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Protein

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

INPP4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

Catalytic activityi

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Activity regulationi

Strongly inhibited by inositol hexakisphosphate.By similarity

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS03227-MONOMER
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
SIGNORiO15327
UniPathwayi
UPA00944

Chemistry databases

SwissLipidsiSLP:000000898

Names & Taxonomyi

Protein namesi
Recommended name:
Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.66)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type II
Gene namesi
Name:INPP4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109452.12
HGNCiHGNC:6075 INPP4B
MIMi607494 gene
neXtProtiNX_O15327

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi8821
OpenTargetsiENSG00000109452
PharmGKBiPA29883

Polymorphism and mutation databases

BioMutaiINPP4B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902351 – 924Type II inositol 3,4-bisphosphate 4-phosphataseAdd BLAST924

Proteomic databases

EPDiO15327
MaxQBiO15327
PaxDbiO15327
PeptideAtlasiO15327
PRIDEiO15327
ProteomicsDBi48591

PTM databases

DEPODiO15327
iPTMnetiO15327
PhosphoSitePlusiO15327

Expressioni

Tissue specificityi

Widely expressed with highest levels occurring in the skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000109452 Expressed in 197 organ(s), highest expression level in heart
CleanExiHS_INPP4B
ExpressionAtlasiO15327 baseline and differential
GenevisibleiO15327 HS

Organism-specific databases

HPAiHPA037681
HPA037682

Interactioni

Protein-protein interaction databases

BioGridi114348, 3 interactors
IntActiO15327, 1 interactor
STRINGi9606.ENSP00000262992

Structurei

3D structure databases

ProteinModelPortaliO15327
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 149C2Add BLAST125

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4428 Eukaryota
ENOG410YV83 LUCA
GeneTreeiENSGT00390000002033
HOGENOMiHOG000113075
HOVERGENiHBG081796
InParanoidiO15327
KOiK01109
PhylomeDBiO15327
TreeFamiTF325637

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR039034 INPP4
PANTHERiPTHR12187 PTHR12187, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15327-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL
60 70 80 90 100
VAPVRDRKLN TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS
110 120 130 140 150
EYPIYEETKI KLTVYDVKDK SHDTVRTSVL PEHKDPPPEV GRSFLGYASF
160 170 180 190 200
KVGELLKSKE QLLVLSLRTS DGGKVVGTIE VSVVKMGEIE DGEADHITTD
210 220 230 240 250
VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR FPTSDNKWMR
260 270 280 290 300
IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV
310 320 330 340 350
LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ
360 370 380 390 400
VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI
410 420 430 440 450
YYSPENTAKA KEVLSNINQL QPLIATHADL LLNSASQHSP DSLKNSLKML
460 470 480 490 500
SEKTELFVHA FKDQLVRSAL LALYTARPGG ILKKPPSPKS STEESSPQDQ
510 520 530 540 550
PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD KLIERDGGSE
560 570 580 590 600
GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ
610 620 630 640 650
SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP
660 670 680 690 700
GFLQQLHTVG LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK
710 720 730 740 750
SNDVLPVITG RREHYVVEVK LPARMFESLP LQIKEGQLLH VYPVLFNVGI
760 770 780 790 800
NEQQTLAERF GDVSLQESIN QENFELLQEY YKIFMEKMPP DYISHFQEQN
810 820 830 840 850
DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT CCKSAKDRTS
860 870 880 890 900
MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF
910 920
NMLQLMAFPK YYRPPEGTYG KADT
Length:924
Mass (Da):104,738
Last modified:December 16, 2008 - v4
Checksum:i57DE9D98E0168D41
GO
Isoform 2 (identifier: O15327-2) [UniParc]FASTAAdd to basket
Also known as: stubby

The sequence of this isoform differs from the canonical sequence as follows:
     125-131: VRTSVLP → IANSSRI
     132-924: Missing.

Show »
Length:131
Mass (Da):14,740
Checksum:iB194BF7E2BBCEC3A
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQN9E7EQN9_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
938Annotation score:
D6RJC3D6RJC3_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
817Annotation score:
E9PCZ3E9PCZ3_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
688Annotation score:
E9PG59E9PG59_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
416Annotation score:
E9PHC0E9PHC0_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
686Annotation score:
D6RDJ7D6RDJ7_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
47Annotation score:
D6RE59D6RE59_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
84Annotation score:
H0YA10H0YA10_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
65Annotation score:
Q9BS68Q9BS68_HUMAN
INPP4B protein
INPP4B
53Annotation score:
D6R9J5D6R9J5_HUMAN
Type II inositol 3,4-bisphosphate 4...
INPP4B
39Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence AAH72447 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319S → A in AAB72153 (PubMed:9295334).Curated1
Sequence conflicti683A → P in AAB72153 (PubMed:9295334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023324311Y → F1 PublicationCorresponds to variant dbSNP:rs1064226Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047696125 – 131VRTSVLP → IANSSRI in isoform 2. 1 Publication7
Alternative sequenceiVSP_047697132 – 924Missing in isoform 2. 1 PublicationAdd BLAST793

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96922 mRNA Translation: AAB72153.1
AY753912 mRNA Translation: AAV28485.1
AC093860 Genomic DNA No translation available.
AC093885 Genomic DNA No translation available.
AC108060 Genomic DNA No translation available.
AC108077 Genomic DNA No translation available.
AC138657 Genomic DNA No translation available.
AC139720 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05081.1
BC017924 mRNA Translation: AAH17924.1
BC072447 mRNA Translation: AAH72447.1 Sequence problems.
BC110918 mRNA Translation: AAI10919.1
BC133005 mRNA Translation: AAI33006.1
CCDSiCCDS3757.1 [O15327-1]
RefSeqiNP_001095139.1, NM_001101669.2 [O15327-1]
NP_001317969.1, NM_001331040.1
NP_003857.2, NM_003866.3 [O15327-1]
UniGeneiHs.176376
Hs.531403
Hs.732573

Genome annotation databases

EnsembliENST00000262992; ENSP00000262992; ENSG00000109452 [O15327-1]
ENST00000506217; ENSP00000424057; ENSG00000109452 [O15327-2]
ENST00000508116; ENSP00000423954; ENSG00000109452 [O15327-1]
ENST00000513000; ENSP00000425487; ENSG00000109452 [O15327-1]
GeneIDi8821
KEGGihsa:8821
UCSCiuc003iix.5 human [O15327-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96922 mRNA Translation: AAB72153.1
AY753912 mRNA Translation: AAV28485.1
AC093860 Genomic DNA No translation available.
AC093885 Genomic DNA No translation available.
AC108060 Genomic DNA No translation available.
AC108077 Genomic DNA No translation available.
AC138657 Genomic DNA No translation available.
AC139720 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05081.1
BC017924 mRNA Translation: AAH17924.1
BC072447 mRNA Translation: AAH72447.1 Sequence problems.
BC110918 mRNA Translation: AAI10919.1
BC133005 mRNA Translation: AAI33006.1
CCDSiCCDS3757.1 [O15327-1]
RefSeqiNP_001095139.1, NM_001101669.2 [O15327-1]
NP_001317969.1, NM_001331040.1
NP_003857.2, NM_003866.3 [O15327-1]
UniGeneiHs.176376
Hs.531403
Hs.732573

3D structure databases

ProteinModelPortaliO15327
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114348, 3 interactors
IntActiO15327, 1 interactor
STRINGi9606.ENSP00000262992

Chemistry databases

SwissLipidsiSLP:000000898

PTM databases

DEPODiO15327
iPTMnetiO15327
PhosphoSitePlusiO15327

Polymorphism and mutation databases

BioMutaiINPP4B

Proteomic databases

EPDiO15327
MaxQBiO15327
PaxDbiO15327
PeptideAtlasiO15327
PRIDEiO15327
ProteomicsDBi48591

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262992; ENSP00000262992; ENSG00000109452 [O15327-1]
ENST00000506217; ENSP00000424057; ENSG00000109452 [O15327-2]
ENST00000508116; ENSP00000423954; ENSG00000109452 [O15327-1]
ENST00000513000; ENSP00000425487; ENSG00000109452 [O15327-1]
GeneIDi8821
KEGGihsa:8821
UCSCiuc003iix.5 human [O15327-1]

Organism-specific databases

CTDi8821
DisGeNETi8821
EuPathDBiHostDB:ENSG00000109452.12
GeneCardsiINPP4B
H-InvDBiHIX0024592
HGNCiHGNC:6075 INPP4B
HPAiHPA037681
HPA037682
MIMi607494 gene
neXtProtiNX_O15327
OpenTargetsiENSG00000109452
PharmGKBiPA29883
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4428 Eukaryota
ENOG410YV83 LUCA
GeneTreeiENSGT00390000002033
HOGENOMiHOG000113075
HOVERGENiHBG081796
InParanoidiO15327
KOiK01109
PhylomeDBiO15327
TreeFamiTF325637

Enzyme and pathway databases

UniPathwayi
UPA00944

BioCyciMetaCyc:HS03227-MONOMER
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
SIGNORiO15327

Miscellaneous databases

ChiTaRSiINPP4B human
GeneWikiiINPP4B
GenomeRNAii8821
PROiPR:O15327
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109452 Expressed in 197 organ(s), highest expression level in heart
CleanExiHS_INPP4B
ExpressionAtlasiO15327 baseline and differential
GenevisibleiO15327 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR039034 INPP4
PANTHERiPTHR12187 PTHR12187, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINP4B_HUMAN
AccessioniPrimary (citable) accession number: O15327
Secondary accession number(s): Q2TAI2
, Q5XLE7, Q6IN59, Q6PJB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 16, 2008
Last modified: September 12, 2018
This is version 138 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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