UniProtKB - O15379 (HDAC3_HUMAN)
Histone deacetylase 3
HDAC3
Functioni
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:23911289, PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28497810, PubMed:28167758).
Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289).
Histone deacetylases act via the formation of large multiprotein complexes (PubMed:23911289).
Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289).
Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity).
Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity).
During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1 (By similarity).
The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).
Also functions as deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14 and RARA (PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28167758).
Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (PubMed:28167758).
In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).
In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:34608293).
Catalyzes decrotonylation of MAPRE1/EB1 (PubMed:34608293).
By similarity9 PublicationsCatalytic activityi
- EC:3.5.1.981 Publication1 Publication
- This reaction proceeds in the forward2 Publications direction.
- H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 135 | By similarity | 1 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- cyclin binding Source: UniProtKB
- DNA-binding transcription factor binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- histone deacetylase activity Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- histone decrotonylase activity Source: UniProtKB
- NF-kappaB binding Source: UniProtKB
- protein de-2-hydroxyisobutyrylase activity Source: UniProtKB
- protein deacetylase activity Source: UniProtKB
- protein decrotonylase activity Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
- transcription corepressor binding Source: UniProtKB
GO - Biological processi
- cellular response to fluid shear stress Source: UniProtKB
- chromatin organization Source: UniProtKB
- circadian regulation of gene expression Source: UniProtKB
- negative regulation of apoptotic process Source: ProtInc
- negative regulation of JNK cascade Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of protein import into nucleus Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of protein ubiquitination Source: UniProtKB
- positive regulation of TOR signaling Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein deacetylation Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of protein stability Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- spindle assembly Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, Hydrolase, Repressor |
Biological process | Biological rhythms, Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
BRENDAi | 3.5.1.98, 2681 |
PathwayCommonsi | O15379 |
Reactomei | R-HSA-1368071, NR1D1 (REV-ERBA) represses gene expression R-HSA-193670, p75NTR negatively regulates cell cycle via SC1 R-HSA-1989781, PPARA activates gene expression R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-3214815, HDACs deacetylate histones R-HSA-350054, Notch-HLH transcription pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9022537, Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9609690, HCMV Early Events R-HSA-9701898, STAT3 nuclear events downstream of ALK signaling R-HSA-9707564, Cytoprotection by HMOX1 R-HSA-9707616, Heme signaling |
SABIO-RKi | O15379 |
SignaLinki | O15379 |
SIGNORi | O15379 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HDAC3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4854, HDAC3 |
MIMi | 605166, gene |
neXtProti | NX_O15379 |
VEuPathDBi | HostDB:ENSG00000171720 |
Subcellular locationi
Cytoskeleton
- mitotic spindle Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- histone deacetylase complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB
- transcription repressor complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 130 – 132 | AGG → VRPP: Impaired protein deacetylase activity without affecting the protein decrotonylase activity. 2 Publications | 3 | |
Mutagenesisi | 298 | Y → F: Strongly decreased protein deacetylase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8841 |
OpenTargetsi | ENSG00000171720 |
PharmGKBi | PA29228 |
Miscellaneous databases
Pharosi | O15379, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1829 |
DrugBanki | DB05015, Belinostat DB11830, Mocetinostat DB06603, Panobinostat DB05223, Pracinostat DB02546, Vorinostat |
DrugCentrali | O15379 |
GuidetoPHARMACOLOGYi | 2617 |
Genetic variation databases
BioMutai | HDAC3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114696 | 1 – 428 | Histone deacetylase 3Add BLAST | 428 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 424 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O15379 |
jPOSTi | O15379 |
MassIVEi | O15379 |
MaxQBi | O15379 |
PaxDbi | O15379 |
PeptideAtlasi | O15379 |
PRIDEi | O15379 |
ProteomicsDBi | 48618 [O15379-1] 48619 [O15379-2] |
PTM databases
iPTMneti | O15379 |
PhosphoSitePlusi | O15379 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000171720, Expressed in right hemisphere of cerebellum and 238 other tissues |
ExpressionAtlasi | O15379, baseline and differential |
Genevisiblei | O15379, HS |
Organism-specific databases
HPAi | ENSG00000171720, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with HDAC7 and HDAC9 (PubMed:11466315, PubMed:10655483).
Interacts with DAXX, KDM4A, HDAC10 and DACH1 (PubMed:10669754, PubMed:11861901, PubMed:14525983, PubMed:15927959).
Found in a complex with NCOR1 and NCOR2 (PubMed:10860984).
Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:11931768).
Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY (PubMed:10898795, PubMed:11006275, PubMed:15297880).
Interacts with BTBD14B (By similarity).
Interacts with GLIS2 (By similarity).
Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation (By similarity).
Component of the Notch corepressor complex (PubMed:19409814).
Interacts with CBFA2T3 and NKAP (PubMed:11533236, PubMed:19409814).
Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1 (PubMed:14633989).
Interacts with ZMYND15 (By similarity).
Interacts with SMRT/NCOR2 and BCL6 on DNA enhancer elements (PubMed:23911289).
Interacts with INSM1 (PubMed:16569215, PubMed:18417529).
Interacts with XBP1 isoform 1; the interaction occurs in endothelial cell (EC) under disturbed flow (PubMed:25190803).
Interacts (via C-terminus) with CCAR2 (via N-terminus) (PubMed:21030595).
Interacts with and deacetylates MEF2D (PubMed:21030595).
Interacts with BEND3 (PubMed:21914818).
Interacts with NKAPL (By similarity).
Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:18279852).
Interacts weakly with CRY1; this interaction is enhanced in the presence of FBXL3 (By similarity).
Interacts with FBXL3 and ARNTL/BMAL1 (By similarity).
Interacts with NCOR1 (By similarity).
Interacts with RARA (PubMed:28167758).
Interacts with SETD5 (By similarity).
By similarity22 Publications(Microbial infection) Interacts with human cytomegalovirus (HHV-5) immediate early protein IE1; this interaction decreases histone acetylation and allows transcriptional activation by the virus.
1 PublicationBinary interactionsi
O15379
GO - Molecular functioni
- cyclin binding Source: UniProtKB
- DNA-binding transcription factor binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- NF-kappaB binding Source: UniProtKB
- transcription corepressor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114368, 282 interactors |
CORUMi | O15379 |
DIPi | DIP-24253N |
IntActi | O15379, 110 interactors |
MINTi | O15379 |
STRINGi | 9606.ENSP00000302967 |
Chemistry databases
BindingDBi | O15379 |
Miscellaneous databases
RNActi | O15379, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O15379 |
SMRi | O15379 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 3 – 316 | Histone deacetylaseAdd BLAST | 314 | |
Regioni | 388 – 428 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 388 – 405 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 411 – 428 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1342, Eukaryota |
GeneTreei | ENSGT00940000160487 |
HOGENOMi | CLU_007727_7_6_1 |
InParanoidi | O15379 |
OMAi | GWLRAFH |
OrthoDBi | 732770at2759 |
PhylomeDBi | O15379 |
TreeFami | TF352182 |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
IDEALi | IID00428 |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP
60 70 80 90 100
YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL
110 120 130 140 150
FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI
160 170 180 190 200
VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
210 220 230 240 250
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDFYQPT
260 270 280 290 300
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV
310 320 330 340 350
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN
360 370 380 390 400
SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP
410 420
EENYSRPEAP NEFYDGDHDN DKESDVEI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ESJ6 | E7ESJ6_HUMAN | Histone deacetylase | HDAC3 | 218 | Annotation score: | ||
E7EW19 | E7EW19_HUMAN | Histone deacetylase 3 | HDAC3 | 53 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 359 | R → L in AAC52038 (PubMed:9464271).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033988 | 411 | N → S. Corresponds to variant dbSNP:rs34901743EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002079 | 1 – 15 | MAKTV…PDVGN → MIVFKPYQASQHDMCR in isoform 2. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66914 mRNA Translation: AAC52038.1 U75697 mRNA Translation: AAB88241.1 U75696 mRNA Translation: AAB88240.1 AF005482 mRNA Translation: AAB87752.1 AF039703 mRNA Translation: AAC98927.1 AF059650 Genomic DNA Translation: AAC26509.1 CH471062 Genomic DNA Translation: EAW61915.1 CH471062 Genomic DNA Translation: EAW61916.1 BC000614 mRNA Translation: AAH00614.1 AF053138, AF053137 Genomic DNA Translation: AAC08351.1 AF053139 Genomic DNA Translation: AAC08352.1 |
CCDSi | CCDS4264.1 [O15379-1] |
PIRi | JC5834 |
RefSeqi | NP_003874.2, NM_003883.3 [O15379-1] |
Genome annotation databases
Ensembli | ENST00000305264.8; ENSP00000302967.3; ENSG00000171720.10 |
GeneIDi | 8841 |
KEGGi | hsa:8841 |
MANE-Selecti | ENST00000305264.8; ENSP00000302967.3; NM_003883.4; NP_003874.2 |
UCSCi | uc003llf.3, human [O15379-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66914 mRNA Translation: AAC52038.1 U75697 mRNA Translation: AAB88241.1 U75696 mRNA Translation: AAB88240.1 AF005482 mRNA Translation: AAB87752.1 AF039703 mRNA Translation: AAC98927.1 AF059650 Genomic DNA Translation: AAC26509.1 CH471062 Genomic DNA Translation: EAW61915.1 CH471062 Genomic DNA Translation: EAW61916.1 BC000614 mRNA Translation: AAH00614.1 AF053138, AF053137 Genomic DNA Translation: AAC08351.1 AF053139 Genomic DNA Translation: AAC08352.1 |
CCDSi | CCDS4264.1 [O15379-1] |
PIRi | JC5834 |
RefSeqi | NP_003874.2, NM_003883.3 [O15379-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4A69 | X-ray | 2.06 | A/B | 1-376 | [»] | |
AlphaFoldDBi | O15379 | |||||
SMRi | O15379 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114368, 282 interactors |
CORUMi | O15379 |
DIPi | DIP-24253N |
IntActi | O15379, 110 interactors |
MINTi | O15379 |
STRINGi | 9606.ENSP00000302967 |
Chemistry databases
BindingDBi | O15379 |
ChEMBLi | CHEMBL1829 |
DrugBanki | DB05015, Belinostat DB11830, Mocetinostat DB06603, Panobinostat DB05223, Pracinostat DB02546, Vorinostat |
DrugCentrali | O15379 |
GuidetoPHARMACOLOGYi | 2617 |
PTM databases
iPTMneti | O15379 |
PhosphoSitePlusi | O15379 |
Genetic variation databases
BioMutai | HDAC3 |
Proteomic databases
EPDi | O15379 |
jPOSTi | O15379 |
MassIVEi | O15379 |
MaxQBi | O15379 |
PaxDbi | O15379 |
PeptideAtlasi | O15379 |
PRIDEi | O15379 |
ProteomicsDBi | 48618 [O15379-1] 48619 [O15379-2] |
Protocols and materials databases
Antibodypediai | 3568, 958 antibodies from 48 providers |
DNASUi | 8841 |
Genome annotation databases
Ensembli | ENST00000305264.8; ENSP00000302967.3; ENSG00000171720.10 |
GeneIDi | 8841 |
KEGGi | hsa:8841 |
MANE-Selecti | ENST00000305264.8; ENSP00000302967.3; NM_003883.4; NP_003874.2 |
UCSCi | uc003llf.3, human [O15379-1] |
Organism-specific databases
CTDi | 8841 |
DisGeNETi | 8841 |
GeneCardsi | HDAC3 |
HGNCi | HGNC:4854, HDAC3 |
HPAi | ENSG00000171720, Low tissue specificity |
MIMi | 605166, gene |
neXtProti | NX_O15379 |
OpenTargetsi | ENSG00000171720 |
PharmGKBi | PA29228 |
VEuPathDBi | HostDB:ENSG00000171720 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1342, Eukaryota |
GeneTreei | ENSGT00940000160487 |
HOGENOMi | CLU_007727_7_6_1 |
InParanoidi | O15379 |
OMAi | GWLRAFH |
OrthoDBi | 732770at2759 |
PhylomeDBi | O15379 |
TreeFami | TF352182 |
Enzyme and pathway databases
BRENDAi | 3.5.1.98, 2681 |
PathwayCommonsi | O15379 |
Reactomei | R-HSA-1368071, NR1D1 (REV-ERBA) represses gene expression R-HSA-193670, p75NTR negatively regulates cell cycle via SC1 R-HSA-1989781, PPARA activates gene expression R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-3214815, HDACs deacetylate histones R-HSA-350054, Notch-HLH transcription pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9022537, Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9609690, HCMV Early Events R-HSA-9701898, STAT3 nuclear events downstream of ALK signaling R-HSA-9707564, Cytoprotection by HMOX1 R-HSA-9707616, Heme signaling |
SABIO-RKi | O15379 |
SignaLinki | O15379 |
SIGNORi | O15379 |
Miscellaneous databases
BioGRID-ORCSi | 8841, 713 hits in 1084 CRISPR screens |
ChiTaRSi | HDAC3, human |
GeneWikii | HDAC3 |
GenomeRNAii | 8841 |
Pharosi | O15379, Tclin |
PROi | PR:O15379 |
RNActi | O15379, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171720, Expressed in right hemisphere of cerebellum and 238 other tissues |
ExpressionAtlasi | O15379, baseline and differential |
Genevisiblei | O15379, HS |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
IDEALi | IID00428 |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HDAC3_HUMAN | |
Accessioni | O15379Primary (citable) accession number: O15379 Secondary accession number(s): D3DQE1 Q9UEV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 224 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families