UniProtKB - O15354 (GPR37_HUMAN)
Protein
Prosaposin receptor GPR37
Gene
GPR37
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.3 Publications
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: ParkinsonsUK-UCL
- G protein-coupled receptor activity Source: ProtInc
- heat shock protein binding Source: ParkinsonsUK-UCL
- Hsp70 protein binding Source: ParkinsonsUK-UCL
- neuropeptide binding Source: UniProtKB
- neuropeptide receptor activity Source: UniProtKB
- peptide binding Source: ParkinsonsUK-UCL
- prosaposin receptor activity Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
- dopamine biosynthetic process Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- locomotion involved in locomotory behavior Source: Ensembl
- negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
- neuropeptide signaling pathway Source: UniProtKB
- positive regulation of dopamine metabolic process Source: Ensembl
- positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | O15354 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | O15354 |
Protein family/group databases
TCDBi | 9.A.14.13.20, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Prosaposin receptor GPR37Alternative name(s): Endothelin B receptor-like protein 1 Short name: ETBR-LP-1 G-protein coupled receptor 37 Parkin-associated endothelin receptor-like receptor Short name: PAELR |
Gene namesi | Name:GPR37 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4494, GPR37 |
MIMi | 602583, gene |
neXtProti | NX_O15354 |
VEuPathDBi | HostDB:ENSG00000170775.2 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: ParkinsonsUK-UCL
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: ParkinsonsUK-UCL
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: UniProtKB
- receptor complex Source: MGI
- ubiquitin ligase complex Source: ParkinsonsUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 265 | ExtracellularSequence analysisAdd BLAST | 239 | |
Transmembranei | 266 – 286 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 287 – 299 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 300 – 320 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 321 – 335 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 336 – 356 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 357 – 379 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 380 – 400 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 401 – 443 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 444 – 464 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 465 – 493 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 494 – 514 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 515 – 531 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 532 – 552 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 553 – 613 | CytoplasmicSequence analysisAdd BLAST | 61 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2861 |
OpenTargetsi | ENSG00000170775 |
PharmGKBi | PA28882 |
Miscellaneous databases
Pharosi | O15354, Tbio |
Chemistry databases
GuidetoPHARMACOLOGYi | 103 |
Genetic variation databases
BioMutai | GPR37 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012799 | 27 – 613 | Prosaposin receptor GPR37Add BLAST | 587 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 222 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 334 ↔ 419 | PROSITE-ProRule annotation |
Post-translational modificationi
Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
EPDi | O15354 |
jPOSTi | O15354 |
MassIVEi | O15354 |
PaxDbi | O15354 |
PeptideAtlasi | O15354 |
PRIDEi | O15354 |
ProteomicsDBi | 48607 |
PTM databases
GlyGeni | O15354, 3 sites |
iPTMneti | O15354 |
PhosphoSitePlusi | O15354 |
Expressioni
Tissue specificityi
Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).1 Publication
Gene expression databases
Bgeei | ENSG00000170775, Expressed in Brodmann (1909) area 46 and 171 other tissues |
Genevisiblei | O15354, HS |
Organism-specific databases
HPAi | ENSG00000170775, Tissue enriched (brain) |
Interactioni
Subunit structurei
Forms a complex with PRKN, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN, thus facilitating PRKN-mediated GPR37 ubiquitination.
Interacts with PACRG.
3 PublicationsBinary interactionsi
Hide detailsO15354
GO - Molecular functioni
- heat shock protein binding Source: ParkinsonsUK-UCL
- Hsp70 protein binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 109119, 77 interactors |
DIPi | DIP-60954N |
IntActi | O15354, 71 interactors |
MINTi | O15354 |
STRINGi | 9606.ENSP00000306449 |
Miscellaneous databases
RNActi | O15354, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 563 – 568 | Poly-Cys | 6 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222396 |
HOGENOMi | CLU_032138_1_0_1 |
InParanoidi | O15354 |
OMAi | SHHKPPP |
OrthoDBi | 947117at2759 |
PhylomeDBi | O15354 |
TreeFami | TF331292 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003909, GPR37_orph |
PANTHERi | PTHR46216, PTHR46216, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01421, GPR37ORPHANR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O15354-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ
60 70 80 90 100
RRGRDAWGPG NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR
110 120 130 140 150
GAEASAAGPP GPPTRPPGPW RWKGARGQEP SETLGRGNPT ALQLFLQISE
160 170 180 190 200
EEEKGPRGAG ISGRSQEQSV KTVPGASDLF YWPRRAGKLQ GSHHKPLSKT
210 220 230 240 250
ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS TNRRVRLKNP
260 270 280 290 300
FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL
310 320 330 340 350
ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF
360 370 380 390 400
TLCALCIDRF RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL
410 420 430 440 450
RQLSKEDLGF SGRAPAERCI IKISPDLPDT IYVLALTYDS ARLWWYFGCY
460 470 480 490 500
FCLPTLFTIT CSLVTARKIR KAEKACTRGN KRQIQLESQM NCTVVALTIL
510 520 530 540 550
YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF
560 570 580 590 600
CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR
610
REMSTFASVG THC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | G → D in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 106 | A → T in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 118 | G → V in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 160 | G → V in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 182 | W → C in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 231 | E → D in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 284 | C → S in AAB70008 (PubMed:9526070).Curated | 1 | |
Sequence conflicti | 304 | A → V in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 329 | L → V in AAC51281 (PubMed:9144577).Curated | 1 | |
Sequence conflicti | 503 – 504 | FC → LG in AAC51281 (PubMed:9144577).Curated | 2 | |
Sequence conflicti | 598 | T → A in AAC51281 (PubMed:9144577).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y12476, Y12477 Genomic DNA Translation: CAA73080.1 AF017262 mRNA Translation: AAB70008.1 U87460 mRNA Translation: AAC51281.1 AF502281 mRNA Translation: AAM18625.2 AC004925 Genomic DNA Translation: AAD08853.1 CH236947 Genomic DNA Translation: EAL24325.1 CH471070 Genomic DNA Translation: EAW83613.1 BC040007 mRNA Translation: AAH40007.1 |
CCDSi | CCDS5792.1 |
PIRi | JC5501 |
RefSeqi | NP_005293.1, NM_005302.3 |
Genome annotation databases
Ensembli | ENST00000303921; ENSP00000306449; ENSG00000170775 |
GeneIDi | 2861 |
KEGGi | hsa:2861 |
UCSCi | uc003vli.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y12476, Y12477 Genomic DNA Translation: CAA73080.1 AF017262 mRNA Translation: AAB70008.1 U87460 mRNA Translation: AAC51281.1 AF502281 mRNA Translation: AAM18625.2 AC004925 Genomic DNA Translation: AAD08853.1 CH236947 Genomic DNA Translation: EAL24325.1 CH471070 Genomic DNA Translation: EAW83613.1 BC040007 mRNA Translation: AAH40007.1 |
CCDSi | CCDS5792.1 |
PIRi | JC5501 |
RefSeqi | NP_005293.1, NM_005302.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109119, 77 interactors |
DIPi | DIP-60954N |
IntActi | O15354, 71 interactors |
MINTi | O15354 |
STRINGi | 9606.ENSP00000306449 |
Chemistry databases
GuidetoPHARMACOLOGYi | 103 |
Protein family/group databases
TCDBi | 9.A.14.13.20, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | O15354, 3 sites |
iPTMneti | O15354 |
PhosphoSitePlusi | O15354 |
Genetic variation databases
BioMutai | GPR37 |
Proteomic databases
EPDi | O15354 |
jPOSTi | O15354 |
MassIVEi | O15354 |
PaxDbi | O15354 |
PeptideAtlasi | O15354 |
PRIDEi | O15354 |
ProteomicsDBi | 48607 |
Protocols and materials databases
Antibodypediai | 17671, 298 antibodies |
DNASUi | 2861 |
Genome annotation databases
Ensembli | ENST00000303921; ENSP00000306449; ENSG00000170775 |
GeneIDi | 2861 |
KEGGi | hsa:2861 |
UCSCi | uc003vli.5, human |
Organism-specific databases
CTDi | 2861 |
DisGeNETi | 2861 |
GeneCardsi | GPR37 |
HGNCi | HGNC:4494, GPR37 |
HPAi | ENSG00000170775, Tissue enriched (brain) |
MIMi | 602583, gene |
neXtProti | NX_O15354 |
OpenTargetsi | ENSG00000170775 |
PharmGKBi | PA28882 |
VEuPathDBi | HostDB:ENSG00000170775.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222396 |
HOGENOMi | CLU_032138_1_0_1 |
InParanoidi | O15354 |
OMAi | SHHKPPP |
OrthoDBi | 947117at2759 |
PhylomeDBi | O15354 |
TreeFami | TF331292 |
Enzyme and pathway databases
PathwayCommonsi | O15354 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | O15354 |
Miscellaneous databases
BioGRID-ORCSi | 2861, 6 hits in 987 CRISPR screens |
ChiTaRSi | GPR37, human |
GeneWikii | GPR37 |
GenomeRNAii | 2861 |
Pharosi | O15354, Tbio |
PROi | PR:O15354 |
RNActi | O15354, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170775, Expressed in Brodmann (1909) area 46 and 171 other tissues |
Genevisiblei | O15354, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003909, GPR37_orph |
PANTHERi | PTHR46216, PTHR46216, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01421, GPR37ORPHANR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR37_HUMAN | |
Accessioni | O15354Primary (citable) accession number: O15354 Secondary accession number(s): A4D0Y6 Q8TD39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families