SOX12

Functionⁱ

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	40 – 108	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 9215677
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
transcription coactivator activity Source: UniProtKB
transcription regulatory region sequence-specific DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell fate commitment
Source: UniProtKB
Inferred from expression patternⁱ
- 9215677
positive regulation of transcription by RNA polymerase II Source: UniProtKB
protein-DNA complex assembly Source: Ensembl
regulation of transcription by RNA polymerase II
Source: UniProtKB
Non-traceable author statementⁱ
- 9215677
spinal cord development Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor SOX-12 Alternative name(s): Protein SOX-22
Gene namesⁱ	Name:SOX12 Synonyms:SOX22
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177732.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11198 SOX12
MIMⁱ	601947 gene
neXtProtⁱ	NX_O15370

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6666
Open Targets More...OpenTargetsⁱ	ENSG00000177732
PharmGKBⁱ	PA36035

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048754	1 – 315	Transcription factor SOX-12Add BLAST		315

Proteomic databases

EPDⁱ	O15370
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15370
PaxDbⁱ	O15370
PeptideAtlas More...PeptideAtlasⁱ	O15370
PRIDEⁱ	O15370
ProteomicsDBⁱ	48613

PTM databases

iPTMnetⁱ	O15370
PhosphoSitePlusⁱ	O15370

Expressionⁱ

Tissue specificityⁱ

Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000177732 Expressed in 196 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_SOX12
Genevisibleⁱ	O15370 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055052 HPA061627

HPAⁱ

HPA055052
HPA061627

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112549, 3 interactors
IntActⁱ	O15370, 3 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15370
SMRⁱ	O15370
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	15 – 22	Poly-Pro	8
Compositional biasⁱ	211 – 217	Poly-Ala	7
Compositional biasⁱ	223 – 250	Asp/Glu-rich (acidic)Add BLAST	28
Compositional biasⁱ	223 – 233	Poly-GluAdd BLAST	11
Compositional biasⁱ	234 – 237	Poly-Ala	4

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG4111TGC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231874
HOVERGENⁱ	HBG094895
InParanoidⁱ	O15370
KEGG Orthology (KO) More...KOⁱ	K09268
OMAⁱ	GDWLMSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	O15370
TreeFamⁱ	TF351735

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR017386 SOX-11/4 IPR031267 SOX-12
PANTHERⁱ	PTHR10270:SF221 PTHR10270:SF221, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
PIRSFⁱ	PIRSF038098 SOX-12/11/4a, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O15370-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW 
        60         70         80         90        100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH 
       110        120        130        140        150
MADYPDYKYR PRKKSKGAPA KARPRPPGGS GGGSRLKPGP QLPGRGGRRA 
       160        170        180        190        200
AGGPLGGGAA APEDDDEDDD EELLEVRLVE TPGRELWRMV PAGRAARGQA 
       210        220        230        240        250
ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG EEETVASGEE 
       260        270        280        290        300
SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA 
       310 
GDWRPSSIAD LVFTY

Length:315

Mass (Da):34,122

Last modified:October 3, 2006 - v2

Checksum:ⁱA5BF539AC505942D

GO

Sequence cautionⁱ

The sequence AAB69627 differs from that shown. Reason: Frameshift at positions 135 and 201.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35612 mRNA Translation: AAB69627.1 Frameshift. AL034548 Genomic DNA No translation available. BC067361 mRNA Translation: AAH67361.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12995.1
NCBI Reference Sequences More...RefSeqⁱ	NP_008874.2, NM_006943.3
UniGeneⁱ	Hs.43627 Hs.712815 Hs.745045 Hs.745058

Genome annotation databases

Ensemblⁱ	ENST00000342665; ENSP00000347646; ENSG00000177732
GeneIDⁱ	6666
KEGGⁱ	hsa:6666
UCSC genome browser More...UCSCⁱ	uc002wdh.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15370	Transcription factor SOX		PANTR		315	UniRef100_O15370

Protein	Similar proteins		Species	Score	Length	Source
O15370	Transcription factor SOX-12		MOUSE		314	UniRef90_Q04890
Transcription factor SOX		CANLF		321
Transcription factor SOX		PANTR		316
Transcription factor SOX		Enhydra lutris kenyoni		316
Transcription factor SOX		PROCO		314
+52

Protein	Similar proteins		Species	Score	Length	Source
O15370	Transcription factor SOX-12		MOUSE		314	UniRef50_Q04890
Transcription factor SOX		CANLF		321
Transcription factor SOX		PANTR		316
Transcription factor SOX		Enhydra lutris kenyoni		316
Transcription factor SOX		PONAB		314
+73

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35612 mRNA Translation: AAB69627.1 Frameshift. AL034548 Genomic DNA No translation available. BC067361 mRNA Translation: AAH67361.1
CCDSⁱ	CCDS12995.1
RefSeqⁱ	NP_008874.2, NM_006943.3
UniGeneⁱ	Hs.43627 Hs.712815 Hs.745045 Hs.745058

3D structure databases

ProteinModelPortalⁱ	O15370
SMRⁱ	O15370
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112549, 3 interactors
IntActⁱ	O15370, 3 interactors

PTM databases

iPTMnetⁱ	O15370
PhosphoSitePlusⁱ	O15370

Proteomic databases

EPDⁱ	O15370
MaxQBⁱ	O15370
PaxDbⁱ	O15370
PeptideAtlasⁱ	O15370
PRIDEⁱ	O15370
ProteomicsDBⁱ	48613

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000342665; ENSP00000347646; ENSG00000177732
GeneIDⁱ	6666
KEGGⁱ	hsa:6666
UCSCⁱ	uc002wdh.5 human

Organism-specific databases

CTDⁱ	6666
DisGeNETⁱ	6666
EuPathDBⁱ	HostDB:ENSG00000177732.7
GeneCardsⁱ	SOX12
HGNCⁱ	HGNC:11198 SOX12
HPAⁱ	HPA055052 HPA061627
MIMⁱ	601947 gene
neXtProtⁱ	NX_O15370
OpenTargetsⁱ	ENSG00000177732
PharmGKBⁱ	PA36035
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG4111TGC LUCA
GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231874
HOVERGENⁱ	HBG094895
InParanoidⁱ	O15370
KOⁱ	K09268
OMAⁱ	GDWLMSS
OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	O15370
TreeFamⁱ	TF351735

Miscellaneous databases

ChiTaRSⁱ	SOX12 human
GeneWikiⁱ	SOX12
GenomeRNAiⁱ	6666
Protein Ontology More...PROⁱ	PR:O15370
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177732 Expressed in 196 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_SOX12
Genevisibleⁱ	O15370 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR017386 SOX-11/4 IPR031267 SOX-12
PANTHERⁱ	PTHR10270:SF221 PTHR10270:SF221, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
PIRSFⁱ	PIRSF038098 SOX-12/11/4a, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX12_HUMAN
Accessionⁱ	O15370Primary (citable) accession number: O15370 Secondary accession number(s): Q5D038, Q9NUD4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	October 3, 2006
	Last modified:	September 12, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Help

UniRef

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Annotation systems

Supporting data

UniProtKB - O15370 (SOX12_HUMAN)

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Transcription factor SOX-12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ