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Protein

Chondroadherin

Gene

CHAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin
Alternative name(s):
Cartilage leucine-rich protein
Gene namesi
Name:CHAD
Synonyms:SLRR4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136457.9
HGNCiHGNC:1909 CHAD
MIMi602178 gene
neXtProtiNX_O15335

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1101
OpenTargetsiENSG00000136457
PharmGKBiPA26445

Polymorphism and mutation databases

BioMutaiCHAD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003277323 – 359ChondroadherinAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 38By similarity
Glycosylationi144O-linked (GalNAc...) serineSequence analysis1
Disulfide bondi304 ↔ 346By similarity
Disulfide bondi306 ↔ 326By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15335
PeptideAtlasiO15335
PRIDEiO15335
ProteomicsDBi48592

PTM databases

PhosphoSitePlusiO15335

Expressioni

Tissue specificityi

Present in chondrocytes at all ages.

Gene expression databases

BgeeiENSG00000136457 Expressed in 132 organ(s), highest expression level in tibia
CleanExiHS_CHAD
ExpressionAtlasiO15335 baseline and differential
GenevisibleiO15335 HS

Organism-specific databases

HPAiHPA018241

Interactioni

Subunit structurei

Mostly monomeric (By similarity). Interacts with collagen type II.By similarity

Protein-protein interaction databases

BioGridi107526, 3 interactors
CORUMiO15335
STRINGi9606.ENSP00000258969

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO15335
SMRiO15335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 52LRRNTAdd BLAST30
Repeati76 – 97LRR 1Add BLAST22
Repeati100 – 121LRR 2Add BLAST22
Repeati124 – 145LRR 3Add BLAST22
Repeati148 – 169LRR 4Add BLAST22
Repeati172 – 193LRR 5Add BLAST22
Repeati196 – 217LRR 6Add BLAST22
Repeati220 – 241LRR 7Add BLAST22
Repeati245 – 266LRR 8Add BLAST22
Repeati269 – 290LRR 9Add BLAST22
Domaini300 – 348LRRCTAdd BLAST49

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000013150
HOVERGENiHBG005324
InParanoidiO15335
KOiK06248
OMAiAFRGCKF
OrthoDBiEOG091G0AYL
PhylomeDBiO15335
TreeFamiTF332659

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

O15335-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS
60 70 80 90 100
EKTKLLNLQR NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ
110 120 130 140 150
LIYLYLSHND IRVLRAGAFD DLTELTYLYL DHNKVTELPR GLLSPLVNLF
160 170 180 190 200
ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE NALSSLQPGA LDDVENLAKF
210 220 230 240 250
HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ SFGRYLETLW
260 270 280 290 300
LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN
310 320 330 340 350
PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT

KRSKKAGRH
Length:359
Mass (Da):40,476
Last modified:February 20, 2007 - v2
Checksum:iCF24D2B5A5DFCF0C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA03H0YA03_HUMAN
Chondroadherin
CHAD
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114L → V in AAC13410 (PubMed:9344663).Curated1
Sequence conflicti166A → P in AAC13410 (PubMed:9344663).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052019312R → Q. Corresponds to variant dbSNP:rs35218093Ensembl.1
Natural variantiVAR_030631350T → I. Corresponds to variant dbSNP:rs2231510Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96769, U96767, U96768 Genomic DNA Translation: AAC13410.1
AF371328 mRNA Translation: AAK51556.1
AK292177 mRNA Translation: BAF84866.1
CH471109 Genomic DNA Translation: EAW94613.1
BC036360 mRNA Translation: AAH36360.1
BC073974 mRNA Translation: AAH73974.1
CCDSiCCDS11568.1
RefSeqiNP_001258.2, NM_001267.2
UniGeneiHs.97220

Genome annotation databases

EnsembliENST00000258969; ENSP00000258969; ENSG00000136457
ENST00000508540; ENSP00000423812; ENSG00000136457
GeneIDi1101
KEGGihsa:1101
UCSCiuc010dbr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96769, U96767, U96768 Genomic DNA Translation: AAC13410.1
AF371328 mRNA Translation: AAK51556.1
AK292177 mRNA Translation: BAF84866.1
CH471109 Genomic DNA Translation: EAW94613.1
BC036360 mRNA Translation: AAH36360.1
BC073974 mRNA Translation: AAH73974.1
CCDSiCCDS11568.1
RefSeqiNP_001258.2, NM_001267.2
UniGeneiHs.97220

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LFNX-ray2.10A/B/C/D23-359[»]
5MX1X-ray2.17A/B20-359[»]
ProteinModelPortaliO15335
SMRiO15335
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107526, 3 interactors
CORUMiO15335
STRINGi9606.ENSP00000258969

PTM databases

PhosphoSitePlusiO15335

Polymorphism and mutation databases

BioMutaiCHAD

Proteomic databases

PaxDbiO15335
PeptideAtlasiO15335
PRIDEiO15335
ProteomicsDBi48592

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258969; ENSP00000258969; ENSG00000136457
ENST00000508540; ENSP00000423812; ENSG00000136457
GeneIDi1101
KEGGihsa:1101
UCSCiuc010dbr.4 human

Organism-specific databases

CTDi1101
DisGeNETi1101
EuPathDBiHostDB:ENSG00000136457.9
GeneCardsiCHAD
HGNCiHGNC:1909 CHAD
HPAiHPA018241
MIMi602178 gene
neXtProtiNX_O15335
OpenTargetsiENSG00000136457
PharmGKBiPA26445
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000013150
HOVERGENiHBG005324
InParanoidiO15335
KOiK06248
OMAiAFRGCKF
OrthoDBiEOG091G0AYL
PhylomeDBiO15335
TreeFamiTF332659

Miscellaneous databases

GenomeRNAii1101
PROiPR:O15335
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136457 Expressed in 132 organ(s), highest expression level in tibia
CleanExiHS_CHAD
ExpressionAtlasiO15335 baseline and differential
GenevisibleiO15335 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCHAD_HUMAN
AccessioniPrimary (citable) accession number: O15335
Secondary accession number(s): A8K812, Q6GTU0, Q96RJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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