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UniProtKB - O15350 (P73_HUMAN)

Protein

Tumor protein p73

Gene

TP73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.3 Publications

Miscellaneous

Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.
Activated and stabilized by interaction with RANBP9.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi194ZincBy similarity1
Metal bindingi197ZincBy similarity1
Metal bindingi258ZincBy similarity1
Metal bindingi262ZincBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Cell cycle, Host-virus interaction, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-139915 Activation of PUMA and translocation to mitochondria
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiO15350
SIGNORiO15350

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p73
Alternative name(s):
p53-like transcription factor
p53-related protein
Gene namesi
Name:TP73
Synonyms:P73
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000078900.14
HGNCiHGNC:12003 TP73
MIMi601990 gene
neXtProtiNX_O15350

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27T → A: Impaired phosphorylation. 1 Publication1
Mutagenesisi99Y → F: Impaired phosphorylation of isoform beta by ABL1. 1 Publication1
Mutagenesisi487Y → A: Loss of interaction with WWOX. 1 Publication1
Mutagenesisi627K → R: Strongly diminishes sumoylation but does not affect transcriptional activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi7161
MalaCardsiTP73
OpenTargetsiENSG00000078900
Orphaneti70573 Small cell lung cancer
PharmGKBiPA36684

Polymorphism and mutation databases

BioMutaiTP73

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857281 – 636Tumor protein p73Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Phosphothreonine; by PLK12 Publications1
Modified residuei28Phosphotyrosine; by SRC and HCK1 Publication1
Modified residuei99Phosphotyrosine; by ABL11 Publication1
Cross-linki627Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); in isoform Alpha1 Publication
Cross-linki627Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.1 Publication
Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO15350
PaxDbiO15350
PeptideAtlasiO15350
PRIDEiO15350
ProteomicsDBi48597
48598 [O15350-10]
48599 [O15350-2]
48600 [O15350-3]
48601 [O15350-4]
48602 [O15350-5]
48603 [O15350-6]
48604 [O15350-8]
48605 [O15350-9]

PTM databases

iPTMnetiO15350
PhosphoSitePlusiO15350

Miscellaneous databases

PMAP-CutDBiO15350

Expressioni

Tissue specificityi

Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.2 Publications

Inductioni

Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction.1 Publication

Gene expression databases

BgeeiENSG00000078900 Expressed in 82 organ(s), highest expression level in right uterine tube
ExpressionAtlasiO15350 baseline and differential
GenevisibleiO15350 HS

Organism-specific databases

HPAiCAB002514
CAB003022
HPA027314
HPA044516

Interactioni

Subunit structurei

Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation.9 Publications
(Microbial infection) Interacts with Epstein-Barr virus protein EBNA6; this interaction inhibits TP73-mediated apoptotic pathway.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi113014, 130 interactors
DIPiDIP-24202N
ELMiO15350
IntActiO15350, 30 interactors
MINTiO15350
STRINGi9606.ENSP00000367545

Structurei

Secondary structure

1636
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00319
ProteinModelPortaliO15350
SMRiO15350
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15350

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini485 – 551SAMAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 46TransactivationBy similarityAdd BLAST46
Regioni131 – 310DNA-bindingSequence analysisAdd BLAST180
Regioni345 – 386OligomerizationSequence analysisAdd BLAST42
Regioni345 – 380Interaction with HIPK21 PublicationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi483 – 487PPxY motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 55Asp/Glu-rich (acidic)Add BLAST55
Compositional biasi168 – 171Poly-Pro4
Compositional biasi391 – 394Poly-Gln4
Compositional biasi483 – 486Poly-Pro4

Domaini

Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL1 tyrosine kinase SH3 domain.1 Publication
The PPxY motif mediates interaction with WWOX.1 Publication

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

eggNOGiENOG410IGE4 Eukaryota
ENOG410XV9W LUCA
GeneTreeiENSGT00390000015092
HOGENOMiHOG000039956
HOVERGENiHBG005201
InParanoidiO15350
KOiK10148
OMAiIWRGLQE
OrthoDBiEOG091G0XY5
PhylomeDBiO15350
TreeFamiTF106101

Family and domain databases

CDDicd08367 P53, 1 hit
cd09571 SAM_tumor-p73, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032646 Tp73
IPR037612 Tumour-p73_SAM
PANTHERiPTHR11447 PTHR11447, 1 hit
PTHR11447:SF21 PTHR11447:SF21, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47719 SSF47719, 1 hit
SSF47769 SSF47769, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequences (12+)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Alpha (identifier: O15350-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD 
        60         70         80         90        100
VFHLEGMTTS VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA 
       110        120        130        140        150
QPSSTFDTMS PAPVIPSNTD YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK 
       160        170        180        190        200
LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV YKKAEHVTDV VKRCPNHELG 
       210        220        230        240        250
RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY EPPQVGTEFT 
       260        270        280        290        300
TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR 
       310        320        330        340        350
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG 
       360        370        380        390        400
DEDTYYLQVR GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS 
       410        420        430        440        450
HLQPPSYGPV LSPMNKVHGG MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP 
       460        470        480        490        500
GMLNNHGHAV PANGEMSSSH SAQSMVSGSH CTPPPPYHAD PSLVSFLTGL 
       510        520        530        540        550
GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT IWRGLQDLKQ 
       560        570        580        590        600
GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG 
       610        620        630 
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH
Length:636
Mass (Da):69,623
Last modified:January 1, 1998 - v1
Checksum:iA467493C5D93EEE0
GO
Isoform Beta (identifier: O15350-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-636: SFLTGLGCPN...KEEFTEAEIH → RTWGP

Note: Produced by alternative splicing of isoform Alpha.
Show »
Length:499
Mass (Da):54,322
Checksum:i0FDC0546E29D683E
GO
Isoform Gamma (identifier: O15350-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-476: SHLQPPSYGP...SSSHSAQSMV → PRDAQQPWPR...EHLPPAEPDH
     477-636: Missing.

Note: Produced by alternative splicing of isoform Alpha. The splicing of exon 11 results in a frameshift from the original reading frame.
Show »
Length:476
Mass (Da):53,026
Checksum:i78D99E725DCEFD5F
GO
Isoform Delta (identifier: O15350-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-403: SHLQ → TWGP
     404-636: Missing.

Note: Produced by alternative splicing of isoform Alpha.
Show »
Length:403
Mass (Da):44,517
Checksum:i72F1A3518940D832
GO
Isoform Epsilon (identifier: O15350-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-445: SHLQPPSYGP...PHSSAATPNL → PRDAQQPWPR...TPLPRRPQPR
     446-526: Missing.

Note: Produced by alternative splicing of isoform Alpha. The splicing of exon 11 results in a frameshift from the original reading frame. The splicing of exon 13 reverts the reading frame to the sequence of isoform Alpha.
Show »
Length:555
Mass (Da):61,694
Checksum:i4C821E6FB836EC32
GO
Isoform Zeta (identifier: O15350-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-495: Missing.

Note: Produced by alternative splicing of isoform Alpha.
Show »
Length:540
Mass (Da):59,887
Checksum:iA996F9FEB731ABD1
GO
Isoform dN-Alpha (identifier: O15350-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT

Note: Produced by alternative promoter usage.
Show »
Length:587
Mass (Da):64,422
Checksum:iE8F1CAE88CED4EBC
GO
Isoform dN-Beta (identifier: O15350-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT
     495-636: SFLTGLGCPN...KEEFTEAEIH → RTWGP

Note: Produced by alternative splicing of isoform dN-Alpha.
Show »
Length:450
Mass (Da):49,121
Checksum:iF1950AE8628B3863
GO
Isoform dN-Gamma (identifier: O15350-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT
     400-476: SHLQPPSYGP...SSSHSAQSMV → PRDAQQPWPR...EHLPPAEPDH
     477-636: Missing.

Note: Produced by alternative splicing of isoform dN-Alpha.
Show »
Length:427
Mass (Da):47,824
Checksum:i9D140E5D48BFB56E
GO
Isoform 10 (identifier: O15350-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Note: No experimental confirmation available.
Show »
Length:565
Mass (Da):62,034
Checksum:i3D989435C093E515
GO
Isoform 11 (identifier: O15350-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVM → MLYVGDPARHLAT
     400-636: Missing.

Show »
Length:350
Mass (Da):38,874
Checksum:i4BA732383EFE92A0
GO
Isoform 12 (identifier: O15350-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-526: SHLQPPSYGP...IYHLQNLTIE → PRDAQQPWPR...PLPRRPQPRQ

Note: No experimental confirmation available.
Show »
Length:555
Mass (Da):61,694
Checksum:i40CC002014B124C7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFW9A0A0C4DFW9_HUMAN
Cellular tumor antigen p53
TP73 hCG_19088
426Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450821 – 71Missing in isoform 10. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0143681 – 62MAQST…TTSVM → MLYVGDPARHLAT in isoform dN-Alpha, isoform dN-Beta, isoform dN-Gamma and isoform 11. 3 PublicationsAdd BLAST62
Alternative sequenceiVSP_053809400 – 636Missing in isoform 11. 1 PublicationAdd BLAST237
Alternative sequenceiVSP_053810400 – 526SHLQP…NLTIE → PRDAQQPWPRSASQRRDEQQ PQRPVHGLGVPLHSATPLPR RPQPRQ in isoform 12. CuratedAdd BLAST127
Alternative sequenceiVSP_006546400 – 495Missing in isoform Zeta. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_006540400 – 476SHLQP…AQSMV → PRDAQQPWPRSASQQRRDEQ QPQRPVHGLGVPLHSATPLP RRPQPRQFFNRIGVSKLHRV FHLPRVTEHLPPAEPDH in isoform Gamma and isoform dN-Gamma. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_006544400 – 445SHLQP…ATPNL → PRDAQQPWPRSASQQRRDEQ QPQRPVHGLGVPLHSATPLP RRPQPR in isoform Epsilon. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_006542400 – 403SHLQ → TWGP in isoform Delta. 1 Publication4
Alternative sequenceiVSP_006543404 – 636Missing in isoform Delta. 1 PublicationAdd BLAST233
Alternative sequenceiVSP_006545446 – 526Missing in isoform Epsilon. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_006541477 – 636Missing in isoform Gamma and isoform dN-Gamma. 2 PublicationsAdd BLAST160
Alternative sequenceiVSP_006539495 – 636SFLTG…EAEIH → RTWGP in isoform Beta and isoform dN-Beta. 3 PublicationsAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11416 mRNA Translation: CAA72220.1
Y11416 mRNA Translation: CAA72221.1
Y11416 mRNA Translation: CAA72219.1
AF079094
, AF079082, AF079083, AF079084, AF079085, AF079086, AF079087, AF079088, AF079089, AF079090, AF079091, AF079092, AF079093 Genomic DNA Translation: AAD39696.1
AF077628
, AF077616, AF077617, AF077618, AF077619, AF077620, AF077621, AF077624, AF077625, AF077626, AF077627 Genomic DNA Translation: AAC61887.1
AY040827 mRNA Translation: AAK81884.1
AY040828 mRNA Translation: AAK81885.1
AY040829 mRNA Translation: AAK81886.1
AB055065 mRNA Translation: BAB87244.1
AB055066 mRNA Translation: BAB87245.1
AK302118 mRNA Translation: BAH13630.1
AK304177 mRNA Translation: BAH14127.1
AK304784 mRNA Translation: BAH14257.1
AL136528 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71464.1
BC117251 mRNA Translation: AAI17252.1
BC117253 mRNA Translation: AAI17254.1
CCDSiCCDS44049.1 [O15350-8]
CCDS44050.1 [O15350-9]
CCDS49.1 [O15350-1]
CCDS55566.1 [O15350-2]
CCDS55567.1 [O15350-13]
CCDS55568.1 [O15350-6]
CCDS55569.1 [O15350-11]
CCDS59965.1 [O15350-4]
RefSeqiNP_001119712.1, NM_001126240.2 [O15350-8]
NP_001119713.1, NM_001126241.2 [O15350-9]
NP_001119714.1, NM_001126242.2
NP_001191113.1, NM_001204184.1 [O15350-2]
NP_001191114.1, NM_001204185.1
NP_001191115.1, NM_001204186.1 [O15350-4]
NP_001191116.1, NM_001204187.1 [O15350-13]
NP_001191117.1, NM_001204188.1 [O15350-6]
NP_001191118.1, NM_001204189.1
NP_001191119.1, NM_001204190.1
NP_001191120.1, NM_001204191.1
NP_001191121.1, NM_001204192.1 [O15350-11]
NP_005418.1, NM_005427.3 [O15350-1]
UniGeneiHs.192132

Genome annotation databases

EnsembliENST00000346387; ENSP00000340740; ENSG00000078900 [O15350-6]
ENST00000354437; ENSP00000346423; ENSG00000078900 [O15350-2]
ENST00000357733; ENSP00000350366; ENSG00000078900 [O15350-13]
ENST00000378285; ENSP00000367534; ENSG00000078900 [O15350-9]
ENST00000378288; ENSP00000367537; ENSG00000078900 [O15350-8]
ENST00000378290; ENSP00000367539; ENSG00000078900 [O15350-11]
ENST00000378295; ENSP00000367545; ENSG00000078900 [O15350-1]
ENST00000603362; ENSP00000474626; ENSG00000078900 [O15350-13]
ENST00000604074; ENSP00000475143; ENSG00000078900 [O15350-4]
ENST00000604479; ENSP00000474322; ENSG00000078900 [O15350-6]
GeneIDi7161
KEGGihsa:7161
UCSCiuc001akp.4 human [O15350-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11416 mRNA Translation: CAA72220.1
Y11416 mRNA Translation: CAA72221.1
Y11416 mRNA Translation: CAA72219.1
AF079094
, AF079082, AF079083, AF079084, AF079085, AF079086, AF079087, AF079088, AF079089, AF079090, AF079091, AF079092, AF079093 Genomic DNA Translation: AAD39696.1
AF077628
, AF077616, AF077617, AF077618, AF077619, AF077620, AF077621, AF077624, AF077625, AF077626, AF077627 Genomic DNA Translation: AAC61887.1
AY040827 mRNA Translation: AAK81884.1
AY040828 mRNA Translation: AAK81885.1
AY040829 mRNA Translation: AAK81886.1
AB055065 mRNA Translation: BAB87244.1
AB055066 mRNA Translation: BAB87245.1
AK302118 mRNA Translation: BAH13630.1
AK304177 mRNA Translation: BAH14127.1
AK304784 mRNA Translation: BAH14257.1
AL136528 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71464.1
BC117251 mRNA Translation: AAI17252.1
BC117253 mRNA Translation: AAI17254.1
CCDSiCCDS44049.1 [O15350-8]
CCDS44050.1 [O15350-9]
CCDS49.1 [O15350-1]
CCDS55566.1 [O15350-2]
CCDS55567.1 [O15350-13]
CCDS55568.1 [O15350-6]
CCDS55569.1 [O15350-11]
CCDS59965.1 [O15350-4]
RefSeqiNP_001119712.1, NM_001126240.2 [O15350-8]
NP_001119713.1, NM_001126241.2 [O15350-9]
NP_001119714.1, NM_001126242.2
NP_001191113.1, NM_001204184.1 [O15350-2]
NP_001191114.1, NM_001204185.1
NP_001191115.1, NM_001204186.1 [O15350-4]
NP_001191116.1, NM_001204187.1 [O15350-13]
NP_001191117.1, NM_001204188.1 [O15350-6]
NP_001191118.1, NM_001204189.1
NP_001191119.1, NM_001204190.1
NP_001191120.1, NM_001204191.1
NP_001191121.1, NM_001204192.1 [O15350-11]
NP_005418.1, NM_005427.3 [O15350-1]
UniGeneiHs.192132

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1COKNMR-A487-554[»]
1DXSX-ray2.54A487-564[»]
2KBYNMR-A/B/C/D351-398[»]
2MPSNMR-B10-25[»]
2NB1NMR-B/D351-398[»]
2WQIX-ray1.70A/B/C/D351-399[»]
2WQJX-ray2.001/2/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z351-383[»]
2WTTX-ray2.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P351-399[»]
2XWCX-ray1.82A112-311[»]
3VD0X-ray2.95A/B/C/D/I/J/K/L115-312[»]
3VD1X-ray2.95A/B/C/D/I/J/K/L115-312[»]
3VD2X-ray4.00A/B/C/D/I/J115-312[»]
4A63X-ray2.27A/C/E/G/I/K112-311[»]
4G82X-ray3.10A/B115-312[»]
4G83X-ray4.00A/B115-312[»]
4GUOX-ray3.19A/B/C/D/I/J/K/L115-312[»]
4GUQX-ray3.70A/B115-312[»]
5HOBX-ray1.22A/B/C/D/E/F/G/H351-398[»]
5HOCX-ray1.36A/B351-398[»]
5KBDX-ray2.80A/B115-312[»]
6FGSNMR-A10-31[»]
DisProtiDP00319
ProteinModelPortaliO15350
SMRiO15350
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113014, 130 interactors
DIPiDIP-24202N
ELMiO15350
IntActiO15350, 30 interactors
MINTiO15350
STRINGi9606.ENSP00000367545

PTM databases

iPTMnetiO15350
PhosphoSitePlusiO15350

Polymorphism and mutation databases

BioMutaiTP73

Proteomic databases

MaxQBiO15350
PaxDbiO15350
PeptideAtlasiO15350
PRIDEiO15350
ProteomicsDBi48597
48598 [O15350-10]
48599 [O15350-2]
48600 [O15350-3]
48601 [O15350-4]
48602 [O15350-5]
48603 [O15350-6]
48604 [O15350-8]
48605 [O15350-9]

Protocols and materials databases

DNASUi7161
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346387; ENSP00000340740; ENSG00000078900 [O15350-6]
ENST00000354437; ENSP00000346423; ENSG00000078900 [O15350-2]
ENST00000357733; ENSP00000350366; ENSG00000078900 [O15350-13]
ENST00000378285; ENSP00000367534; ENSG00000078900 [O15350-9]
ENST00000378288; ENSP00000367537; ENSG00000078900 [O15350-8]
ENST00000378290; ENSP00000367539; ENSG00000078900 [O15350-11]
ENST00000378295; ENSP00000367545; ENSG00000078900 [O15350-1]
ENST00000603362; ENSP00000474626; ENSG00000078900 [O15350-13]
ENST00000604074; ENSP00000475143; ENSG00000078900 [O15350-4]
ENST00000604479; ENSP00000474322; ENSG00000078900 [O15350-6]
GeneIDi7161
KEGGihsa:7161
UCSCiuc001akp.4 human [O15350-1]

Organism-specific databases

CTDi7161
DisGeNETi7161
EuPathDBiHostDB:ENSG00000078900.14
GeneCardsiTP73
HGNCiHGNC:12003 TP73
HPAiCAB002514
CAB003022
HPA027314
HPA044516
MalaCardsiTP73
MIMi601990 gene
neXtProtiNX_O15350
OpenTargetsiENSG00000078900
Orphaneti70573 Small cell lung cancer
PharmGKBiPA36684
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGE4 Eukaryota
ENOG410XV9W LUCA
GeneTreeiENSGT00390000015092
HOGENOMiHOG000039956
HOVERGENiHBG005201
InParanoidiO15350
KOiK10148
OMAiIWRGLQE
OrthoDBiEOG091G0XY5
PhylomeDBiO15350
TreeFamiTF106101

Enzyme and pathway databases

ReactomeiR-HSA-139915 Activation of PUMA and translocation to mitochondria
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiO15350
SIGNORiO15350

Miscellaneous databases

ChiTaRSiTP73 human
EvolutionaryTraceiO15350
GeneWikiiP73
GenomeRNAii7161
PMAP-CutDBiO15350
PROiPR:O15350
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078900 Expressed in 82 organ(s), highest expression level in right uterine tube
ExpressionAtlasiO15350 baseline and differential
GenevisibleiO15350 HS

Family and domain databases

CDDicd08367 P53, 1 hit
cd09571 SAM_tumor-p73, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032646 Tp73
IPR037612 Tumour-p73_SAM
PANTHERiPTHR11447 PTHR11447, 1 hit
PTHR11447:SF21 PTHR11447:SF21, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47719 SSF47719, 1 hit
SSF47769 SSF47769, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP73_HUMAN
AccessioniPrimary (citable) accession number: O15350
Secondary accession number(s): B7Z7J4
, B7Z8Z1, B7Z9C1, C9J521, O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 212 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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