UniProtKB - O15405 (TOX3_HUMAN)
TOX high mobility group box family member 3
TOX3
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 255 – 323 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- chromatin DNA binding Source: GO_Central
- phosphoprotein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- transcription coactivator activity Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- negative regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of apoptotic process Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Apoptosis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O15405 |
Names & Taxonomyi
Protein namesi | Recommended name: TOX high mobility group box family member 3Alternative name(s): CAG trinucleotide repeat-containing gene F9 protein Trinucleotide repeat-containing gene 9 protein |
Gene namesi | Name:TOX3 Synonyms:CAGF9, TNRC9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000103460.16 |
HGNCi | HGNC:11972, TOX3 |
MIMi | 611416, gene |
neXtProti | NX_O15405 |
Subcellular locationi
Nucleus
- Nucleus Curated
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27324 |
OpenTargetsi | ENSG00000103460 |
PharmGKBi | PA162406752 |
Miscellaneous databases
Pharosi | O15405, Tbio |
Polymorphism and mutation databases
BioMutai | TOX3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286353 | 1 – 576 | TOX high mobility group box family member 3Add BLAST | 576 |
Proteomic databases
EPDi | O15405 |
jPOSTi | O15405 |
MassIVEi | O15405 |
MaxQBi | O15405 |
PaxDbi | O15405 |
PeptideAtlasi | O15405 |
PRIDEi | O15405 |
ProteomicsDBi | 48642 [O15405-1] 48643 [O15405-2] |
PTM databases
iPTMneti | O15405 |
PhosphoSitePlusi | O15405 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000103460, Expressed in frontal cortex and 176 other tissues |
ExpressionAtlasi | O15405, baseline and differential |
Genevisiblei | O15405, HS |
Organism-specific databases
HPAi | ENSG00000103460, Tissue enhanced (stomach) |
Interactioni
Subunit structurei
Homodimer.
Interacts with CREB1; the interaction is not depolarization dependent.
Interacts with CREBBP (via C-terminus) (By similarity).
Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death.
Interacts with CREB1 (phosphorylated form).
By similarity1 PublicationGO - Molecular functioni
- phosphoprotein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 118139, 15 interactors |
IntActi | O15405, 4 interactors |
MINTi | O15405 |
STRINGi | 9606.ENSP00000219746 |
Miscellaneous databases
RNActi | O15405, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 32 – 35 | Poly-Asn | 4 | |
Compositional biasi | 245 – 250 | Poly-Lys | 6 | |
Compositional biasi | 431 – 572 | Gln-richAdd BLAST | 142 |
Domaini
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000158043 |
HOGENOMi | CLU_030650_1_0_1 |
InParanoidi | O15405 |
OMAi | QQHHMQL |
OrthoDBi | 1465513at2759 |
PhylomeDBi | O15405 |
TreeFami | TF106481 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDVRFYPAAA GDPASLDFAQ CLGYYGYSKF GNNNNYMNMA EANNAFFAAS
60 70 80 90 100
EQTFHTPSLG DEEFEIPPIT PPPESDPALG MPDVLLPFQA LSDPLPSQGS
110 120 130 140 150
EFTPQFPPQS LDLPSITISR NLVEQDGVLH SSGLHMDQSH TQVSQYRQDP
160 170 180 190 200
SLIMRSIVHM TDAARSGVMP PAQLTTINQS QLSAQLGLNL GGASMPHTSP
210 220 230 240 250
SPPASKSATP SPSSSINEED ADEANRAIGE KRAAPDSGKK PKTPKKKKKK
260 270 280 290 300
DPNEPQKPVS AYALFFRDTQ AAIKGQNPNA TFGEVSKIVA SMWDSLGEEQ
310 320 330 340 350
KQVYKRKTEA AKKEYLKALA AYRASLVSKA AAESAEAQTI RSVQQTLAST
360 370 380 390 400
NLTSSLLLNT PLSQHGTVSA SPQTLQQSLP RSIAPKPLTM RLPMNQIVTS
410 420 430 440 450
VTIAANMPSN IGAPLISSMG TTMVGSAPST QVSPSVQTQQ HQMQLQQQQQ
460 470 480 490 500
QQQQQMQQMQ QQQLQQHQMH QQIQQQMQQQ HFQHHMQQHL QQQQQHLQQQ
510 520 530 540 550
INQQQLQQQL QQRLQLQQLQ HMQHQSQPSP RQHSPVASQI TSPIPAIGSP
560 570
QPASQQHQSQ IQSQTQTQVL SQVSIF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BTZ9 | H3BTZ9_HUMAN | TOX high mobility group box family ... | TOX3 | 166 | Annotation score: | ||
J3QQQ6 | J3QQQ6_HUMAN | TOX high mobility group box family ... | TOX3 | 60 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055952 | 128 | V → M. Corresponds to variant dbSNP:rs16951186Ensembl. | 1 | |
Natural variantiVAR_055953 | 572 | Q → P. Corresponds to variant dbSNP:rs13332816Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043095 | 1 – 28 | MDVRF…YYGYS → MKCQPRSGARRIEERLHYLI TTYL in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_043096 | 52 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299202 mRNA Translation: BAG61242.1 AC007490 Genomic DNA No translation available. U80736 mRNA Translation: AAB91435.1 |
CCDSi | CCDS54008.1 [O15405-2] CCDS54009.1 [O15405-1] |
RefSeqi | NP_001073899.2, NM_001080430.3 [O15405-1] NP_001139660.1, NM_001146188.2 [O15405-2] |
Genome annotation databases
Ensembli | ENST00000219746; ENSP00000219746; ENSG00000103460 [O15405-1] ENST00000407228; ENSP00000385705; ENSG00000103460 [O15405-2] |
GeneIDi | 27324 |
KEGGi | hsa:27324 |
UCSCi | uc002egw.3, human [O15405-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299202 mRNA Translation: BAG61242.1 AC007490 Genomic DNA No translation available. U80736 mRNA Translation: AAB91435.1 |
CCDSi | CCDS54008.1 [O15405-2] CCDS54009.1 [O15405-1] |
RefSeqi | NP_001073899.2, NM_001080430.3 [O15405-1] NP_001139660.1, NM_001146188.2 [O15405-2] |
3D structure databases
SMRi | O15405 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118139, 15 interactors |
IntActi | O15405, 4 interactors |
MINTi | O15405 |
STRINGi | 9606.ENSP00000219746 |
PTM databases
iPTMneti | O15405 |
PhosphoSitePlusi | O15405 |
Polymorphism and mutation databases
BioMutai | TOX3 |
Proteomic databases
EPDi | O15405 |
jPOSTi | O15405 |
MassIVEi | O15405 |
MaxQBi | O15405 |
PaxDbi | O15405 |
PeptideAtlasi | O15405 |
PRIDEi | O15405 |
ProteomicsDBi | 48642 [O15405-1] 48643 [O15405-2] |
Protocols and materials databases
Antibodypediai | 28333, 333 antibodies |
DNASUi | 27324 |
Genome annotation databases
Ensembli | ENST00000219746; ENSP00000219746; ENSG00000103460 [O15405-1] ENST00000407228; ENSP00000385705; ENSG00000103460 [O15405-2] |
GeneIDi | 27324 |
KEGGi | hsa:27324 |
UCSCi | uc002egw.3, human [O15405-1] |
Organism-specific databases
CTDi | 27324 |
DisGeNETi | 27324 |
EuPathDBi | HostDB:ENSG00000103460.16 |
GeneCardsi | TOX3 |
HGNCi | HGNC:11972, TOX3 |
HPAi | ENSG00000103460, Tissue enhanced (stomach) |
MIMi | 611416, gene |
neXtProti | NX_O15405 |
OpenTargetsi | ENSG00000103460 |
PharmGKBi | PA162406752 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000158043 |
HOGENOMi | CLU_030650_1_0_1 |
InParanoidi | O15405 |
OMAi | QQHHMQL |
OrthoDBi | 1465513at2759 |
PhylomeDBi | O15405 |
TreeFami | TF106481 |
Enzyme and pathway databases
PathwayCommonsi | O15405 |
Miscellaneous databases
BioGRID-ORCSi | 27324, 6 hits in 867 CRISPR screens |
ChiTaRSi | TOX3, human |
GenomeRNAii | 27324 |
Pharosi | O15405, Tbio |
PROi | PR:O15405 |
RNActi | O15405, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103460, Expressed in frontal cortex and 176 other tissues |
ExpressionAtlasi | O15405, baseline and differential |
Genevisiblei | O15405, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TOX3_HUMAN | |
Accessioni | O15405Primary (citable) accession number: O15405 Secondary accession number(s): B4DRD0, B5MCW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations