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Protein

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

INPP4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (Probable). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by inositol hexakisphosphate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.By similarity
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03227-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O15327

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00944

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000898

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.661 Publication)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INPP4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000109452.12

Human Gene Nomenclature Database

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HGNCi
HGNC:6075 INPP4B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607494 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15327

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8821

Open Targets

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OpenTargetsi
ENSG00000109452

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29883

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
INPP4B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902351 – 924Type II inositol 3,4-bisphosphate 4-phosphataseAdd BLAST924

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15327

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15327

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15327

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15327

PeptideAtlas

More...
PeptideAtlasi
O15327

PRoteomics IDEntifications database

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PRIDEi
O15327

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48591

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
O15327

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15327

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15327

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels occurring in the skeletal muscle and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000109452 Expressed in 197 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_INPP4B

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15327 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15327 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037681
HPA037682

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114348, 3 interactors

Protein interaction database and analysis system

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IntActi
O15327, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000262992

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O15327

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 149C2Add BLAST125

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4428 Eukaryota
ENOG410YV83 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157587

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113075

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081796

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15327

KEGG Orthology (KO)

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KOi
K01109

Database of Orthologous Groups

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OrthoDBi
129165at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O15327

TreeFam database of animal gene trees

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TreeFami
TF325637

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035892 C2_domain_sf
IPR039034 INPP4

The PANTHER Classification System

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PANTHERi
PTHR12187 PTHR12187, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15327-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL
60 70 80 90 100
VAPVRDRKLN TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS
110 120 130 140 150
EYPIYEETKI KLTVYDVKDK SHDTVRTSVL PEHKDPPPEV GRSFLGYASF
160 170 180 190 200
KVGELLKSKE QLLVLSLRTS DGGKVVGTIE VSVVKMGEIE DGEADHITTD
210 220 230 240 250
VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR FPTSDNKWMR
260 270 280 290 300
IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV
310 320 330 340 350
LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ
360 370 380 390 400
VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI
410 420 430 440 450
YYSPENTAKA KEVLSNINQL QPLIATHADL LLNSASQHSP DSLKNSLKML
460 470 480 490 500
SEKTELFVHA FKDQLVRSAL LALYTARPGG ILKKPPSPKS STEESSPQDQ
510 520 530 540 550
PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD KLIERDGGSE
560 570 580 590 600
GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ
610 620 630 640 650
SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP
660 670 680 690 700
GFLQQLHTVG LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK
710 720 730 740 750
SNDVLPVITG RREHYVVEVK LPARMFESLP LQIKEGQLLH VYPVLFNVGI
760 770 780 790 800
NEQQTLAERF GDVSLQESIN QENFELLQEY YKIFMEKMPP DYISHFQEQN
810 820 830 840 850
DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT CCKSAKDRTS
860 870 880 890 900
MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF
910 920
NMLQLMAFPK YYRPPEGTYG KADT
Length:924
Mass (Da):104,738
Last modified:December 16, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57DE9D98E0168D41
GO
Isoform 2 (identifier: O15327-2) [UniParc]FASTAAdd to basket
Also known as: stubby

The sequence of this isoform differs from the canonical sequence as follows:
     125-131: VRTSVLP → IANSSRI
     132-924: Missing.

Show »
Length:131
Mass (Da):14,740
Checksum:iB194BF7E2BBCEC3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQN9E7EQN9_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
938Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJC3D6RJC3_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
817Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCZ3E9PCZ3_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
688Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PG59E9PG59_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHC0E9PHC0_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
686Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE59D6RE59_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDJ7D6RDJ7_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA10H0YA10_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9BS68Q9BS68_HUMAN
INPP4B protein
INPP4B
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9J5D6R9J5_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH72447 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti319S → A in AAB72153 (PubMed:9295334).Curated1
Sequence conflicti683A → P in AAB72153 (PubMed:9295334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023324311Y → F1 PublicationCorresponds to variant dbSNP:rs1064226Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047696125 – 131VRTSVLP → IANSSRI in isoform 2. 1 Publication7
Alternative sequenceiVSP_047697132 – 924Missing in isoform 2. 1 PublicationAdd BLAST793

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U96922 mRNA Translation: AAB72153.1
AY753912 mRNA Translation: AAV28485.1
AC093860 Genomic DNA No translation available.
AC093885 Genomic DNA No translation available.
AC108060 Genomic DNA No translation available.
AC108077 Genomic DNA No translation available.
AC138657 Genomic DNA No translation available.
AC139720 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05081.1
BC017924 mRNA Translation: AAH17924.1
BC072447 mRNA Translation: AAH72447.1 Sequence problems.
BC110918 mRNA Translation: AAI10919.1
BC133005 mRNA Translation: AAI33006.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3757.1 [O15327-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001095139.1, NM_001101669.2 [O15327-1]
NP_001317969.1, NM_001331040.1
NP_003857.2, NM_003866.3 [O15327-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.176376
Hs.531403
Hs.732573

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262992; ENSP00000262992; ENSG00000109452 [O15327-1]
ENST00000506217; ENSP00000424057; ENSG00000109452 [O15327-2]
ENST00000508116; ENSP00000423954; ENSG00000109452 [O15327-1]
ENST00000513000; ENSP00000425487; ENSG00000109452 [O15327-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8821

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8821

UCSC genome browser

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UCSCi
uc003iix.5 human [O15327-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96922 mRNA Translation: AAB72153.1
AY753912 mRNA Translation: AAV28485.1
AC093860 Genomic DNA No translation available.
AC093885 Genomic DNA No translation available.
AC108060 Genomic DNA No translation available.
AC108077 Genomic DNA No translation available.
AC138657 Genomic DNA No translation available.
AC139720 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05081.1
BC017924 mRNA Translation: AAH17924.1
BC072447 mRNA Translation: AAH72447.1 Sequence problems.
BC110918 mRNA Translation: AAI10919.1
BC133005 mRNA Translation: AAI33006.1
CCDSiCCDS3757.1 [O15327-1]
RefSeqiNP_001095139.1, NM_001101669.2 [O15327-1]
NP_001317969.1, NM_001331040.1
NP_003857.2, NM_003866.3 [O15327-1]
UniGeneiHs.176376
Hs.531403
Hs.732573

3D structure databases

ProteinModelPortaliO15327
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114348, 3 interactors
IntActiO15327, 1 interactor
STRINGi9606.ENSP00000262992

Chemistry databases

SwissLipidsiSLP:000000898

PTM databases

DEPODiO15327
iPTMnetiO15327
PhosphoSitePlusiO15327

Polymorphism and mutation databases

BioMutaiINPP4B

Proteomic databases

EPDiO15327
jPOSTiO15327
MaxQBiO15327
PaxDbiO15327
PeptideAtlasiO15327
PRIDEiO15327
ProteomicsDBi48591

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262992; ENSP00000262992; ENSG00000109452 [O15327-1]
ENST00000506217; ENSP00000424057; ENSG00000109452 [O15327-2]
ENST00000508116; ENSP00000423954; ENSG00000109452 [O15327-1]
ENST00000513000; ENSP00000425487; ENSG00000109452 [O15327-1]
GeneIDi8821
KEGGihsa:8821
UCSCiuc003iix.5 human [O15327-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8821
DisGeNETi8821
EuPathDBiHostDB:ENSG00000109452.12

GeneCards: human genes, protein and diseases

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GeneCardsi
INPP4B

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0024592
HGNCiHGNC:6075 INPP4B
HPAiHPA037681
HPA037682
MIMi607494 gene
neXtProtiNX_O15327
OpenTargetsiENSG00000109452
PharmGKBiPA29883

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4428 Eukaryota
ENOG410YV83 LUCA
GeneTreeiENSGT00940000157587
HOGENOMiHOG000113075
HOVERGENiHBG081796
InParanoidiO15327
KOiK01109
OrthoDBi129165at2759
PhylomeDBiO15327
TreeFamiTF325637

Enzyme and pathway databases

UniPathwayi
UPA00944

BioCyciMetaCyc:HS03227-MONOMER
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
SIGNORiO15327

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
INPP4B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
INPP4B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8821

Protein Ontology

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PROi
PR:O15327

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109452 Expressed in 197 organ(s), highest expression level in heart
CleanExiHS_INPP4B
ExpressionAtlasiO15327 baseline and differential
GenevisibleiO15327 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR039034 INPP4
PANTHERiPTHR12187 PTHR12187, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINP4B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15327
Secondary accession number(s): Q2TAI2
, Q5XLE7, Q6IN59, Q6PJB4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 16, 2008
Last modified: January 16, 2019
This is version 140 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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