Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor YY2

Gene

YY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.1 Publication

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene MBTPS2.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri283 – 305C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 365C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor YY2
Alternative name(s):
Yin and yang 2
Short name:
YY-2
Zinc finger protein 631
Gene namesi
Name:YY2
Synonyms:ZNF631
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000230797.2
HGNCiHGNC:31684 YY2
MIMi300570 gene
neXtProtiNX_O15391

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi404281
OpenTargetsiENSG00000230797
PharmGKBiPA134976542

Polymorphism and mutation databases

BioMutaiYY2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237601 – 372Transcription factor YY2Add BLAST372

Proteomic databases

EPDiO15391
MaxQBiO15391
PaxDbiO15391
PeptideAtlasiO15391
PRIDEiO15391
ProteomicsDBi48626

PTM databases

iPTMnetiO15391
PhosphoSitePlusiO15391

Expressioni

Tissue specificityi

Expressed in kidney, liver, spleen and testis but not in colon.1 Publication

Gene expression databases

BgeeiENSG00000230797 Expressed in 86 organ(s), highest expression level in testis
CleanExiHS_YY2
GenevisibleiO15391 HS

Organism-specific databases

HPAiHPA030335

Interactioni

Protein-protein interaction databases

BioGridi135656, 5 interactors
IntActiO15391, 3 interactors
STRINGi9606.ENSP00000389381

Structurei

3D structure databases

ProteinModelPortaliO15391
SMRiO15391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 102Mediates transcriptional activationAdd BLAST71
Regioni237 – 372Mediates transcriptional repressionAdd BLAST136

Sequence similaritiesi

Belongs to the YY transcription factor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri283 – 305C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 365C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000008232
HOVERGENiHBG006823
InParanoidiO15391
KOiK09201
OMAiSIEDEHF
OrthoDBiEOG091G03FM
PhylomeDBiO15391
TreeFamiTF106493

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

O15391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNEDFSIT QDLEIPADIV ELHDINVEPL PMEDIPTESV QYEDVDGNWI
60 70 80 90 100
YGGHNHPPLM VLQPLFTNTG YGDHDQEMLM LQTQEEVVGY CDSDNQLGND
110 120 130 140 150
LEDQLALPDS IEDEHFQMTL ASLSASAAST STSTQSRSKK PSKKPSGKSA
160 170 180 190 200
TSTEANPAGS SSSLGTRKWE QKQMQVKTLE GEFSVTMWSP NDNNDQGAVG
210 220 230 240 250
EGQAENPPDY SEYLKGKKLP PGGLPGIDLS DPKQLAEFTK VKPKRSKGEP
260 270 280 290 300
PKTVPCSYSG CEKMFRDYAA MRKHLHIHGP RVHVCAECGK AFLESSKLRR
310 320 330 340 350
HQLVHTGEKP FQCTFEGCGK RFSLDFNLRT HLRIHTGDKP FVCPFDVCNR
360 370
KFAQSTNLKT HILTHVKTKN NP
Length:372
Mass (Da):41,347
Last modified:January 1, 1998 - v1
Checksum:i5AEAB49C09CE6FF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9I → T in AAS68634 (PubMed:15087442).Curated1
Sequence conflicti144K → R in AAS68634 (PubMed:15087442).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039586103D → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs147081325Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY567472 mRNA Translation: AAS68634.1
AK091850 mRNA Translation: BAG52427.1
U73479 Genomic DNA Translation: AAD08633.1
CH471074 Genomic DNA Translation: EAW98983.1
BC137215 mRNA Translation: AAI37216.1
BC137217 mRNA Translation: AAI37218.1
CCDSiCCDS14202.1
RefSeqiNP_996806.2, NM_206923.3
UniGeneiHs.673601

Genome annotation databases

EnsembliENST00000429584; ENSP00000389381; ENSG00000230797
GeneIDi404281
KEGGihsa:404281
UCSCiuc011mjp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY567472 mRNA Translation: AAS68634.1
AK091850 mRNA Translation: BAG52427.1
U73479 Genomic DNA Translation: AAD08633.1
CH471074 Genomic DNA Translation: EAW98983.1
BC137215 mRNA Translation: AAI37216.1
BC137217 mRNA Translation: AAI37218.1
CCDSiCCDS14202.1
RefSeqiNP_996806.2, NM_206923.3
UniGeneiHs.673601

3D structure databases

ProteinModelPortaliO15391
SMRiO15391
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135656, 5 interactors
IntActiO15391, 3 interactors
STRINGi9606.ENSP00000389381

PTM databases

iPTMnetiO15391
PhosphoSitePlusiO15391

Polymorphism and mutation databases

BioMutaiYY2

Proteomic databases

EPDiO15391
MaxQBiO15391
PaxDbiO15391
PeptideAtlasiO15391
PRIDEiO15391
ProteomicsDBi48626

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429584; ENSP00000389381; ENSG00000230797
GeneIDi404281
KEGGihsa:404281
UCSCiuc011mjp.2 human

Organism-specific databases

CTDi404281
DisGeNETi404281
EuPathDBiHostDB:ENSG00000230797.2
GeneCardsiYY2
HGNCiHGNC:31684 YY2
HPAiHPA030335
MIMi300570 gene
neXtProtiNX_O15391
OpenTargetsiENSG00000230797
PharmGKBiPA134976542
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000008232
HOVERGENiHBG006823
InParanoidiO15391
KOiK09201
OMAiSIEDEHF
OrthoDBiEOG091G03FM
PhylomeDBiO15391
TreeFamiTF106493

Miscellaneous databases

GenomeRNAii404281
PROiPR:O15391
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000230797 Expressed in 86 organ(s), highest expression level in testis
CleanExiHS_YY2
GenevisibleiO15391 HS

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTYY2_HUMAN
AccessioniPrimary (citable) accession number: O15391
Secondary accession number(s): B2RP10, Q6Q1S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 1, 1998
Last modified: October 10, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again