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UniProtKB - O15400 (STX7_HUMAN)

Entry version 189 (07 Apr 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

Syntaxin-7

Gene

STX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15400

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STX7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11442, STX7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603217, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15400

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000079950.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 238CytoplasmicSequence analysisAdd BLAST237
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei239 – 259Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini260 – 261VesicularSequence analysis2

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8417

Open Targets

More...OpenTargetsi		ENSG00000079950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36239

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15400, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STX7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002102132 – 261Syntaxin-7Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei4PhosphothreonineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15400

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15400

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15400

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15400

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15400

PeptideAtlas

More...PeptideAtlasi		O15400

PRoteomics IDEntifications database

More...PRIDEi		O15400

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48639 [O15400-1]
48640 [O15400-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O15400-1 [O15400-1]

2D gel databases

USC-OGP 2-DE database

More...OGPi		O15400

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15400

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15400

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O15400

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000079950, Expressed in forebrain and 244 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15400, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000079950, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes.

Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity).

Interacts with VPS11, VPS16 and VPS18.

Interacts with VPS33A.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O15400
With#Exp.IntAct
ANKS6 [Q68DC2]3EBI-3221827,EBI-7054139
AQP6 [Q13520]3EBI-3221827,EBI-13059134
ARL13B [Q3SXY8]3EBI-3221827,EBI-11343438
CERS4 [Q9HA82]3EBI-3221827,EBI-2622997
CISD2 [Q8N5K1]3EBI-3221827,EBI-1045797
CREB3L1 [Q96BA8]5EBI-3221827,EBI-6942903
CYBRD1 [Q53TN4]3EBI-3221827,EBI-8637742
EBP [Q15125]3EBI-3221827,EBI-3915253
ELOVL5 [Q9NYP7]3EBI-3221827,EBI-11037623
FAM174A [Q8TBP5]3EBI-3221827,EBI-18636064
FAM210B [Q96KR6]3EBI-3221827,EBI-18938272
FKBP7 [Q9Y680]3EBI-3221827,EBI-3918971
GJC3 [Q8NFK1]3EBI-3221827,EBI-20110678
HSD17B11 [Q8NBQ5]3EBI-3221827,EBI-1052304
HSD17B13 [Q7Z5P4]3EBI-3221827,EBI-18053395
JAGN1 [Q8N5M9]3EBI-3221827,EBI-10266796
LIME1 [Q9H400]3EBI-3221827,EBI-2830566
LSMEM2 [Q8N112]3EBI-3221827,EBI-10264855
MFF - isoform 5 [Q9GZY8-5]3EBI-3221827,EBI-11956541
MGST3 [O14880]3EBI-3221827,EBI-724754
MRM1 [Q6IN84]3EBI-3221827,EBI-5454865
MTUS1 - isoform 3 [Q9ULD2-3]3EBI-3221827,EBI-18051665
REEP1 [Q9H902]3EBI-3221827,EBI-1644241
RETREG3 [Q86VR2]3EBI-3221827,EBI-10192441
RIC3 - isoform 4 [Q7Z5B4-5]3EBI-3221827,EBI-12375429
SAR1A [Q9NR31]3EBI-3221827,EBI-3920694
SLC10A1 [Q14973]3EBI-3221827,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-3221827,EBI-18159983
STX1A [Q16623]3EBI-3221827,EBI-712466
STX2 - isoform 1 [P32856-2]3EBI-3221827,EBI-11956649
STX4 [Q12846]7EBI-3221827,EBI-744942
TM4SF19 [Q96DZ7]3EBI-3221827,EBI-6448756
TMEM205 [Q6UW68]3EBI-3221827,EBI-6269551
TMEM241 [Q24JQ0]3EBI-3221827,EBI-18172866
TMEM267 [Q0VDI3]3EBI-3221827,EBI-17555467
TMEM80 [Q96HE8]3EBI-3221827,EBI-11742770
TMPRSS2 - isoform 2 [O15393-2]4EBI-3221827,EBI-12345267
TMX2 [Q9Y320]3EBI-3221827,EBI-6447886
VPS11 [Q9H270]2EBI-3221827,EBI-373380
VPS18 [Q9P253]2EBI-3221827,EBI-1053363
ZFYVE27 [Q5T4F4]3EBI-3221827,EBI-3892947

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114003, 162 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O15400

Database of interacting proteins

More...DIPi		DIP-57384N

Protein interaction database and analysis system

More...IntActi		O15400, 114 interactors

Molecular INTeraction database

More...MINTi		O15400

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356918

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15400, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15400

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 227t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili47 – 69Sequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0811, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214440

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059257_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15400

Identification of Orthologs from Complete Genome Data

More...OMAi		HMENGLN

Database of Orthologous Groups

More...OrthoDBi		1204812at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15400

TreeFam database of animal gene trees

More...TreeFami		TF315607

Family and domain databases

Conserved Domains Database

More...CDDi		cd00179, SynN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010989, SNARE
IPR006012, Syntaxin/epimorphin_CS
IPR006011, Syntaxin_N
IPR000727, T_SNARE_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05739, SNARE, 1 hit
PF14523, Syntaxin_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00503, SynN, 1 hit
SM00397, t_SNARE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47661, SSF47661, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00914, SYNTAXIN, 1 hit
PS50192, T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O15400-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYTPGVGGD PAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ 
        60         70         80         90        100
QLQQKQQYTN QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS 
       110        120        130        140        150
LTNFQKVQRQ AAEREKEFVA RVRASSRVSG SFPEDSSKER NLVSWESQTQ 
       160        170        180        190        200
PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG 
       210        220        230        240        250
DVIDSIEANV ENAEVHVQQA NQQLSRAADY QRKSRKTLCI IILILVIGVA 
       260 
IISLIIWGLN H
Length:261
Mass (Da):29,816
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42AC173F0233ACDA
GO
Isoform 2 (identifier: O15400-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-261: RKSRKTLCIIILILVIGVAIISLIIWGLNH → KKDSCMLM

Show »
Length:239
Mass (Da):27,400
Checksum:i6F35F3042EECF335
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12A → T in AAC51851 (PubMed:9358037).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012938232 – 261RKSRK…WGLNH → KKDSCMLM in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U77942 mRNA Translation: AAC51851.1
AL357034 Genomic DNA No translation available.
AL589691 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48029.1
CH471051 Genomic DNA Translation: EAW48030.1
BC011975 mRNA Translation: AAH11975.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5153.1 [O15400-1]
CCDS87441.1 [O15400-2]

NCBI Reference Sequences

More...RefSeqi		NP_001313507.1, NM_001326578.1 [O15400-1]
NP_001313508.1, NM_001326579.1 [O15400-1]
NP_001313509.1, NM_001326580.1 [O15400-2]
NP_003560.2, NM_003569.2 [O15400-1]
XP_011534480.1, XM_011536178.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367937; ENSP00000356914; ENSG00000079950 [O15400-2]
ENST00000367941; ENSP00000356918; ENSG00000079950 [O15400-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8417

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8417

UCSC genome browser

More...UCSCi		uc003qdg.3, human [O15400-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77942 mRNA Translation: AAC51851.1
AL357034 Genomic DNA No translation available.
AL589691 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48029.1
CH471051 Genomic DNA Translation: EAW48030.1
BC011975 mRNA Translation: AAH11975.1
CCDSiCCDS5153.1 [O15400-1]
CCDS87441.1 [O15400-2]
RefSeqiNP_001313507.1, NM_001326578.1 [O15400-1]
NP_001313508.1, NM_001326579.1 [O15400-1]
NP_001313509.1, NM_001326580.1 [O15400-2]
NP_003560.2, NM_003569.2 [O15400-1]
XP_011534480.1, XM_011536178.1

3D structure databases

SMRiO15400
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114003, 162 interactors
CORUMiO15400
DIPiDIP-57384N
IntActiO15400, 114 interactors
MINTiO15400
STRINGi9606.ENSP00000356918

PTM databases

iPTMnetiO15400
PhosphoSitePlusiO15400
SwissPalmiO15400

Genetic variation databases

BioMutaiSTX7

2D gel databases

OGPiO15400

Proteomic databases

EPDiO15400
jPOSTiO15400
MassIVEiO15400
MaxQBiO15400
PaxDbiO15400
PeptideAtlasiO15400
PRIDEiO15400
ProteomicsDBi48639 [O15400-1]
48640 [O15400-2]
TopDownProteomicsiO15400-1 [O15400-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		729, 162 antibodies

The DNASU plasmid repository

More...DNASUi		8417

Genome annotation databases

EnsembliENST00000367937; ENSP00000356914; ENSG00000079950 [O15400-2]
ENST00000367941; ENSP00000356918; ENSG00000079950 [O15400-1]
GeneIDi8417
KEGGihsa:8417
UCSCiuc003qdg.3, human [O15400-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8417
DisGeNETi8417

GeneCards: human genes, protein and diseases

More...GeneCardsi		STX7
HGNCiHGNC:11442, STX7
HPAiENSG00000079950, Low tissue specificity
MIMi603217, gene
neXtProtiNX_O15400
OpenTargetsiENSG00000079950
PharmGKBiPA36239
VEuPathDBiHostDB:ENSG00000079950.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0811, Eukaryota
GeneTreeiENSGT01000000214440
HOGENOMiCLU_059257_1_1_1
InParanoidiO15400
OMAiHMENGLN
OrthoDBi1204812at2759
PhylomeDBiO15400
TreeFamiTF315607

Enzyme and pathway databases

PathwayCommonsiO15400

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8417, 7 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STX7, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STX7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8417
PharosiO15400, Tbio

Protein Ontology

More...PROi		PR:O15400
RNActiO15400, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000079950, Expressed in forebrain and 244 other tissues
GenevisibleiO15400, HS

Family and domain databases

CDDicd00179, SynN, 1 hit
InterProiView protein in InterPro
IPR010989, SNARE
IPR006012, Syntaxin/epimorphin_CS
IPR006011, Syntaxin_N
IPR000727, T_SNARE_dom
PfamiView protein in Pfam
PF05739, SNARE, 1 hit
PF14523, Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503, SynN, 1 hit
SM00397, t_SNARE, 1 hit
SUPFAMiSSF47661, SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914, SYNTAXIN, 1 hit
PS50192, T_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTX7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15400
Secondary accession number(s): E1P579, Q5SZW2, Q96ES9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 189 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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