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Protein

TOX high mobility group box family member 3

Gene

TOX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi255 – 323HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 3
Alternative name(s):
CAG trinucleotide repeat-containing gene F9 protein
Trinucleotide repeat-containing gene 9 protein
Gene namesi
Name:TOX3
Synonyms:CAGF9, TNRC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103460.16
HGNCiHGNC:11972 TOX3
MIMi611416 gene
neXtProtiNX_O15405

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27324
OpenTargetsiENSG00000103460
PharmGKBiPA162406752

Polymorphism and mutation databases

BioMutaiTOX3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863531 – 576TOX high mobility group box family member 3Add BLAST576

Proteomic databases

EPDiO15405
MaxQBiO15405
PaxDbiO15405
PeptideAtlasiO15405
PRIDEiO15405
ProteomicsDBi48642
48643 [O15405-2]

PTM databases

iPTMnetiO15405
PhosphoSitePlusiO15405

Expressioni

Tissue specificityi

Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.1 Publication

Inductioni

Up-regulated by GPR39 in neuronal cells.1 Publication

Gene expression databases

BgeeiENSG00000103460 Expressed in 162 organ(s), highest expression level in frontal cortex
CleanExiHS_TOX3
ExpressionAtlasiO15405 baseline and differential
GenevisibleiO15405 HS

Organism-specific databases

HPAiHPA040376

Interactioni

Subunit structurei

Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) (By similarity). Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118139, 3 interactors
IntActiO15405, 4 interactors
MINTiO15405
STRINGi9606.ENSP00000219746

Structurei

3D structure databases

ProteinModelPortaliO15405
SMRiO15405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 35Poly-Asn4
Compositional biasi245 – 250Poly-Lys6
Compositional biasi431 – 572Gln-richAdd BLAST142

Domaini

the C-terminus is required for calcium responsiveness but not for transactivation activity.By similarity
The N-terminus is absolutely necessary for transactivation activity.By similarity

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000230949
HOVERGENiHBG051183
InParanoidiO15405
OMAiQYRQDHS
OrthoDBiEOG091G12A3
PhylomeDBiO15405
TreeFamiTF106481

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVRFYPAAA GDPASLDFAQ CLGYYGYSKF GNNNNYMNMA EANNAFFAAS
60 70 80 90 100
EQTFHTPSLG DEEFEIPPIT PPPESDPALG MPDVLLPFQA LSDPLPSQGS
110 120 130 140 150
EFTPQFPPQS LDLPSITISR NLVEQDGVLH SSGLHMDQSH TQVSQYRQDP
160 170 180 190 200
SLIMRSIVHM TDAARSGVMP PAQLTTINQS QLSAQLGLNL GGASMPHTSP
210 220 230 240 250
SPPASKSATP SPSSSINEED ADEANRAIGE KRAAPDSGKK PKTPKKKKKK
260 270 280 290 300
DPNEPQKPVS AYALFFRDTQ AAIKGQNPNA TFGEVSKIVA SMWDSLGEEQ
310 320 330 340 350
KQVYKRKTEA AKKEYLKALA AYRASLVSKA AAESAEAQTI RSVQQTLAST
360 370 380 390 400
NLTSSLLLNT PLSQHGTVSA SPQTLQQSLP RSIAPKPLTM RLPMNQIVTS
410 420 430 440 450
VTIAANMPSN IGAPLISSMG TTMVGSAPST QVSPSVQTQQ HQMQLQQQQQ
460 470 480 490 500
QQQQQMQQMQ QQQLQQHQMH QQIQQQMQQQ HFQHHMQQHL QQQQQHLQQQ
510 520 530 540 550
INQQQLQQQL QQRLQLQQLQ HMQHQSQPSP RQHSPVASQI TSPIPAIGSP
560 570
QPASQQHQSQ IQSQTQTQVL SQVSIF
Length:576
Mass (Da):63,342
Last modified:May 1, 2007 - v2
Checksum:i0CE15100A96E1478
GO
Isoform 2 (identifier: O15405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MDVRFYPAAAGDPASLDFAQCLGYYGYS → MKCQPRSGARRIEERLHYLITTYL
     52-52: Missing.

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):63,100
Checksum:i4447F1086050C823
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQQ6J3QQQ6_HUMAN
TOX high mobility group box family ...
TOX3
60Annotation score:
H3BTZ9H3BTZ9_HUMAN
TOX high mobility group box family ...
TOX3
166Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055952128V → M. Corresponds to variant dbSNP:rs16951186Ensembl.1
Natural variantiVAR_055953572Q → P. Corresponds to variant dbSNP:rs13332816Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430951 – 28MDVRF…YYGYS → MKCQPRSGARRIEERLHYLI TTYL in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_04309652Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299202 mRNA Translation: BAG61242.1
AC007490 Genomic DNA No translation available.
U80736 mRNA Translation: AAB91435.1
CCDSiCCDS54008.1 [O15405-2]
CCDS54009.1 [O15405-1]
RefSeqiNP_001073899.2, NM_001080430.3 [O15405-1]
NP_001139660.1, NM_001146188.2 [O15405-2]
UniGeneiHs.132574
Hs.460789

Genome annotation databases

EnsembliENST00000219746; ENSP00000219746; ENSG00000103460 [O15405-1]
ENST00000407228; ENSP00000385705; ENSG00000103460 [O15405-2]
GeneIDi27324
KEGGihsa:27324
UCSCiuc002egw.3 human [O15405-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299202 mRNA Translation: BAG61242.1
AC007490 Genomic DNA No translation available.
U80736 mRNA Translation: AAB91435.1
CCDSiCCDS54008.1 [O15405-2]
CCDS54009.1 [O15405-1]
RefSeqiNP_001073899.2, NM_001080430.3 [O15405-1]
NP_001139660.1, NM_001146188.2 [O15405-2]
UniGeneiHs.132574
Hs.460789

3D structure databases

ProteinModelPortaliO15405
SMRiO15405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118139, 3 interactors
IntActiO15405, 4 interactors
MINTiO15405
STRINGi9606.ENSP00000219746

PTM databases

iPTMnetiO15405
PhosphoSitePlusiO15405

Polymorphism and mutation databases

BioMutaiTOX3

Proteomic databases

EPDiO15405
MaxQBiO15405
PaxDbiO15405
PeptideAtlasiO15405
PRIDEiO15405
ProteomicsDBi48642
48643 [O15405-2]

Protocols and materials databases

DNASUi27324
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219746; ENSP00000219746; ENSG00000103460 [O15405-1]
ENST00000407228; ENSP00000385705; ENSG00000103460 [O15405-2]
GeneIDi27324
KEGGihsa:27324
UCSCiuc002egw.3 human [O15405-1]

Organism-specific databases

CTDi27324
DisGeNETi27324
EuPathDBiHostDB:ENSG00000103460.16
GeneCardsiTOX3
H-InvDBiHIX0013031
HGNCiHGNC:11972 TOX3
HPAiHPA040376
MIMi611416 gene
neXtProtiNX_O15405
OpenTargetsiENSG00000103460
PharmGKBiPA162406752
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000230949
HOVERGENiHBG051183
InParanoidiO15405
OMAiQYRQDHS
OrthoDBiEOG091G12A3
PhylomeDBiO15405
TreeFamiTF106481

Miscellaneous databases

ChiTaRSiTOX3 human
GenomeRNAii27324
PROiPR:O15405
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103460 Expressed in 162 organ(s), highest expression level in frontal cortex
CleanExiHS_TOX3
ExpressionAtlasiO15405 baseline and differential
GenevisibleiO15405 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOX3_HUMAN
AccessioniPrimary (citable) accession number: O15405
Secondary accession number(s): B4DRD0, B5MCW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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