Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Branched-chain-amino-acid aminotransferase, mitochondrial

Gene

BCAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei168Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.6.1.42 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70895 Branched-chain amino acid catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O15382

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferase, mitochondrial (EC:2.6.1.42)
Short name:
BCAT(m)
Alternative name(s):
Placental protein 18
Short name:
PP18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCAT2
Synonyms:BCATM, BCT2, ECA40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105552.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:977 BCAT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
113530 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15382

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi342C → A: Reduces activity about 6-fold. 1 Publication1
Mutagenesisi345C → A: Slight reduction of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
587

Open Targets

More...
OpenTargetsi
ENSG00000105552

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25289

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3616354

Drug and drug target database

More...
DrugBanki
DB04074 Alpha-ketoisovalerate
DB00142 L-Glutamic Acid
DB00167 L-Isoleucine
DB00149 L-Leucine
DB02635 N-[O-Phosphono-Pyridoxyl]-Isoleucine
DB00114 Pyridoxal Phosphate
DB02142 Pyridoxamine-5'-Phosphate

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2893

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCAT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 27MitochondrionAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000127128 – 392Branched-chain-amino-acid aminotransferase, mitochondrialAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei229N6-(pyridoxal phosphate)lysine1
Modified residuei321N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15382

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15382

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15382

PeptideAtlas

More...
PeptideAtlasi
O15382

PRoteomics IDEntifications database

More...
PRIDEi
O15382

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48623
48624 [O15382-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15382

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15382

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105552 Expressed in 214 organ(s), highest expression level in body of stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_BCAT2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15382 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15382 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054091

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107062, 17 interactors

Protein interaction database and analysis system

More...
IntActi
O15382, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000322991

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15382

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1392
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15382

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15382

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O15382

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0975 Eukaryota
COG0115 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009532

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276704

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050678

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15382

KEGG Orthology (KO)

More...
KOi
K00826

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15382

TreeFam database of animal gene trees

More...
TreeFami
TF300882

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01557 BCAT_beta_family, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001544 Aminotrans_IV
IPR018300 Aminotrans_IV_CS
IPR036038 Aminotransferase-like
IPR005786 B_amino_transII
IPR033939 BCAT_family

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01063 Aminotran_4, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006468 BCAT1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56752 SSF56752, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01123 ilvE_II, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00770 AA_TRANSFER_CLASS_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: O15382-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAALGQIW ARKLLSVPWL LCGPRRYASS SFKAADLQLE MTQKPHKKPG
60 70 80 90 100
PGEPLVFGKT FTDHMLMVEW NDKGWGQPRI QPFQNLTLHP ASSSLHYSLQ
110 120 130 140 150
LFEGMKAFKG KDQQVRLFRP WLNMDRMLRS AMRLCLPSFD KLELLECIRR
160 170 180 190 200
LIEVDKDWVP DAAGTSLYVR PVLIGNEPSL GVSQPTRALL FVILCPVGAY
210 220 230 240 250
FPGGSVTPVS LLADPAFIRA WVGGVGNYKL GGNYGPTVLV QQEALKRGCE
260 270 280 290 300
QVLWLYGPDH QLTEVGTMNI FVYWTHEDGV LELVTPPLNG VILPGVVRQS
310 320 330 340 350
LLDMAQTWGE FRVVERTITM KQLLRALEEG RVREVFGSGT ACQVCPVHRI
360 370 380 390
LYKDRNLHIP TMENGPELIL RFQKELKEIQ YGIRAHEWMF PV
Length:392
Mass (Da):44,288
Last modified:May 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC07047264B190DA
GO
Isoform B (identifier: O15382-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-100: Missing.

Show »
Length:300
Mass (Da):33,777
Checksum:i656A626FEC867073
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KSI3B3KSI3_HUMAN
Branched-chain-amino-acid aminotran...
BCAT2
352Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXF9M0QXF9_HUMAN
Branched-chain-amino-acid aminotran...
BCAT2
445Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ10M0QZ10_HUMAN
Branched-chain-amino-acid aminotran...
BCAT2
405Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZP4M0QZP4_HUMAN
Branched-chain-amino-acid aminotran...
BCAT2
313Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2K7M0R2K7_HUMAN
Branched-chain-amino-acid aminotran...
BCAT2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB53087 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154V → L in AAB53087 (PubMed:8702755).Curated1
Sequence conflicti207T → N in AAB53087 (PubMed:8702755).Curated1
Sequence conflicti214 – 216DPA → EPT in AAB53087 (PubMed:8702755).Curated3
Sequence conflicti253L → F in AAB53087 (PubMed:8702755).Curated1
Sequence conflicti326A → P in AAB53087 (PubMed:8702755).Curated1
Sequence conflicti330G → A in AAB53087 (PubMed:8702755).Curated1
Sequence conflicti349R → G in AAB53087 (PubMed:8702755).Curated1
Sequence conflicti357L → F in AAB53087 (PubMed:8702755).Curated1
Sequence conflicti370L → F in AAB53087 (PubMed:8702755).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048234186T → R2 PublicationsCorresponds to variant dbSNP:rs11548193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0002369 – 100Missing in isoform B. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U68418 mRNA Translation: AAB67672.1
AF268047 mRNA Translation: AAK38368.1
AF268048 mRNA Translation: AAK38369.1
AK314548 mRNA Translation: BAG37134.1
CH471177 Genomic DNA Translation: EAW52403.1
BC001900 mRNA Translation: AAH01900.1
BC004243 mRNA Translation: AAH04243.2
U62739 mRNA Translation: AAB53087.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12735.1 [O15382-1]
CCDS54290.1 [O15382-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001158245.1, NM_001164773.1 [O15382-2]
NP_001181.2, NM_001190.3 [O15382-1]
NP_001271254.1, NM_001284325.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.512670

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316273; ENSP00000322991; ENSG00000105552 [O15382-1]
ENST00000545387; ENSP00000440973; ENSG00000105552 [O15382-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
587

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:587

UCSC genome browser

More...
UCSCi
uc002pkr.4 human [O15382-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68418 mRNA Translation: AAB67672.1
AF268047 mRNA Translation: AAK38368.1
AF268048 mRNA Translation: AAK38369.1
AK314548 mRNA Translation: BAG37134.1
CH471177 Genomic DNA Translation: EAW52403.1
BC001900 mRNA Translation: AAH01900.1
BC004243 mRNA Translation: AAH04243.2
U62739 mRNA Translation: AAB53087.1 Different initiation.
CCDSiCCDS12735.1 [O15382-1]
CCDS54290.1 [O15382-2]
RefSeqiNP_001158245.1, NM_001164773.1 [O15382-2]
NP_001181.2, NM_001190.3 [O15382-1]
NP_001271254.1, NM_001284325.1
UniGeneiHs.512670

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EKFX-ray1.95A/B28-392[»]
1EKPX-ray2.50A/B28-392[»]
1EKVX-ray2.25A/B28-392[»]
1KT8X-ray1.90A/B28-392[»]
1KTAX-ray1.90A/B28-392[»]
2A1HX-ray1.80A/B28-392[»]
2HDKX-ray2.40A/B28-392[»]
2HG8X-ray1.80A/B28-392[»]
2HGWX-ray1.98A/B28-392[»]
2HGXX-ray1.80A/B28-392[»]
2HHFX-ray1.80A/B28-392[»]
5BWRX-ray2.20A/B28-392[»]
5BWTX-ray2.20A/B28-392[»]
5BWUX-ray2.17A/B28-392[»]
5BWVX-ray1.86A/B28-392[»]
5BWWX-ray1.82A/B28-392[»]
5BWXX-ray1.70A/B28-392[»]
5CR5X-ray1.61A/B28-392[»]
5HNEX-ray2.04A/B28-392[»]
5I5SX-ray2.06A/B28-392[»]
5I5TX-ray2.31A/B28-392[»]
5I5UX-ray2.40A/B28-392[»]
5I5VX-ray1.94A/B28-392[»]
5I5WX-ray2.40A/B28-392[»]
5I5XX-ray1.65A/B28-392[»]
5I5YX-ray1.81A/B28-392[»]
5I60X-ray2.12A/B28-392[»]
5MPRX-ray1.60A28-392[»]
ProteinModelPortaliO15382
SMRiO15382
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107062, 17 interactors
IntActiO15382, 4 interactors
STRINGi9606.ENSP00000322991

Chemistry databases

BindingDBiO15382
ChEMBLiCHEMBL3616354
DrugBankiDB04074 Alpha-ketoisovalerate
DB00142 L-Glutamic Acid
DB00167 L-Isoleucine
DB00149 L-Leucine
DB02635 N-[O-Phosphono-Pyridoxyl]-Isoleucine
DB00114 Pyridoxal Phosphate
DB02142 Pyridoxamine-5'-Phosphate
GuidetoPHARMACOLOGYi2893

PTM databases

iPTMnetiO15382
PhosphoSitePlusiO15382

Polymorphism and mutation databases

BioMutaiBCAT2

Proteomic databases

EPDiO15382
MaxQBiO15382
PaxDbiO15382
PeptideAtlasiO15382
PRIDEiO15382
ProteomicsDBi48623
48624 [O15382-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
587
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316273; ENSP00000322991; ENSG00000105552 [O15382-1]
ENST00000545387; ENSP00000440973; ENSG00000105552 [O15382-2]
GeneIDi587
KEGGihsa:587
UCSCiuc002pkr.4 human [O15382-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
587
DisGeNETi587
EuPathDBiHostDB:ENSG00000105552.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCAT2
HGNCiHGNC:977 BCAT2
HPAiHPA054091
MIMi113530 gene
neXtProtiNX_O15382
OpenTargetsiENSG00000105552
PharmGKBiPA25289

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0975 Eukaryota
COG0115 LUCA
GeneTreeiENSGT00390000009532
HOGENOMiHOG000276704
HOVERGENiHBG050678
InParanoidiO15382
KOiK00826
PhylomeDBiO15382
TreeFamiTF300882

Enzyme and pathway databases

BRENDAi2.6.1.42 2681
ReactomeiR-HSA-70895 Branched-chain amino acid catabolism
SABIO-RKiO15382

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BCAT2 human
EvolutionaryTraceiO15382

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
587

Protein Ontology

More...
PROi
PR:O15382

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105552 Expressed in 214 organ(s), highest expression level in body of stomach
CleanExiHS_BCAT2
ExpressionAtlasiO15382 baseline and differential
GenevisibleiO15382 HS

Family and domain databases

CDDicd01557 BCAT_beta_family, 1 hit
InterProiView protein in InterPro
IPR001544 Aminotrans_IV
IPR018300 Aminotrans_IV_CS
IPR036038 Aminotransferase-like
IPR005786 B_amino_transII
IPR033939 BCAT_family
PfamiView protein in Pfam
PF01063 Aminotran_4, 1 hit
PIRSFiPIRSF006468 BCAT1, 1 hit
SUPFAMiSSF56752 SSF56752, 1 hit
TIGRFAMsiTIGR01123 ilvE_II, 1 hit
PROSITEiView protein in PROSITE
PS00770 AA_TRANSFER_CLASS_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCAT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15382
Secondary accession number(s): B2RB87
, O00269, Q96KG1, Q9BTB6, Q9BUU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 2, 2002
Last modified: December 5, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again