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Protein

Syntaxin-7

Gene

STX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

GO - Molecular functioni

  • chloride channel inhibitor activity Source: UniProtKB
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: MGI
  • syntaxin binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-7
Gene namesi
Name:STX7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000079950.13
HGNCiHGNC:11442 STX7
MIMi603217 gene
neXtProtiNX_O15400

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 238CytoplasmicSequence analysisAdd BLAST237
Transmembranei239 – 259Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini260 – 261VesicularSequence analysis2

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8417
OpenTargetsiENSG00000079950
PharmGKBiPA36239

Polymorphism and mutation databases

BioMutaiSTX7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002102132 – 261Syntaxin-7Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei4PhosphothreonineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO15400
MaxQBiO15400
PaxDbiO15400
PeptideAtlasiO15400
PRIDEiO15400
ProteomicsDBi48639
48640 [O15400-2]
TopDownProteomicsiO15400-1 [O15400-1]

2D gel databases

OGPiO15400

PTM databases

iPTMnetiO15400
PhosphoSitePlusiO15400
SwissPalmiO15400

Miscellaneous databases

PMAP-CutDBiO15400

Expressioni

Tissue specificityi

Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Gene expression databases

BgeeiENSG00000079950 Expressed in 230 organ(s), highest expression level in forebrain
CleanExiHS_STX7
GenevisibleiO15400 HS

Organism-specific databases

HPAiCAB062564
HPA001467

Interactioni

Subunit structurei

Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114003, 104 interactors
CORUMiO15400
DIPiDIP-57384N
IntActiO15400, 54 interactors
MINTiO15400
STRINGi9606.ENSP00000356918

Structurei

3D structure databases

ProteinModelPortaliO15400
SMRiO15400
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 227t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 69Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00450000040239
HOGENOMiHOG000188453
HOVERGENiHBG053083
InParanoidiO15400
KOiK08488
OMAiADVHVQQ
OrthoDBiEOG091G0HKZ
PhylomeDBiO15400
TreeFamiTF315607

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O15400-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYTPGVGGD PAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ
60 70 80 90 100
QLQQKQQYTN QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS
110 120 130 140 150
LTNFQKVQRQ AAEREKEFVA RVRASSRVSG SFPEDSSKER NLVSWESQTQ
160 170 180 190 200
PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG
210 220 230 240 250
DVIDSIEANV ENAEVHVQQA NQQLSRAADY QRKSRKTLCI IILILVIGVA
260
IISLIIWGLN H
Length:261
Mass (Da):29,816
Last modified:January 23, 2007 - v4
Checksum:i42AC173F0233ACDA
GO
Isoform 2 (identifier: O15400-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-261: RKSRKTLCIIILILVIGVAIISLIIWGLNH → KKDSCMLM

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):27,400
Checksum:i6F35F3042EECF335
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → T in AAC51851 (PubMed:9358037).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012938232 – 261RKSRK…WGLNH → KKDSCMLM in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77942 mRNA Translation: AAC51851.1
AL357034 Genomic DNA No translation available.
AL589691 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48029.1
CH471051 Genomic DNA Translation: EAW48030.1
BC011975 mRNA Translation: AAH11975.1
CCDSiCCDS5153.1 [O15400-1]
CCDS87441.1 [O15400-2]
RefSeqiNP_001313507.1, NM_001326578.1 [O15400-1]
NP_001313508.1, NM_001326579.1 [O15400-1]
NP_001313509.1, NM_001326580.1 [O15400-2]
NP_003560.2, NM_003569.2 [O15400-1]
XP_011534480.1, XM_011536178.1
UniGeneiHs.593148
Hs.605992

Genome annotation databases

EnsembliENST00000367937; ENSP00000356914; ENSG00000079950 [O15400-2]
ENST00000367941; ENSP00000356918; ENSG00000079950 [O15400-1]
GeneIDi8417
KEGGihsa:8417
UCSCiuc003qdg.3 human [O15400-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77942 mRNA Translation: AAC51851.1
AL357034 Genomic DNA No translation available.
AL589691 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48029.1
CH471051 Genomic DNA Translation: EAW48030.1
BC011975 mRNA Translation: AAH11975.1
CCDSiCCDS5153.1 [O15400-1]
CCDS87441.1 [O15400-2]
RefSeqiNP_001313507.1, NM_001326578.1 [O15400-1]
NP_001313508.1, NM_001326579.1 [O15400-1]
NP_001313509.1, NM_001326580.1 [O15400-2]
NP_003560.2, NM_003569.2 [O15400-1]
XP_011534480.1, XM_011536178.1
UniGeneiHs.593148
Hs.605992

3D structure databases

ProteinModelPortaliO15400
SMRiO15400
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114003, 104 interactors
CORUMiO15400
DIPiDIP-57384N
IntActiO15400, 54 interactors
MINTiO15400
STRINGi9606.ENSP00000356918

PTM databases

iPTMnetiO15400
PhosphoSitePlusiO15400
SwissPalmiO15400

Polymorphism and mutation databases

BioMutaiSTX7

2D gel databases

OGPiO15400

Proteomic databases

EPDiO15400
MaxQBiO15400
PaxDbiO15400
PeptideAtlasiO15400
PRIDEiO15400
ProteomicsDBi48639
48640 [O15400-2]
TopDownProteomicsiO15400-1 [O15400-1]

Protocols and materials databases

DNASUi8417
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367937; ENSP00000356914; ENSG00000079950 [O15400-2]
ENST00000367941; ENSP00000356918; ENSG00000079950 [O15400-1]
GeneIDi8417
KEGGihsa:8417
UCSCiuc003qdg.3 human [O15400-1]

Organism-specific databases

CTDi8417
DisGeNETi8417
EuPathDBiHostDB:ENSG00000079950.13
GeneCardsiSTX7
HGNCiHGNC:11442 STX7
HPAiCAB062564
HPA001467
MIMi603217 gene
neXtProtiNX_O15400
OpenTargetsiENSG00000079950
PharmGKBiPA36239
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00450000040239
HOGENOMiHOG000188453
HOVERGENiHBG053083
InParanoidiO15400
KOiK08488
OMAiADVHVQQ
OrthoDBiEOG091G0HKZ
PhylomeDBiO15400
TreeFamiTF315607

Miscellaneous databases

ChiTaRSiSTX7 human
GeneWikiiSTX7
GenomeRNAii8417
PMAP-CutDBiO15400
PROiPR:O15400
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079950 Expressed in 230 organ(s), highest expression level in forebrain
CleanExiHS_STX7
GenevisibleiO15400 HS

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX7_HUMAN
AccessioniPrimary (citable) accession number: O15400
Secondary accession number(s): E1P579, Q5SZW2, Q96ES9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 172 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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