[»]
2AS5X-ray2.70F/G502-594[»]
ProteinModelPortaliO15409
SMRiO15409
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125073, 28 interactors
DIPiDIP-29004N
IntActiO15409, 16 interactors
MINTiO15409
STRINGi9606.ENSP00000386200

PTM databases

iPTMnetiO15409
PhosphoSitePlusiO15409

Polymorphism and mutation databases

BioMutaiFOXP2

Proteomic databases

jPOSTiO15409
PaxDbiO15409
PeptideAtlasiO15409
PRIDEiO15409
ProteomicsDBi48644
48645 [O15409-2]
48646 [O15409-4]
48647 [O15409-5]
48648 [O15409-6]
48649 [O15409-7]
48650 [O15409-8]
48651 [O15409-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350908; ENSP00000265436; ENSG00000128573 [O15409-1]
ENST00000360232; ENSP00000353367; ENSG00000128573 [O15409-6]
ENST00000378237; ENSP00000367482; ENSG00000128573 [O15409-7]
ENST00000393489; ENSP00000377129; ENSG00000128573 [O15409-2]
ENST00000393494; ENSP00000377132; ENSG00000128573 [O15409-1]
ENST00000403559; ENSP00000385069; ENSG00000128573 [O15409-9]
ENST00000408937; ENSP00000386200; ENSG00000128573 [O15409-4]
ENST00000412402; ENSP00000405470; ENSG00000128573 [O15409-8]
ENST00000441290; ENSP00000416825; ENSG00000128573 [O15409-8]
ENST00000635109; ENSP00000489457; ENSG00000128573 [O15409-8]
GeneIDi93986
KEGGihsa:93986
UCSCiuc003vgx.3 human [O15409-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93986
DisGeNETi93986
EuPathDBiHostDB:ENSG00000128573.23

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FOXP2
GeneReviewsiFOXP2
HGNCiHGNC:13875 FOXP2
HPAiHPA000382
HPA000383
HPA001679
MalaCardsiFOXP2
MIMi602081 phenotype
605317 gene
neXtProtiNX_O15409
OpenTargetsiENSG00000128573
Orphaneti251061 7q31 microdeletion syndrome
209908 Childhood apraxia of speech
PharmGKBiPA28242

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00940000155480
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiO15409
KOiK09409
OMAiDHMDSNG
OrthoDBi836427at2759
PhylomeDBiO15409
TreeFamiTF326978

Enzyme and pathway databases

SIGNORiO15409

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FOXP2 human
EvolutionaryTraceiO15409

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FOXP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
93986

Protein Ontology

More...
PROi
PR:O15409

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128573 Expressed in 182 organ(s), highest expression level in stomach
ExpressionAtlasiO15409 baseline and differential
GenevisibleiO15409 HS

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOXP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15409
Secondary accession number(s): A0AUV6
, A4D0U8, A6NNW4, B4DLD9, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: January 16, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again