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Protein

Prosaposin receptor GPR37

Gene

GPR37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.3 Publications

GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: ParkinsonsUK-UCL
  • G protein-coupled receptor activity Source: ProtInc
  • heat shock protein binding Source: ParkinsonsUK-UCL
  • Hsp70 protein binding Source: ParkinsonsUK-UCL
  • peptide binding Source: ParkinsonsUK-UCL
  • prosaposin receptor activity Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiO15354

Protein family/group databases

TCDBi9.A.14.13.20 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37
Alternative name(s):
Endothelin B receptor-like protein 1
Short name:
ETBR-LP-1
G-protein coupled receptor 37
Parkin-associated endothelin receptor-like receptor
Short name:
PAELR
Gene namesi
Name:GPR37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000170775.2
HGNCiHGNC:4494 GPR37
MIMi602583 gene
neXtProtiNX_O15354

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 265ExtracellularSequence analysisAdd BLAST239
Transmembranei266 – 286Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini287 – 299CytoplasmicSequence analysisAdd BLAST13
Transmembranei300 – 320Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini321 – 335ExtracellularSequence analysisAdd BLAST15
Transmembranei336 – 356Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini357 – 379CytoplasmicSequence analysisAdd BLAST23
Transmembranei380 – 400Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini401 – 443ExtracellularSequence analysisAdd BLAST43
Transmembranei444 – 464Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini465 – 493CytoplasmicSequence analysisAdd BLAST29
Transmembranei494 – 514Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini515 – 531ExtracellularSequence analysisAdd BLAST17
Transmembranei532 – 552Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini553 – 613CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2861
OpenTargetsiENSG00000170775
PharmGKBiPA28882

Chemistry databases

GuidetoPHARMACOLOGYi103

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001279927 – 613Prosaposin receptor GPR37Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi334 ↔ 419PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiO15354
PaxDbiO15354
PeptideAtlasiO15354
PRIDEiO15354
ProteomicsDBi48607

PTM databases

iPTMnetiO15354
PhosphoSitePlusiO15354

Expressioni

Tissue specificityi

Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).1 Publication

Gene expression databases

BgeeiENSG00000170775 Expressed in 149 organ(s), highest expression level in Brodmann (1909) area 46
CleanExiHS_GPR37
GenevisibleiO15354 HS

Organism-specific databases

HPAiHPA042903
HPA068009

Interactioni

Subunit structurei

Forms a complex with PRKN, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN, thus facilitating PRKN-mediated GPR37 ubiquitination. Interacts with PACRG.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC6A3Q019592EBI-15639515,EBI-6661445

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109119, 27 interactors
DIPiDIP-60954N
IntActiO15354, 1 interactor
STRINGi9606.ENSP00000306449

Structurei

3D structure databases

ProteinModelPortaliO15354
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi563 – 568Poly-Cys6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000252922
HOVERGENiHBG051808
InParanoidiO15354
KOiK04243
OMAiSDLYYWP
OrthoDBiEOG091G04SU
PhylomeDBiO15354
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003909 GPR37_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01421 GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15354-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ
60 70 80 90 100
RRGRDAWGPG NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR
110 120 130 140 150
GAEASAAGPP GPPTRPPGPW RWKGARGQEP SETLGRGNPT ALQLFLQISE
160 170 180 190 200
EEEKGPRGAG ISGRSQEQSV KTVPGASDLF YWPRRAGKLQ GSHHKPLSKT
210 220 230 240 250
ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS TNRRVRLKNP
260 270 280 290 300
FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL
310 320 330 340 350
ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF
360 370 380 390 400
TLCALCIDRF RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL
410 420 430 440 450
RQLSKEDLGF SGRAPAERCI IKISPDLPDT IYVLALTYDS ARLWWYFGCY
460 470 480 490 500
FCLPTLFTIT CSLVTARKIR KAEKACTRGN KRQIQLESQM NCTVVALTIL
510 520 530 540 550
YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF
560 570 580 590 600
CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR
610
REMSTFASVG THC
Length:613
Mass (Da):67,114
Last modified:January 1, 1999 - v2
Checksum:i5A1AB269ED63E765
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93G → D in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti106A → T in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti118G → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti160G → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti182W → C in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti231E → D in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti284C → S in AAB70008 (PubMed:9526070).Curated1
Sequence conflicti304A → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti329L → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti503 – 504FC → LG in AAC51281 (PubMed:9144577).Curated2
Sequence conflicti598T → A in AAC51281 (PubMed:9144577).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12476, Y12477 Genomic DNA Translation: CAA73080.1
AF017262 mRNA Translation: AAB70008.1
U87460 mRNA Translation: AAC51281.1
AF502281 mRNA Translation: AAM18625.2
AC004925 Genomic DNA Translation: AAD08853.1
CH236947 Genomic DNA Translation: EAL24325.1
CH471070 Genomic DNA Translation: EAW83613.1
BC040007 mRNA Translation: AAH40007.1
CCDSiCCDS5792.1
PIRiJC5501
RefSeqiNP_005293.1, NM_005302.3
UniGeneiHs.406094
Hs.731392

Genome annotation databases

EnsembliENST00000303921; ENSP00000306449; ENSG00000170775
GeneIDi2861
KEGGihsa:2861
UCSCiuc003vli.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12476, Y12477 Genomic DNA Translation: CAA73080.1
AF017262 mRNA Translation: AAB70008.1
U87460 mRNA Translation: AAC51281.1
AF502281 mRNA Translation: AAM18625.2
AC004925 Genomic DNA Translation: AAD08853.1
CH236947 Genomic DNA Translation: EAL24325.1
CH471070 Genomic DNA Translation: EAW83613.1
BC040007 mRNA Translation: AAH40007.1
CCDSiCCDS5792.1
PIRiJC5501
RefSeqiNP_005293.1, NM_005302.3
UniGeneiHs.406094
Hs.731392

3D structure databases

ProteinModelPortaliO15354
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109119, 27 interactors
DIPiDIP-60954N
IntActiO15354, 1 interactor
STRINGi9606.ENSP00000306449

Chemistry databases

GuidetoPHARMACOLOGYi103

Protein family/group databases

TCDBi9.A.14.13.20 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiO15354
PhosphoSitePlusiO15354

Proteomic databases

EPDiO15354
PaxDbiO15354
PeptideAtlasiO15354
PRIDEiO15354
ProteomicsDBi48607

Protocols and materials databases

DNASUi2861
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303921; ENSP00000306449; ENSG00000170775
GeneIDi2861
KEGGihsa:2861
UCSCiuc003vli.5 human

Organism-specific databases

CTDi2861
DisGeNETi2861
EuPathDBiHostDB:ENSG00000170775.2
GeneCardsiGPR37
HGNCiHGNC:4494 GPR37
HPAiHPA042903
HPA068009
MIMi602583 gene
neXtProtiNX_O15354
OpenTargetsiENSG00000170775
PharmGKBiPA28882
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000252922
HOVERGENiHBG051808
InParanoidiO15354
KOiK04243
OMAiSDLYYWP
OrthoDBiEOG091G04SU
PhylomeDBiO15354
TreeFamiTF331292

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiO15354

Miscellaneous databases

GeneWikiiGPR37
GenomeRNAii2861
PROiPR:O15354
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170775 Expressed in 149 organ(s), highest expression level in Brodmann (1909) area 46
CleanExiHS_GPR37
GenevisibleiO15354 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003909 GPR37_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01421 GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR37_HUMAN
AccessioniPrimary (citable) accession number: O15354
Secondary accession number(s): A4D0Y6
, O00348, O14768, Q8TD39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1999
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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