UniProtKB - O15350 (P73_HUMAN)
Tumor protein p73
TP73
Functioni
Miscellaneous
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 194 | ZincBy similarity | 1 | |
Metal bindingi | 197 | ZincBy similarity | 1 | |
Metal bindingi | 258 | ZincBy similarity | 1 | |
Metal bindingi | 262 | ZincBy similarity | 1 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- identical protein binding Source: UniProtKB
- MDM2/MDM4 family protein binding Source: CAFA
- metal ion binding Source: UniProtKB-KW
- p53 binding Source: CAFA
- protein kinase binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- transcription factor binding Source: ParkinsonsUK-UCL
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- activation of MAPK activity Source: Ensembl
- cell cycle arrest Source: InterPro
- cellular response to DNA damage stimulus Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage Source: ProtInc
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
- kidney development Source: Ensembl
- mismatch repair Source: ProtInc
- negative regulation of cardiac muscle cell proliferation Source: MGI
- negative regulation of cell population proliferation Source: AgBase
- negative regulation of neuron differentiation Source: Ensembl
- positive regulation of cell cycle arrest Source: ParkinsonsUK-UCL
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein tetramerization Source: InterPro
- regulation of apoptotic process Source: Reactome
- regulation of gene expression Source: MGI
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle Source: MGI
- regulation of signal transduction by p53 class mediator Source: Reactome
- response to drug Source: Ensembl
- response to organonitrogen compound Source: Ensembl
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Apoptosis, Cell cycle, Host-virus interaction, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O15350 |
Reactomei | R-HSA-139915, Activation of PUMA and translocation to mitochondria R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | O15350 |
SIGNORi | O15350 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein p73Alternative name(s): p53-like transcription factor p53-related protein |
Gene namesi | Name:TP73 Synonyms:P73 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000078900.14 |
HGNCi | HGNC:12003, TP73 |
MIMi | 601990, gene |
neXtProti | NX_O15350 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: HPA
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: AgBase
Other locations
- cell junction Source: HPA
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 27 | T → A: Impaired phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 99 | Y → F: Impaired phosphorylation of isoform beta by ABL1. 1 Publication | 1 | |
Mutagenesisi | 487 | Y → A: Loss of interaction with WWOX. 1 Publication | 1 | |
Mutagenesisi | 627 | K → R: Strongly diminishes sumoylation but does not affect transcriptional activity. 1 Publication | 1 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 7161 |
MalaCardsi | TP73 |
OpenTargetsi | ENSG00000078900 |
Orphaneti | 70573, Small cell lung cancer |
PharmGKBi | PA36684 |
Miscellaneous databases
Pharosi | O15350, Tbio |
Chemistry databases
DrugBanki | DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Polymorphism and mutation databases
BioMutai | TP73 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185728 | 1 – 636 | Tumor protein p73Add BLAST | 636 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | Phosphothreonine; by PLK12 Publications | 1 | |
Modified residuei | 28 | Phosphotyrosine; by SRC and HCK1 Publication | 1 | |
Modified residuei | 99 | Phosphotyrosine; by ABL11 Publication | 1 | |
Cross-linki | 627 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); in isoform Alpha1 Publication | ||
Cross-linki | 627 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O15350 |
MassIVEi | O15350 |
MaxQBi | O15350 |
PaxDbi | O15350 |
PeptideAtlasi | O15350 |
PRIDEi | O15350 |
ProteomicsDBi | 48597 [O15350-1] 48598 [O15350-10] 48599 [O15350-2] 48600 [O15350-3] 48601 [O15350-4] 48602 [O15350-5] 48603 [O15350-6] 48604 [O15350-8] 48605 [O15350-9] 6877 8551 |
PTM databases
iPTMneti | O15350 |
PhosphoSitePlusi | O15350 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000078900, Expressed in right uterine tube and 94 other tissues |
ExpressionAtlasi | O15350, baseline and differential |
Genevisiblei | O15350, HS |
Organism-specific databases
HPAi | ENSG00000078900, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain.
Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX.
Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain).
Interacts with YAP1 (phosphorylated form).
Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation.
9 Publications(Microbial infection) Interacts with Epstein-Barr virus protein EBNA6; this interaction inhibits TP73-mediated apoptotic pathway.
1 PublicationBinary interactionsi
Hide detailsO15350
Isoform Alpha [O15350-1]
With | #Exp. | IntAct |
---|---|---|
CASP8AP2 [Q9UKL3] | 2 | EBI-389619,EBI-2339650 |
ITCH [Q96J02] | 5 | EBI-389619,EBI-1564678 |
YAP1 [P46937] | 7 | EBI-389619,EBI-1044059 |
E6 [P03126] from Human papillomavirus type 16. | 2 | EBI-389619,EBI-1177242 |
Isoform dN-Alpha [O15350-8]
With | #Exp. | IntAct |
---|---|---|
ITCH [Q96J02] | 2 | EBI-5651259,EBI-1564678 |
RNF144B [Q7Z419] | 2 | EBI-5651259,EBI-2129982 |
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- MDM2/MDM4 family protein binding Source: CAFA
- p53 binding Source: CAFA
- protein kinase binding Source: UniProtKB
- transcription factor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 113014, 148 interactors |
DIPi | DIP-24202N |
ELMi | O15350 |
IntActi | O15350, 35 interactors |
MINTi | O15350 |
STRINGi | 9606.ENSP00000367545 |
Miscellaneous databases
RNActi | O15350, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O15350 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15350 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 485 – 551 | SAMAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | TransactivationBy similarityAdd BLAST | 46 | |
Regioni | 131 – 310 | DNA-bindingSequence analysisAdd BLAST | 180 | |
Regioni | 345 – 386 | OligomerizationSequence analysisAdd BLAST | 42 | |
Regioni | 345 – 380 | Interaction with HIPK21 PublicationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 483 – 487 | PPxY motif | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 55 | Asp/Glu-rich (acidic)Add BLAST | 55 | |
Compositional biasi | 168 – 171 | Poly-Pro | 4 | |
Compositional biasi | 391 – 394 | Poly-Gln | 4 | |
Compositional biasi | 483 – 486 | Poly-Pro | 4 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QQ48, Eukaryota |
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_1_0_1 |
InParanoidi | O15350 |
OMAi | FQHLWSS |
PhylomeDBi | O15350 |
TreeFami | TF106101 |
Family and domain databases
CDDi | cd08367, P53, 1 hit cd09571, SAM_tumor-p73, 1 hit |
DisProti | DP00319 |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR001660, SAM IPR013761, SAM/pointed_sf IPR032646, Tp73 IPR037612, Tumour-p73_SAM |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF47769, SSF47769, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
s (12+)i Sequence
Sequence statusi: Complete.
This entry describes 12 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 12 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD
60 70 80 90 100
VFHLEGMTTS VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA
110 120 130 140 150
QPSSTFDTMS PAPVIPSNTD YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK
160 170 180 190 200
LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV YKKAEHVTDV VKRCPNHELG
210 220 230 240 250
RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY EPPQVGTEFT
260 270 280 290 300
TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
310 320 330 340 350
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG
360 370 380 390 400
DEDTYYLQVR GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS
410 420 430 440 450
HLQPPSYGPV LSPMNKVHGG MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP
460 470 480 490 500
GMLNNHGHAV PANGEMSSSH SAQSMVSGSH CTPPPPYHAD PSLVSFLTGL
510 520 530 540 550
GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT IWRGLQDLKQ
560 570 580 590 600
GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
610 620 630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH
The sequence of this isoform differs from the canonical sequence as follows:
495-636: SFLTGLGCPN...KEEFTEAEIH → RTWGP
The sequence of this isoform differs from the canonical sequence as follows:
400-476: SHLQPPSYGP...SSSHSAQSMV → PRDAQQPWPR...EHLPPAEPDH
477-636: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
400-403: SHLQ → TWGP
404-636: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
400-445: SHLQPPSYGP...PHSSAATPNL → PRDAQQPWPR...TPLPRRPQPR
446-526: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
400-495: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT
The sequence of this isoform differs from the canonical sequence as follows:
1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT
495-636: SFLTGLGCPN...KEEFTEAEIH → RTWGP
The sequence of this isoform differs from the canonical sequence as follows:
1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT
400-476: SHLQPPSYGP...SSSHSAQSMV → PRDAQQPWPR...EHLPPAEPDH
477-636: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-71: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT
400-636: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
400-526: SHLQPPSYGP...IYHLQNLTIE → PRDAQQPWPR...PLPRRPQPRQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFW9 | A0A0C4DFW9_HUMAN | Cellular tumor antigen p53 | TP73 hCG_19088 | 426 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045082 | 1 – 71 | Missing in isoform 10. 1 PublicationAdd BLAST | 71 | |
Alternative sequenceiVSP_014368 | 1 – 62 | MAQST…TTSVM → MLYVGDPARHLAT in isoform dN-Alpha, isoform dN-Beta, isoform dN-Gamma and isoform 11. 3 PublicationsAdd BLAST | 62 | |
Alternative sequenceiVSP_053809 | 400 – 636 | Missing in isoform 11. 1 PublicationAdd BLAST | 237 | |
Alternative sequenceiVSP_053810 | 400 – 526 | SHLQP…NLTIE → PRDAQQPWPRSASQRRDEQQ PQRPVHGLGVPLHSATPLPR RPQPRQ in isoform 12. CuratedAdd BLAST | 127 | |
Alternative sequenceiVSP_006546 | 400 – 495 | Missing in isoform Zeta. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_006540 | 400 – 476 | SHLQP…AQSMV → PRDAQQPWPRSASQQRRDEQ QPQRPVHGLGVPLHSATPLP RRPQPRQFFNRIGVSKLHRV FHLPRVTEHLPPAEPDH in isoform Gamma and isoform dN-Gamma. 2 PublicationsAdd BLAST | 77 | |
Alternative sequenceiVSP_006544 | 400 – 445 | SHLQP…ATPNL → PRDAQQPWPRSASQQRRDEQ QPQRPVHGLGVPLHSATPLP RRPQPR in isoform Epsilon. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_006542 | 400 – 403 | SHLQ → TWGP in isoform Delta. 1 Publication | 4 | |
Alternative sequenceiVSP_006543 | 404 – 636 | Missing in isoform Delta. 1 PublicationAdd BLAST | 233 | |
Alternative sequenceiVSP_006545 | 446 – 526 | Missing in isoform Epsilon. 1 PublicationAdd BLAST | 81 | |
Alternative sequenceiVSP_006541 | 477 – 636 | Missing in isoform Gamma and isoform dN-Gamma. 2 PublicationsAdd BLAST | 160 | |
Alternative sequenceiVSP_006539 | 495 – 636 | SFLTG…EAEIH → RTWGP in isoform Beta and isoform dN-Beta. 3 PublicationsAdd BLAST | 142 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1COK | NMR | - | A | 487-554 | [»] | |
1DXS | X-ray | 2.54 | A | 487-564 | [»] | |
2KBY | NMR | - | A/B/C/D | 351-398 | [»] | |
2MPS | NMR | - | B | 10-25 | [»] | |
2NB1 | NMR | - | B/D | 351-398 | [»] | |
2WQI | X-ray | 1.70 | A/B/C/D | 351-399 | [»] | |
2WQJ | X-ray | 2.00 | 1/2/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z | 351-383 | [»] | |
2WTT | X-ray | 2.30 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P | 351-399 | [»] | |
2XWC | X-ray | 1.82 | A | 112-311 | [»] | |
3VD0 | X-ray | 2.95 | A/B/C/D/I/J/K/L | 115-312 | [»] | |
3VD1 | X-ray | 2.95 | A/B/C/D/I/J/K/L | 115-312 | [»] | |
3VD2 | X-ray | 4.00 | A/B/C/D/I/J | 115-312 | [»] | |
4A63 | X-ray | 2.27 | A/C/E/G/I/K | 112-311 | [»] | |
4G82 | X-ray | 3.10 | A/B | 115-312 | [»] | |
4G83 | X-ray | 4.00 | A/B | 115-312 | [»] | |
4GUO | X-ray | 3.19 | A/B/C/D/I/J/K/L | 115-312 | [»] | |
4GUQ | X-ray | 3.70 | A/B | 115-312 | [»] | |
5HOB | X-ray | 1.22 | A/B/C/D/E/F/G/H | 351-398 | [»] | |
5HOC | X-ray | 1.36 | A/B | 351-398 | [»] | |
5KBD | X-ray | 2.80 | A/B | 115-312 | [»] | |
6FGS | NMR | - | A | 10-31 | [»] | |
6IJQ | NMR | - | A | 10-25 | [»] | |
SMRi | O15350 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113014, 148 interactors |
DIPi | DIP-24202N |
ELMi | O15350 |
IntActi | O15350, 35 interactors |
MINTi | O15350 |
STRINGi | 9606.ENSP00000367545 |
Chemistry databases
DrugBanki | DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
iPTMneti | O15350 |
PhosphoSitePlusi | O15350 |
Polymorphism and mutation databases
BioMutai | TP73 |
Proteomic databases
jPOSTi | O15350 |
MassIVEi | O15350 |
MaxQBi | O15350 |
PaxDbi | O15350 |
PeptideAtlasi | O15350 |
PRIDEi | O15350 |
ProteomicsDBi | 48597 [O15350-1] 48598 [O15350-10] 48599 [O15350-2] 48600 [O15350-3] 48601 [O15350-4] 48602 [O15350-5] 48603 [O15350-6] 48604 [O15350-8] 48605 [O15350-9] 6877 8551 |
Protocols and materials databases
Antibodypediai | 3467, 1100 antibodies |
DNASUi | 7161 |
Genome annotation databases
Organism-specific databases
CTDi | 7161 |
DisGeNETi | 7161 |
EuPathDBi | HostDB:ENSG00000078900.14 |
GeneCardsi | TP73 |
HGNCi | HGNC:12003, TP73 |
HPAi | ENSG00000078900, Tissue enhanced (brain) |
MalaCardsi | TP73 |
MIMi | 601990, gene |
neXtProti | NX_O15350 |
OpenTargetsi | ENSG00000078900 |
Orphaneti | 70573, Small cell lung cancer |
PharmGKBi | PA36684 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ48, Eukaryota |
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_1_0_1 |
InParanoidi | O15350 |
OMAi | FQHLWSS |
PhylomeDBi | O15350 |
TreeFami | TF106101 |
Enzyme and pathway databases
PathwayCommonsi | O15350 |
Reactomei | R-HSA-139915, Activation of PUMA and translocation to mitochondria R-HSA-6803204, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803205, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | O15350 |
SIGNORi | O15350 |
Miscellaneous databases
BioGRID-ORCSi | 7161, 10 hits in 870 CRISPR screens |
ChiTaRSi | TP73, human |
EvolutionaryTracei | O15350 |
GeneWikii | P73 |
GenomeRNAii | 7161 |
Pharosi | O15350, Tbio |
PROi | PR:O15350 |
RNActi | O15350, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000078900, Expressed in right uterine tube and 94 other tissues |
ExpressionAtlasi | O15350, baseline and differential |
Genevisiblei | O15350, HS |
Family and domain databases
CDDi | cd08367, P53, 1 hit cd09571, SAM_tumor-p73, 1 hit |
DisProti | DP00319 |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR001660, SAM IPR013761, SAM/pointed_sf IPR032646, Tp73 IPR037612, Tumour-p73_SAM |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF47769, SSF47769, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P73_HUMAN | |
Accessioni | O15350Primary (citable) accession number: O15350 Secondary accession number(s): B7Z7J4 Q9NTK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 229 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM