UniProtKB - O15400 (STX7_HUMAN)
Syntaxin-7
STX7
Functioni
GO - Molecular functioni
- chloride channel inhibitor activity Source: UniProtKB
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: MGI
- syntaxin binding Source: UniProtKB
GO - Biological processi
- intracellular protein transport Source: GO_Central
- organelle assembly Source: UniProtKB
- organelle localization Source: UniProtKB
- positive regulation of receptor localization to synapse Source: UniProtKB
- positive regulation of T cell mediated cytotoxicity Source: UniProtKB
- regulation of protein localization to plasma membrane Source: UniProtKB
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O15400 |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-7 |
Gene namesi | Name:STX7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11442, STX7 |
MIMi | 603217, gene |
neXtProti | NX_O15400 |
VEuPathDBi | HostDB:ENSG00000079950.13 |
Subcellular locationi
Endosome
- Early endosome membrane By similarity; Single-pass type IV membrane protein By similarity
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: UniProtKB
- late endosome Source: UniProtKB
- recycling endosome Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- azurophil granule Source: UniProtKB
- lysosomal membrane Source: UniProtKB
- lysosome Source: UniProtKB
Plasma Membrane
- immunological synapse Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- endocytic vesicle Source: UniProtKB
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
- SNARE complex Source: GO_Central
- synaptic vesicle Source: GO_Central
- tertiary granule Source: UniProtKB
- vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 238 | CytoplasmicSequence analysisAdd BLAST | 237 | |
Transmembranei | 239 – 259 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 261 | VesicularSequence analysis | 2 |
Keywords - Cellular componenti
Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8417 |
OpenTargetsi | ENSG00000079950 |
PharmGKBi | PA36239 |
Miscellaneous databases
Pharosi | O15400, Tbio |
Genetic variation databases
BioMutai | STX7 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000210213 | 2 – 261 | Syntaxin-7Add BLAST | 260 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 4 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 75 | PhosphoserineCombined sources | 1 | |
Modified residuei | 79 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 125 | PhosphoserineBy similarity | 1 | |
Modified residuei | 126 | PhosphoserineCombined sources | 1 | |
Modified residuei | 129 | PhosphoserineCombined sources | 1 | |
Modified residuei | 205 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O15400 |
jPOSTi | O15400 |
MassIVEi | O15400 |
MaxQBi | O15400 |
PaxDbi | O15400 |
PeptideAtlasi | O15400 |
PRIDEi | O15400 |
ProteomicsDBi | 48639 [O15400-1] 48640 [O15400-2] |
TopDownProteomicsi | O15400-1 [O15400-1] |
2D gel databases
OGPi | O15400 |
PTM databases
iPTMneti | O15400 |
PhosphoSitePlusi | O15400 |
SwissPalmi | O15400 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000079950, Expressed in forebrain and 244 other tissues |
Genevisiblei | O15400, HS |
Organism-specific databases
HPAi | ENSG00000079950, Low tissue specificity |
Interactioni
Subunit structurei
Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes.
Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity).
Interacts with VPS11, VPS16 and VPS18.
Interacts with VPS33A.
By similarity1 PublicationBinary interactionsi
Hide detailsO15400
GO - Molecular functioni
- SNARE binding Source: MGI
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114003, 162 interactors |
CORUMi | O15400 |
DIPi | DIP-57384N |
IntActi | O15400, 114 interactors |
MINTi | O15400 |
STRINGi | 9606.ENSP00000356918 |
Miscellaneous databases
RNActi | O15400, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 165 – 227 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 47 – 69 | Sequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0811, Eukaryota |
GeneTreei | ENSGT01000000214440 |
HOGENOMi | CLU_059257_1_1_1 |
InParanoidi | O15400 |
OMAi | HMENGLN |
OrthoDBi | 1204812at2759 |
PhylomeDBi | O15400 |
TreeFami | TF315607 |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF14523, Syntaxin_2, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYTPGVGGD PAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ
60 70 80 90 100
QLQQKQQYTN QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS
110 120 130 140 150
LTNFQKVQRQ AAEREKEFVA RVRASSRVSG SFPEDSSKER NLVSWESQTQ
160 170 180 190 200
PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG
210 220 230 240 250
DVIDSIEANV ENAEVHVQQA NQQLSRAADY QRKSRKTLCI IILILVIGVA
260
IISLIIWGLN H
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | A → T in AAC51851 (PubMed:9358037).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012938 | 232 – 261 | RKSRK…WGLNH → KKDSCMLM in isoform 2. CuratedAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77942 mRNA Translation: AAC51851.1 AL357034 Genomic DNA No translation available. AL589691 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48029.1 CH471051 Genomic DNA Translation: EAW48030.1 BC011975 mRNA Translation: AAH11975.1 |
CCDSi | CCDS5153.1 [O15400-1] CCDS87441.1 [O15400-2] |
RefSeqi | NP_001313507.1, NM_001326578.1 [O15400-1] NP_001313508.1, NM_001326579.1 [O15400-1] NP_001313509.1, NM_001326580.1 [O15400-2] NP_003560.2, NM_003569.2 [O15400-1] XP_011534480.1, XM_011536178.1 |
Genome annotation databases
Ensembli | ENST00000367937; ENSP00000356914; ENSG00000079950 [O15400-2] ENST00000367941; ENSP00000356918; ENSG00000079950 [O15400-1] |
GeneIDi | 8417 |
KEGGi | hsa:8417 |
UCSCi | uc003qdg.3, human [O15400-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77942 mRNA Translation: AAC51851.1 AL357034 Genomic DNA No translation available. AL589691 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48029.1 CH471051 Genomic DNA Translation: EAW48030.1 BC011975 mRNA Translation: AAH11975.1 |
CCDSi | CCDS5153.1 [O15400-1] CCDS87441.1 [O15400-2] |
RefSeqi | NP_001313507.1, NM_001326578.1 [O15400-1] NP_001313508.1, NM_001326579.1 [O15400-1] NP_001313509.1, NM_001326580.1 [O15400-2] NP_003560.2, NM_003569.2 [O15400-1] XP_011534480.1, XM_011536178.1 |
3D structure databases
SMRi | O15400 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114003, 162 interactors |
CORUMi | O15400 |
DIPi | DIP-57384N |
IntActi | O15400, 114 interactors |
MINTi | O15400 |
STRINGi | 9606.ENSP00000356918 |
PTM databases
iPTMneti | O15400 |
PhosphoSitePlusi | O15400 |
SwissPalmi | O15400 |
Genetic variation databases
BioMutai | STX7 |
2D gel databases
OGPi | O15400 |
Proteomic databases
EPDi | O15400 |
jPOSTi | O15400 |
MassIVEi | O15400 |
MaxQBi | O15400 |
PaxDbi | O15400 |
PeptideAtlasi | O15400 |
PRIDEi | O15400 |
ProteomicsDBi | 48639 [O15400-1] 48640 [O15400-2] |
TopDownProteomicsi | O15400-1 [O15400-1] |
Protocols and materials databases
Antibodypediai | 729, 162 antibodies |
DNASUi | 8417 |
Genome annotation databases
Ensembli | ENST00000367937; ENSP00000356914; ENSG00000079950 [O15400-2] ENST00000367941; ENSP00000356918; ENSG00000079950 [O15400-1] |
GeneIDi | 8417 |
KEGGi | hsa:8417 |
UCSCi | uc003qdg.3, human [O15400-1] |
Organism-specific databases
CTDi | 8417 |
DisGeNETi | 8417 |
GeneCardsi | STX7 |
HGNCi | HGNC:11442, STX7 |
HPAi | ENSG00000079950, Low tissue specificity |
MIMi | 603217, gene |
neXtProti | NX_O15400 |
OpenTargetsi | ENSG00000079950 |
PharmGKBi | PA36239 |
VEuPathDBi | HostDB:ENSG00000079950.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0811, Eukaryota |
GeneTreei | ENSGT01000000214440 |
HOGENOMi | CLU_059257_1_1_1 |
InParanoidi | O15400 |
OMAi | HMENGLN |
OrthoDBi | 1204812at2759 |
PhylomeDBi | O15400 |
TreeFami | TF315607 |
Enzyme and pathway databases
PathwayCommonsi | O15400 |
Miscellaneous databases
BioGRID-ORCSi | 8417, 7 hits in 997 CRISPR screens |
ChiTaRSi | STX7, human |
GeneWikii | STX7 |
GenomeRNAii | 8417 |
Pharosi | O15400, Tbio |
PROi | PR:O15400 |
RNActi | O15400, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079950, Expressed in forebrain and 244 other tissues |
Genevisiblei | O15400, HS |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF14523, Syntaxin_2, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX7_HUMAN | |
Accessioni | O15400Primary (citable) accession number: O15400 Secondary accession number(s): E1P579, Q5SZW2, Q96ES9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 189 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families