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UniProtKB - O15381 (NVL_HUMAN)

Entry version 179 (23 Feb 2022)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
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Protein

Nuclear valosin-containing protein-like

Gene

NVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966).

Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824).

Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651).

Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).

7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi305 – 312ATP1 Publication8
Nucleotide bindingi622 – 629ATP1 Publication8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15381

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O15381

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear valosin-containing protein-likeCurated
Short name:
NVLp
Short name:
Nuclear VCP-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NVLImported
Synonyms:NVL21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8070, NVL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602426, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15381

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143748

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi51 – 52KR → AA: Loss of nucleolar localization and interaction with RPL5. 1 Publication2
Mutagenesisi85 – 86KR → AA: Decreased nuclear localization. Complete loss of nuclear localization; when associated with 218-A--A-220 and 230-A--A-232. 1 Publication2
Mutagenesisi173W → A: Abolishes binding to MTREX. 1 Publication1
Mutagenesisi175I → E: Impairs binding to MTREX. 1 Publication1
Mutagenesisi176D → A: Impairs the binding of MTREX. 1 Publication1
Mutagenesisi218 – 220KRK → AAA: Decreased nuclear localization; when associated with 230-A--A-232. Complete loss of nuclear localization; when associated with 85-A-A-86 and 230-A--A-232. 1 Publication3
Mutagenesisi230 – 232RKK → AAA: Decreased nuclear localization when associated with 218-A--A-220. Complete loss of nuclear localization; when associated with 85-A-A-86 and 218-A--A-220. 1 Publication3
Mutagenesisi311K → M: Loss of ATP-binding. Significant reduction in interaction with TERT and in telomerase activity. Loss of interaction with MTREX. 1 Publication2 Publications1
Mutagenesisi365E → Q: Decreases 60S ribosomes synthesis. Strongly decreases 60S ribosomal subunit synthesis, enhances interaction with WDR74 and increases association of WDR74 and MTREX as well as induces partial migration of WDR74 to the nucleoplasm; when associated with Q-682. 2 Publications1
Mutagenesisi628K → M: Loss of ATP-binding. No effect on interaction with TERT, MTREX and RPL5 and on telomerase activity. Significant reduction in the level of the 60S ribosomal subunit. 1 Publication4 Publications1
Mutagenesisi682E → Q: Decreases 60S ribosomes synthesis. Strongly decreases 60S ribosomal subunit synthesis, enhances interaction with WDR74 and increases association of WDR74 and MTREX as well as induces partial migration of WDR74 to the nucleoplasm; when associated with Q-365. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		4931

Open Targets

More...OpenTargetsi		ENSG00000143748

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31857

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15381, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NVL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000845881 – 856Nuclear valosin-containing protein-likeAdd BLAST856

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei70N6-acetyllysineBy similarity1
Modified residuei134PhosphoserineCombined sources1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei156N6-acetyllysineBy similarity1
Modified residuei191PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei211PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15381

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15381

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15381

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15381

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15381

PeptideAtlas

More...PeptideAtlasi		O15381

PRoteomics IDEntifications database

More...PRIDEi		O15381

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4595
4771
48620 [O15381-1]
48621 [O15381-2]
48622 [O15381-3]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		O15381

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O15381, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15381

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O15381

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15381

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143748, Expressed in sural nerve and 164 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15381, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15381, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143748, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCL/nucleolin (PubMed:21474449). Isoform 1 and isoform 2 interact with TERT and isoform 1 exhibits a higher binding affinity for TERT compared to isoform 2 (PubMed:22226966).

Isoform 1 interacts with MTREX in an ATP-dependent manner; the interaction is required to associate NVL with nuclear RNA exosome (PubMed:26166824, PubMed:31358741, PubMed:16782053).

Isoform 1 interacts with RPL5 in an ATP-dependent manner (PubMed:15469983).

Interacts with WDR74 (through WDR repeats); the interaction is independent of RNA or pre-60S ribosome particles (PubMed:28416111).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110985, 128 interactors

Protein interaction database and analysis system

More...IntActi		O15381, 62 interactors

Molecular INTeraction database

More...MINTi		O15381

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000281701

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15381, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1856
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15381

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O15381

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 220Interaction with RPL51 PublicationAdd BLAST220
Regioni84 – 175DisorderedSequence analysisAdd BLAST92
Regioni197 – 236DisorderedSequence analysisAdd BLAST40
Regioni267 – 474Interaction with WDR741 PublicationAdd BLAST208
Regioni496 – 523DisorderedSequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi49 – 52Nucleolar localization signal1 Publication4
Motifi85 – 88Nuclear localization signal1 Publication4
Motifi218 – 232Nuclear localization signal1 PublicationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 162Polar residuesSequence analysisAdd BLAST53
Compositional biasi199 – 221Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi496 – 512Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0733, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00570000079239

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000688_12_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15381

Identification of Orthologs from Complete Genome Data

More...OMAi		TCAIKRI

Database of Orthologous Groups

More...OrthoDBi		194195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15381

TreeFam database of animal gene trees

More...TreeFami		TF314681

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.2010, 1 hit
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR038100, NLV2_N_sf
IPR031996, NVL2_nucleolin-bd
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00004, AAA, 2 hits
PF17862, AAA_lid_3, 2 hits
PF16725, Nucleolin_bd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00674, AAA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15381-1) [UniParc]FASTAAdd to basket
Also known as: NVLp.2

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR 
        60         70         80         90        100
KRNAFRIQVE KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY 
       110        120        130        140        150
SDDDSSMEDY PDPQSANHMN SSLLSLYRKG NPDSVSNTPE MEQRETTSST 
       160        170        180        190        200
PRISSKTGSI PLKTPAKDSE GGWFIDKTPS VKKDSFFLDL SCEKSNPKKP 
       210        220        230        240        250
ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG EIEAVLQKKA 
       260        270        280        290        300
KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG 
       310        320        330        340        350
VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF 
       360        370        380        390        400
EQAVSNAPCI IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA 
       410        420        430        440        450
TARVLVIGAT NRPDSLDPAL RRAGRFDREI CLGIPDEASR ERILQTLCRK 
       460        470        480        490        500
LRLPQAFDFC HLAHLTPGFV GADLMALCRE AAMCAVNRVL MKLQEQQKKN 
       510        520        530        540        550
PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP LSEEQMQGLC 
       560        570        580        590        600
IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP 
       610        620        630        640        650
VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE 
       660        670        680        690        700
LLNMYVGESE RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR 
       710        720        730        740        750
VVNQLLTEMD GLEARQQVFI MAATNRPDII DPAILRPGRL DKTLFVGLPP 
       760        770        780        790        800
PADRLAILKT ITKNGTKPPL DADVNLEAIA GDLRCDCYTG ADLSALVREA 
       810        820        830        840        850
SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS KKDQIMYERL 

QESLSR
Length:856
Mass (Da):95,051
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A8B373FCAFB99B7
GO
Isoform 2 (identifier: O15381-2) [UniParc]FASTAAdd to basket
Also known as: NVLp.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:750
Mass (Da):82,746
Checksum:i56AF88DF9129D618
GO
Isoform 3 (identifier: O15381-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     115-205: Missing.

Show »
Length:659
Mass (Da):72,733
Checksum:i0728D502901260F5
GO
Isoform 4 (identifier: O15381-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     320-320: G → GAECSGMITAHCSFDFSGSNDPPASASQ

Show »
Length:667
Mass (Da):73,280
Checksum:iE46F119F9E1C345A
GO
Isoform 5 (identifier: O15381-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-205: Missing.

Show »
Length:765
Mass (Da):85,038
Checksum:iA34DEE65ED8A82D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWK7E7EWK7_HUMAN
Nuclear valosin-containing protein-...
NVL
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGD8E9PGD8_HUMAN
Nuclear valosin-containing protein-...
NVL
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PH71E9PH71_HUMAN
Nuclear valosin-containing protein-...
NVL
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6P7C9J6P7_HUMAN
Nuclear valosin-containing protein-...
NVL
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP83C9JP83_HUMAN
Nuclear valosin-containing protein-...
NVL
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF01F8WF01_HUMAN
Nuclear valosin-containing protein-...
NVL
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV72A0A087WV72_HUMAN
Nuclear valosin-containing protein-...
NVL
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048109295V → I. Corresponds to variant dbSNP:rs12084919Ensembl.1
Natural variantiVAR_015890359C → G1 Publication1
Natural variantiVAR_048110404V → I. Corresponds to variant dbSNP:rs34631151Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0453341 – 216Missing in isoform 4. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_0077711 – 106Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST106
Alternative sequenceiVSP_007772115 – 205Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_045335320G → GAECSGMITAHCSFDFSGSN DPPASASQ in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U68140 mRNA Translation: AAB70457.1
U78772 mRNA Translation: AAB70460.1
AK297396 mRNA Translation: BAG59836.1
AK298244 mRNA Translation: BAG60510.1
AC092809 Genomic DNA No translation available.
BC012105 mRNA Translation: AAH12105.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1541.1 [O15381-1]
CCDS1542.1 [O15381-2]
CCDS58062.1 [O15381-4]
CCDS58063.1 [O15381-5]

NCBI Reference Sequences

More...RefSeqi		NP_001230075.1, NM_001243146.1 [O15381-4]
NP_001230076.1, NM_001243147.1 [O15381-5]
NP_002524.2, NM_002533.3 [O15381-1]
NP_996671.1, NM_206840.2 [O15381-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000281701; ENSP00000281701; ENSG00000143748
ENST00000340871; ENSP00000341362; ENSG00000143748 [O15381-4]
ENST00000391875; ENSP00000375747; ENSG00000143748 [O15381-2]
ENST00000469075; ENSP00000417826; ENSG00000143748 [O15381-5]
ENST00000469968; ENSP00000419420; ENSG00000143748 [O15381-3]
ENST00000482491; ENSP00000417213; ENSG00000143748 [O15381-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4931

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000281701.11; ENSP00000281701.6; NM_002533.4; NP_002524.2

UCSC genome browser

More...UCSCi		uc001hok.4, human [O15381-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68140 mRNA Translation: AAB70457.1
U78772 mRNA Translation: AAB70460.1
AK297396 mRNA Translation: BAG59836.1
AK298244 mRNA Translation: BAG60510.1
AC092809 Genomic DNA No translation available.
BC012105 mRNA Translation: AAH12105.1
CCDSiCCDS1541.1 [O15381-1]
CCDS1542.1 [O15381-2]
CCDS58062.1 [O15381-4]
CCDS58063.1 [O15381-5]
RefSeqiNP_001230075.1, NM_001243146.1 [O15381-4]
NP_001230076.1, NM_001243147.1 [O15381-5]
NP_002524.2, NM_002533.3 [O15381-1]
NP_996671.1, NM_206840.2 [O15381-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X8AX-ray2.60A574-845[»]
6RO1X-ray3.07B167-216[»]
SMRiO15381
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110985, 128 interactors
IntActiO15381, 62 interactors
MINTiO15381
STRINGi9606.ENSP00000281701

PTM databases

GlyGeniO15381, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO15381
MetOSiteiO15381
PhosphoSitePlusiO15381

Genetic variation databases

BioMutaiNVL

2D gel databases

SWISS-2DPAGEiO15381

Proteomic databases

EPDiO15381
jPOSTiO15381
MassIVEiO15381
MaxQBiO15381
PaxDbiO15381
PeptideAtlasiO15381
PRIDEiO15381
ProteomicsDBi4595
4771
48620 [O15381-1]
48621 [O15381-2]
48622 [O15381-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34637, 216 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		4931

Genome annotation databases

EnsembliENST00000281701; ENSP00000281701; ENSG00000143748
ENST00000340871; ENSP00000341362; ENSG00000143748 [O15381-4]
ENST00000391875; ENSP00000375747; ENSG00000143748 [O15381-2]
ENST00000469075; ENSP00000417826; ENSG00000143748 [O15381-5]
ENST00000469968; ENSP00000419420; ENSG00000143748 [O15381-3]
ENST00000482491; ENSP00000417213; ENSG00000143748 [O15381-4]
GeneIDi4931
KEGGihsa:4931
MANE-SelectiENST00000281701.11; ENSP00000281701.6; NM_002533.4; NP_002524.2
UCSCiuc001hok.4, human [O15381-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4931
DisGeNETi4931

GeneCards: human genes, protein and diseases

More...GeneCardsi		NVL
HGNCiHGNC:8070, NVL
HPAiENSG00000143748, Low tissue specificity
MIMi602426, gene
neXtProtiNX_O15381
OpenTargetsiENSG00000143748
PharmGKBiPA31857
VEuPathDBiHostDB:ENSG00000143748

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0733, Eukaryota
GeneTreeiENSGT00570000079239
HOGENOMiCLU_000688_12_3_1
InParanoidiO15381
OMAiTCAIKRI
OrthoDBi194195at2759
PhylomeDBiO15381
TreeFamiTF314681

Enzyme and pathway databases

PathwayCommonsiO15381
SignaLinkiO15381

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4931, 761 hits in 1051 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NVL, human
EvolutionaryTraceiO15381

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NVL_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4931
PharosiO15381, Tbio

Protein Ontology

More...PROi		PR:O15381
RNActiO15381, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143748, Expressed in sural nerve and 164 other tissues
ExpressionAtlasiO15381, baseline and differential
GenevisibleiO15381, HS

Family and domain databases

Gene3Di1.10.10.2010, 1 hit
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR038100, NLV2_N_sf
IPR031996, NVL2_nucleolin-bd
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00004, AAA, 2 hits
PF17862, AAA_lid_3, 2 hits
PF16725, Nucleolin_bd, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00674, AAA, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNVL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15381
Secondary accession number(s): B4DMC4, B4DP98, Q96EM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 1, 1998
Last modified: February 23, 2022
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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