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Protein

Monocarboxylate transporter 7

Gene

SLC16A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

  • monocarboxylic acid transmembrane transporter activity Source: GO_Central
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.1.13.15 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 7
Short name:
MCT 7
Alternative name(s):
Monocarboxylate transporter 6
Short name:
MCT 6
Solute carrier family 16 member 6
Gene namesi
Name:SLC16A6
Synonyms:MCT6, MCT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108932.11
HGNCiHGNC:10927 SLC16A6
MIMi603880 gene
neXtProtiNX_O15403

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 62ExtracellularSequence analysisAdd BLAST20
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 91CytoplasmicSequence analysis8
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 118ExtracellularSequence analysis6
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 149CytoplasmicSequence analysis10
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 184ExtracellularSequence analysisAdd BLAST14
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 299CytoplasmicSequence analysisAdd BLAST94
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 330ExtracellularSequence analysis10
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 358CytoplasmicSequence analysis7
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 381ExtracellularSequence analysis2
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 423CytoplasmicSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 452ExtracellularSequence analysis8
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 523CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9120
OpenTargetsiENSG00000108932
PharmGKBiPA35818

Chemistry databases

DrugBankiDB00119 Pyruvic acid

Polymorphism and mutation databases

BioMutaiSLC16A6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114001 – 523Monocarboxylate transporter 7Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphoserineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15403
PaxDbiO15403
PeptideAtlasiO15403
PRIDEiO15403
ProteomicsDBi48641

PTM databases

iPTMnetiO15403
PhosphoSitePlusiO15403

Expressioni

Gene expression databases

BgeeiENSG00000108932 Expressed in 178 organ(s), highest expression level in caput epididymis
CleanExiHS_SLC16A6
ExpressionAtlasiO15403 baseline and differential
GenevisibleiO15403 HS

Organism-specific databases

HPAiHPA054459
HPA066328

Interactioni

Protein-protein interaction databases

BioGridi114568, 6 interactors
IntActiO15403, 5 interactors
STRINGi9606.ENSP00000319991

Structurei

3D structure databases

ProteinModelPortaliO15403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000049166
HOVERGENiHBG006386
InParanoidiO15403
KOiK08183
OMAiAFAPAIM
OrthoDBiEOG091G04FE
PhylomeDBiO15403
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030766 MCT7
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF20 PTHR11360:SF20, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O15403-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQNKLKLCS KANVYTEVPD GGWGWAVAVS FFFVEVFTYG IIKTFGVFFN
60 70 80 90 100
DLMDSFNESN SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLVVMLGGLL
110 120 130 140 150
VSTGMVAASF SQEVSHMYVA IGIISGLGYC FSFLPTVTIL SQYFGKRRSI
160 170 180 190 200
VTAVASTGEC FAVFAFAPAI MALKERIGWR YSLLFVGLLQ LNIVIFGALL
210 220 230 240 250
RPIFIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS GVELTTSPKN
260 270 280 290 300
VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF
310 320 330 340 350
GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV
360 370 380 390 400
LNREPIRKIY IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG
410 420 430 440 450
GTHIPLLAED DVVGIEKMSS AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY
460 470 480 490 500
SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ HHHSGETKVV SHRGKTLQDI
510 520
PEDFLEMDLA KNEHRVHVQM EPV
Length:523
Mass (Da):57,393
Last modified:September 23, 2008 - v2
Checksum:i994FB5DCB9404340
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX92A0A087WX92_HUMAN
Monocarboxylate transporter 7
SLC16A6
522Annotation score:
J3KS02J3KS02_HUMAN
Monocarboxylate transporter 7
SLC16A6
85Annotation score:
J3KTN2J3KTN2_HUMAN
Monocarboxylate transporter 7
SLC16A6
129Annotation score:

Sequence cautioni

The sequence AAC52014 differs from that shown. Reason: Frameshift at positions 401 and 416.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti481H → R in AAC52014 (PubMed:9425115).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053656121I → T. Corresponds to variant dbSNP:rs35397826Ensembl.1
Natural variantiVAR_053657204F → I1 PublicationCorresponds to variant dbSNP:rs7222013Ensembl.1
Natural variantiVAR_053658217E → D. Corresponds to variant dbSNP:rs3744307Ensembl.1
Natural variantiVAR_053659221E → V. Corresponds to variant dbSNP:rs4410141Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79745 mRNA Translation: AAC52014.1 Frameshift.
CH471099 Genomic DNA Translation: EAW89052.1
BC064832 mRNA Translation: AAH64832.1
CCDSiCCDS11675.1
RefSeqiNP_001167637.1, NM_001174166.1
NP_004685.2, NM_004694.4
XP_011523763.1, XM_011525461.2
XP_016880780.1, XM_017025291.1
XP_016880781.1, XM_017025292.1
UniGeneiHs.42645

Genome annotation databases

EnsembliENST00000327268; ENSP00000319991; ENSG00000108932
ENST00000580666; ENSP00000462985; ENSG00000108932
GeneIDi9120
KEGGihsa:9120
UCSCiuc002jgz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79745 mRNA Translation: AAC52014.1 Frameshift.
CH471099 Genomic DNA Translation: EAW89052.1
BC064832 mRNA Translation: AAH64832.1
CCDSiCCDS11675.1
RefSeqiNP_001167637.1, NM_001174166.1
NP_004685.2, NM_004694.4
XP_011523763.1, XM_011525461.2
XP_016880780.1, XM_017025291.1
XP_016880781.1, XM_017025292.1
UniGeneiHs.42645

3D structure databases

ProteinModelPortaliO15403
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114568, 6 interactors
IntActiO15403, 5 interactors
STRINGi9606.ENSP00000319991

Chemistry databases

DrugBankiDB00119 Pyruvic acid

Protein family/group databases

TCDBi2.A.1.13.15 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO15403
PhosphoSitePlusiO15403

Polymorphism and mutation databases

BioMutaiSLC16A6

Proteomic databases

MaxQBiO15403
PaxDbiO15403
PeptideAtlasiO15403
PRIDEiO15403
ProteomicsDBi48641

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327268; ENSP00000319991; ENSG00000108932
ENST00000580666; ENSP00000462985; ENSG00000108932
GeneIDi9120
KEGGihsa:9120
UCSCiuc002jgz.3 human

Organism-specific databases

CTDi9120
DisGeNETi9120
EuPathDBiHostDB:ENSG00000108932.11
GeneCardsiSLC16A6
H-InvDBiHIX0039198
HGNCiHGNC:10927 SLC16A6
HPAiHPA054459
HPA066328
MIMi603880 gene
neXtProtiNX_O15403
OpenTargetsiENSG00000108932
PharmGKBiPA35818
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000049166
HOVERGENiHBG006386
InParanoidiO15403
KOiK08183
OMAiAFAPAIM
OrthoDBiEOG091G04FE
PhylomeDBiO15403
TreeFamiTF313792

Miscellaneous databases

GenomeRNAii9120
PROiPR:O15403
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108932 Expressed in 178 organ(s), highest expression level in caput epididymis
CleanExiHS_SLC16A6
ExpressionAtlasiO15403 baseline and differential
GenevisibleiO15403 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR030766 MCT7
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF20 PTHR11360:SF20, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT7_HUMAN
AccessioniPrimary (citable) accession number: O15403
Secondary accession number(s): Q6P1X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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