UniProtKB - O15394 (NCAM2_HUMAN)
Protein
Neural cell adhesion molecule 2
Gene
NCAM2
Organism
Homo sapiens (Human)
Status
Functioni
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- axonal fasciculation Source: Ensembl
- neuron cell-cell adhesion Source: ProtInc
- sensory perception of smell Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | O15394 |
Names & Taxonomyi
Protein namesi | Recommended name: Neural cell adhesion molecule 2Short name: N-CAM-2 Short name: NCAM-2 |
Gene namesi | Name:NCAM2 Synonyms:NCAM21 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7657, NCAM2 |
MIMi | 602040, gene |
neXtProti | NX_O15394 |
VEuPathDBi | HostDB:ENSG00000154654.14 |
Subcellular locationi
Plasma membrane
Nucleus
- nuclear body Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- axon Source: Ensembl
- integral component of membrane Source: ProtInc
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 697 | ExtracellularSequence analysisAdd BLAST | 678 | |
Transmembranei | 698 – 718 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 719 – 837 | CytoplasmicSequence analysisAdd BLAST | 119 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4685 |
OpenTargetsi | ENSG00000154654 |
PharmGKBi | PA31460 |
Miscellaneous databases
Pharosi | O15394, Tbio |
Genetic variation databases
BioMutai | NCAM2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000015018 | 20 – 837 | Neural cell adhesion molecule 2Add BLAST | 818 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 93 | Curated | ||
Disulfide bondi | 136 ↔ 186 | Curated | ||
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 219 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 232 ↔ 281 | Curated | ||
Glycosylationi | 309 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 322 ↔ 380 | Curated | ||
Glycosylationi | 406 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 419 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 422 ↔ 475 | Curated | ||
Glycosylationi | 445 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 562 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 765 | PhosphoserineBy similarity | 1 | |
Modified residuei | 780 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 786 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | O15394 |
MassIVEi | O15394 |
MaxQBi | O15394 |
PaxDbi | O15394 |
PeptideAtlasi | O15394 |
PRIDEi | O15394 |
ProteomicsDBi | 48635 [O15394-1] 6923 |
PTM databases
GlyConnecti | 1546, 7 N-Linked glycans (3 sites) |
GlyGeni | O15394, 12 sites |
iPTMneti | O15394 |
PhosphoSitePlusi | O15394 |
SwissPalmi | O15394 |
Expressioni
Tissue specificityi
Expressed most strongly in adult and fetal brain.
Gene expression databases
Bgeei | ENSG00000154654, Expressed in corpus callosum and 122 other tissues |
ExpressionAtlasi | O15394, baseline and differential |
Genevisiblei | O15394, HS |
Organism-specific databases
HPAi | ENSG00000154654, Tissue enhanced (adrenal gland, brain) |
Interactioni
Binary interactionsi
O15394
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-2679983,EBI-2679983 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 110765, 5 interactors |
DIPi | DIP-56211N |
IntActi | O15394, 6 interactors |
STRINGi | 9606.ENSP00000383392 |
Miscellaneous databases
RNActi | O15394, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O15394 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15394 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 108 | Ig-like C2-type 1Add BLAST | 88 | |
Domaini | 113 – 202 | Ig-like C2-type 2Add BLAST | 90 | |
Domaini | 208 – 297 | Ig-like C2-type 3Add BLAST | 90 | |
Domaini | 302 – 396 | Ig-like C2-type 4Add BLAST | 95 | |
Domaini | 401 – 491 | Ig-like C2-type 5Add BLAST | 91 | |
Domaini | 498 – 591 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 593 – 688 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3510, Eukaryota |
GeneTreei | ENSGT00940000157860 |
InParanoidi | O15394 |
OMAi | HGGVPIN |
OrthoDBi | 129648at2759 |
PhylomeDBi | O15394 |
TreeFami | TF326195 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR009138, Neural_cell_adh |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 4 hits |
PRINTSi | PR01838, NCAMFAMILY |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS50835, IG_LIKE, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O15394-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLLLSFYLL GLLVSSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES
60 70 80 90 100
IDWYNPQGEK IISTQRVVVQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG
110 120 130 140 150
QTQEATVVLE IYQKLTFREV VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY
160 170 180 190 200
HNEEVTTISD NRFAMLANNN LQILNINKSD EGIYRCEGRV EARGEIDFRD
210 220 230 240 250
IIVIVNVPPA ISMPQKSFNA TAERGEEMTF SCRASGSPEP AISWFRNGKL
260 270 280 290 300
IEENEKYILK GSNTELTVRN IINSDGGPYV CRATNKAGED EKQAFLQVFV
310 320 330 340 350
QPHIIQLKNE TTYENGQVTL VCDAEGEPIP EITWKRAVDG FTFTEGDKSL
360 370 380 390 400
DGRIEVKGQH GSSSLHIKDV KLSDSGRYDC EAASRIGGHQ KSMYLDIEYA
410 420 430 440 450
PKFISNQTIY YSWEGNPINI SCDVKSNPPA SIHWRRDKLV LPAKNTTNLK
460 470 480 490 500
TYSTGRKMIL EIAPTSDNDF GRYNCTATNH IGTRFQEYIL ALADVPSSPY
510 520 530 540 550
GVKIIELSQT TAKVSFNKPD SHGGVPIHHY QVDVKEVASE IWKIVRSHGV
560 570 580 590 600
QTMVVLNNLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH
610 620 630 640 650
GQPSSGKSFK LSITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH
660 670 680 690 700
IILEHLQWTM GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG
710 720 730 740 750
LGAVIGLGVA ALLLILVVTD VSCFFIRQCG LLMCITRRMC GKKSGSSGKS
760 770 780 790 800
KELEEGKAAY LKDGSKEPIV EMRTEDERVT NHEDGSPVNE PNETTPLTEP
810 820 830
EKLPLKEEDG KEALNPETIE IKVSNDIIQS KEDDSKA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH9KV31 | H9KV31_HUMAN | Neural cell adhesion molecule 2 | NCAM2 | 819 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | E → R in AAB80803 (PubMed:9226371).Curated | 1 | |
Sequence conflicti | 72 | E → G in AAB80803 (PubMed:9226371).Curated | 1 | |
Sequence conflicti | 163 | F → L in AAB80803 (PubMed:9226371).Curated | 1 | |
Sequence conflicti | 374 | D → G in AAB80803 (PubMed:9226371).Curated | 1 | |
Sequence conflicti | 662 – 667 | YEVQIT → MKFRLP in AAB80803 (PubMed:9226371).Curated | 6 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047897 | 347 | D → N. Corresponds to variant dbSNP:rs35654962Ensembl. | 1 | |
Natural variantiVAR_047898 | 350 | L → P1 PublicationCorresponds to variant dbSNP:rs232518Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056637 | 1 – 18 | MSLLL…VSSGQ → MVRSDSGGQVYLDYHNRQGL FVDWKYNEALYLEEGQPETY YRT in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_056638 | 399 | Y → S in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_056639 | 400 – 837 | Missing in isoform 2. 1 PublicationAdd BLAST | 438 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75330 mRNA Translation: AAB80803.1 AK302870 mRNA Translation: BAH13827.1 AP001114 Genomic DNA No translation available. AP001115 Genomic DNA No translation available. AP001136 Genomic DNA No translation available. AP001137 Genomic DNA No translation available. AP001138 Genomic DNA No translation available. AP001252 Genomic DNA No translation available. BC052946 mRNA Translation: AAH52946.1 |
CCDSi | CCDS42910.1 [O15394-1] |
RefSeqi | NP_004531.2, NM_004540.3 [O15394-1] XP_016883847.1, XM_017028358.1 |
Genome annotation databases
Ensembli | ENST00000400546; ENSP00000383392; ENSG00000154654 [O15394-1] |
GeneIDi | 4685 |
KEGGi | hsa:4685 |
UCSCi | uc002yld.3, human [O15394-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75330 mRNA Translation: AAB80803.1 AK302870 mRNA Translation: BAH13827.1 AP001114 Genomic DNA No translation available. AP001115 Genomic DNA No translation available. AP001136 Genomic DNA No translation available. AP001137 Genomic DNA No translation available. AP001138 Genomic DNA No translation available. AP001252 Genomic DNA No translation available. BC052946 mRNA Translation: AAH52946.1 |
CCDSi | CCDS42910.1 [O15394-1] |
RefSeqi | NP_004531.2, NM_004540.3 [O15394-1] XP_016883847.1, XM_017028358.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DOC | NMR | - | A | 486-591 | [»] | |
2JLL | X-ray | 2.30 | A | 301-689 | [»] | |
2KBG | NMR | - | A | 592-693 | [»] | |
2V5T | X-ray | 2.00 | A | 115-301 | [»] | |
2VAJ | X-ray | 2.70 | A | 21-113 | [»] | |
2WIM | X-ray | 3.00 | A/B | 19-301 | [»] | |
2XY1 | X-ray | 1.90 | A | 209-398 | [»] | |
2XY2 | X-ray | 1.77 | A | 19-207 | [»] | |
2XYC | X-ray | 2.65 | A | 301-591 | [»] | |
SMRi | O15394 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110765, 5 interactors |
DIPi | DIP-56211N |
IntActi | O15394, 6 interactors |
STRINGi | 9606.ENSP00000383392 |
PTM databases
GlyConnecti | 1546, 7 N-Linked glycans (3 sites) |
GlyGeni | O15394, 12 sites |
iPTMneti | O15394 |
PhosphoSitePlusi | O15394 |
SwissPalmi | O15394 |
Genetic variation databases
BioMutai | NCAM2 |
Proteomic databases
jPOSTi | O15394 |
MassIVEi | O15394 |
MaxQBi | O15394 |
PaxDbi | O15394 |
PeptideAtlasi | O15394 |
PRIDEi | O15394 |
ProteomicsDBi | 48635 [O15394-1] 6923 |
Protocols and materials databases
Antibodypediai | 22282, 287 antibodies |
Genome annotation databases
Ensembli | ENST00000400546; ENSP00000383392; ENSG00000154654 [O15394-1] |
GeneIDi | 4685 |
KEGGi | hsa:4685 |
UCSCi | uc002yld.3, human [O15394-1] |
Organism-specific databases
CTDi | 4685 |
DisGeNETi | 4685 |
GeneCardsi | NCAM2 |
HGNCi | HGNC:7657, NCAM2 |
HPAi | ENSG00000154654, Tissue enhanced (adrenal gland, brain) |
MIMi | 602040, gene |
neXtProti | NX_O15394 |
OpenTargetsi | ENSG00000154654 |
PharmGKBi | PA31460 |
VEuPathDBi | HostDB:ENSG00000154654.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3510, Eukaryota |
GeneTreei | ENSGT00940000157860 |
InParanoidi | O15394 |
OMAi | HGGVPIN |
OrthoDBi | 129648at2759 |
PhylomeDBi | O15394 |
TreeFami | TF326195 |
Enzyme and pathway databases
PathwayCommonsi | O15394 |
Miscellaneous databases
BioGRID-ORCSi | 4685, 7 hits in 875 CRISPR screens |
ChiTaRSi | NCAM2, human |
EvolutionaryTracei | O15394 |
GenomeRNAii | 4685 |
Pharosi | O15394, Tbio |
PROi | PR:O15394 |
RNActi | O15394, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154654, Expressed in corpus callosum and 122 other tissues |
ExpressionAtlasi | O15394, baseline and differential |
Genevisiblei | O15394, HS |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR009138, Neural_cell_adh |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 4 hits |
PRINTSi | PR01838, NCAMFAMILY |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCAM2_HUMAN | |
Accessioni | O15394Primary (citable) accession number: O15394 Secondary accession number(s): A8MQ06, B7Z841, Q7Z7F2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 10, 2021 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references