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Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi60Manganese 2By similarity1
Metal bindingi61Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi441Manganese 2By similarity1
Metal bindingi496Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • peptidyl-threonine dephosphorylation Source: UniProtKB
  • protein dephosphorylation Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

SIGNORiO15355

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 1C
Protein phosphatase 2C isoform gamma
Short name:
PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene namesi
Name:PPM1G
Synonyms:PPM1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115241.10
HGNCiHGNC:9278 PPM1G
MIMi605119 gene
neXtProtiNX_O15355

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5496
OpenTargetsiENSG00000115241
PharmGKBiPA33606

Chemistry databases

ChEMBLiCHEMBL3351199

Polymorphism and mutation databases

BioMutaiPPM1G

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000577502 – 546Protein phosphatase 1GAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Modified residuei22Omega-N-methylarginineCombined sources1
Modified residuei122PhosphothreonineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei383N6-acetyllysineCombined sources1
Modified residuei527PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

EPDiO15355
PaxDbiO15355
PeptideAtlasiO15355
PRIDEiO15355
ProteomicsDBi48608

PTM databases

DEPODiO15355
iPTMnetiO15355
PhosphoSitePlusiO15355
SwissPalmiO15355

Expressioni

Tissue specificityi

Widely expressed. Most abundant in testis, skeletal muscle, and heart.

Gene expression databases

BgeeiENSG00000115241 Expressed in 222 organ(s), highest expression level in testis
CleanExiHS_PPM1G
ExpressionAtlasiO15355 baseline and differential
GenevisibleiO15355 HS

Organism-specific databases

HPAiHPA035530
HPA035531

Interactioni

Subunit structurei

Interacts with NOL3; may dephosphorylate NOL3.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi111491, 112 interactors
CORUMiO15355
DIPiDIP-29404N
IntActiO15355, 62 interactors
MINTiO15355
STRINGi9606.ENSP00000264714

Chemistry databases

BindingDBiO15355

Structurei

3D structure databases

ProteinModelPortaliO15355
SMRiO15355
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 505PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST480

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 322Glu-richPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0699 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00920000149079
HOGENOMiHOG000233896
HOVERGENiHBG053647
InParanoidiO15355
KOiK17499
OMAiGWRNSQE
OrthoDBiEOG091G0D0W
PhylomeDBiO15355
TreeFamiTF354280

Family and domain databases

CDDicd00143 PP2Cc, 2 hits
Gene3Di3.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 2 hits
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15355-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA
110 120 130 140 150
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP
210 220 230 240 250
SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR
360 370 380 390 400
CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI
410 420 430 440 450
GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ
460 470 480 490 500
EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC
510 520 530 540
IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD
Length:546
Mass (Da):59,272
Last modified:January 1, 1998 - v1
Checksum:i084C16F8252330D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13936 mRNA Translation: CAA74245.1
BC022061 mRNA Translation: AAH22061.1
BC000057 mRNA Translation: AAH00057.1
CCDSiCCDS1752.1
RefSeqiNP_817092.1, NM_177983.2
UniGeneiHs.643951

Genome annotation databases

EnsembliENST00000344034; ENSP00000342778; ENSG00000115241
GeneIDi5496
KEGGihsa:5496

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13936 mRNA Translation: CAA74245.1
BC022061 mRNA Translation: AAH22061.1
BC000057 mRNA Translation: AAH00057.1
CCDSiCCDS1752.1
RefSeqiNP_817092.1, NM_177983.2
UniGeneiHs.643951

3D structure databases

ProteinModelPortaliO15355
SMRiO15355
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111491, 112 interactors
CORUMiO15355
DIPiDIP-29404N
IntActiO15355, 62 interactors
MINTiO15355
STRINGi9606.ENSP00000264714

Chemistry databases

BindingDBiO15355
ChEMBLiCHEMBL3351199

PTM databases

DEPODiO15355
iPTMnetiO15355
PhosphoSitePlusiO15355
SwissPalmiO15355

Polymorphism and mutation databases

BioMutaiPPM1G

Proteomic databases

EPDiO15355
PaxDbiO15355
PeptideAtlasiO15355
PRIDEiO15355
ProteomicsDBi48608

Protocols and materials databases

DNASUi5496
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344034; ENSP00000342778; ENSG00000115241
GeneIDi5496
KEGGihsa:5496

Organism-specific databases

CTDi5496
DisGeNETi5496
EuPathDBiHostDB:ENSG00000115241.10
GeneCardsiPPM1G
HGNCiHGNC:9278 PPM1G
HPAiHPA035530
HPA035531
MIMi605119 gene
neXtProtiNX_O15355
OpenTargetsiENSG00000115241
PharmGKBiPA33606
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0699 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00920000149079
HOGENOMiHOG000233896
HOVERGENiHBG053647
InParanoidiO15355
KOiK17499
OMAiGWRNSQE
OrthoDBiEOG091G0D0W
PhylomeDBiO15355
TreeFamiTF354280

Enzyme and pathway databases

SIGNORiO15355

Miscellaneous databases

ChiTaRSiPPM1G human
GeneWikiiPPM1G
GenomeRNAii5496
PROiPR:O15355
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115241 Expressed in 222 organ(s), highest expression level in testis
CleanExiHS_PPM1G
ExpressionAtlasiO15355 baseline and differential
GenevisibleiO15355 HS

Family and domain databases

CDDicd00143 PP2Cc, 2 hits
Gene3Di3.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 2 hits
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPM1G_HUMAN
AccessioniPrimary (citable) accession number: O15355
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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