UniProtKB - O15370 (SOX12_HUMAN)
Protein
Transcription factor SOX-12
Gene
SOX12
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (By similarity). Acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (By similarity). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (By similarity). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 40 – 108 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- cell fate commitment Source: InterPro
- positive regulation of regulatory T cell differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
- spinal cord development Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O15370 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-12Alternative name(s): Protein SOX-22 |
Gene namesi | Name:SOX12 Synonyms:SOX22 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177732.7 |
HGNCi | HGNC:11198, SOX12 |
MIMi | 601947, gene |
neXtProti | NX_O15370 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
Other locations
- protein-DNA complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6666 |
OpenTargetsi | ENSG00000177732 |
PharmGKBi | PA36035 |
Miscellaneous databases
Pharosi | O15370, Tbio |
Polymorphism and mutation databases
BioMutai | SOX12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048754 | 1 – 315 | Transcription factor SOX-12Add BLAST | 315 |
Proteomic databases
EPDi | O15370 |
MassIVEi | O15370 |
MaxQBi | O15370 |
PaxDbi | O15370 |
PeptideAtlasi | O15370 |
PRIDEi | O15370 |
ProteomicsDBi | 48613 |
PTM databases
iPTMneti | O15370 |
PhosphoSitePlusi | O15370 |
Expressioni
Tissue specificityi
Expressed most abundantly in the CNS (PubMed:9215677). Expressed in the heart, pancreas, thymus, testis and ovary (PubMed:9215677). Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes (PubMed:9215677).1 Publication
Developmental stagei
Expressed in the fetal brain, lung, liver, and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000177732, Expressed in cortical plate and 207 other tissues |
Genevisiblei | O15370, HS |
Organism-specific databases
HPAi | ENSG00000177732, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112549, 3 interactors |
IntActi | O15370, 3 interactors |
STRINGi | 9606.ENSP00000347646 |
Miscellaneous databases
RNActi | O15370, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 283 – 315 | Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2By similarityAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 15 – 22 | Poly-Pro | 8 | |
Compositional biasi | 211 – 217 | Poly-Ala | 7 | |
Compositional biasi | 223 – 250 | Asp/Glu-rich (acidic)Add BLAST | 28 | |
Compositional biasi | 223 – 233 | Poly-GluAdd BLAST | 11 | |
Compositional biasi | 234 – 237 | Poly-Ala | 4 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000163140 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | O15370 |
OMAi | GEPAWCK |
OrthoDBi | 1186233at2759 |
PhylomeDBi | O15370 |
TreeFami | TF351735 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031267, SOX-12 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF221, PTHR10270:SF221, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O15370-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGS GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
AGGPLGGGAA APEDDDEDDD EELLEVRLVE TPGRELWRMV PAGRAARGQA
210 220 230 240 250
ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG EEETVASGEE
260 270 280 290 300
SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA
310
GDWRPSSIAD LVFTY
Sequence cautioni
The sequence AAB69627 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35612 mRNA Translation: AAB69627.1 Frameshift. AL034548 Genomic DNA No translation available. BC067361 mRNA Translation: AAH67361.1 |
CCDSi | CCDS12995.1 |
RefSeqi | NP_008874.2, NM_006943.3 |
Genome annotation databases
Ensembli | ENST00000342665; ENSP00000347646; ENSG00000177732 |
GeneIDi | 6666 |
KEGGi | hsa:6666 |
UCSCi | uc002wdh.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35612 mRNA Translation: AAB69627.1 Frameshift. AL034548 Genomic DNA No translation available. BC067361 mRNA Translation: AAH67361.1 |
CCDSi | CCDS12995.1 |
RefSeqi | NP_008874.2, NM_006943.3 |
3D structure databases
SMRi | O15370 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112549, 3 interactors |
IntActi | O15370, 3 interactors |
STRINGi | 9606.ENSP00000347646 |
PTM databases
iPTMneti | O15370 |
PhosphoSitePlusi | O15370 |
Polymorphism and mutation databases
BioMutai | SOX12 |
Proteomic databases
EPDi | O15370 |
MassIVEi | O15370 |
MaxQBi | O15370 |
PaxDbi | O15370 |
PeptideAtlasi | O15370 |
PRIDEi | O15370 |
ProteomicsDBi | 48613 |
Protocols and materials databases
Antibodypediai | 6130, 218 antibodies |
Genome annotation databases
Ensembli | ENST00000342665; ENSP00000347646; ENSG00000177732 |
GeneIDi | 6666 |
KEGGi | hsa:6666 |
UCSCi | uc002wdh.5, human |
Organism-specific databases
CTDi | 6666 |
DisGeNETi | 6666 |
EuPathDBi | HostDB:ENSG00000177732.7 |
GeneCardsi | SOX12 |
HGNCi | HGNC:11198, SOX12 |
HPAi | ENSG00000177732, Low tissue specificity |
MIMi | 601947, gene |
neXtProti | NX_O15370 |
OpenTargetsi | ENSG00000177732 |
PharmGKBi | PA36035 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000163140 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | O15370 |
OMAi | GEPAWCK |
OrthoDBi | 1186233at2759 |
PhylomeDBi | O15370 |
TreeFami | TF351735 |
Enzyme and pathway databases
PathwayCommonsi | O15370 |
Miscellaneous databases
BioGRID-ORCSi | 6666, 19 hits in 872 CRISPR screens |
ChiTaRSi | SOX12, human |
GeneWikii | SOX12 |
GenomeRNAii | 6666 |
Pharosi | O15370, Tbio |
PROi | PR:O15370 |
RNActi | O15370, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177732, Expressed in cortical plate and 207 other tissues |
Genevisiblei | O15370, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031267, SOX-12 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF221, PTHR10270:SF221, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX12_HUMAN | |
Accessioni | O15370Primary (citable) accession number: O15370 Secondary accession number(s): Q5D038, Q9NUD4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | October 3, 2006 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM