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Protein

V-type proton ATPase subunit e 1

Gene

ATP6V0E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  • ATPase coupled ion transmembrane transporter activity Source: UniProtKB
  • proton-transporting ATPase activity, rotational mechanism Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS03712-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport
SIGNORiO15342

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit e 1
Short name:
V-ATPase subunit e 1
Alternative name(s):
V-ATPase 9.2 kDa membrane accessory protein
V-ATPase M9.2 subunit
Vacuolar proton pump subunit e 1
Gene namesi
Name:ATP6V0E1
Synonyms:ATP6H, ATP6V0E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113732.8
HGNCiHGNC:863 ATP6V0E1
MIMi603931 gene
neXtProtiNX_O15342

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113732
PharmGKBiPA25151

Polymorphism and mutation databases

BioMutaiATP6V0E1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717401 – 81V-type proton ATPase subunit e 1Add BLAST81

Proteomic databases

PaxDbiO15342
PRIDEiO15342
ProteomicsDBi48593
TopDownProteomicsiO15342

PTM databases

GlyConnecti1899

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000113732 Expressed in 234 organ(s), highest expression level in endometrium
CleanExiHS_ATP6V0E1
ExpressionAtlasiO15342 baseline and differential
GenevisibleiO15342 HS

Interactioni

Subunit structurei

Composed of at least 10 subunits.

Protein-protein interaction databases

BioGridi114473, 11 interactors
IntActiO15342, 15 interactors
STRINGi9606.ENSP00000427941

Structurei

3D structure databases

ProteinModelPortaliO15342
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase e1/e2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3500 Eukaryota
ENOG41121M0 LUCA
GeneTreeiENSGT00390000000728
HOGENOMiHOG000265078
HOVERGENiHBG003974
InParanoidiO15342
KOiK02153
OMAiTAVCCWM
OrthoDBiEOG091G113P
PhylomeDBiO15342
TreeFamiTF300290

Family and domain databases

InterProiView protein in InterPro
IPR008389 ATPase_V0-cplx_e1/e2_su
IPR017385 ATPase_V0-cplx_e1/e2_su_met
PANTHERiPTHR12263 PTHR12263, 1 hit
PfamiView protein in Pfam
PF05493 ATP_synt_H, 1 hit
PIRSFiPIRSF038097 V-ATP_synth_e1/e2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O15342-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYHGLTVPL IVMSVFWGFV GFLVPWFIPK GPNRGVIITM LVTCSVCCYL
60 70 80
FWLIAILAQL NPLFGPQLKN ETIWYLKYHW P
Length:81
Mass (Da):9,374
Last modified:January 23, 2007 - v2
Checksum:i9A47F16FDD2B2027
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHL5E5RHL5_HUMAN
V-type proton ATPase subunit e 1
ATP6V0E1
58Annotation score:
J3KN48J3KN48_HUMAN
V-type proton ATPase subunit e 1
ATP6V0E1
65Annotation score:

Sequence cautioni

The sequence CAA75571 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15286 mRNA Translation: CAA75571.1 Different initiation.
CR456856 mRNA Translation: CAG33137.1
CR542131 mRNA Translation: CAG46928.1
AK312068 mRNA Translation: BAG35004.1
CH471062 Genomic DNA Translation: EAW61417.1
CH471062 Genomic DNA Translation: EAW61418.1
BC119714 mRNA Translation: AAI19715.1
BC119715 mRNA Translation: AAI19716.1
CCDSiCCDS4383.1
RefSeqiNP_003936.1, NM_003945.3
UniGeneiHs.484188

Genome annotation databases

EnsembliENST00000517669; ENSP00000427941; ENSG00000113732
ENST00000519374; ENSP00000429690; ENSG00000113732
GeneIDi8992
KEGGihsa:8992
UCSCiuc003mcd.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15286 mRNA Translation: CAA75571.1 Different initiation.
CR456856 mRNA Translation: CAG33137.1
CR542131 mRNA Translation: CAG46928.1
AK312068 mRNA Translation: BAG35004.1
CH471062 Genomic DNA Translation: EAW61417.1
CH471062 Genomic DNA Translation: EAW61418.1
BC119714 mRNA Translation: AAI19715.1
BC119715 mRNA Translation: AAI19716.1
CCDSiCCDS4383.1
RefSeqiNP_003936.1, NM_003945.3
UniGeneiHs.484188

3D structure databases

ProteinModelPortaliO15342
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114473, 11 interactors
IntActiO15342, 15 interactors
STRINGi9606.ENSP00000427941

PTM databases

GlyConnecti1899

Polymorphism and mutation databases

BioMutaiATP6V0E1

Proteomic databases

PaxDbiO15342
PRIDEiO15342
ProteomicsDBi48593
TopDownProteomicsiO15342

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000517669; ENSP00000427941; ENSG00000113732
ENST00000519374; ENSP00000429690; ENSG00000113732
GeneIDi8992
KEGGihsa:8992
UCSCiuc003mcd.2 human

Organism-specific databases

CTDi8992
EuPathDBiHostDB:ENSG00000113732.8
GeneCardsiATP6V0E1
HGNCiHGNC:863 ATP6V0E1
MIMi603931 gene
neXtProtiNX_O15342
OpenTargetsiENSG00000113732
PharmGKBiPA25151
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3500 Eukaryota
ENOG41121M0 LUCA
GeneTreeiENSGT00390000000728
HOGENOMiHOG000265078
HOVERGENiHBG003974
InParanoidiO15342
KOiK02153
OMAiTAVCCWM
OrthoDBiEOG091G113P
PhylomeDBiO15342
TreeFamiTF300290

Enzyme and pathway databases

BioCyciMetaCyc:HS03712-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport
SIGNORiO15342

Miscellaneous databases

ChiTaRSiATP6V0E1 human
GeneWikiiATP6V0E1
GenomeRNAii8992
PROiPR:O15342
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113732 Expressed in 234 organ(s), highest expression level in endometrium
CleanExiHS_ATP6V0E1
ExpressionAtlasiO15342 baseline and differential
GenevisibleiO15342 HS

Family and domain databases

InterProiView protein in InterPro
IPR008389 ATPase_V0-cplx_e1/e2_su
IPR017385 ATPase_V0-cplx_e1/e2_su_met
PANTHERiPTHR12263 PTHR12263, 1 hit
PfamiView protein in Pfam
PF05493 ATP_synt_H, 1 hit
PIRSFiPIRSF038097 V-ATP_synth_e1/e2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVA0E1_HUMAN
AccessioniPrimary (citable) accession number: O15342
Secondary accession number(s): B2R557, D3DQM1, Q6IBE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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